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All Journal Jurnal Biologi Tropis The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Mandala of Health : A Scientific Journal
Nuriasti, Rovera
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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THE IMMUNE RESPONSE TO HUMAN IMMUNODEFICIENCY VIRUS Nuriasti, Rovera; Putri, Dyah Arista; Aulia, Rashieka Salma
Mandala Of Health Vol 18 No 1 (2025): Mandala of Health: A scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.1.15497

Abstract

Human Immunodeficiency Virus (HIV) is an infectious agent that disrupts the immune system by destroying CD4+ T lymphocytes, thereby triggering a decline in immune function and the development of Acquired Immunodeficiency Syndrome (AIDS). HIV employs a complex infection mechanism, including binding to host cell receptors, integration of genetic material, and modulation of the immune system to evade detection. The immune response to HIV involves the innate immune system, such as the activation of macrophages and dendritic cells through pattern recognition receptors, as well as the adaptive immune system through the activity of cytotoxic T cells and antibody production by B cells. However, HIV utilizes various strategies to evade immune responses, including rapid mutation and down-regulation of immune molecule expression. Antiretroviral therapy (ART) is the primary strategy for inhibiting HIV replication and maintaining immune system function, and it has been proven effective in reducing the morbidity and mortality associated with HIV infection, although a curative therapy has yet to be discovered.
Effectiveness of Combination Therapy of Stereotactic Body Radiation Therapy with Lenvatinib in Advanced Hepatocellular Carcinoma Putri, Alifia Sabira; Nuriasti, Rovera; Pambudi, Balqis Prudena Kurnia; Fauzan, Naufal Revaldy; Maudina, Baiq Zaskia; Prawira, Yoga; Larasati, Anak Agung Ayu Regina; Budyono, Catarina
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 2 (2025): VOLUME 26, NUMBER 2, AGUSTUS, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2622025168-175

Abstract

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and has a high mortality rate, especially in advanced stages. Treatment of advanced HCC remains a significant challenge due to limited effective therapeutic options. This study examines the effectiveness of combining Stereotactic Body Radiation Therapy (SBRT) and Lenvatinib in advanced HCC patients. SBRT is a high-precision radiation technique that allows high-dose irradiation of tumor targets with minimal damage to surrounding healthy tissues. At the same time, Lenvatinib is a multikinase inhibitor that inhibits several critical molecular pathways in angiogenesis and tumor cell proliferation. The results showed that the combination of SBRT and Lenvatinib significantly improved overall survival (OS) by reducing the risk of death by 63%, progression-free survival (PFS) reduced the risk of tumor progression by 67%, intrahepatic tumor progression-free survival (IHPFS) showed a decrease of 71%, objective remission rate (ORR) was also higher in the combination group (56.8%), and disease control rate (DCR) of 91.9% which was higher than the use of Lenvatinib alone. However, this combination therapy also carries a higher risk of side effects, including hypertension and diarrhea, which require close monitoring and dose adjustment. This study suggests combining SBRT and Lenvatinib may be a more practical approach to treating advanced HCC. However, the treatment strategy needs to be tailored to the patient's condition to minimize the risk of toxicity.
Caring for HIV Person in Dermatology Jibriel, Diaz Azhalea; Dharma, Yoga Prawira Wedha Swara; Nuriasti, Rovera; Pambudi, Balqis Prudena Kurnia; Sugiono, Muhammad Rafly Adrian; Febriana, Nanggi Qoriatul; Dwiandika, Rizki Ary; Zulkifli, Yasmin Sabrina; Larasati, A. A. A. Regina; Senna, Cantika Brilliant; Tahriani, Ridha; Arif Zuhan
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10075

Abstract

More than 90% of individuals infected with Human Immunodeficiency Virus (HIV) exhibit skin abnormalities that can serve as important clues for early diagnosis, monitoring disease progression, and assessing the effectiveness of antiretroviral therapy (ART). However, the diverse presentation of skin problems often complicates clinical management. Methods: This article is based on a literature review of various international and national publications on skin manifestations in HIV patients, as well as dermatological management guidelines. The analysis focused on the types of skin infections, non-infectious conditions, side effects of ART, and recommended treatment strategies. Results: The literature review revealed that skin problems in HIV patients include fungal infections (such as candidiasis, dermatophytosis), bacterial (CA-MRSA, syphilis), viral (HSV, VZV, HPV, molluscum contagiosum), and non-infectious conditions such as seborrheic dermatitis, psoriasis, and severe drug reactions. These skin conditions are influenced by a weakened immune system, treatment side effects, and socioeconomic factors. Treatment requires a combination of ART therapy, dermatological care tailored to the type of skin problem, and psychosocial support. Conclusion: Skin manifestations in HIV patients reflect their immune system and quality of life. Comprehensive treatment, including ART, dermatological therapy, and a psychosocial approach, has been shown to be effective in reducing morbidity and stigma. The results of this study underscore the importance of interdisciplinary collaboration to improve treatment outcomes for HIV patients with skin problems in Indonesia.
The Effects of Gonorrhea on Women's Reproductive Health Wedha , Yoga Prawira; Azhalea, Diaz; Nuriasti, Rovera; Prudena, Balqis; Rafly, Muhammad; Qoriatul , Nanggi; Ary, Rizky; Sabrina, Yasmin; Regina, Anak Agung Ayu; Brilliant , Cantika; Tahriani, Ridha
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10288

Abstract

Neisseria gonorrhoeae is the bacteria that causes gonorrhea, a sexually transmitted infection (STI). The reproductive system, rectum, and pharynx are particularly susceptible to this infection. Both men and women can have gonorrhea, but women frequently have moderate or even nonexistent symptoms, which makes the infection go undiagnosed and untreated. This raises the possibility of severe side effects like infertility, pelvic inflammatory disease (PID), and transmission to fetuses or infants. According to a World Health Organization (WHO) assessment, gonorrhea is still a common global health issue, particularly in underdeveloped nations. Factors such as low awareness of STIs, limited access to health services, and increasing antibiotic resistance contribute to the challenges of controlling this disease. Throughout the twentieth century, gonorrhea (GO) was the most prevalent sexually transmitted infection (STI) globally due to delayed diagnosis. Gonorrhea was more common in women than in men in 2009, and the most common sources of reporting for women were emergency rooms (5.8%), STI clinics (16.7%), family planning clinics (9.1%), and other health department clinics (8.1%). Other sources of reporting were private physicians and health maintenance organizations (30.9%). According to WHO figures from 2012, there were 78 million GO infection cases. The frequency was 0.8% for women and 0.6% for males among those aged 15 to 49. According to WHO estimates from 2016, the combined global prevalence of urogenital gonorrhea (the percentage of the world's population that has gonorrhea in a given year) was 0.9% for women and 0.7% for men, or 30.6 million cases globally.
Behavioral and Physiological Symptoms of Dementia (BPSD): A Literature Review Larasati, Anak Agung Ayu Regina; Nuriasti, Rovera; Febriana, Nanggi Qoriatul; Dwiandika, Rizki Ary; Mahardika, Agustine
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10291

Abstract

Dementia is a progressive syndrome characterized by cognitive decline, impacting daily functioning. Behavioral and Psychological Symptoms of Dementia (BPSD), including sleep disturbances, hallucinations, delusions, apathy, depression, and agitation, are prevalent in over 90% of patients, further exacerbating their quality of life and increasing caregiver burden. This research aims to evaluate the effectiveness of both pharmacological and non-pharmacological interventions in managing BPSD, focusing on non-pharmacological methods such as cognitive therapy and social stimulation. Data was collected through a comprehensive review of recent studies, analyzing interventions and their outcomes in reducing BPSD symptoms. The findings reveal that non-pharmacological approaches are more effective in reducing agitation and depression, with cognitive therapy showing up to 75% effectiveness. In contrast, pharmacological treatments, though useful for acute symptoms, offer limited long-term benefits. The research underscores the need for integrated, evidence-based approaches, combining medical and psychosocial support to improve patient care and alleviate caregiver stress. These findings suggest the importance of adopting holistic management strategies, particularly those that reduce isolation and enhance social interaction, in the long-term care of dementia patients.
Co-Authors Arif Zuhan Ary, Rizky Aulia, Rashieka Salma Azhalea, Diaz Brilliant , Cantika Catarina Budyono, Catarina Dharma, Yoga Prawira Wedha Swara Dwiandika, Rizki Ary Fauzan, Naufal Revaldy Febriana, Nanggi Qoriatul Jibriel, Diaz Azhalea Larasati, A. A. A. Regina Larasati, Anak Agung Ayu Regina Mahardika, Agustine Maudina, Baiq Zaskia Pambudi, Balqis Prudena Kurnia Prawira, Yoga Prudena, Balqis Putri, Alifia Sabira Putri, Dyah Arista Qoriatul , Nanggi Rafly, Muhammad Regina, Anak Agung Ayu Sabrina, Yasmin Senna, Cantika Brilliant Sugiono, Muhammad Rafly Adrian Tahriani, Ridha Wedha , Yoga Prawira Zulkifli, Yasmin Sabrina