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All Journal Farmaka International Journal of Integrated Health Sciences Althea Medical Journal Jurnal Kesehatan Andalas Indonesian Journal of Biotechnology Journal of Applied Science, Engineering, Technology, and Education Jurnal Integrasi Kesehatan dan Sains Studies in Learning and Teaching Jurnal Vokasi Kesehatan
Afiat Berbudi
Department Of Biomedical Sciences, Parasitology Division, Faculty Of Medicine, Padjadjaran University, Bandung, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

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REVIEW: AKTIVITAS IMMUNOMODULATOR TANAMAN SAMBILOTO (Andrographis paniculata Nees) Maulana Yusuf Alkandahri; Anas Subarnas; Afiat Berbudi
Farmaka Vol 16, No 3 (2018): Farmaka (September)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (194.811 KB) | DOI: 10.24198/jf.v16i3.14237

Abstract

Artikel ini mengulas tentang aktivitas immunomodulator tanaman sambiloto (Andrographis paniculata Nees.) yang digunakan sebagai terapi alternatif dalam meningkatkan sistem imunitas tubuh. Sambiloto (Andrographis paniculata Nees) merupakan tanaman asli Indonesia yang banyak diteliti saat ini, terutama aktivitas immunomodulator yang dimilikinya. Aktivitas immunomodulator dari sambiloto ini disebabkan karena adanya kandungan senyawa aktif berupa deoxyandrographolide, andrographolide, 14-deoxy-11, neoandrographolide, 12- didehydroandrographolide, homoandrographolide, diterpenoid dan flavonoid yang terkandung di dalam sambiloto. Sebagai agen immunomodulator, sambiloto dapat digunakan sebagai immunostimulator yang meningkatkan respon imun saat kekebalan tubuh menurun, dan juga bisa menjadi imunosupresor yang dapat menurunkan respon kekebalan tubuh saat sistem kekebalan tubuh meningkat melebihi kondisi tubuh normal. Selain itu, sebagai immunomodulator, sambiloto juga mampu menormalkan kondisi tubuh meskipun terjadi infeksi.Kata kunci : Sambiloto, Andrographis paniculata Nees., Immunomodulator, Andrographolide
Performance of CO1 and ITS2 nested PCR in molecular identification of ordinary scabies (Sarcoptes scabiei var. hominis) Gita Dwi Prasasty; Miftahurrizqiyah Miftahurrizqiyah; Chairil Anwar; Dwi Handayani; Dalilah Dalilah; Ahmad Ghiffari; Inda Astri Aryani; Nunuk Dyah Retno Lastuti; Afiat Berbudi
Indonesian Journal of Biotechnology Vol 26, No 4 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijbiotech.64472

Abstract

Scabies is a global disease with a high prevalence, causing morbidity and even mortality, especially in poor and developing countries. However, it is often misdiagnosed due to varied and unspecified lesions. The gold standard technique for diagnosis is a microscopic examination, which requires experienced experts in finding mites, mainly in ordinary scabies. CO1 and ITS2 genes have been widely used in molecular identification to detect Sarcoptes scabiei and its variants. This study aimed to determine and compare the sensitivity and specificity of CO1 and ITS2 S. scabiei genes to the microscopic examination of scabies skin scrapings. The skin scrapings of 52 subjects with scabies diagnosed by anamnesis, physical examination, and dermoscopic examination were examined under a microscope and analyzed by nested PCR. The diagnostic test result showed that the sensitivity of nested PCR of both CO1 and ITS2 genes to micro‐ scope examination was 100%. However, the specificity of both CO1 and ITS2 nested PCR was poor (24% and 0%). Hence, CO1 and ITS2 nested PCR could be more suitable for screening ordinary scabies in humans than the microscopic examination.
Characteristics and Complications of Tuberculous Meningitis Patients with Hydrochepalus Undergone Fluid Diversion in Dr. Hasan Sadikin General Hospital, Bandung Adriani Lawrencia Novalia; Afiat Berbudi; Ahmad Faried; Heda Melinda Nataprawira
International Journal of Integrated Health Sciences Vol 6, No 1 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (181.71 KB) | DOI: 10.15850/ijihs.v6n1.1048

Abstract

Objective: To describe the clinical characteristics and complications observed in tuberculous meningitis (TBM) patients with hydrocephalus who had undergone fluid diversion management.Methods: This was a cross-sectional descriptive observational study involving 28 TBM patients with hydrocephalus aged 0–5 years who had undergone ventriculoperitoneal shunt or extraventricular drainage in the period of July 2011 to July 2016 in Dr. Hasan Sadikin General Hospital, Bandung. Age, gender, head circumferences, nutritional status, and classical characteristics such as sunset eye, frontal bossing, cracked pot sign, venectation as well as complications such as infection, phlebitis, and exposed shunt documented in the hospital medical records were analyzed.Result: The study discovered that infant group was predominant (21/28). Some of the patients had macrocephalus (7/28) and 18 had good nutrition status (18/28). There were 4 patients with frontal bossing characteristics (4/28) and almost none was found with others classic hydrocephalus characteristics. This study found no complication such as infection, phlebitis, and exposed shunt in TBM patients with hydrocephalus who had undergone fluid diversion therapy in Dr. Hasan Sadikin General Hospital, Bandung.Conclusion: One of the most dominan characteristics of TBM patients with hydrocephalus is frontal bossing. Tuberculous meningitis patients with hydrocephalus in our center did not show any fluid diversion-related complications such as infection, phlebitis, or exposed shunt.Keywords: Tuberculous meningitis, hydrocephalus, fluid diversion DOI: 10.15850/ijihs.v6n1.1048
Perbandingan Efek Samping Lokal dengan Sistemik Pascavaksinasi COVID-19 Booster pada Anggota Paguyuban Pasundan yang Diberi Vaksin AstraZeneca Muhammad Fadhil; Gianita Yulia Lestari; Afiat Berbudi
Jurnal Integrasi Kesehatan dan Sains Vol 5, No 1 (2023): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v5i1.10211

Abstract

AbstrakTujuan penelitian adalah untuk membandingkan efek samping terhadap vaksinasi booster COVID-19 menggunakan vaksin AstraZeneca serta membandingkan efek samping lokal dengan sistemik. Penelitian dilakukan di lingkungan Paguyuban Pasundan pada Februari 2022, model penelitian analitik observasional dengan pendekatan kohort prospektif menggunakan sampel data primer diambil dari google form sebagai media pengisian kuesioner dengan pengambilan sampel dilakukan secara acak, kemudian data dikumpulkan dan diproses dengan program Microsoft Excel dan SPSS versi 26,0. Jumlah subjek dalam penelitian ini 119 responden yang seluruhnya anggota Paguyuban Pasundan. Jenis vaksinasi kesatu dan kedua yang diterima responden adalah Sinovac, untuk vaksinasi ketiga adalah AstraZeneca. Efek samping yang timbul pada vaksinasi booster menggunakan vaksin AstraZeneca didominasi oleh efek samping lokal seperti nyeri di bahu tempat suntikan (56%) dan pegal tempat suntikan (56%), diikuti dengan efek samping sistemik seperti nyeri otot seluruh tubuh (28,5%), demam (27%), dan kepala pusing (25,2%). Hasil independen t-test terdapat nilai probabilitas sebesar 0,001 (<0,05), terdapat perbedaan signifikan efek samping lokal dengan sistemik. Disimpulkan bahwa efek samping lokal lebih sering dirasakan dibanding dengan efek samping sistemik.Kata kunci: Booster, COVID-19, efek samping, vaksinA Comparison of Local and Systemic Side Effects Post-Covid-19 Booster Vaccination on Paguyuban Pasundan Members who were Given the AstraZeneca VaccineAbstractThis study aimed to comparison the side effects of the COVID-19 booster vaccination using the AstraZeneca vaccine, and to compare the local and systemic side effects. This study was accomplished in the Paguyuban Pasundan environment in February 2022. The research model was observational analytic with a prospective cohort approach using primary data samples taken from Google Form as a medium for filling out questionnaires with a simple random sampling. Afterwards, the data was gathered and processed using Microsoft Excel and SPSS version 26.0. The respondents in this study were 119 persons who were all members of the Paguyuban Pasundan. The vaccines 1 and 2 received by the respondents were Sinovac, the vaccines 3 were AstraZeneca. The side effects arising from booster vaccination using AstraZeneca vaccine were dominated by local side effects such as pain at the injection site on shoulder (56%), injection site soreness (56%), followed by systemic side effects like muscle aches throughout the body (28.5%), fever (27%), and headache (25.2%). The results of the independent t-test revealed a probability value of 0.001 (<0.05). This can be inferred that there are significant differences in local and systemic side effects. Thus, it can be concluded that local side effects are reported more often than systemic side effects.Keywords: Booster, COVID-19, side-effects, vaccine
Pemberian Ekstrak Curcuma Longa L. Meningkatkan Proliferasi Sel MEF yang dilakukan Scratch Test Afiat Berbudi; Muhammad Ifham Hanif; Almahitta Cintami Putri
Jurnal Vokasi Kesehatan Vol 5, No 1 (2019): JANUARI 2019
Publisher : Poltekkes Kemenkes Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (321.03 KB) | DOI: 10.30602/jvk.v5i1.183

Abstract

Abstract: Proliferation Enhancement of Curcuma Longa L. Extract Treatment in MEF Cell Cultres that Treated by Scratch Test. Wound prevalence is still high and becomes a problem of healing process. Improper wounds management can cause wound healing disturbance, so that the healing process will be longer. For this reason, alternative medicine is required to shorten healing process and reduce medical costs. This study aims to determine the effect of Curcuma longa L. extract on enhancement of mouse embryonic fibroblast cell proliferation carried out in vitro scratch test with the research method using a laboratory in vitro experimental design and 24 hour observation. Observations were carried out for 24 hours with variations in Curcuma longa L. extract concentration 2.5 ppm, 5 ppm, 10 ppm, 25 ppm and 50 ppm. The results showed that Curcuma longa L extract was able to accelerate the proliferation of mouse embryonic fbroblast cells which scratch test. After 24 hours, the highest gap closure were observed in mouse embryonic fbroblast cell culture using dose of 2.5 ppm of Curcuma longa L. extract administration. At a dose of ≥10 ppm it does not show proliferation in embryonic fbroblast mouse cells but causes toxicity to cells. Abstrak: Pemberian Ekstrak Curcuma Longa L. Meningkatkan Proliferasi Sel MEF yang dilakukan Scratch Test. Prevalensi luka yang tinggi masih menjadi permasalahan tersendiri dalam proses penyembuhan. Penanganan luka yang tidak tepat dapat menyebabkan gangguan penyembuhan sehingga proses penyembuhan menjadi panjang. Untuk itu perlu alternatif pengobatan yang dapat mempersingkat penyembuhan dengan biaya pengobatan yang lebih murah. Penetian ini bertujuan mengetahui pengaruh pemberian ekstrak Curcuma longa L. terhadap peningkatan proliferasi sel mouse embryonic fibroblast yang dilakukan scratch test secara in vitro dengan metode penelitian menggunakan desain eksperimen in vitro laboratoris dan dilakukan pengamatan selama 24 jam. Variasi konsentrasi ekstrak Curcuma longa L menggunakan dosis 2.5 ppm, 5 ppm, 10 ppm, 25 ppm dan 50 ppm. Hasil pengamatan menunjukkan bahwa ekstrak Curcuma longa L. mampu mempercepat proliferasi sel mouse embryonic fbroblast yang dilakukan scratch test dengan dosis optimum 2.5 ppm. Pada dosis ≥10 ppm tidak menunjukkan proliferasi pada sel mouse embryonic fbroblast tetapi menyebabkan toksisitas pada sel.
Korelasi Status Nutrisi dengan Tingkat Kadar Hemoglobin Darah pada Anak Usia Sekolah Dasar Markidam di Desa Cilame Kabupaten Bandung Lenny Oktorina; Fadhli Dharmansyach Hakim; Josep Dharmadi Buntoro; Afiat Berbudi; Bayu Ewangga
Jurnal Kesehatan Andalas Vol 12, No 1 (2023): Online March 2023
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i1.2154

Abstract

Malnutrition has many adverse effects, including a decrease in hemoglobin levels, or known as anemia. Malnutrition caused by nutritional deficiencies can affect the decrease in hemoglobin levels or anemia. Objective: To determined the correlation between nutritional status and hemoglobin levels in Markidam elementary school-age children in Cilame Village Methods: This cross-sectional study uses primary data from research subjects who have agreed. The number of subject research that has been taken was 143 respondents. Anthropometric examinations using weight scales and microtoise were then carried out in a plotting process to determine the nutritional status of respondents. The hemoglobin level was used as a rapid diagnostic test tool with the Easytouch brand type GCHB. Spearman test to find out the results of this research hypothesis. Results:  Hemoglobin levels did not have a significant correlation with nutritional status. This could be seen from the significance value (p-value) of 0,172, where this value is greater than 0,05. Conclusion: There is no correlation between nutritional status and hemoglobin level at the age of elementary school children.Keywords: anemia, hemoglobin, nutritional status
Effectiveness of Learning Management System and Peer Assessment Method in Parasitology Learning at Padjadjaran University, Faculty of Medicine Afiat Berbudi; Faqih Achmad Rabbani; Kurnia Wahyudi
Studies in Learning and Teaching Vol. 5 No. 1 (2024): April
Publisher : Indonesia Approach Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46627/silet.v5i1.351

Abstract

The early 2020 COVID-19 pandemic disrupted community activities, including education. Online education and various teaching methods have been implemented by the Indonesian government to reduce classroom learning. This study investigates the impact of asynchronous learning and peer assessment in the parasitology course via the Learning Management System (LMS). This quantitative study evaluated the effectiveness of Learning Management System to facilitate asynchronous learning and peer assessment in the fifth-semester parasitology course. All 247 course students were the study's target group. The data was acquired using a structured questionnaire. A quantitative analysis was done utilizing Sugiyono's efficacy formula. To draw relevant conclusions, qualitative questionnaire data was recorded and rigorously analyzed. The survey indicated that 37% of respondents thought LMS was beneficial for Parasitology E-learning and 39% said it improved course understanding. In the GIS system, 91% of participants said peer assessment helped them comprehend parasitology topics. This study demonstrates that the LMS can effectively and efficiently facilitate peer assessment to address the challenges in providing feedback to students in order to improve learning outcomes.
Determinant of Hypertension among Adults in West Java, Indonesia: Analysis of National Basic Health Research Data 2018 Karlen, Jannatin; Berbudi, Afiat; Wahyudi, Kurnia
Althea Medical Journal Vol 10, No 4 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n4.2826

Abstract

Background: Hypertension is a serious health problem worldwide. Many studies on the determinants of hypertension have been done, however studies in West Java are still very minimal. This study aimed to determine the risk factors for hypertension among adults in West Java, Indonesia.Methods: This study used a cross-sectional method with a quantitative approach using secondary data from the National Basic Health Research 2018. The final number of individuals sampled was 46,186 people. Data analysis was performed using simple logistic regression and multiple logistic regression methods.Results: The mean age of the sample was 42.97 years (SD=15.37), and females were the predominant (52.95%). The majority of samples consumed sweet beverages (31.06%) and salty foods more than once a day (29.22%), did not smoke (59.17%), had a normal body mass index (BMI) (53.78 %), and had experienced gum disease and dental problems in the last year (56.75 %). Physical activity in metabolic equivalent task (MET) minute was 5,917.79. There was a significant positive association between age and hypertension, with an odds ratio (OR) of 1.06 and a 95% confidence interval (CI) of 1.05–1.06. Furthermore, the analysis found a significant negative correlation between physical activity and hypertension, with an OR of 0.999 and a 95% CI of 0.9999874–0.9999962.Conclusions: Hypertension is significantly associated with age, whereas physical exercise is negatively associated. Priority should be given to elderly individuals and people with a high BMI for interventions such as routine blood pressure monitoring and education.
Korelasi Status Nutrisi dengan Tingkat Kadar Hemoglobin Darah pada Anak Usia Sekolah Dasar Markidam di Desa Cilame Kabupaten Bandung Oktorina, Lenny; Hakim, Fadhli Dharmansyach; Buntoro, Josep Dharmadi; Berbudi, Afiat; Ewangga, Bayu
Jurnal Kesehatan Andalas Vol. 12 No. 1 (2023): Online March 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i1.2154

Abstract

Malnutrition has many adverse effects, including a decrease in hemoglobin levels, or known as anemia. Malnutrition caused by nutritional deficiencies can affect the decrease in hemoglobin levels or anemia. Objective: To determined the correlation between nutritional status and hemoglobin levels in Markidam elementary school-age children in Cilame Village Methods: This cross-sectional study uses primary data from research subjects who have agreed. The number of subject research that has been taken was 143 respondents. Anthropometric examinations using weight scales and microtoise were then carried out in a plotting process to determine the nutritional status of respondents. The hemoglobin level was used as a rapid diagnostic test tool with the Easytouch brand type GCHB. Spearman test to find out the results of this research hypothesis. Results:  Hemoglobin levels did not have a significant correlation with nutritional status. This could be seen from the significance value (p-value) of 0,172, where this value is greater than 0,05. Conclusion: There is no correlation between nutritional status and hemoglobin level at the age of elementary school children.Keywords: anemia, hemoglobin, nutritional status
Effects of Achasin Protein on Snail (Achatina Fulica) Mucus on Healing Cuts (Vulnus Scissum) in Mice (Mus Musculus) Skin Triasmara, Wahyu; Berbudi, Afiat; Windria, Sarasati
Journal of Applied Science, Engineering, Technology, and Education Vol. 5 No. 1 (2023)
Publisher : PT Mattawang Mediatama Solution

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35877/454RI.asci1139

Abstract

Snail mucus Achasin protein is a protein that has important biological functions, besides being intended to prevent evaporation, and assist smooth movement, it is also needed to protect the body from mechanical injuries. This research is expected to increase knowledge about the effect of achasin protein on snail mucus on wound healing and can provide scientific information to the public about the use and benefits of snail mucus as a traditional medicine for healing cuts on the skin of mice ( Mus Musculus ). This type of research is a literature review study that aims to examine the effect of achasin protein on snail mucus ( Achatina Fulica ) on the healing of cuts on the skin of mice ( mus musculus ). Sources of data used in this study used a literature review with relevant sources such as books, official documents, publications, and relevant research results. The results of this study were the achasin protein in snail mucus (Achatina Fulica) can accelerate the healing of cuts (vulnus scissum) on the skin of mice (mus musculus). The content of achasin isolate is also useful as an antibacterial and painkiller. So that people can take advantage of snail slime as an alternative to traditional medicine derived from natural ingredients that have been clinically tested for their efficacy.
Co-Authors Adriani Lawrencia Novalia Ahmad Faried Ahmad Ghiffari Almahitta Cintami Putri Anas Subarnas Bayu Ewangga Buntoro, Josep Dharmadi Chairil Anwar Cintami Putri, Almahitta Dwi Handayani Ewangga, Bayu Fadhli Dharmansyach Hakim Faqih Achmad Rabbani Gianita Yulia Lestari Gita Dwi Prasasty Hakim, Fadhli Dharmansyach Heda Melinda Nataprawira Ifham Hanif, Muhammad Inda Astri Aryani Josep Dharmadi Buntoro Karlen, Jannatin Kurnia Wahyudi Kurnia Wahyudi, Kurnia Lenny Oktorina Maulana Yusuf Alkandahri Miftahurrizqiyah Miftahurrizqiyah Muhammad Fadhil Muhammad Ifham Hanif Nunuk Dyah Retno Lastuti Oktorina, Lenny Sarasati Windria Triasmara, Wahyu