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All Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Majalah Farmaseutik Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Jurnal Riset Kefarmasian Indonesia Jurnal Mandala Pengabdian Masyarakat Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Komunitas Farmasi Nasional Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Prayoga, Tria
Sekolah Tinggi Ilmu Kesehatan IKIFA
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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UJI AKTIVITAS ANTIBAKTERI EKSTRAK BUNGA KECOMBRANG (Etlingera elatior (Jack) R. M.Sm.) TERHADAP BAKTERI Staphylococcus aureus Sp. Helmidanora, Rusdiati; Yullia Sukawaty; Divya Miranti; Tria Prayoga; Nia Lisnawati
Jurnal Ilmiah Manuntung Vol 10 No 1 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v10i1.769

Abstract

Kecombrang plant contains essential oils which are bioactive, including 0.0735% in the leaves. in flowers 0.0334%, in stems 0.0029% and in rhizomes 0.0021%. Combrang flowers (Etlingera elatior (Jack)) have effective antibacterial activity. The aim of this research was to determine the level of ethanol extract of kecombrang flowers from Pampang village (100-500 masl), East Kalimantan in inhibiting Staphylococcus aureus bacteria. The object studied was the inhibitory zone of kecombrang flower extract against Staphylococcus aureus bacteria. Extract preparation was carried out using the maceration method using 96% ethanol solvent, antibacterial activity testing was carried out using the well method with extract concentrations of 10%, 20%, 40%, 60% and positive control chloramphenicol and negative control DMSO. The results of this study were that 96% ethanol extract of kecombrang flowers had antibacterial activity against Staphylococcus aureus bacteria with a maximum concentration of 60% and had a medium category inhibitory power of 5.933 mm.
ANALISIS PREDIKSI EFEK ANTIINFLAMASI PADA PIPER PORPHYROPHYLLUM SECARA IN SILICO Prayoga, Tria; Rahmat, Deni; Sandhiutami, Ni Made Dwi; Desmiaty, Yesi
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 1 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.2352

Abstract

This study aims to predict the anti-inflammatory effects of compounds in Piper porphyrophyllum using in silico methods. The compounds were analyzed using AutoDock software to evaluate their binding potential with the target protein and Lipinski's rule of five to assess their drug-likeness based on pharmacokinetic properties. Qualitative results show that compounds such as 4'-hydroxy-3',5,7-trimethoxyflavone, 4',5-dihydroxy-3',7-dimethoxyflavone, and 5-hydroxy-3',4',7-trimethoxyflavone form significant interactions with key residues on the target protein. Quantitatively, these compounds exhibit more negative binding free energy compared to the natural ligand (-7.34 kcal/mol), with values of -8.35 kcal/mol, -8.13 kcal/mol, and -8.20 kcal/mol, respectively, indicating stronger binding affinity. Evaluation using Lipinski's rule shows that these compounds meet the criteria as potential drug candidates. In conclusion, this in silico method can predict the potential of Piper porphyrophyllum compounds as anti-inflammatory agents, supporting further research for experimental validation.
Co-Authors CHANDRA, PRA Deshinta Imelia Divya Miranti Efrilia, Mega Efrilia, Mega Fauziah, Sarah Fidri Setia Ningsih ika agustina Lisnawati, Nia Mega Efrilia Mekasari, Nur Mudinillah, Adam Ni Made Dwi Sandhiutami Nia Lisnawati Nur Mekasari NURUL HIDAYAH Panca Bayu Chandra, Pra Putri Eka Sari Putri Eka Sari Rahayu, Wiwit Setya Rahmat Widiyanto RAHMAT, DENI Robby, Rohima Rusdiati Helmidanora Widiyanto, Rahmat Yesi Desmiaty, Yesi Yullia Sukawaty