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Anti Acne Cream Formulation Ethanol Extract of Katuk Leaves (Sauropus androgynus (L.) Merr against Staphylococcus Epidermis and Staphylococcus Aureus Juvita Herdianty; Arif Wijayanto
Journal of Global Research in Public Health Vol. 7 No. 2 (2022): December
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/jgrph.v7i2.402

Acne is a skin problem that generally occurs during puberty. Under normal conditions, during puberty, there are Staphylococcus epidermal bacteria and Propionibacterium acnes that proliferate so that inflammation occurs, causing acne on the skin. Since ancient times, our ancestors believed in the use of natural ingredients to treat various diseases, one of which was katuk leaves. Katuk plants have secondary metabolic compounds such as alkaloids, saponins, flavonoids and tannins. The potential of Katuk leaves has been tested for many pharmacological activities, such as antibacterial, antihypertensive, anti-infective, antihyperlipidemic, antianemic and also increases milk production. Katuk leaves are often used in the form of extracts as antibacterial, so it needs to be developed into a pharmaceutical preparation to increase its use. One of the pharmaceutical preparations is cream preparations to treat the causes of acne. This study aims to determine the ability of katuk leaf extract cream to act as an antibacterial against Staphylococcus Epidermis and Staphylococcus Aureus bacteria.. The design of this study is an experimental method, making katuk leaf extract by maceration method by immersing in 70% ethanol solution for 5 days. After 5 days, the pulp and filtrate were separated and then evaporated using a Vacuum Rotary Evaporator to obtain a thick extract. The preparation of katuk leaf extract cream was carried out with a concentration of 10%, 15%, 20% and an antibacterial test was carried out using the pitting method. The antibacterial test results of the katuk leaf cream extract showed an inhibition zone marked with a clear area around the well. Katuk leaf extract cream was able to inhibit the growth of S. aureus and S. epidermis bacteria with the best concentration in formula 3, namely the concentration of katuk leaf extract of 20%.

Formulation and Physical Stability Test Preparation of Anti-Acne Gel Extract of Tebu Leaves (Saccharum officinarum (Linn) as Antibacterial Against Staphylococcus Epidermis Arif Wijayanto; Juvita Herdianty
Journal of Global Research in Public Health Vol. 7 No. 2 (2022): December
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/jgrph.v7i2.403

Increased processing of Tebu as sugar causes the resulting waste, namely the shoots of Tebu leaves. The phenolic and flavonoid compounds in Tebu are reported to have strong antioxidant, anti-inflammatory, antimutation and tyrosine inhibitor activities. Infectious diseases are diseases caused by the presence of pathogenic microbes, one of which causes infection, namely bacteria. Utilization of Tebu waste is expected to produce alternative products in the form of antibacterial preparations, especially anti-acne. Staphylococcus epidermis is one of the bacteria that causes infection on skin with acne. This study aims to determine the physical stability of the preparation Tebu leaf extract anti acne gel and its antibacterial activity against Staphylococcus Epidermis bacteria. Methods: This research design is an experimental method, making Tebu leaves extract by weighing as much as 400 grams of fine powder of Tebu leaves then put in a maceration container, closed then added 70% 2 liters of ethanol until completely submerged and stored for 24 hours protected from direct sunlight while stirring occasionally. Then filtered, separated the dregs and filtrate. The dregs were re-extracted with the same amount of new 70% ethanol for 2 days. The obtained 70% ethanol filtrate was evaporated to obtain a thick extract using a Vacuum Rotary Evaporator. Tebu leaves extract gel was made at a concentration of 5%, 10%, 15% and an antibacterial test was carried out using the well diffusion method. Results: The results of the physical stability test of the acne extract cream showed that the results met the requirements both in terms of pH, dispersion test, homogeneity. The results of the antibacterial test of Tebu leaves extract showed the presence of a zone of bacterial inhibition which was indicated by the presence of a clear area around the well. Conclusion: The results of the evaluation showed that the Tebu leaves extract gel met the requirements for the physical quality of the gel preparation, both organoleptic, pH, viscosity, adhesion, and spreadability. Tebu leaves extract gel was able to inhibit the growth of S. epidermis bacteria with the best concentration in 3rd formula, consentration 15% Tebu leaves extract gel.

Providing Educational Videos to Improve Knowledge and Attitudes Towards Anemia Prevention For Teenage Females at SMPN 4 Madiun City Yusmarisnasari; Riza Yuliawati; Amarin Yudhana; Ukik Agustina; Juvita Herdianty
Indonesian Journal of Nutritional Epidemiology and Reproductive Vol. 7 No. 3 (2024): September
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/ijner.v7i3.318

Based on the survey data on the prevalence of anemia in Indonesia by the Regional Health Research (Riskesdas) in 2018, it can be seen that children aged 15-24 years suffer from anemia by 32%. Adolescent girls are more susceptible to anemia due to the influence of a diet that does not meet balanced nutrition and the menstrual process every month. In Madiun City, based on anemia screening in grades 7 and 10 in the first quarter of 2024, the prevalence of anemia among adolescent girls was 39.67%. This shows that not all adolescent girls are aware of the dangers of anemia and efforts to prevent it. Therefore, a communication strategy is needed to prevent anemia in adolescent girls through health promotion media. This study aims to determine the effect of video media in increasing knowledge and attitudes towards preventing anemia among adolescent girls in SMPN 4 Madiun City. The design of this research is a pre-experimental one group pre-test and post-test design. The sample in this study were 7th and 8th grade students of SMPN 4 Madiun City, a total of 279 people using cluster random sampling. Data analysis in this study used the Wilcoxon test. The results of the study average score of knowledge about anemia prevention in adolescent girls with video media showed pretest (49.91), posttest (76.55) while the average score of attitude of adolescent girls showed pretest (70.75), posttest (79.59). The results of data analysis with the Wilcoxon test obtained the results of statistical tests of knowledge before and after intervention with a significance value of 0.000 <0.05 and the results of statistical tests of attitudes before and after intervention showed a significance value of 0.000 <0.05 which means that the p value of 0.000 <0.05 which means H0 is rejected, namely there are differences in knowledge and attitudes towards anemia prevention before and after providing anemia education video for adolescent girls at SMPN 4 Madiun City. Health promotion through video media is one of the communication strategies that can improve knowledge and attitudes about anemia prevention in adolescent girls. This research is expected to be developed until the intervention of the behavior of adolescent girls toward anemia prevention.

Antibacterial Activity Test and Wound Healing Infection Telang Leaf Extract (Clitoria ternatea L.) in Hyperglycemic Rabbits Arif Wijayanto; Juvita Herdianty; Adjie Wahyu Pradana
Strada Journal of Pharmacy Vol. 4 No. 1 (2022): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v4i1.46

This study was conducted to determine the antibacterial activity and wound healing of Telang (Clitoria ternatea L.) leaf extract against Staphylococcus aureus ATCC 25293 and Escherichia coli ATCC 25922 in 15 New Zealand rabbits aged 3-5 months weighing 1500–2500 grams of hyperglycemia induced by alloxan and randomly divided into 5 groups, namely normal, negative control (cream base), positive control (Sagestam® which each gram contains Gentamycin Sulfate equivalent to 1 mg of Gentamycin), topical administration of 10% and 20% Telang leaf extract cream. The back skin of the hyperglycemic rabbit was injured with a punch biopsy with a diameter of 5 mm, a depth of ± 0.5 mm, then treated according to the test group for 14 days. Parameters measured included wound diameter and histological observations of infected and non-infected wounds in hyperglycemic rabbits. The results showed that 10% Telang leaf extract cream had antibacterial activity against S. aureus and E. coli which was comparable to the positive control, namely the diameter of the inhibition zone against S. aureus and E. coli was 27.3mm and 18.5mm. Telang leaf extract cream also had infection wound healing activity which was comparable to positive control in hyperglycemic rabbits, wound healing activity for infected wounds was 0.9 mm and non-infected wounds were 0.8 mm.

Lip Cream Formulation With Natural Dyes From Secang Wood Leather Luluk Aniqoh Meliana; Juvita Herdianty; Arif Wijayanto
Strada Journal of Pharmacy Vol. 4 No. 2 (2022): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v4i2.65

Colorants are an important part of decorative cosmetics, including in lip cream preparations. Secang bark (Caesalpinia Sappan) contains chemical compounds of flavonoids, polyphenols, tannins and essential oils. Researchers formulate lip cream preparations by utilizing natural pigments contained in the bark of secang wood. The preparations were made with various concentrations of sappan bark extract, namely 15%, 20%, and 25%. Evaluation of the preparations made is an evaluation of physical quality including organoleptic tests, homogeneity, pH, spreadability, adhesion, smearing power, photostability, and stability tests by centrifugation method. Evaluation of safety was carried out through irritation test with patch test method and preference test. The results of the evaluation of lip cream preparations showed that all formulas had good greasing power and homogeneity, were physically stable which was characterized by no separation, and had good dispersibility, spreadability, and stable pH value. All preparations during storage for 21 days did not show changes in texture and odor. Then in terms of color, both organoleptically and photostability testing did not show a decrease in color intensity. Based on respondents' responses, the most preferred formula is formula II with the addition of an extract of 20%.

Antibacterial Test of Liquid Soap Preparations Rambutan Peel Extract (Nephelium lappaceum Linn) the Growth of Staphylococcus Aureus Juvita Herdianty; Luluk Aniqoh Meliana Putri; Arif Wijayanto
Strada Journal of Pharmacy Vol. 4 No. 2 (2022): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v4i2.66

Long-term use of antibiotics leads to resistance. Rambutan fruit is a fruit which grows seasonally, but the utilization of the fruit skin is still lacking. Several studies have been carried out but limited to the flesh and leaves. The purpose of this study was to utilize rambutan peel waste into a liquid soap preparation and then carry out an antibacterial test against Staphylococcus aureus bacteria. The content of compounds from the skin of rambutan fruit (Nephelium lappaceium Linn) is thought to have antibacterial properties. The content test was carried out using a phytochemical screening method. The screening results of rambutan peel extract showed the presence of alkaloids, flavonoids, saponins, and tannins. The antibacterial test method used the well diffusion method with concentrations of 20% 40%, 60% positive control of Biore liquid soap and negative control of soap base. The test parameters for liquid soap preparations include: organoleptic test, homogeneity test, pH test, foam height. The results showed the best concentration of 60% had the ability as an antibacterial against Staphylococcus aureus.

Test The Wound Healing Activity Of Nephelium Lappaceium Fructus Cortex Extract Ointment On New Zealand Rabbits Arif Wijayanto; Luluk Aniqoh Meliana Putri; Juvita Herdianty
Strada Journal of Pharmacy Vol. 4 No. 2 (2022): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v4i2.67

Nephelium lappaceium Linn.(Rambutan) is a natural ingredient rich in active substances that are beneficial to human health. In this study, the use of Nephelium lappaceium fructus cortex was used for the healing of open wounds where Nephelium lappaceium fructus cortex contains tannins which are expected to help heal open wounds. The content test was carried out using the phytochemical screening method of Nephelium lappaceium fructus cortex extract which showed the presence of alkaloids, flavonoids, saponins, and tannins, then a wound healing test was carried out with Nephelium lappaceium fructus cortex extract which was divided into 5 groups randomly, namely normal, negative control (Vaseline album) , positive control (Betadine salp® each gram contains 10% Povidone Iodine), presented topically 7.5% and 15% Nephelium lappaceium fructus cortex extract ointment. The back skin of New Zealand rabbits is 3-5 months old, weighs 1500–2000grams, has normal and healthy activities and has agile activities, is normal and in healthy condition, then was injured with a punch biopsy with a diameter of 5 mm, a depth of ± 0.5 mm, then treatment according to the test group for 21 days. Parameters measured included wound diameter in rabbits. The results showed that the ointment extract of Nephelium lappaceium fructus cortex 15% had an open wound healing activity which was comparable to a positive control with an open wound healing activity of 0.2mm.

Formulation Of Mephenamic Acid Granules With Pvp And Avicel Mixture On The Physical Of Granules Juvita Herdianty; Arif Wijayanto; Atary Anggita
Strada Journal of Pharmacy Vol. 5 No. 1 (2023): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v5i1.87

Mefenamic acid is a drug that is often used to relieve pain. Mefenamic acid is a drug used as an analgesic, antipyretic, and non-steroidal anti-inflammatory drug (NSAID). In the BCS (Biopharmaceutical Classification System) it is included in the class II category, namely its low solubility with high permeability. To overcome this, it is necessary to make efforts to increase solubility to obtain good bioavailability. This study aims to formulate granules using a mixture of Polyvinyl Pyrrolidone (PVP) and Avicel for the physical properties of the granules in three formulations. Preparation of granules using the wet garnulation method by making three formulations with varying concentrations of PVP, namely 1%, 2% and 3%. The results of the evaluation of the physical properties of mefenamic acid granules showed that the flow properties of the three formulas met the requirements, namely > 10 grams/second. The water content test showed that the three formulas met the requirements with a range of 2-5%, while the angle of repose test of the three formulas was only formula 1 which met the requirements, namely less than <30o.

Activity Testing Of Katuk Leaf Ethyl Acetate Fraction Gel Preparation (Sauropus Androgynus (L.) Merr.) On Healing Wistar Strain White Rat Burns Mintarti; Juvita Herdianty
Strada Journal of Pharmacy Vol. 5 No. 2 (2023): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v5i2.98

Burns are a condition of loss or damage to skin tissue due to contact between the skin and a heat source. The ethyl acetate fraction of katuk leaves (Sauropus Androgynus (L.) Merr.) is known to be able to help accelerate the healing process of burns because it contains flavonoids, alkaloids, tannins and saponins. The purpose of this study was to analyze the effect of giving the ethyl acetate fraction of katuk leaves and to find out the best concentration of the fraction in healing burns. This study was a laboratory experimental study using the Post Test Control Only Group Design approach using 25 male white rats divided into 5 groups (each group consisted of 5 rats). The treatment groups were K+ (bioplacenton), K- (base), the ethyl acetate fraction of katuk leaves which consisted of several concentrations, namely F I (5%), F II (10%), F III (20%). The parameters observed were a decrease in the diameter of the burn wound and healing of the skin of the rats. Based on the results of observations of healing of burns, statistically showed a significant difference between groups with a p value <0.05. The best concentration in healing burns on the rat's back was a concentration of 20% with a healing percentage of 83.11%, followed by a concentration of 10% (66.71%), a concentration of 5% (56.00%). The healing activity of burns in the positive control with a healing percentage of 82.35%. So the best burn healing activity was in the ethyl acetate fraction of katuk leaves with a concentration of 20% with a healing percentage of 83.11%.

Formulation of capsule preparations with variations in aerosil concentration on the results of preparation evaluation Arif Wijayanto; Juvita Herdianty
Strada Journal of Pharmacy Vol. 2 No. 1 (2020): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v2i1.132

Capsules can be defined as a solid dosage form, where one or more types of drugs and/or other inert ingredients are contained in a shell or small container that can dissolve in water (Ansel 2005). Gelatin is a suitable material for making capsule shells because it is edible and soluble, forms a strong, thin-layered shell and changes from solution to gel form slightly above ambient temperature. Gelatin immediately dissolves in water at body temperature and does not dissolve if the temperature drops below 30°C (Agoes, 2008). Based on the test results, the disintegration time for F1 capsules is 2.12 minutes; F2 is 2.21 minutes; and F3, namely 2.27 minutes. These three formulas meet the requirements, namely not less or equal to 15 minutes. Based on the test results, F1 3.44 seconds, F2 3.76 seconds, F3 3.24 seconds, the flow speed of these three formulas meets the flow speed requirements, namely flow speed ≥ 10 g/second. The flow speed of the three formulas is in the good category, namely 2-10 g/sec which is said to be very good while it is said to be good. The flow speed is good because Aerosil has a very small and fine particle size. Apart from being an absorbent, aerosols are also able to improve flow properties by reducing friction between particles and by averaging test results from angles of repose F1 45°, F2 43° and F3 53°. In the weight uniformity test at F 1,2,3 it does not meet the requirements for factors that influence weight uniformity, namely lack of accuracy, different drug weights due to uneven distribution.

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