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All Journal Jurnal Farmasi Klinik Indonesia MITRA: Jurnal Pemberdayaan Masyarakat Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Ilmu Kefarmasian Indonesia Abdimas Galuh : Jurnal Pengabdian Kepada Masyarakat Narra J Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Journal of Urban Health Research
Cokro, Fonny
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Other

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Effectiveness And Safety Of Erdosteinie In Management Of Chronic Obstructive Pulmonary Disease (COPD): A Systematic And Meta-Analysis Yolanda, Lorensia; Gunawan, Catherine Keiko; Sumarpo, Anton; Sahamastuti, Agnes Anania Triavika; Cokro, Fonny
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 9 (2025): Volume 12 Nomor 9
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i9.20524

Abstract

Chronic obstructive pulmonary disease (COPD) is a chronic lung disease that cause limitation in the airflow and chronic inflammation. Erdosteine has been proposed as a potential therapeutic option for COPD management, based on its antioxidant activity and anti-inflammatory properties. The purpose of this systematic review and meta-analysis is to evaluate the effectiveness and safety of erdosteine in COPD patients. Multiple databases have been involved in the literature study following PRISMA guidelines, identifying randomized controlled trials (RCTs) that compared erdosteine with placebo. A total of seven studies were included in the qualitative analysis, and nine were analyzed quantitatively. Meta-analysis results indicated that erdosteine significantly improved forced expiratory volume in one second (FEV1), reduced reactive oxygen species (ROS) and 8-isoprostan levels, and lowered interleukin-8 (IL-8) concentrations. Subgroup analyses demonstrated greater benefits in patients with moderate to severe COPD (stage II/III). Safety analysis revealed that erdosteine was generally well-tolerated, with only mild adverse effects reported. However, study limitations included high heterogeneity and potential bias in some trials. Overall, the findings suggest that erdosteine is an effective and safe adjunct therapy for COPD.
Identifikasi Bakteri dalam Air RWH Rusunawa Muara Baru dan Evaluasi Tanaman Obat dengan Aktivitas Antibakteri Nurcahyanti, Agustina Dwi Retno; Cokro, Fonny; Gokok, Silvia; Lady, Jullietta; Jap, Adeline
Jurnal Dimas Vol 5 No 1 (2023): Jurnal Pengabdian Kepada Masyarakat
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/dimas.v5i1.56

Abstract

Abstrak: Keberadaa Rusunawa Muara Baru sangat membantu warga karena biaya sewa yang tergolong murah dan rusun yang dilengkapi dengan fasilitas lengkap. Meskipun demikian, salah satu permasalahan yang dihadapi oleh warga adalah ketersediaan air sehingga sejak 2017 dibangunlah system Rain Water Harvesting (RWH). Kualitas air RWH sangat beragam yang umumnya dipengaruhi oleh letak geografis, iklim, kondisi lingkungan sekitar, kotoran hewan, volume dan retensi air dalam tempat penampung, kondisi atap, kondisi pipa dan sistem penyimpanan, serta pemeliharaan. Beberapa studi melaporkan air RWH dapat terkontaminasi oleh mikroba dan dapat mengakibatkan penyakit akut maupun kronis serta wabah. Kegiatan pengabdian dimulai dengan pengambilan sampel air RWH pada April 2021 di Rusunawa Muara Baru menggunakan panduan internasional Lembaga Kesehatan Dunia (WHO International Guideline). Selanjutnya uji mikrobiologi dan potensi antimikroba dari beberapa tanaman obat dilakukan. Melalui kegiatan ini ditemukan 3 jenis bakteri pada sampel air RWH Rusunawa Muara Baru, yaitu: Klebsiella pneumonia, Escherichia coli, dan Pseudomonas aeruginosa melalui karakterisasi 16S rRNA. Lima tanaman obat Indonesia yang berpotensi sebagai antibakteri untuk mencegah permasalahan kebersihan air RWH, yaitu Azadirachta indica (Daun Mimba), Artocarpus altilis (Daun Sukun), Psidium guajava (Daun Jambu), Curcuma zanthorrhiza (Temulawak), and Lagerstroemia speciosa (Bungur). Selanjutnya, kegiatan pengabdian masyarakat akan difokuskan pada pembuatan produk antiseptik berbasis tanaman obat potensial. Abstract: Muara Baru Rusunawa offers benefits and helps residents because of the affordable price and well-equipped facilities. Nevertheless, one of the problems is the availability of water. In 2017, the Rain Water Harvesting (RWH) system was built. RWH water quality varies widely and is influenced by geographical location, climate, environmental conditions, animal waste, volume and water retention in reservoirs, roof conditions, pipe and storage system conditions, and maintenance. Several studies report that microbes can contaminate RWH water and can cause acute and chronic diseases and epidemics. Current service activities began with RWH water sampling in April 2021 at Rusunawa Muara Baru using the international guidelines of the World Health Organization (WHO International Guideline). Furthermore, several medicinal plants' microbiological tests and antimicrobial potential were carried out. Through this activity, three types of bacteria were found in the water sample of the RWH Rusunawa Muara Baru, namely: Klebsiella pneumonia, Escherichia coli, and Pseudomonas aeruginosa through characterization of 16S rRNA. Five Indonesian medicinal plants have the potential as antibacterials to prevent RWH water hygiene problems, namely Azadirachta indica (Neem Leaves), Artocarpus altilis (Breadfruit Leaves), Psidium guajava (Guava Leaves), Curcuma zanthorrhiza (Temulawak), and Lagerstroemia speciosa (Bungur). Furthermore, community service activities will make antiseptic products based on potential medicinal plants.
Co-Authors Abdul Rahem Abdul Rahem, Abdul Agnes Anania Triavika Sahamastuti Agustina Dwi Retno Nurcahyanti Andrelia, Evelyn Trisia Anton Sumarpo Arrang, Sherly Tandi Dion Notario Erlia Anggrainy Sianipar Evi Martha Felicia Christian Franciscus C. Kristianto Genoveva Della Gokok, Silvia Gunawan, Catherine Keiko Heri setiawan Jap, Adeline Jenny Jokimawidjaja Jonathan A. N. Solang Kristianto, Franciscus C. Lady, Jullietta Lisa Aditama, Lisa Lorensia Yolanda Meilani Eka Putri Nathacia Nathacia Pangestuning Sekarsari Pattirajawane, Ignatius Danny Rani Sauriasari, Rani Sagala, Reynelda Juliani Shelly Caroline Sherly T. Arrang Tahapary, Dicky L. Yolanda, Lorensia