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All Journal Jurnal Buana Farma JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Kesehatan Farmasi Nusantara Scientific Medical Research Journal PCJN Pharmaceutical and Clinical Journal of Nusantara Herbal Medicine Journal Journal of Pharmaceutical and Sciences.
Bangar, Roy Indrianto
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Profil Aktivitas Antioksidan Ekstrak Polar dan Non-Polar Umbi Porang (Amorphophallus muelleri Blume) Menggunakan Uji DPPH Sihotang, Nova Ria Ovelti; Bangar, Roy Indrianto; Syahputra, Hariyadi Dharmawan
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.221

Abstract

Porang tuber (Amorphophallus muelleri Blume) is an Indonesian native commodity rich in glucomannan polysaccharides and potentially serves as a natural antioxidant source to counteract free radicals that trigger degenerative diseases. Objective of the researchv to map the antioxidant activity profile of non-polar, semi-polar, and polar extract s of porang tuber and determine the IC50 value using the DPPH method. Porang tuber powder was extracted through multilevel maceration using n-hexane, chloroform, ethyl acetate, and ethanol solvents. Antioxidant activity was tested using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method with UV-Vis Spectrophotometry at 517 nm, utilizing Vitamin C and Quercetin as positive controls. Result: The results showed that all extract possessed extremely strong antioxidant activity. The lowest IC50 value was obtained from the ethyl acetate extract at 3.44 ppm, followed by the ethanol extract at 3.61 ppm and the n-hexane extract at 3.81 ppm. The activity of the ethyl acetate extract was stronger than the positive controls, Vitamin C (3.75 ppm) and Quercetin (4.52 ppm). Multilevel extraction is effective in separating the active compounds of porang tuber, with the semi-polar extract (ethyl acetate) exhibiting the most optimal and extremely strong antioxidant potential.
FORMULASI MASKER GEL DENGAN EKSTRAK DAUN MANGGA ARUMANIS (Mangifera Indica L.) SEBAGAI BAHAN AKTIF Helgiera, Tasyah; Br Ginting, Astriani Natalia; Bangar, Roy Indrianto
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1626

Abstract

Exposure to ultraviolet (UV) radiation and environmental pollution can generate free radicals that contribute to skin damage and accelerate premature aging. One approach to protect the skin from these effects is the use of antioxidants derived from natural sources. Arumanis mango leaves (Mangifera indica L.) contain secondary metabolites such as flavonoids, tannins, and saponins which have potential antioxidant activity and can be utilized as active ingredients in cosmetic formulations. This study aimed to formulate a gel mask containing ethanol extract of arumanis mango leaves and to evaluate the physical quality of the preparation. The extract was obtained using the maceration method with 96% ethanol as the solvent. The gel mask was formulated into three different extract concentrations, namely 0%, 4%, and 6%. The physical evaluation included organoleptic test, homogeneity, pH, spreadability, and drying time tests. The results showed that the gel mask preparations exhibited good physical characteristics, with homogeneous appearance, pH values ranging from 5.16–6.26, spreadability of 5.5–6.8 cm, and drying time of 17–20 minutes. The variation in extract concentration affected the color of the preparation but did not significantly influence the overall physical stability of the gel. Therefore, ethanol extract of arumanis mango leaves can be formulated into a gel mask preparation that meets the physical quality requirements for skincare products.
FORMULASI SEDIAAN HAND BODY GEL DENGAN SARI BUAH RAMBUTAN (Nephelium lappaceum L.) Azizah, Nailan; Simanjuntak, Nerly Juli Pranita; Bangar, Roy Indrianto
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1673

Abstract

Rambutan fruit (Nephelium lappaceum L.) contains vitamins A, B, and C, which act as antioxidants and are beneficial for skin health. The utilization of rambutan fruit juice in a hand body gel formulation aims to produce a natural moisturizing product that is safe for use. This study was conducted experimentally by formulating rambutan fruit juice into hand body gel at concentrations of 3%, 5%, and 7%, along with a blank formulation. Each formulation was evaluated for its physical properties, including organoleptic characteristics, homogeneity, pH, spreadability, and viscosity. In addition, skin irritation testing and skin moisture testing using a skin analyzer were performed over three weeks of use. The results showed that all formulations had good physical quality, pH values suitable for the skin, and did not cause irritation. Skin moisture testing indicated an increase in skin moisture in all formulations, with the 7% concentration showing the highest improvement. In conclusion, rambutan fruit juice can be formulated into a hand body gel that is safe and effective as a skin moisturizer, with the 7% concentration being the best formulation.
PENGARUH JENIS PELARUT TERHADAP AKTIVITAS ANTIOKSIDAN EKSTRAK KULIT KAYU RARU (Cotylelobium melanoxylon (Hook.f) Pierre) MELALUI UJI DPPH Sibagariang, Nurhadijah; Bangar, Roy Indrianto; Ikhtiari, Refi
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2181

Abstract

Hubungan Kejadian DRP dan Outcome Klinis Pasien Pediatri Vinando, Vinando; Simanjuntak, Nerly Juli Pranita; Bangar, Roy Indrianto
Jurnal Kesehatan Farmasi Vol 8 No 1 (2026): Jurnal Kesehatan Farmasi
Publisher : Jurusan Farmasi, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jkpharm.v8i1.3741

Abstract

Latar Belakang: Salah satu penyakit kompleks yang sering dialami oleh anak-anak adalah penyakit saluran pernafasan. Tenaga kesehatan sering mengalami masalah dalam pelayanan kesehatan seperti pemberian dosis obat yang tepat, sediaan obat yang tepat, dan lain sebagainya. Sehingga menyebabkan suatu kejadian yang mengganggu hasil kesehatan penyakit saluran napas yang berhubungan dengan pengobatan yang diberikan sering dikaitkan dengan masalah terkait obat atau dikenal dengan Drug Related Problems (DRP). Drug Related Problems (DRP) mempunyai pengaruh terhadap outcome klinis terapi pasien. Sehingga peneliti ingin meninjau lebih lanjut kemungkinan kejadian DRP yang dapat terjadi serta melakukan evaluasi hubungan kejadian DRP dengan hasil klinis pada pasien pediatric yang menderita penyakit saluran pernafasan pada instalasi rawat inap. Metode: Penelitian ini dilakukan secara observasional analitik dan dilakukan teknik total sampling dalam pengambilan sampe dimana sampel yang diambil hanya memenuhi kriteria inklusi. Setelah dilakukan pengambilan sampel dianalisis DRP berdasarkan pedoman American Society of Health Pharmacist (ASHP). Jumlah DRP yang didapatkan dikorelasikan dengan hasil klinis pasien menggunakan uji statistic. Uji statistic yang digunakan adalah metode chi-square dan didapatkan nilai p-value untuk mengetahui signifikansi kedua hubungan tersebut. Hasil: Pada penelitian ini didapatkan jumlah kasus yang sesuai dengan syarat inklusi adalah 114 kasus. Jumlah kejadian DRP adalah 445 dari keseluruhan dimana setiap DRP yang ada terhitung satu. Uji chi-square didapatkan nilai p-value dengan hasil 0.000 yang menandakan bahwa terdapat hubungan yang signifikan antara kenaikan jumlah DRP dengan penurunan outcome klinis yang diterima pasien. Kesimpulan: Terdapat hubungan yang signifikan antara kenaikan jumlah DRP dengan penurunan hasil klinis ehingga perlu dilakukan peninjauan kembali oleh tenaga kefarmasian untuk mendapatkan outcome klinis yang baik oleh pasien.
STUDI FORMULASI GEL EKSTRAK KULIT RARU (COTYLELOBIUM MELANOXYLON PIERRE) SEBAGAI AGEN ANTIBAKTERI gulo, Michelle Veronica Gulo; Bangar, Roy Indrianto; Ikhtiari, Refi
Jurnal Kesehatan Farmasi Vol 8 No 1 (2026): Jurnal Kesehatan Farmasi
Publisher : Jurusan Farmasi, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jkpharm.v8i1.3748

Abstract

Acne is a skin condition affecting adolescents and young adults, characterized by an imbalance in the skin microbiome, excessive sebum production, and the accumulation of keratin, triggered by the bacteria Propionibacterium acnes, a significant pathogenic factor. Acne can be treated with antibiotics, but long-term antibiotic use can have side effects if used incorrectly. Raru wood has pharmacological potential due to its content of secondary metabolites such as flavonoids, tannins, saponins, and triterpenoids. Raru bark extract was developed into a gel dosage form to optimize its treatment effectiveness. The purpose of this study was to determine the gel formulation and antibacterial effectiveness of raru bark extract in the gel preparation. The research method was experimental, involving the formulation and evaluation of the gel, as well as testing its antibacterial activity using the disc method at a concentration of 3%, negative controls, and positive controls.
MOLECULER DOCKING SENYAWA BIOAKTIF KULIT RARU (Cotylelobium melanoxylon) TERHADAP TARGET α-GLUKOSIDASE DAN α-AMILASE Hutagulung, Josita Jenny Haryanti; Bangar, Roy Indrianto
Jurnal Kesehatan Farmasi Vol 8 No 1 (2026): Jurnal Kesehatan Farmasi
Publisher : Jurusan Farmasi, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jkpharm.v8i1.3749

Abstract

Diabetes mellitus is a metabolic disease that affects the body’s ability to control blood glucose levels, making effective treatments necessary to reduce postprandial glucose increases. Flavonoid compounds from raru bark (Cotylelobium melanoxylon) have shown potential as inhibitors of carbohydrate-digesting enzymes, especially α-amylase and α-glucosidase. This study aimed to evaluate the antidiabetic potential of flavonoid compounds from raru bark using an in silico approach with molecular docking. Five flavonoid compounds—rutin, isoquercetin, quercetin, quercitrin, and isoquercitrin—were tested to examine their binding ability to the target enzymes. The results showed that rutin and isoquercetin had lower binding energy values than the standard ligand, indicating more stable interactions and stronger enzyme inhibition. These findings suggest that flavonoid compounds from raru bark may be developed as natural antidiabetic agents; however, further in vitro and in vivo studies are needed to confirm their safety and effectiveness.
Therapeutic Efficacy of Topical Bay Leaf (Syzygium polyanthum) Extract Gel on Macroscopic Ulcer Healing in Alloxan-Induced Diabetic Rats Permata Gulo, Elastis; Yunus, Muhammad; Bangar, Roy Indrianto
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 4 No. 02 (2026): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v4i02.182

Abstract

Diabetes mellitus is a chronic disease that impairs wound healing due to oxidative stress and prolonged inflammation. Bay leaf (Syzygium polyanthum) contains bioactive compounds with potential therapeutic effects in promoting tissue repair. This study aimed to evaluate the effectiveness of topical bay leaf extract gel on macroscopic wound healing in alloxan-induced diabetic rats. This experimental in vivo study used 30 male rats divided into six groups: normal control, negative control, positive control (Bioplacenton), and treatment groups receiving extract gel at concentrations of 2.5%, 5%, and 10%. Diabetes was induced using alloxan, followed by burn wound creation and topical treatment for 14 days. The results showed that treatment groups exhibited faster wound healing compared to the negative control. The 2.5% and 10% extract gel groups demonstrated more optimal wound closure, comparable to the positive control by day 14. These findings indicate that flavonoid and phenolic compounds in bay leaf contribute to antioxidant and anti-inflammatory activities, supporting tissue regeneration. In conclusion, bay leaf extract gel is effective in accelerating wound healing in diabetic conditions. Further studies are recommended to investigate histopathological changes and molecular mechanisms.
Co-Authors Asyrun Alkhairi Lubis Azizah, Nailan Br Ginting, Astriani Natalia Br Sembiring, Novitaria gulo, Michelle Veronica Gulo Harahap, Daimah Wirdatus Sanaun Helgiera, Tasyah Hutagulung, Josita Jenny Haryanti IKHTIARI, REFI Khairatunawa, Tisa Lumban Gaol, Irma Yohana Manullang, Lampita Bellina Muhammad Yunus Naibaho, Novrika Desclarita Ningsih, Wulan Seppia Novriani, Erida Panjaitan, Hotma sarito Permata Gulo, Elastis Razoki, Razoki Sembiring , Novitaria Br Sibagariang, Nurhadijah Sihotang, Nova Ria Ovelti Sihotang, Nurhanifah Simanjuntak, Nerly Juli Pranita Siregar, Nurhakiki Syahputra, Hariyadi Dharmawan Vera Estefania Kaban vina andriani Vinando, Vinando Waruwu, Loice Desy Krisna Yanti