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All Journal Jurnal Pengabdian kepada Masyarakat Journal of Health and Medical Science JHTS Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran Indonesian Health Journal Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Haryanto Haryanto
Universitas Muhammadiyah Makassar
Agriculture, Biological Sciences & Forestry Humanities Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Daun Sirih Hutan (Piper Aduncum) Terhadap Penghambatan Transport Glukosa Menggunakan Ileum Tikus Putih (Rattus Novergicus) dengan Metode Infusa Haryanto Haryanto; Febriyanti Aswinda
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 2 (2025): March: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i2.1161

Abstract

Diabetes mellitus is one of the chronic diseases whose prevalence is increasing worldwide. This disease is characterized by high blood glucose levels due to impaired insulin production or function, the hormone that regulates blood sugar levels. This study aims to examine the effect of wild betel leaf extract (Piper aduncum) on the inhibition of glucose transport using the ileum of white rats (Rattus norvegicus) with the infusion method. This research is a pre-experimental study with a posttest-only control design using white rats and wild betel leaves. The study demonstrates that wild betel leaves (Piper aduncum L.) and red betel leaves (Piper crocatum) have significant potential in inhibiting glucose transport and reducing blood sugar levels. This is evident from the significant decrease in the rate of glucose transport after the administration of wild betel leaf extract, indicating an inhibitory effect on glucose transporters such as SGLT-1 and GLUT-2.
Perbandingan Efektivitas Paracetamol vs Ibuprofen dalam Manajemen Demam Dewasa: Analisis Berbasis Data Real-World Nur Amalinda; Haryanto Haryanto
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 3 (2025): May: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i3.1300

Abstract

Fever is the body's response to infection or inflammation, which often indicates a certain medical condition. One common treatment for fever is the use of antipyretic drugs. The purpose of this study was to evaluate the effectiveness of antipyretic drugs in lowering body temperature in adult patients with fever. The method used was a clinical trial with a randomized controlled trial (RCT) design, involving 100 adult patients with fever ≥38°C. Patients were divided into two groups: the group receiving antipyretic drugs (paracetamol) and the placebo group. Body temperature measurements were taken every 2 hours for 24 hours after drug administration. The results showed that the group receiving antipyretic drugs experienced a significant decrease in body temperature compared to the placebo group (p <0.05). The side effects that appeared were relatively mild and not dangerous..
Hubungan Konsentrasi Ekstrak Daun Puring dengan Variabilitas Parameter Bioaktivitas Haryanto Haryanto; Ainun Jariyah; Norita Norita; Nia Agustina; Rarah Maulidya Putri; Hastata Hastata; Naylha Salsabila Hs; Naylha Musdalifa Rabbani; Hanabila Putri; Husnul Khatimah; Najwa Nur Sahdrina
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 6 (2025): November: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i6.1937

Abstract

The puring plant (Codiaeum variegatum), which has been known as an ornamental plant, apparently has significant therapeutic potential, supported by the presence of secondary metabolites such as flavonoids, tannins, saponins and alkaloids. Various modern studies report the biological activity of croton leaves, including anti-cholesterol, anti-hyperglycemia, antibacterial effects, and their use in biosurfactant formulations. However, studies on how varying extract concentrations influence bioactivity parameters quantitatively are still limited, especially in the context of dose-response relationships involving many biological parameters in one series of research. Therefore, this research was conducted to evaluate eight bioactivity parameters, namely PSM, SSSP, DSSP, SL, RO, SM, PSL, and ANA at croton leaf extract concentrations of 1%, 2%, and 4%. This research uses a laboratory experimental approach by extracting croton leaves through a maceration method using ethanol, then formulated in three concentration levels. Each parameter was analyzed quantitatively to observe the pattern of changes in biological response to variations in the dose administered. The results showed that most of the PSM, SSSP, DSSP, SL, and PSL parameters showed an optimum response at a concentration of 2%, which indicates that there is a most effective dose point before a decrease in activity occurs at the highest concentration. In contrast, several parameters such as RO, SM, and ANA showed a more fluctuating response, even the ANA parameter gave the highest value at a concentration of 4%, indicating that certain activities require higher compound levels to be achieved. In general, the response pattern found was not linear, but instead formed an optimum curve typical of the bioactivity of plant extracts. These findings confirm that determining dosage is very important in the use of croton leaf extract, both for pharmacological purposes and for the formulation of natural ingredient-based products.
Co-Authors Adinda Maharani Afandi Afandi Ainun Jariah Ainun Jariyah Alya Nurul Pertiwi Amalia, nur Rezky Amri Alwi Andi Alisa Alsa Andi Ulfah Magefirah Rasyid Andri Anugrah Pratama Anshari Masri Aqila, Jihan Aulia, Andi Latifa Dian Fadillah Dian Indra Aulia Fatika, Irul Febriyanti Aswinda felisa Fitri Ramadani Fitrinaya Fitrinaya Fityatun Usman Hajir, Ramadhani Hanabila Putri Hardianti Hardianti HARIANTI Harianti Haryanto Gite, Hasry Awlia Hastata Hastata Husnul Khatimah Izzah, Aqila Nurul Khaerani, Husnul Lestari, Nur Widya Maharani, Desvita Masyhuri Muhaimin Muh. Rizman Naim Muhammad Guntur Muhammad Halim Ramadhan Muhammad Taufiq Duppa Musfirah Musfirah Nadia Azzahra Najwa Nur Sahdrina Naylha Musdalifa Rabbani Naylha Salsabila Hs Nia Agustina Norita Norita Nur Amalinda Nur Fadila Rustam Nur Halisah Nur Khadijah Anasyah Nurfadilah Nurfadilah Nurfadillah Nurfadillah Putri Indah Ramadhani Putri, Nur Antasasyah Rahayu, Gita Rahayu, Nur Alam Rahmadani Rahmadani Rana Muthia Najwa Rarah Maulidya Putri Ratri Pramudita Resti Resti Rifdah Rifdah Rini Ariyanti Rismawati Kalean Sri Widyastuti Sry Rahmatia Rauf Suci Aulia Rahmadani Sulaiman Sulaiman Sulfiana Sulfiana Sumiati Sumiati Sumiati Sumiati Syafruddin Syafruddin Ummu Aidah Yuniarsyah Yuniarsyah Yuyun Sri Wahyuni ZUL KIFLI, ZUL Zulkifli Halid