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All Journal Open Access Health Scientific Journal Journal of Global Research in Public Health Indonesian Journal of Nutritional Epidemiology and Reproductive Strada Journal of Pharmacy
Juvita Herdianty
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Chemistry Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Formulation of Fibrauren tinctoria Lour. Extract Serum, As an Antioxidant with the 1,1-Diphenyl 2-Picryhydrazyl (DPPH) Method Wijayanto, Arif; Herdianty, Juvita; Putri, Luluk Aniqoh Meliana; Sumanto, Ardhi Broto
Open Access Health Scientific Journal Vol. 6 No. 2 (2025): August 2025
Publisher : Griya Eka Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55700/oahsj.v6i2.125

Abstract

Background: Serum is a preparation with a high concentration of active ingredients and low viscosity, which delivers a thin film of active ingredients to the skin surface. The use of Fibraurea tinctoria has been carried out since ancient times by the Dayak, Banjar, and Kutai tribes as a traditional treatment for liver disease, diabetes, and to increase the body's immunity from various causes of disease such as bacteria. Fibraurea tinctoria is believed to be able to ward off the negative effects caused by free radicals such as antioxidants.Methods: This experimental study investigated the antioxidant activity of Fibraurea tinctoria extract serum with varying concentrations of hydroxyethyl cellulose 1.0%, 1.5%, and 2.0% using the DPPH methods, which is simple, easy, fast, and sensitive, and requires a small sample. This method provides information on the reactivity of the tested compound with a stable radical. Evaluations of the Fibraurea tinctoria extract serum preparation was carried out by observing the results of physical quality tests, including organoleptic tests, homogeneity tests, pH tests, adhesion tests, and spreadability tests. The serum preparation was tested for 3 days and stored at room temperature. Data were analyzed descriptively by comparing it with the Indonesian National Standard.Results: The results showed that the serum extract preparations of Fibraurea tinctoria F1st, F2nd, and F3rd showed varying IC₅₀ values, where lower values ​​indicated stronger antioxidant potential. Formulation F3rd showed the lowest IC₅₀ value (3.11 ppm), F2nd (3.74 ppm) and F1st (4.67 ppm), all of which were stronger than the base (5.11 ppm).Conclusion: In this research, formulations F1st, F2nd, and F3rd had the highest antioxidant activity, with F3rd at a concentration of 2.0%. The identified strong antioxidant activity is the main basis for the potential of Fibraurea tinctoria extract serum as an active antioxidant ingredient.
Anti-Acne Activity Evaluation Of Cyperus rotundus L. Rhizome Fraction Gel Against Staphylococcus aureus And Propionibacterium acnes Qadariah, Musdalifah; Juvita Herdianty; Luluk Aniqoh Meliana Putri; Ardhi Broto Sumanto
Strada Journal of Pharmacy Vol. 7 No. 2 (2025): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v7i2.203

Abstract

Acne is an inflammatory skin condition often caused by bacteria such as Propionibacterium acnes and Staphylococcus aureus. The increasing incidence of antibiotic resistance encourages the search for alternatives from natural ingredients. Nut grass rhizome (Cyperus rotundus L.) is known to have antibacterial compounds. This study aimed to formulate a gel from the fractions of nut grass rhizome, test its activity against acne-causing bacteria, and identify the most potent fraction. This study employed a laboratory experimental design. The nut grass rhizome was extracted with 70% ethanol and then fractionated by liquid-liquid partitioning using n-hexane, ethyl acetate, and water as solvents. Each fraction was formulated into a gel at a 5% concentration, and its antibacterial activity was tested using the well diffusion method. All gel formulas met the physical quality evaluation requirements. The ethyl acetate fraction (F2) exhibited the strongest antibacterial activity, with an average inhibition zone of 19.48 ± 0.99 mm (moderate category) against Staphylococcus aureus and 25.86 ± 0.65 mm (strong category) against Propionibacterium acnes. The nut grass rhizome fraction gel preparation possesses anti-acne activity. The ethyl acetate fraction proved to be the most potent, showing efficacy against Propionibacterium acnes (inhibition zone 25.86 mm) that was statistically equivalent to the positive control (p = 0.767).
Formulation and Stability Test of Herbal Cosmetic Preparations of Aloe Vera Body Lotion to Increase Competitiveness of Pharmapreneurs Herdianty, Juvita; Wijayanto, Arif
Open Access Health Scientific Journal Vol. 4 No. 2 (2023): August 2023
Publisher : Griya Eka Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55700/oahsj.v4i2.45

Abstract

Background: In recent years, the herbal cosmetic industry has experienced significant growth along with increasing public awareness of the importance of natural and environmentally friendly products. Herbal cosmetics not only offer beauty benefits but also provide added value for skin health. However, the main challenge faced by pharmapreneurs is how to ensure the stability and effectiveness of the products they offer in a competitive market.This study aimed to formulate and test the stability of herbal cosmetic preparations, and evaluate their impact on market competitiveness. By understanding the factors that affect product stability, pharmapreneurs are expected to be able to improve the quality and attractiveness of their products.Methods: This study was conducted by formulating several herbal cosmetic preparations, including creams and serums, using natural ingredients such as aloe vera extract, jojoba oil, and essential oils. Stability tests were carried out using storage methods at varying temperatures and humidity, as well as organoleptic tests and periodic pH measurements. The data obtained were analyzed using descriptive statistics to determine changes that occurred during the testing period.Results: The results showed that the formulated herbal cosmetic preparations had good stability, with minimal changes in pH and organoleptic characteristics during the testing period.Conclusion: Product shows potential to compete in the market, with positive feedback from consumers in terms of effectiveness and safety of use.
Co-Authors Adjie Wahyu Pradana Alfara Derista Felany Amarin Yudhana Ardhi Broto Sumanto Arif Wijayanto Arif Wijayanto Arif Wijayanto, Arif Atary Anggita Candra Asih Setyaningrum, Candra Devita Riafinola Ema Mayasari Ivan Junius Mesak Lutfiati Anam, Indri Mintarti Nola Nonita Nengsieh Putri, Luluk Aniqoh Meliana Qadariah, Musdalifah Riza Yuliawati Rizka Nursilah Ode Saifullah Al Fahmi Sri Rahayu Dwi P. Ukik Agustina Yusmarisnasari