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All Journal BIOTROPIA - The Southeast Asian Journal of Tropical Biology Jurnal Biomedika dan Kesehatan
Pratiwi, Arini Dian
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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INTRA-SPESIFIC DIVERSITY OF BUTTERFLY PEA (Clitoria ternatea L.) REVEALED BY ISSR WITH INVARIABLE ITS RECORDS Yusuf, Adib Fakhruddin; Latifah, Vida Rahma; Nurcahyati, Vivi Indah; Nurhasanah, Anggun Diyan; Widyasari, Adristi Shafa; Nainggolan, Ananto Puradi; Hasibuan, Aldy Riau Wansyah; Hidayat, Madyan Akmal; Karmilah, Karmilah; Pratiwi, Arini Dian; Aurantika, Rindu; Hasanah, Muslifah; Aristya, Ganies Riza; Handayani, Niken Satuti Nur; Arisuryanti, Tuty; Lesmana, Indra; Daryono, Budi Setiadi
BIOTROPIA Vol. 32 No. 1 (2025): BIOTROPIA Vol. 32 No. 1 April 2025
Publisher : SEAMEO BIOTROP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11598/btb.2025.32.1.2362

Abstract

Article Highlights:- The ITS region exhibits no genetic variation among butterfly pea genotypes.- ISSR reveals high polymorphism, proving effective for genetic diversity analysis.- White single and purple single genotypes show the greatest genetic distance.- ISSR-6 ((CT)₈TG) demonstrates the highest polymorphism and reliability for assessment.- The ITS sequences have been deposited in GenBank under the accession IDs PQ198055–PQ198061. ABSTRACTClitoria ternatea L., a perennial plant in the Fabaceae, is recognized for its resilience in tropical climates and its diverse applications in both culinary and medicinal fields. However, the limited exploration of its genetic diversity constrains breeding efforts aimed at improving desirable traits. This limitation highlights the need to optimize selection strategies, identify superior genotypes, and preserve valuable genetic resources for long-term conservation and crop enhancement. This study aimed to explore genetic variation using molecular markers to analyze C. ternatea genotypes based on petal architecture and color differences. To assess the genetic diversity of C. ternatea, Sanger sequencing of the Internal Transcribed Spacer (ITS) region and Inter-Simple Sequence Repeat (ISSR) markers were applied to seven wild populations from Sleman, Yogyakarta. The ITS region exhibited no genetic variation, indicating its conserved nature and limited ability to differentiate genotypes. In contrast, ISSR markers effectively detected genetic variation, identifying 62 polymorphic fragments out of 162 total bands. The highest genetic distance (0.297) was observed between the WS and PS genotypes, whereas the double-petal genotypes (WD and PD) displayed the closest phenetic relationship. Among the ISSR primers, UBC-808, UBC-812, and ISSR-6 exhibited high PIC and RP values, confirming their reliability in genetic diversity analysis. These results underscore the utility of ISSR markers as a robust tool for genetic diversity assessment, offering valuable insights for breeding programs and germplasm conservation in C. ternatea.
Gambaran Penyakit Neurodegeneratif: Huntington, Alzheimer, dan Parkinson: Sebuah Tinjauan Karlina, Ina; Andriyani, Eka Fitri Siti; Pratiwi, Arini Dian; Prasasti, Filosofia Florista Tesla Aulia; Tunjung, Woro Anindito Sri; Rohmah, Zuliyati; Nuriliani, Ardaning
Jurnal Biomedika dan Kesehatan Vol 7 No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.113-123

Abstract

Neurodegenerative diseases occur due to dysfunction of the nervous system, which is accompanied by memory and movement disorders. Neurodegenerative diseases can be viewed from an etiological and pathological perspective (pathophysiological and histopathological). The most common neurodegenerative diseases are Huntington's, Alzheimer's, and Parkinson's. This review article will review the etiology and pathology of Huntington's, Alzheimer's, and Parkinson's diseases. The method used in this writing uses journals and books from Google Scholar, PubMed, ResearchGate, and the Web. The keywords used are etiology, pathology, pathophysiology, histopathology, neurodegenerative disease, Huntington's, Alzheimer's, and Parkinson's. The author limited the last 10 years of literature used. Based on a literature review, it is known that the etiology of Huntington's disease is caused by mutations in the huntingtin gene on chromosome four. The pathology of Huntington's disease is caused by unstable expansion of trinucleotide-encoded polyglutamine (CAG) repeats. One of the histopathological features of Huntington's disease can be identified from increased iron levels in the striata of the brain. The etiology of Alzheimer's disease involves interactions between genetic factors, lifestyle, environment, and the aging process. The pathology of Alzheimer's disease occurs due to the presence of apolipoprotein and its relationship to 3 mutated genes. The histopathology of Alzheimer's disease is identified by the presence of neuronal cell death, which is characterized by the shrinking of the nuclei of brain neuronal cells and the cytoplasm has a more eosinophilic color. The etiology of Parkinson's disease is progressive nerve damage to certain areas of the brain. The pathophysiology of Parkinson's disease is thought to involve a reduction in striatal dopamine, which causes an increase in inhibitory output from the globus pallidus pars interna/substantia nigra pars reticulata (Gpi/SNr), resulting in movement suppression. Histopathologically, Parkinson's disease is characterized by degeneration of neurons and neurophagia. This review concludes that Huntington's, Alzheimer's, and Parkinson's diseases can be caused by aging and genetic factors. The pathology of the disease is due to mutations, increased levels of iron, apolipoprotein, neuronal cell death, increased inhibitory output, and neuronal degeneration. The symptoms caused can be motoric, cognitive, and psychiatric.
Co-Authors Andriyani, Eka Fitri Siti Ardaning Nuriliani Aurantika, Rindu BUDI SETIADI DARYONO Ganies Riza Aristya Hasanah, Muslifah Hasibuan, Aldy Riau Wansyah Hidayat, Madyan Akmal Indra Lesmana Karlina, Ina Karmilah, Karmilah Latifah, Vida Rahma Nainggolan, Ananto Puradi Niken Satuti Nur Handayani Nurcahyati, Vivi Indah Nurhasanah, Anggun Diyan Prasasti, Filosofia Florista Tesla Aulia Rohmah, Zuliyati Tuty Arisuryanti, Tuty Widyasari, Adristi Shafa Woro Anindito Sri Tunjung Yusuf, Adib Fakhruddin