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All Journal Jurnal Biologi Tropis Mandala of Health : A Scientific Journal
Hudhori, Syalsa
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Public Health

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Literature Study: Acute Myeloid Leukimia (AML) Pramesti, Evane Dyahayu; Dhevi, Ni Made Saithanya Gitanjali; Hudhori, Syalsa; Salsabila, Ericha Zabrina; Asriantin, Isna; Anggoro, Joko
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10082

Abstract

Leukemia is a cancer that originates from cells that initially develop into blood cells. Leukemia can be classified as acute or chronic, depending on how quickly the disease appears and how it progresses in the body. This literature review aims to determine the treatment for patients with AML depending on the subtype. This literature review used journal review methods and data searches through various sources. The results of the literature study found that Acute Myeloid Leukemia (AML) is divided into six subtypes. AML is caused by clonal transformation of hematopoietic cells through chromosomal abnormalities and gene mutations, with risk factors including exposure to radiation, benzene, smoking, chemotherapy therapy, the development of chronic myeloid neoplasms, aging, and predisposing diseases. Diagnosis of AML involves peripheral blood and bone marrow analysis, immunophenotyping, cytogenetics, molecular cytogenetics, and imaging to detect the presence and characteristics of leukemic cells. Treatment of AML includes induction therapy, consolidation therapy, and response monitoring, with special considerations for the selection of chemotherapy regimens, stem cell transplantation, and transfusion support to manage associated complications. In conclusion, Acute Myeloid Leukemia (AML) is a condition in which myeloblasts undergo excessive proliferation and fail to differentiate into granulocytes. This condition causes the bone marrow to fill with myeloblasts.
CURRENT DIAGNOSIS AND MANAGEMENT OF CROHN’S DISEASE: A LITERATURE-BASED REVIEW Pambudi, Novanda Ayu Dila Putri; Siregar, Chivan Agustinus; Santoso, Arysatya Syandana Ararya; Sari, Padmi Kartika; Rachman, Amanda Azkiyah; Hudhori, Syalsa; Muharis, Nihal Ahmad
Mandala Of Health Vol 18 No 2 (2025): Mandala of Health: A Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.2.17307

Abstract

Crohn’s disease is a chronic inflammatory disorder of the gastrointestinal tract with increasing global incidence, shifting from a predominantly Western condition to a rising burden in Asia and other developing regions. Diagnosis requires a multimodal approach, integrating history, laboratory testing, endoscopy with validated activity scores, histopathology, and imaging such as magnetic resonance enterography or intestinal ultrasound. The 2024 ECCO guidelines emphasize fecal biomarkers like calprotectin as non-invasive monitoring tools within a treat-to-target strategy. Management includes pharmacological therapy (corticosteroids, immunomodulators, biologics, and novel small molecules), non-pharmacological measures (exclusive enteral nutrition, micronutrient supplementation, and diet modification), and surgery for refractory strictures, perforations, or complex fistulas. Beyond physical symptoms, Crohn’s disease carries a significant psychosocial burden, underscoring the need for nutritional and psychological support. Despite therapeutic advances, no curative treatment exists. Future research should focus on identifying more accurate biomarkers, improving accessibility to advanced therapies in low-resource settings, and exploring innovative approaches such as precision medicine, microbiota-targeted therapy, and genetic-based interventions.
The Relationship of Medication Adherence in Type 2 Diabetes Mellitus Patients with HbA1c Profile at Mataram University Hudhori, Syalsa; Wardani, Indah Sapta; Isnaeni, Wilya
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10407

Abstract

Type 2 Diabetes Mellitus (DM) requires optimal glycemic control. Medication adherence is key to achieving HbA1c targets, but local data at Universitas Mataram Hospital is still limited. This study aimed to analyze the relationship between medication adherence and HbA1c profiles in type 2 DM patients. An analytical cross-sectional study was conducted in May 2025 with 40 randomly selected samples. Adherence was measured using the MMAS-8 questionnaire, and HbA1c data came from medical records. Data analysis used the Chi-Square test. Results showed 50% of subjects were adherent and 50% were non-adherent. Regarding glycemic control, 70% had controlled HbA1c. Statistical analysis found no significant relationship between adherence and HbA1c profile (p-value = 0.490). However, a proportional trend showed the adherent group had a higher percentage of HbA1c control (75%) than the non-adherent group (65%). Conclusion, there was no statistically significant relationship between medication adherence and HbA1c profiles. Despite this, the observed clinical trend indicates that adherence remains an important factor to consider in DM management, alongside other determinants like diet and physical activity.
Co-Authors Anggoro, Joko Asriantin, Isna Dhevi, Ni Made Saithanya Gitanjali Indah Sapta Wardani Isnaeni, Wilya Muharis, Nihal Ahmad Pambudi, Novanda Ayu Dila Putri Pramesti, Evane Dyahayu Rachman, Amanda Azkiyah Salsabila, Ericha Zabrina Santoso, Arysatya Syandana Ararya Sari, Padmi Kartika Siregar, Chivan Agustinus