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Formulation of Wangi Pandan Leaves (Pandanus Amaryllifolius Roxb) to smooth, moisturize and repair the skin Juvita Herdianty; Alfara Derista Felany
Strada Journal of Pharmacy Vol. 2 No. 1 (2020): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v2i1.134

Bodyscrub is one of the products that is the result of rapid technological developments today, bodyscrub scrubs are used to maintain the cleanliness and freshness of body skin, bodyscrub products vary greatly starting from price, packaging color, softness of texture and aroma (Nina Hairiyah, Nuryati, and Fitri Nordiyah, 2022).The aim of using a body scrub is to remove dead skin cells, dirt and open pores so that the skin becomes brighter and whiter. Currently, there are many types of body scrubs circulating in society with various benefits ranging from smoothing the skin to whitening the skin (Hairiyah, N., & Nuryati, 2020) Medicinal plants have traditionally been used to treat many diseases and maintain health in Southeast Asia, many plants are described as having traditional medicinal properties. One of the plants that can be used in cosmetics is fragrant pandan leaves (pandanus amaryllifolius roxb) which is a tropical plant from the pandanaceae family. Pandan leaves can also be called pine leaves. because it resembles a pineapple with long, spiral green leaves. narrow and rope-shaped. Pandan leaves contain phytochemical compounds such as steroids, carbohydrates, phenols, flavones, alkaloids, glycosides, amino acids and many vitamins. The appearance and function of the skin is maintained by an important balance between water. This study aims to formulate and evaluate the physical quality results of pandan wangi leaves powder body scrub cream with emulgator concentrations of 15%, 14% and 13% stearic acid, and 1%, 2% and 3% triethanolamine. Experimental research method to determine variations in the concentration of stearic acid and triethanolamine emulsifiers. Observation of the results of evaluating the physical quality of the preparation includes organoleptic tests, homogeneity, pH, stickiness tests, spreadability tests and emulsion type. The result It can be concluded that the fragrant pandan leaf powder body scrub preparation can moisturize the skin, shows a homogeneous scrub with a semi-solid shape, is light green in color and has a typical pandan smell, has a neutral pH of 7.4 and 7.2 on day 7, the pH value is not appropriate The desired number is 6, this is because the preparation is influenced by the number of emulsifiers used. The more stearic acid, the lower the pH because of the large number of acid groups contained in stearic acid, while the more triethanolamine will cause the pH to be high due to the presence of basic groups contained in triethanolamine. with a spreadability of 5.1 cm and 4.83 cm on day 7. This is because the emulsifier concentration is high and the surfactant concentration is low, so the viscosity is very high so the spreadability is low. and the results of adhesion were 88.33 seconds and 49.33 seconds on day 7, adhesion was influenced by the viscosity of the base. Stickiness is closely related to viscosity.

VARIATION OF MANIHOT AMYLUM AS A DISINTEGRANT IN TABLET FORMULATION RESULTS WITH THE ACTIVE INGREDIENTS PARACETAMOL, IBUPROFEN AND CAFFEINE Juvita Herdianty; Nola Nonita Nengsieh
Strada Journal of Pharmacy Vol. 2 No. 2 (2020): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v2i2.137

In general, oral medications must first dissolve in digestive fluids before they can be absorbed through the intestinal wall. Therefore, increasing the dissolution rate is a rate determining step that can increase drug absorption, especially for substances that are difficult to dissolve (Giang, T.P. 1987). One drug that is difficult to dissolve is ibuprofen. Ibuprofen is an analgesic, antipyretic, non-steroidal anti-inflammatory drug with water solubility of 0.049 mg/ml and is almost insoluble (Bhattamishra, S.D and Padhy, R.K. 2009). In addition to the active ingredients, tablets can also contain excipients such as diluents, binders, disintegrants, lubricants (lubricants, non-stick agents, glidants) and in some cases can contain flavoring or coloring agents. (Shamsuni, 2007). Ibuprofen in Ibuprofen in the Class II Drug biopharmaceutical classification system has poor solubility and is very permeable (Dressman and Butler, 2001). Ibuprofen is too uniform and has poor flow characteristics (Resenack, Muller, 2002). This study aims to formulate and evaluate the physical quality results of manihot amylum with desintegran of 3%, 5% and 10%. Experimental research method to determine variations in the concentration of manihot amylum Observation of the results of evaluating the physical quality of the preparation includes organoleptic tests, water content, flow time, repose angle, pH, disintegration time test and tablet hardness testing. The results of this research indicate that there is an influence of differences in the concentration of manihot amylum has a There is a water content test for all formulations that meet the requirements, namely <5%. In the test, the disintegration time of the formulation met the requirements, namely less than 15 minutes. The pH test of all formulations meets the requirements. In the flow time test all formulations met the requirements. In the angle of repose test the preparation meets the requirements. However, when the tablet hardness test does not meet the requirements, it can occur due to the influence of the binder used in the formulation

FORMULATION OF GRANULES AND TABLETS ACTIVE INGREDIENT PARACETAMOL IBUPROFEN AND ITS EVALUATION RESULTS Arif Wijayanto; Juvita Herdianty
Strada Journal of Pharmacy Vol. 3 No. 2 (2021): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v3i2.139

Granulation is a process of increasing the powder size where a powder mixture that has a small cohesive force is changed into a larger particle size. Granulation begins with mixing the required active ingredients, so that a form of active ingredient is achieved through a mixing process (Musnamar, 2005). Dry granulation (slugging) is processing active ingredient and excipient particles by pressing the dry mixture into a solid mass. After it becomes a solid mass, it is then broken down again to produce particles that are larger than the original powder (granule). Dry granulation is used for active ingredients that have an effective dose that is too high to be directly compressed, active ingredients that are sensitive to heating and humidity, active ingredients that are difficult to flow (Chaerunnisa et al, 2009). Ibu profen is a derivative of propionic acid which has strong analgesic, antipyretic and not too strong anti-inflammatory properties. Ibuprofen has a dose-dependent duration of around 9-8 hours which is longer than the half-life. The recommended dose varies depending on body mass and indication. Paracetamol has poor compactibility and fluidity, which causes difficulties during compression with drugs that have poor compactibility in large doses. It is most appropriate to use the granulation method in this practicum using the dry granulation method because ibuprofen is not resistant to heat or moisture. Prepare tools and materials, Weighing 175 grams of Acetaminophen, 100 grams of Ibuprofen, 7.3 grams of Manihot Starch (F1= 10.95 g, F2= 36.5 g, F3= 73 g), 7.3 grams of PVP, and (F1= 0, 13985 g, F2= 0.08875 g, F3=0.00845 g), mix ad homogeneously (inner phase), The resulting internal phase mixture is inserted into the die on a tablet press, until slugs are formed, with each weighing more than 500 mg. Put the slugging results into the mortar then grind slowly until granules are formed, Sift the granules with a no 12 mesh sieve. In testing the water content of F1 granules, it was found that the granules met the water content requirements because they had a percent value of less than 5%, which was 2.55% in F1. Meanwhile, water content has not yet been obtained for F2, F3 and K-, because the slugging process cannot be carried out. Testing the angle of repose F1 before compression is 24°, after compression is 25°. At F2 before compression it is 25°, at F3 before compression it is 30°. The test results of all formulations met a good angle of repose range of 25 - 30°, but did not match the formula design. In flow time testing. According to the Indonesian Ministry of Health, 2018 stated that the flow speed is good if the granules flow <10 seconds. In F1, the flow time before they become granules is 50 seconds and after they become granules it is 6.39 seconds, where these results meet the literature. Meanwhile, for F2, F3, and K-, no results were obtained after becoming granules because the formulation could not go through the slugging process.

Variations in the type of abrasive material used in the formulation of body scrub preparations on the evaluation of the preparation Juvita Herdianty; Arif Wijayanto
Strada Journal of Pharmacy Vol. 3 No. 2 (2021): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v3i2.141

Cosmetics are products that are used to clean and beautify the skin. Body scrubs or what is commonly known as bath scrubs are scrubs that are used when the skin is wet. How to use it is by applying it evenly to the skin of the body and then rubbing it slowly. Body scrub components, which consist of fat components, can increase skin moisture. The water phase can increase hydration for fresh-looking skin. Surfactants in body scrubs can also replace the role of soap. One form of body scrub dosage form that is widely available on the market is the cream dosage form (Paradila et al., 2022). The caffeine content in coffee can make the skin moist so it feels smoother and firmer. Arabica coffee beans contain antioxidants which can provide benefits, one of which is preventing cell damage due to exposure to free radicals. Arabica coffee with a concentration of 2% shows a good exfoliating agent that does not irritate the skin and improves the appearance of the skin without side effects (Putri et al., 2021). This study aims to formulate and evaluate the physical quality results of coffee powder body scrub cream with emulgator concentrations of 15%, 14% and 13% stearic acid, and 1%, 2% and 3% triethanolamine. Experimental research method to determine variations in the concentration of stearic acid and triethanolamine emulsifiers. Observation of the results of evaluating the physical quality of the preparation includes organoleptic tests, homogeneity, pH, stickiness tests, spreadability tests and emulsion type. The results of this research indicate that there is an influence of differences in the concentration of stearic acid and triethanolamine in that F1 has a denser form than F2 and F3, after storage for 3 weeks F2 and F3 experienced a color change to light brown. This shows that the formulation has the best properties for body scrub cream preparations, is stable and meets the requirements based on organoleptic tests, homogeneity tests, pH tests in accordance with the standard facial skin pH in general, namely 4.5-7, while for the emulsion type test, and the stability test that was carried out on day 12 did not experience any changes or phase separation, namely F1 with a stearic acid concentration of 15% and triethanolamine 1%.

Antibacterial Activity Test of Combination of Chitosan and Ethanol Extract of Cocoa Leaves (Theobroma Cacao L.) Against Salmonella Typhi Bacteria Saifullah Al Fahmi; Luluk Aniqoh Meliana Putri; Ivan Junius Mesak; Juvita Herdianty
Strada Journal of Pharmacy Vol. 6 No. 2 (2024): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v6i2.148

Introduction:Typhoid fever is a systemic infectious disease caused by the bacterium Salmonella typhi. The increasing antibiotic resistance of Salmonella typhi has spurred interest in natural antibacterial agents. This study examines the antibacterial activity of a combination of chitosan and ethanol extract of cocoa leaves (Theobroma cacao L.) against Salmonella typhi. Methods: The research involved extracting cocoa leaves using ethanol and combining the extract with chitosan. The antibacterial activity was evaluated using the well diffusion method on Salmonella typhi. The combination of chitosan and cocoa leaf extract was tested at various concentrations, and chloramphenicol was used as a positive control. Results: The combination of chitosan and cocoa leaf extract showed significant antibacterial activity, with the best results obtained at higher concentrations. The zone of inhibition for the combination at 600 ppm was comparable to that of the positive control of chloramphenicol. Conclusion: The study suggests that the combination of chitosan and cocoa leaf extract has the potential to be developed as an alternative treatment for typhoid fever, particularly against antibiotic-resistant strains of Salmonella typhi.

Fomulation And Physical Quality Testing Of A Scrub Gel With Ethanol (70%) Extract Of Pineapple Core (Ananas comosus (L.) Merr.) Rizka Nursilah Ode; Juvita Herdianty; Sri Rahayu Dwi P.; Arif Wijayanto
Strada Journal of Pharmacy Vol. 6 No. 2 (2024): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v6i2.150

Scrubs are widely used in cosmetic care, primarily for exfoliation to remove dead skin cells. This study used a 70% ethanol extract from pineapple cores (Ananas comosus (L.) Merr.), which contains active compounds such as bromelain, flavonoids, and saponins. These compounds were formulated into a scrub gel that potentially benefits skin health, especially in exfoliation. The aim of this study was to evaluate good physical quality characteristics, including organoleptic properties, homogeneity, pH, viscosity, adhesion, and spreadability, based on varying concentrations of ethanol extract from pineapple cores. This research employed a true experimental method with a post-test only design to determine the best physical quality of scrub gel formulations containing pineapple core extract (Ananas comosus (L.) Merr.) at three extract concentrations: 3%, 5%, and 10%. The physical quality evaluation of the scrub gel, including organoleptic properties, homogeneity, viscosity, adhesion, and spreadability, showed good results and met the standards. However, the pH testing results for the three formulations did not meet the standards, as they were relatively neutral to slightly acidic (6.48-7.58). The hedonic test results indicated that Formulation 2 (5%) received the highest ratings in terms of aroma and texture, while Formulation 1 (3%) and Formulation 3 (10%) also showed a tendency to be preferred in certain aspects, particularly in terms of color and texture. The Kruskal-Wallis test followed by the Mann-Whitney test showed significant differences in pH, viscosity, and adhesion (p-value: 0.46-0.05 ≤ 0.05). Meanwhile, the One-Way ANOVA test on spreadability showed a very significant difference in spreadability, with Formulation 3 and the negative control having the highest spreadability (p-value <0.005). The concentration of pineapple core extract affects the physical and sensory characteristics of the scrub gel, with the addition of active pineapple core extract at a concentration starting from 3% already showing good physical characteristics.

Formulation of Acetaminophen Granules with Porang Tuber Amylum (Amorphophallusoncophyllus) that Meets the Parameters of Particle Size Distribution and Destruction Time Arif Wijayanto; Juvita Herdianty
Strada Journal of Pharmacy Vol. 6 No. 1 (2024): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v6i1.168

Many farmers are interested in planting porang tubers, with many farmers planting porang tubers, the price of porang tubers will decrease during harvest . Porang tubers have several contents, namely starch, glucomannan, fiber, fat, protein, minerals and vitamins. Glucomannan content can be used as a tablet binder, thickener, gilling agent, film former, coating material emulsifier, and stabilizer. The purpose of this study was to determine the concentration of porang tuber flour as a binder in Acetaminophenum granules using the wet granulation method. Granules were made into three formulations with variations in the concentration of porang tuber flour, namely FI 5%, FII 7.5% and FIII 10%. GRANULES were tested for tablet uniformity, tablet hardness, tablet fragility , disintegration time, and granule size distribution. The data obtained were analyzed using Kruskal Wallis. The results of the analysis showed that variations in the concentration of porang tuber flour had different effects, based on the Kruskal Wallis analysis which showed a significant value of 0.10 (p> 0.05). The formulation that has a good physical quality test is formulation III, with a tablet hardness value of 6.84 kg and a disintegration time of 5.74 minutes which is almost close to the control (+) 14.27 kg and 6.38 minutes. The higher the concentration of porang tuber flour , the higher, the longer the disintegration time.

A Physical Quality and Antioxidant Test of Strawberry Leaf Fraction Lotion DPPH Method (1,1- Diphenyl-2- Picryhydrazyl) Candra Asih Setyaningrum, Candra; Arif Wijayanto; Juvita Herdianty; Devita Riafinola Andaririt
Strada Journal of Pharmacy Vol. 7 No. 1 (2025): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v7i1.176

Lotion is a cosmetic preparation that functions to moisturize and protect the skin by providing a soothing effect. This research utilizes natural ingredients in the form of strawberry leaf extract (Fragaria vesca) to create a lotion formulation with high antioxidant activity. The objective of this study is to determine the effect of varying concentrations of strawberry leaf extract on the physical quality and antioxidant activity of the lotion. This experimental study involved formulating lotions with different concentrations of strawberry leaf extract at 2%, 4%, and 6%. The antioxidant activity was evaluated using the DPPH (1,1-Diphenyl-2-Picrylhydrazyl) method to measure the extract's ability to scavenge free radicals. The main active component in strawberry leaf extract is polyphenol compounds, which act as natural antioxidants in cosmetic products. The results showed that the strawberry leaf fraction lotion had a soft texture, green color, and a characteristic strawberry leaf scent. The pH test had a significance value of 0.00. The viscosity test also had a significance value of 0.00. The adhesion test results showed a significance value of 0.00, and the spreadability test also had a significance value of 0.00. The DPPH antioxidant test showed regression values of 0.932 for the positive control, 0.854 for the negative control, 0.948 for F1, 0.985 for F2, and 0.967 for F3. This study provides strong evidence that strawberry leaf fraction is suitable as an active ingredient in antioxidant cosmetic products, with the potential to compete with conventional ingredients. The SPSS test results showed a significant effect of concentration on free radical inhibition, as well as significant differences in pH, spreadability, and adhesion tests among the formulations. However, some groups did not meet the assumptions of normality and homogeneity, indicating the need for alternative analytical methods for further validation

Determinants of Pulmonary TB Incidence in Children Aged 0-14 Years in the Work Area of UPTD Puskesmas Sukorame Lutfiati Anam, Indri; Ema Mayasari; Juvita Herdianty
Indonesian Journal of Nutritional Epidemiology and Reproductive Vol. 8 No. 2 (2025): May
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/ijner.v8i2.335

Tuberculosis is an infectious disease that can attack people of all ages caused by the bacteria Mycobacterium tuberculosis. Parental knowledge plays a role in parental behavior and awareness of disease prevention efforts. Exposure to cigarettes causes a decrease in the immune system, making it susceptible to disease. Nutritional status also plays a role in the body's immunity, where a body with good nutritional intake will strengthen the body's immunity so that it can attack incoming foreign antigens. BCG immunization is a basic immunization that must be given to children to help prevent tuberculosis. The purpose the research to find out the determinants of the incidence of pulmonary TB in children aged 0-14 years in the Sukorame Community Health Center UPTD Working Area. This research is a quantitative study using a cross sectional method. The research samples were positive TB sufferers and TB suspects who were recorded in children's TB reports in the Sukorame Community Health Center working area. The sampling technique uses purposive sampling. Data analysis used SPSS software with the chi square statistical test. Results: Based on the results of the chi square test, it was found that parents' knowledge about pulmonary TB had a p-value of 0.059 for children, family smoking habits had a p-value of 0.021 for children, children's nutritional status had a p-value of 1.000 for children, and children's BCG immunization status had a p-value of 0.577 for children's pulmonary TB. It can be concluded that the variable family smoking habits is related to the incidence of pulmonary TB in children, while the variables of knowledge, nutritional status and BCG immunization have no relationship.

Formulation And Physical Quality Test Of Black Glutinous Rice (Oryza Sativa L. Var. Glutinosa) And Olive Oil Body Scrub Herdianty, Juvita; Aniqoh Meliana Putri, Luluk; Wijayanto, Arif
Open Access Health Scientific Journal Vol. 6 No. 2 (2025): August 2025
Publisher : Griya Eka Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55700/oahsj.v6i2.97

Background: The purpose of using a body scrub is to remove dead skin cells and dirt, and unclog pores, resulting in brighter, whiter skin. Many types of body scrubs are available today, each with a variety of benefits, from smoothing to whitening. Black glutinous rice is currently a popular choice for use in cosmetics. Black glutinous rice contains 109.52–256.61 mg of anthocyanin per 100 grams. The antioxidant activity of anthocyanins can be enhanced by the presence of other phytochemicals, such as flavanols, catechins, or vitamins, which are also commonly found in fruit.Methods: This research method is experimental in making body scrub preparations from black sticky rice as the active ingredient with varying concentrations of 5%, 10%, and 15%. Evaluation of the body scrub preparations by looking at the results of the physical quality of the preparations which include organoleptic tests, homogeneity tests, pH tests, adhesion tests, and spreadability tests. The body scrub preparations will be tested for 3 days and stored at room temperature. Data are analyzed descriptively by comparing them to the Indonesian National Standard.Results: The results of the study showed that the preparation met the physical quality requirements, the results of organoleptic quality, namely the formulation of body scrub preparations F1, F2, and F3. The results of the pH test of F1, F2, F3 were in the range of 6.03-6.48, the results of the spreadability test showed results in the range of 4.48-6.98, and the adhesion test produced a range of 0.2.30 -0.2.45.Conclusion: The conclusion of this study is that the formulations F1, F2 and F3 with the addition of olive oil have good physical quality, are stable and meet the Indonesian National Standard.

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