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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Jurnal Kedokteran Anatomica (Anatomica Medical Journal) ORBITA: Jurnal Pendidikan dan Ilmu Fisika Sumatera Medical Journal Jurnal Ners IJOEP : International Journal of Ecophysiology SCRIPTA SCORE Scientific Medical Journal Essential: Essence of Scientific Medical Journal Jurnal Kedokteran Ibnu Nafis
Anggraini, Dwi Rita
Department Of Anatomy, Faculty Of Medicine Universitas Sumatera Utara, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Mekanisme Sinergis Ekstrak Etanol Serai dan Slow Interval Training terhadap Leptin, MDA, dan Histologi Adiposit pada Obesitas: Narrative Review Raudhatul Jannah; Yetty Machrina; Dwi Rita Anggraini
Jurnal Ners Vol. 10 No. 2 (2026): APRIL 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i2.56975

Abstract

Abstrak Latar Belakang: Obesitas merupakan faktor risiko utama sindrom metabolik yang berhubungan erat dengan stres oksidatif, resistensi leptin, dan remodeling jaringan adiposa. Kombinasi terapi herbal—khususnya ekstrak etanol serai (Cymbopogon citratus)—dan latihan fisik terstruktur berpotensi mengatasi disregulasi metabolik tersebut secara sinergis. Namun, bukti ilmiah mengenai mekanisme biologis kombinasi keduanya masih sangat terbatas. Tujuan: Review ini bertujuan menganalisis secara kritis jalur mekanistik efek kombinasi ekstrak etanol C. citratus dan slow interval training terhadap kadar serum leptin, kadar MDA, dan gambaran histologi sel adiposit pada model obesitas. Metode: Narrative review sistematis terhadap 28 artikel dari database Scopus, PubMed, ScienceDirect, dan Google Scholar (2020–2025), menggunakan kata kunci terstruktur dan kriteria inklusi–eksklusi ketat. Hasil dan Pembahasan: C. citratus mengandung senyawa bioaktif (citral, geraniol, limonene) yang terbukti menghambat peroksidasi lipid, menurunkan ekspresi TNF-α dan IL-6, serta memodulasi jalur PPARγ-adipogenesis. Slow interval training pada intensitas 50–70% HRmax mengaktifkan jalur AMPK-PGC1α, meningkatkan lipolisis, dan memperbaiki sensitivitas reseptor leptin (LepRb) melalui regulasi SOCS3. Secara sinergis, kombinasi keduanya diduga bekerja melalui reduksi stres oksidatif → normalisasi sinyal JAK2/STAT3 → pemulihan sensitivitas leptin → remodeling histomorfometri adiposit. Kesimpulan: Kombinasi C. citratus dan slow interval training memiliki potensi sinergis yang secara mekanistik dapat menurunkan MDA, memulihkan sensitivitas leptin, dan memperbaiki morfologi adiposit pada kondisi obesitas Kata Kunci: Cymbopogon citratus; leptin; malondialdehyde; slow interval training; adiposit; obesitas; stres oksidatif
The Effect of Intra-Arterial Heparin on Neurogenesis in Neurogenic Areas of the Adult Rat Brain: A Narrative Literature Review Based on Ki-67 and Doublecortin Expression Mohammad Fauzy Saleh; Dwi Rita Anggraini; Andre Marolop Pangihutan Siahaan
Jurnal Ners Vol. 10 No. 3 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i3.57976

Abstract

Abstract Background: Adult neurogenesis—the continuous generation of new neurons in the subgranular zone (SGZ) of the hippocampal dentate gyrus and the subventricular zone (SVZ)—represents a fundamental process of neural plasticity with implications for cognition, memory, and recovery from neurological injury. Heparin, a widely employed anticoagulant, has emerged as a pharmacological agent with pleiotropic effects on the central nervous system, including modulation of growth factor signaling pathways critical to neurogenesis. Objective: This narrative literature review aims to critically synthesize current evidence on the effects of intra-arterial heparin administration on adult neurogenesis, with particular focus on Ki-67 (cellular proliferation) and Doublecortin (DCX; immature neuron migration) as immunohistochemical biomarkers. Methods: A comprehensive search of Scopus, PubMed, ScienceDirect, and Google Scholar databases was conducted using predefined search strings. Studies published between 2015 and 2025 were prioritized, supplemented by seminal foundational works. Fifteen primary articles met inclusion criteria. Results: Converging evidence indicates that heparin exerts neuroproliferative and neuroprotective effects through its interactions with fibroblast growth factor-2 (FGF-2), brain-derived neurotrophic factor (BDNF), and the Wnt/β-catenin and NF-κB signaling pathways. Intra-arterial administration potentiates these effects by restoring microvascular perfusion, thereby facilitating the survival of Ki-67+ progenitor cells and the maturation of DCX+ neuroblasts in neurogenic niches. Conclusion: Intra-arterial heparin demonstrates significant potential as a pro-neurogenic intervention in adult rodent models, supporting its translational investigation in clinical neuropathological conditions. Standardized biomarker protocols combining Ki-67 and DCX immunolabeling are recommended for future preclinical studies. Keywords: adult neurogenesis; heparin; Ki-67; Doublecortin (DCX); neural progenitor cells; subgranular zone; subventricular zone
Factors Affecting Junior High School Students' 4C Skills: An Empirical Study Dwi Anggraini Harita Putri; Usmeldi Usmeldi
Jurnal Penelitian Pendidikan IPA Vol 9 No SpecialIssue (2023): UNRAM journals and research based on science education, science applic
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9iSpecialIssue.5793

Abstract

The purpose of this research is to find out factors that can affecting Junior High School Students' 4C Skills such as self-efficacy, learning motivation, liveliness, mathematical literacy, and scientific literacy can significantly influence students' 4C skills. This study is quantitative research using a survey method. In addition, the effect of each construct on the 4C skills is estimated through the Partial Least Square Structural Equation Model (PLS-SEM). The research results show that self-efficacy, scientific literacy, learning motivation and activeness have a significant effect on 4C skills. Mathematical literacy does not have a significant effect on 4C skills, but scientific literacy has a mediating effect on the relationship between mathematical literacy and 4C skills. Therefore, it is expected that students will further improve their skills in realizing the demands of globalization.
Co-Authors Andre Marolop Pangihutan Siahaan Caesar, Fahrezi Daulay, Milahayati Feriyawati, Lita Haslinda ira Cinta Lestari Lubis, Nenni Dwi Aprianti Lumongga, fitriani Mohammad Fauzy Saleh Muhammad Ichwan Nurul Fauziah Pasaribu, Saadatur Rizqillah Raudhatul Jannah Ricky Alexander Chandra Rina Amelia Rina Yunita Sinaga, Ade Putra Fratama Siti Syarifah Sitorus, Mega Sari Suryani Eka Mustika Syafriani Siregar, Rosmayanti Syafruddin Ilyas Tamara Lubis Tri Widyawati Usmeldi Usmeldi Westi Widia Wati Wijaya, Vincent Yetty Machrina Yoan Carolina Panggabean Yunita Sari Pane Zahra, Khairina