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All Journal Jurnal Pengabdian kepada Masyarakat Journal of Health and Medical Science JHTS Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran Indonesian Health Journal Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Haryanto Haryanto
Universitas Muhammadiyah Makassar
Agriculture, Biological Sciences & Forestry Humanities Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Hubungan Konsentrasi Ekstrak Daun Puring dengan Variabilitas Parameter Bioaktivitas Haryanto Haryanto; Ainun Jariyah; Norita Norita; Nia Agustina; Rarah Maulidya Putri; Hastata Hastata; Naylha Salsabila Hs; Naylha Musdalifa Rabbani; Hanabila Putri; Husnul Khatimah; Najwa Nur Sahdrina
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 6 (2025): November: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i6.1937

Abstract

The puring plant (Codiaeum variegatum), which has been known as an ornamental plant, apparently has significant therapeutic potential, supported by the presence of secondary metabolites such as flavonoids, tannins, saponins and alkaloids. Various modern studies report the biological activity of croton leaves, including anti-cholesterol, anti-hyperglycemia, antibacterial effects, and their use in biosurfactant formulations. However, studies on how varying extract concentrations influence bioactivity parameters quantitatively are still limited, especially in the context of dose-response relationships involving many biological parameters in one series of research. Therefore, this research was conducted to evaluate eight bioactivity parameters, namely PSM, SSSP, DSSP, SL, RO, SM, PSL, and ANA at croton leaf extract concentrations of 1%, 2%, and 4%. This research uses a laboratory experimental approach by extracting croton leaves through a maceration method using ethanol, then formulated in three concentration levels. Each parameter was analyzed quantitatively to observe the pattern of changes in biological response to variations in the dose administered. The results showed that most of the PSM, SSSP, DSSP, SL, and PSL parameters showed an optimum response at a concentration of 2%, which indicates that there is a most effective dose point before a decrease in activity occurs at the highest concentration. In contrast, several parameters such as RO, SM, and ANA showed a more fluctuating response, even the ANA parameter gave the highest value at a concentration of 4%, indicating that certain activities require higher compound levels to be achieved. In general, the response pattern found was not linear, but instead formed an optimum curve typical of the bioactivity of plant extracts. These findings confirm that determining dosage is very important in the use of croton leaf extract, both for pharmacological purposes and for the formulation of natural ingredient-based products.
Eksplorasi Sifat Analgesik Minyak Sereh Wangi: Bukti In Vivo pada Model Hewan Laboratorium Dhini Andriani; Haryanto Haryanto
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 2 (2025): April : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v1i4.609

Abstract

Pain is a physiological response to tissue damage that can reduce quality of life if not treated properly. This study aims to evaluate the analgesic activity of Plant extract in mice (Mus musculus) as a laboratory animal model. Analgesic tests were carried out using the writhing test method to assess the peripheral analgesic effect and the hot plate test to assess the central analgesic effect. Mice were divided into several treatment groups that received Plant  extract at different doses, as well as positive and negative controls. The results showed that administration of Plant  extract significantly reduced the number of abdominal contractions in the writhing test and increased the latency time in the hot plate test compared to the negative control group (p < 0.05). The highest analgesic effect was found at the highest dose, and the results approached the effectiveness of the positive control.    
Karakterisasi Tingkat Toksisitas Ekstrak Etanol Daun Trembesi (Samanea saman (Jacq.) Merr.) melalui Analisis Hubungan Konsentrasi–Mortalitas dan Estimasi Nilai LC₅₀ dengan Metode Probit Haryanto Haryanto; Nurul Izzatul Jannah; Azzahra Ramadani; Nur Azizah Khairani; Nur Sahra; Dhiva Rabiatul Maulia; Nasifa kayla putri; Muh. Yusuf Al-Habib Rachman
Journal of Health and Medical Science Vol. 5 No. 3 (2026): Volume 5 Nomor 3 Juli 2026
Publisher : CV. Pusdikra Mitra Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51178/jhms.v5i3.3655

Abstract

Daun trembesi (Samanea saman (Jacq.) Merr.) diketahui mengandung berbagai metabolit sekunder, seperti flavonoid, tanin, saponin, alkaloid, dan terpenoid yang berpotensi memberikan aktivitas biologis, namun informasi mengenai tingkat toksisitasnya masih terbatas. Penelitian ini bertujuan untuk mengkarakterisasi tingkat toksisitas ekstrak etanol 70% daun trembesi melalui analisis hubungan konsentrasi–mortalitas dan estimasi nilai LC₅₀ menggunakan metode probit. Penelitian ini merupakan penelitian eksperimental laboratorium dengan larva Artemia salina Leach sebagai organisme uji. Ekstrak diperoleh melalui metode maserasi menggunakan etanol 70%, kemudian dibuat dalam beberapa variasi konsentrasi, yaitu 10, 100, 500, 1.000, 5.000, dan 10.000 ppm. Masing-masing konsentrasi diuji terhadap 10 ekor larva Artemia salina dengan waktu pengamatan selama 24 jam. Data persentase kematian dianalisis menggunakan analisis probit untuk menentukan hubungan antara log konsentrasi dan respons mortalitas serta mengestimasi nilai LC₅₀. Hasil penelitian menunjukkan bahwa peningkatan konsentrasi ekstrak menyebabkan peningkatan persentase kematian larva, yaitu dari 6,89% pada konsentrasi 10 ppm menjadi 97,05% pada konsentrasi 10.000 ppm. Analisis probit menghasilkan nilai LC₅₀ sebesar 100,46 mg/L (ppm), yang berdasarkan klasifikasi toksisitas termasuk dalam kategori moderat (moderately toxic). Temuan ini menunjukkan bahwa ekstrak etanol 70% daun trembesi memiliki aktivitas toksik yang nyata terhadap Artemia salina serta berpotensi menjadi sumber senyawa bioaktif yang dapat dikembangkan lebih lanjut melalui pengujian farmakologi dan toksikologi lanjutan untuk memastikan efektivitas dan keamanannya.
Penentuan Nilai LC₅₀ Ekstrak Etanol 80% Daun Trembesi (Samanea saman (Jacq.) Merr.) Menggunakan Metode BSLT Haryanto Haryanto; Resky Aulifiyah Haswari.B; Aulya Nurul Imama R; Agung Nur Aqdi; Rahasia Rahasia; Ilmi Nurashilah; Alya Salsabila; Risya Nida Kaffyiah Sereang; Mawar Sahid
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 4 (2026): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i4.2353

Abstract

Samanea saman (Jacq.) Merr. leaves contain various secondary metabolites with potential biological activities; therefore, preliminary toxicity testing is necessary to evaluate their safety and bioactive potential. This study aimed to determine the Lethal Concentration 50 (LC₅₀) value of the 80% ethanol extract of Samanea saman leaves using probit analysis and to classify its toxicity level. An experimental study was conducted using the Brine Shrimp Lethality Test (BSLT) with Artemia salina Leach larvae as the test organism. The extract was tested at concentrations of 10, 100, 500, 1,000, and 5,000 ppm. Larval mortality was recorded after the incubation period, and the data were analyzed using probit analysis to determine the LC₅₀ value. The results showed that larval mortality increased with increasing extract concentration, reaching 18.42%, 23.33%, 45.83%, 70.83%, and 88.89%, respectively. Probit analysis revealed an LC₅₀ value of 301.72 mg/L (ppm). Based on the toxicity classification, this value falls into the moderately toxic category, indicating that the 80% ethanol extract of Samanea saman leaves exhibits toxic activity against Artemia salina larvae. These findings suggest that the extract has promising potential as a source of bioactive compounds and warrants further investigation, including the isolation and identification of active constituents, cytotoxicity evaluation, and safety assessment in more complex biological systems.
Co-Authors Adinda Maharani Afandi Afandi Agung Nur Aqdi Ainun Jariah Ainun Jariyah Alya Nurul Pertiwi Alya Salsabila Amri Alwi Andi Alisa Alsa Andi Ulfah Magefirah Rasyid Andri Anugrah Pratama Anshari Masri Aqila, Jihan Aulya Nurul Imama R Azzahra Ramadani Dhini Andriani Dhiva Rabiatul Maulia Dian Fadillah Dian Indra Aulia Febriyanti Aswinda felisa Fitrinaya Fitrinaya Fityatun Usman Hanabila Putri Hardianti Hardianti HARIANTI Harianti Hastata Hastata Husnul Khatimah Ilmi Nurashilah Izzah, Aqila Nurul Masyhuri Muhaimin Mawar Sahid Muh. Rizman Naim Muh. Yusuf Al-Habib Rachman Muhammad Guntur Muhammad Halim Ramadhan Muhammad Taufiq Duppa Musfirah Musfirah Nadia Azzahra Najwa Nur Sahdrina Nasifa kayla putri Naylha Musdalifa Rabbani Naylha Salsabila Hs Nia Agustina Norita Norita Nur Amalinda Nur Azizah Khairani Nur Fadila Rustam Nur Halisah Nur Khadijah Anasyah Nur Sahra Nurfadilah Nurfadilah Nurfadillah Nurfadillah Nurul Izzatul Jannah Putri Indah Ramadhani Rahasia Rahasia Rahmadani Rahmadani Rana Muthia Najwa Rarah Maulidya Putri Ratri Pramudita Resky Aulifiyah Haswari.B Resti Resti Rifdah Rifdah Rini Ariyanti Rismawati Kalean Risya Nida Kaffyiah Sereang Sri Widyastuti Sry Rahmatia Rauf Suci Aulia Rahmadani Sulaiman Sulaiman Sulfiana Sulfiana Sumiati Sumiati Sumiati Sumiati Syafruddin Syafruddin Ummu Aidah Yuniarsyah Yuniarsyah Yuyun Sri Wahyuni ZUL KIFLI, ZUL Zulkifli Halid