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All Journal Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASIMED (JFM) Jurnal Kesehatan Tambusai Archives Pharmacia Journal of Experimental and Clinical Pharmacy (JECP) Duta Pharma Journal Proceeding of International Conference Health, Science And Technology (ICOHETECH) Prosiding Seminar Informasi Kesehatan Nasional
Rahmatillah, Annie
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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FORMULASI DAN UJI ANTIOKSIDAN SEDIAAN TONER EKSTRAK DAUN LAVENDER PERANCIS (LAVANDULA DENTATA) MENGGUNAKAN METODE DPPH (2,2-DIPHENYL-1-PICRYLHYDRAZYL) Yusuf, Dea Sagitarina; Wardani, Tatiana Siska; Rahmatillah, Annie
Jurnal Kesehatan Tambusai Vol. 6 No. 3 (2025): SEPTEMBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i3.50310

Abstract

Radikal bebas akibat paparan polusi, sinar ultraviolet, asap rokok, dan faktor lingkungan lain dapat memicu kerusakan sel kulit serta mempercepat penuaan dini. Kondisi ini terjadi karena radikal bebas merusak kolagen, elastin, dan membran sel sehingga kulit kehilangan kekenyalannya. Untuk mengatasinya, diperlukan senyawa antioksidan yang mampu menetralkan radikal bebas. Salah satu sumber antioksidan alami adalah Lavender Perancis (Lavandula dentata), yang diketahui mengandung flavonoid dan berbagai senyawa bioaktif dengan aktivitas antioksidan. Penelitian ini bertujuan memformulasikan sediaan toner dari ekstrak daun Lavandula dentata serta mengevaluasi aktivitas antioksidannya menggunakan metode DPPH (2,2-diphenyl-1-picrylhydrazyl). Penelitian bersifat eksperimental dengan rancangan kuantitatif komparatif. Ekstrak diperoleh melalui metode maserasi menggunakan etanol 96% lalu diformulasikan menjadi toner dengan konsentrasi 0,5%, 1%, dan 1,5%. Evaluasi sediaan meliputi uji organoleptik, pH, homogenitas, dan iritasi, sedangkan uji aktivitas antioksidan dilakukan dengan spektrofotometer UV-Vis pada panjang gelombang 517 nm menggunakan perhitungan IC50 dari persamaan regresi linier. Hasil penelitian menunjukkan semua formula toner memenuhi persyaratan fisik, memiliki pH 5,1–5,9, tampak homogen, serta tidak menimbulkan iritasi. Ekstrak Lavandula dentata memiliki aktivitas antioksidan sangat kuat dengan IC50 19,0693 ppm. Adapun formula toner 0,5%, 1%, dan 1,5% masing-masing menghasilkan IC50 sebesar 111,005 ppm, 94,5532 ppm, dan 90,3029 ppm. Formula 1,5% merupakan yang terbaik karena memiliki nilai IC50 terendah. Dengan demikian, toner ekstrak daun Lavandula dentata stabil secara fisik dan berpotensi dikembangkan sebagai kosmetik antioksidan alami.
PROFILING MARKER AKTIF SIANIDIN-3-O-GLUKOSIDA PADA EKSTRAK ETANOL BEKATUL BERAS HITAM DAN BEKATUL BERAS MERAH Rahmatillah, Annie; Fitriawati, Anna; Sari, Sindy Avita
Prosiding Seminar Informasi Kesehatan Nasional 2024: SIKesNas 2024
Publisher : Fakultas Ilmu Kesehatan Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/sikenas.vi.3880

Abstract

Bekatul beras merupakan salah satu bahan obat alam yang telah terbukti memiliki berbagai aktivitas farmakologi secara in vitro dan in vivo. Bekatul beras kaya akan serat, tocopherol, tocotrienol, oryzanol, vitamin B kompleks dan berbagai macam senyawa fenolik seperti antosianin. Aktivitas farmakologi bekatul beras dipengaruhi oleh kadar senyawa yang bertanggung jawab didalamnya. Penelitian ini merupakan penelitian eksperimental. Analisis kualitatif dengan membandingkan waktu retensi senyawa target dan standar yang berada antara 2,0-2,1 menit. Kuantifikasi kadar didasarkan pada kurva baku dari isolat sianidin-3-O-glukosida dari range 2.10-4 – 1.10-3 % b/v, didapatkan koefisisen korelasi lebih dari 0.99. Didapatkan konsentrasi sianidin-3-O-glukosida didalam ekstrak etanol BBH dan BBM secara berturut-turut 0.012 %b/b dan 1.38x10-3 %b/b. Terbukti bahwa kandungan sianidin-3-O-glukosida dalam ekstrak BBH lebih besar dari ekstrak BBM. Pada ekstrak etanol, kadar antosianin total paling tinggi terdapat pada bekatul beras hitam, yaitu 328,4 ±34,76 mg/100g ekstrak, sedangkan untuk ekstrak etanol bekatul beras merah hanya sebesar 214,3 ±17,39 mg/100g ekstrak.
OPTIMIZATION OF CLAY MASK FORMULA FROM LEAF SI KEJUT (Mimosa pudica L.) EXRACT USING SIMPLEX LATTICE DESIGN METHOD Fitriawati, Anna; Rahmatillah, Annie; Agustiningrum, Nurul
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2025: Proceeding of the 6th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/bss4fn77

Abstract

Clay mask is a facial mask used to remove dirt and blackheads from the skin. It is particularly suitable for acne-prone skin, as clay masks provide a refreshing sensation, absorb excess oil, and help manage blackheads. Mimosa pudica, commonly known as the "Sensitive Plant" or "Touch-me-not," contains bioactive compounds such as alkaloids, flavonoids, tannins, and saponins. According to a study by Utami et al. (2021), Mimosa pudica L. leaves exhibit strong inhibitory effects against Propionibacterium acnes, the primary bacterium responsible for acne. The objective of this research is to determine the optimal formulation of ethanol extract from Mimosa pudica leaves in a clay mask using the Simplex Lattice Design (SLD) method. Optimization was performed by comparing two clay base formulations—kaolin and bentonite. Physical quality testing included organoleptic evaluation, homogeneity, adhesion strength, spreadability, pH testing, and drying time. The results of the physical quality tests were analyzed using Design Expert software. Through the Simplex Lattice Design (SLD) method, the optimal formula was identified as Formula I, containing 34.75% kaolin and 6.25% bentonite.
ANALISIS GAP KINERJA DAN KEPUASAN PASIEN DI INSTALASI FARMASI RUMAH SAKIT UNIVERSITAS SEBELAS MARET Marwiyati, Vivin; Rahmatillah, Annie
Duta Pharma Journal Vol. 4 No. 1 (2024): DUTA PHARMA JOURNAL
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Performance measurement using a descriptive case study method. This research is intended to determine the performance of the Sebelas Maret University Hospital Pharmacy Installation. to see the performance achievements that have been made as well as the basis for further performance improvements. This research aims to determine the performance of the Pharmacy Installation at Sebelas Maret University Hospital. This research is a type of non-experimental research with a descriptive evaluative design. Data were obtained retrospectively and prospectively. Data criteria include qualitative and quantitative data. Qualitative data through interviews and direct observation. Quantitative data through questionnaires. Keywords: Performance, Pharmaceutical Installations, Customer Perspective, Growth Perspective and Learning.
Synergistic Impact of The Combination of Moringa Leaves and Butterfly Pea Flowers Infusion on Cognitive Enhancement Annie Rahmatillah; Anna Fitriawati; Anisa Fadilah Kumala Putri
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/n9214f64

Abstract

Oxidative stress can induce memory loss, which may be mitigated by antioxidants. Moringa leaves (Moringa oleifera) and butterfly pea flowers (Clitoria ternatea) possess flavonoid chemicals that function as natural antioxidants. This study seeks to evaluate the impact of combined Moringa leaf and butterfly pea flower infusions on enhancing the memory of mice and to identify the optimal dosage. The research utilized male white mice (Mus musculus), categorized into six groups: a normal group, a negative control (aquadest), a positive control (Ginkgo biloba), and three treatment groups receiving various infusion doses. The procedure had three phases: acclimatization (T0), intraperitoneal administration of hyoscine butylbromide (T1), and therapy (T2). The manufacture of INDUK BUNTEL (an infusion of moringa leaves and butterfly pea flowers) was conducted using an infusion extraction method. Testing on test subjects was conducted utilizing the Radial Arm Maze methodology. The findings indicated that the infusion combination at dose III (100 mg/KgBW: 100 mg/KgBW) was the most efficacious in enhancing the memory of mice. The mean mistake rate in mice was 16.44%, representing the lowest score among the treatment groups. The one-way ANOVA test indicated no significant difference across treatment groups with three distinct dose combinations (p > 0.05).
Co-Authors 'Arifah, Zainul Agustiningrum, Nurul Anisa Fadilah Kumala Putri Anna Fitriawati Apriliya, Intan Bagas Ardiyantoro Fatika Puteri Rosyi Prabowo Ika Trisharyanti Dian Kusumowati Insani, Fitri Nur Irhamadi Malik Larasati, Karina Dwi Luthfiyanti, Niken Mahendra, Andika Dwi Marwiyati, Vivin Pratama, Kharisma Jayak Puspita Sari, Mawar Dela Putri, Anisa Fadilah Kumala Qurniawati, Eka Rahmat Hidayat Riza Monasyifa Rohmana, Vivin Marwiyati Rosi Hayyu Anjani Saputri, Dina Tika Sari, Sindy Avita UTARI SITA ARDANI Wardani, Tatiana Siska YULIANA RIZQI DWI RATNA Yusuf, Dea Sagitarina ZAKIAH FATHIANA