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All Journal Jurnal Sains Teknologi dan Lingkungan (JSTL) Jurnal Biologi Tropis
Hasanah, Mielosita
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Immunology & microbiology Public Health

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Efektivitas Terapi pada Gangguan Kecemasan Hasanah, Mielosita; Hairy, Fathinah Salsabilla; Nursiain, Aziza Chantiqka Aulia; Ananda, Asti
JURNAL SAINS TEKNOLOGI & LINGKUNGAN Vol. 11 No. 2 (2025): JURNAL SAINS TEKNOLOGI & LINGKUNGAN
Publisher : LPPM Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jstl.v11i2.868

Abstract

Anxiety disorders are psychological conditions characterized by excessive and pathological anxiety or worry, and they remain a significant mental health concern in both developed and developing countries. Managing these disorders requires effective therapeutic interventions, both psychological and pharmacological. This article reviews various therapeutic approaches used in the treatment of anxiety disorders, including cognitive behavioral therapy (CBT), dialectical behavior therapy (DBT), supportive therapies, and pharmacological treatments. The review focuses on the effectiveness, mechanisms of action, and factors influencing the success of each therapy. Findings indicate that CBT consistently demonstrates high effectiveness in reducing symptoms across different types of anxiety disorders. Appropriate and comprehensive therapy selection based on individual conditions is essential to improve clinical outcomes and patient prognosis.
A Systematic Literature Review of The Bronchiectasis Anugrah, Yunan Prabu Jaya; Hasanah, Mielosita; Mikailla, Romy Healthy; Nitzana, Lale Nubya; Ilmiah, Janiya Abdila
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.9994

Abstract

Bronchiectasis is a chronic respiratory condition marked by irreversible dilation of the bronchi, leading to persistent cough and excessive sputum production. This study aims to describe the pathophysiology, clinical features, diagnosis, and management strategies of bronchiectasis, with emphasis on current approaches relevant to the Indonesian context. A narrative literature review was conducted using national and international sources. Key clinical and radiological findings, treatment modalities, and prognosis indicators were summarized, with reference to validated scoring systems such as FACED and Bronchiectasis Severity Index (BSI). Bronchiectasis is most prevalent among women and the elderly. Common etiologies include post-infectious lung disease, cystic fibrosis, and chronic inflammation. HRCT is the gold standard for diagnosis. Management focuses on airway clearance, antibiotic therapy, and reducing exacerbations. Prognosis varies depending on severity, but early and personalized treatment improves outcomes. Bronchiectasis remains under-recognized in Indonesia, despite its significant burden. Timely diagnosis using HRCT and targeted therapy can improve patient quality of life and reduce complications. Efforts should be made to increase clinical awareness, improve diagnostic access, and promote preventive measures such as immunization, smoking cessation, and early treatment of respiratory infections.
Lung Abscess: Literature Review of Risk Factors, Classification, Clinical Manifestations, Diagnosis, and Prevention Nitzana, Lale Nubya; Hasanah, Mielosita; Mikailla, Romy Healthy; Anugrah, Yunan Prabu Jaya; Ilmiah, Janiya Abdila; Ajmala, Indana Eva
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10343

Abstract

A lung abscess is the formation of a thick-walled cavity filled with purulent material due to suppuration and necrosis of the lung parenchyma. Cases of lung abscess are relatively rare today and were most common in the pre-prebiotic era due to the lack of treatment for bacterial infections. This literature review aims to obtain information related to lung abscess its etiology, diagnostics, and treatment options. The article was compiled using a literature search through databases such as PubMed, ScienceDirect, and Google Scholar using the keyword "lung abscess." The findings indicate that lung abscess is a condition characterized by the formation of a pus-filled cavity resulting from suppuration and necrosis of lung tissue. This disease is commonly caused by anaerobic bacterial infection, although aerobic bacteria may also play a role. Despite its relatively low incidence today, lung abscess remains an important clinical problem as it can arise as a complication of pneumonia or tuberculosis. Diagnosis is established through medical history, physical examination, and supporting investigations such as radiology and sputum culture. Management includes long-term antibiotic therapy, drainage, and surgical intervention for refractory cases. Preventive efforts involve maintaining oral hygiene, reducing alcohol consumption, and avoiding aspiration risk factors. Therefore, comprehensive understanding of the definition, pathogenesis, clinical features, diagnosis, and management of lung abscess is essential to support clinical practice in pulmonary medicine.
Chronic Myeloid Leukemia: Etiology, Risk Factors, Pathophysiology, Diagnosis, Management, and Prognosis Patandianan, Firdaus Kamma; Hasanah, Mielosita; Mikaila, Romy Healthy; Athalia, Ihza Namira; Nitzana, Lale Nubya; Hairy, Fathinah Salsabila
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10589

Abstract

The Philadelphia chromosome is a hallmark of Chronic Myeloid Leukemia (CML), a hematopoietic stem cell disease caused by the reciprocal translocation t(9;22)(q34;q11) that creates the oncogenic fusion gene BCR-ABL1, which persistently activates tyrosine kinase and encourages unchecked myeloid cell proliferation. This literature review aims to describe the pathophysiology, clinical manifestations, diagnosis, treatment, and prognosis of CML based on recent studies. Literature searches were conducted through PubMed, Google Scholar, and official institutional websites using the keywords “Chronic Myeloid Leukemia,” “Philadelphia chromosome,” and “BCR-ABL1.” CML accounts for approximately 15–20% of all leukemia cases and progresses through three phases: chronic, accelerated, and blast crisis. The BCR-ABL1 fusion gene constitutively activates multiple oncogenic pathways, including JAK/STAT, PI3K/AKT, and RAS/RAF, leading to enhanced proliferation and resistance to apoptosis. Diagnosis is established through hematologic examination and molecular testing using PCR or FISH for BCR-ABL1 detection. The mainstay treatments include tyrosine kinase inhibitors such as imatinib, dasatinib, and nilotinib, with stem cell transplantation reserved for advanced cases. With early diagnosis and appropriate therapy, overall survival exceeds 80% at eight years. In conclusion, CML is a chronic hematologic malignancy driven by BCR-ABL1, and advances in molecular-targeted therapy have transformed it into a manageable chronic disease with significantly improved patient outcomes.
Co-Authors Ajmala, Indana Eva ANANDA, ASTI Anugrah, Yunan Prabu Jaya Athalia, Ihza Namira Hairy, Fathinah Salsabila Hairy, Fathinah Salsabilla Ilmiah, Janiya Abdila Mikaila, Romy Healthy Mikailla, Romy Healthy Nitzana, Lale Nubya Nursiain, Aziza Chantiqka Aulia Patandianan, Firdaus Kamma