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All Journal Jurnal Kedokteran Brawijaya Indonesian Journal of Human Nutrition Majalah Obstetri dan Ginekologi Medical Laboratory Technology Journal Journal of Nursing Care and Biomolecular Jurnal Ilmiah Kesehatan Media Husada Journal of Issues in Midwifery Heart Science Journal Babali Nursing Research Jurnal Promotif Preventif Jurnal Locus Penelitian dan Pengabdian Asian Journal of Health Research INJURITY: Journal of Interdisciplinary Studies Journal of Community Health and Preventive Medicine (JOCHAPM) Media Penelitian dan Pengembangan Kesehatan Jurnal Info Kesehatan
I Wayan Agung Indrawan
Departemen Obstetri & Ginekologi Fakultas Kedokteran Universitas Brawijaya Malang
Aerospace Engineering Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : Asian Journal of Health Research

 1 
Anaemia and Family Income are associated with Preeclampsia Maternal Death in Jember District, Indonesia Mergy Gayatri; Nurul Fathiyyah; Jesica Mulyadi; Diadjeng Setya Wardani; I Wayan Agung Indrawan
Asian Journal of Health Research Vol. 1 No. 2 (2022): Volume 1 No 2 (August) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (751.36 KB) | DOI: 10.55561/ajhr.v1i2.45

Abstract

Introduction: Preeclampsia is a pregnancy-related complication causing maternal morbidity and mortality. This study aimed to determine the relationship between anaemia and family income, and maternal death from preeclampsia in Jember district. Materials and Methods: Case-control, using medical maternal autopsy verbal, from January 2016 to December 2019. 43 mortality cases from preeclampsia, and 43 controls were included in this study. Chi-square test was to test the relationship between anaemia and family income, and maternal death from preeclampsia. Results: Mothers who died from preeclampsia were more likely to have anaemia (83.72%), and being low income (86.05%). Anaemia (OR 3.703, 95% CI p-value 0.009) and low income (OR 4.032, 95% CI, p –value 0.007) were associated with preeclampsia maternal mortality. Conclusions: To reduce the prevalence of death from preeclampsia, preventive measurement for anaemia during pregnancy should be undertaken. In addition, women with low income during pregnancy should be encouraged to have health insurance.
Effect of Red Bean Extract (Phaseolus Vulgaris L. Sp) on Il-6 Levels and AMH Levels as The Prevention of Premature Ovarian Failure in Mice Model of The Systemic Lupus Erythematosus Adin Permana; Mukhamad Nooryanto; I Wayan Agung Indrawan; Cholid Rohman Riskianto
Asian Journal of Health Research Vol. 1 No. 3 (2022): Volume 1 No 3 (December) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v1i3.51

Abstract

Introduction: Continuous SLE treatment causes Premature Ovarian Failure (POF) and occurred in 27.3% SLE patients treated with cyclophosphamide. IL-6 plays a critical role in the B cell hyperactivity and immunopathology of human SLE. Phaseolus Vulgaris L. Sp have a high total phenolic content and have been shown to have anti-inflammatory and antioxidant effects. This study’s objective is to prove the effect of red beans (Phaseoulus vulgaris L. sp.) in reducing inflammation (IL-6) and increasing AMH levels. Methods: This is a true experimental design with a post-test-only controlled group design. The sample used in this study was 25 female Babic mice divided in two control groups and three treatment groups. Subjects were given intraperitoneal injection of Pristan (0.5 ml), busulfan (30 mg/kg BW), cyclophosphamide (120 mg/kg BW) to induce POF. ANA test was carried out to prone SLE induction was success. Red bean extract was given at 50 mg/kg BW (in treatment group 1), 75 mg/kg BW (in treatment group 2), and 100 mg/kg BW (in treatment group 3). Data of IL-6 and AMH levels in mice serum were obtained by measurement using ELISA. Results: The study showed a significant difference in ANA levels with a p-value of 0.000 in every sample. The study has proven a significant decrease in IL-6 levels with a p-value of 0.000 and a significant increase in AMH levels at a dose of 100 mg/kg BW (P3) with a p-value of 0.000. Conclusion: Phaseolus vulgaris extract had a significant effect on follicle changes in Balb/c mice in dose of 50 mg/kg and 75 mg/kg but not significantly reduce inflammation (IL-6).
Maternal Comorbidities with Full-Term Pregnancy Who Gave Birth to Low Birth Weight Babies at Dr. Saiful Anwar Malang General Hospital I Wayan Agung Indrawan; Obi Candra Kapisa
Asian Journal of Health Research Vol. 2 No. 1 (2023): Volume 2 No 1 (April) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i1.85

Abstract

Introduction: Stunting is a challenge for children's growth and development in the future, which has long-term impacts in the form of reduced cognitive abilities, decreased productivity, and increased risk of infection and non-communicable diseases. Low birth weight (LBW) is a major determinant of stunting in Indonesia. Various multidimensional factors contribute to low birth weight, including maternal factors. Material and Methods: Quantitative descriptive research was conducted at Dr. Saiful Anwar general hospital from July 2021 to September 2022. The variables studied were age, education, occupation, parity status, medical history, number of antenatal care controls, height, mother's body mass index, and baby's birth weight. Results: Of the 54 full-term pregnant women, the majority who delivered LBW babies were nulliparous (42.6%), aged 20-35 years during pregnancy (79.6%), had a history of hypertension during pregnancy (25.9%), antenatal care visits 1-5 times (48.1%), high school degree (48.1%), housewives (75.9%), height ranging between 151-160 cm (64.8%), and BMI 18.5 to 25 kg/m 2 (51.9%). Conclusion: Maternal factors that contribute to the birth of LBW babies include low parities, age 20 to 35 years during pregnancy, hypertension in pregnancy, infrequent antenatal care visits, high school degree, work as a housewife, height ranging between 151 -160 cm, and had a normal BMI. The representation of the mother's BMI and educational level in this study differs from that in previous studies.
Comparison of the Effects of Dienogest and Leuprolide Acetat on Serum Interferon (IFN-Æ”) Levels in a Mouse Model of Endometriosis (Mus musculus) Maria Antonia Barbara Batu Mali; Siskanita Nur Fitriana; Sutrisno Sutrisno; Husnul Khotimah; I Wayan Arsana Wiyasa; I Wayan Agung Indrawan; Maharani Maharani
Asian Journal of Health Research Vol. 2 No. 2 (2023): Volume 2 No 2 (August) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i2.111

Abstract

Introduction: Endometriosis is a medical condition in which there is abnormal growth of tissue resembling the endometrium outside the uterus. It can cause symptoms of pain and/or infertility. The current medical therapy focuses on reducing estradiol levels or stimulating progesterone response. One of the most effective options for medical treatment is the use of GnRH analogs. Dienogest have a direct anti-inflammatory effect on endometriotic stromal cells. However, a comparison of the anti-inflammatory effects of these drugs on IFN-Æ” has not been previously investigated. Therefore, this study aims to compare the effects of reducing IFN-Æ” by both Dienogest and Leuprolide Acetat in a mouse model. Material and Methods: This study employed a post-test only control group design and involved 4 groups, namely the negative control group, positive control group, and two treatment groups: one group administered Dienogest at a dosage of 0.0052 milligrams per day for 14 days, and the other administered Leuprolide Acetat at a dosage of 0.00975 milligrams once every 5 days for a period of 14 days. Serum IFN-Æ” levels were measured using Enzyme-Linked Immunosorbent Assay (ELISA). The data were subsequently analyzed using IBM SPSS 25 with One-Way ANOVA test. Results: This study demonstrated that Leuprolide Acetat significantly decreased serum levels of IFN-Æ”, whereas Dienogest actually increased the levels . Conclusion: In a mouse model of endometriosis (Mus musculus), Leuprolide Acetat effectively reduced the levels of IFN-Æ” (pro-inflammatory). Conversely, Dienogest increased the levels of IFN-Æ” (anti-inflammatory) in the mouse model of endometriosis.
Genital Tuberculosis with Pleuritis and Intra-abdominal Tuberculosis Widowati, Ayu Rizky; Indrawan, I Wayan Agung; Tantular, Rezki
Asian Journal of Health Research Vol. 4 No. 2 (2025): Volume 4 No 2 (August) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i2.247

Abstract

Introduction: Female Genital Tuberculosis (FGTB) is a rare but serious form of extrapulmonary tuberculosis that significantly impacts female reproductive health. It accounts for 15–20% of extrapulmonary TB cases and is found in 5–10% of infertile women. Diagnosis is often delayed due to nonspecific symptoms and the difficulty of confirming infection through histopathology. Case Presentation: A 35-year-old woman presented with abdominal pain, nausea, vomiting, vaginal discharge, and postcoital bleeding. A cervical biopsy confirmed tuberculous cervicitis, supported by systemic TB symptoms and a left pleural effusion, leading to a diagnosis of extrapulmonary TB. She was treated with a full course of anti-TB therapy and referred for fertility evaluation due to persistent amenorrhea, where hysteroscopy revealed intrauterine adhesions and granulomas, confirming suspected genital TB and suggesting Asherman’s syndrome as a complication. Conclusion: Female Genital Tuberculosis is a rare cause of infertility; early diagnosis using integrative methods and awareness of genital TB transmission are essential for timely treatment and improved reproductive outcomes.
Co-Authors Adin Permana Ana Paramita Prastiwi Auliya, Faiza Fardha Ayodya, Cut Oullya Azzahra, Salsabila Syifa Bambang Rahardjo Cholid Rohman Riskianto Diadjeng Setya Wardani Endang Sriwahyuni Ernungtyas, Niken Febrina Farida, Leny Gema Alya Salsabila Hanifarizani, Rahma Dian Hastuti, Novianti Tri Hinisa, Fariha Nuzulul Husnul Khotimah Indahwati, Lilik Intan, Dara Jesica Mulyadi Leni Ria Ariana Lestaluhu, Viqy Maharani Maharani Maria Antonia Barbara Batu Mali Mergy Gayatri Mukhamad Nooryanto Nanik Setijowati Nanik Setijowati Nurdiana Nurdiana Nurul Fathiyyah Obi Candra Kapisa Panjarwanto, Dwi Andhika Paraningtyas Aulia Ilmi Permana, Adin Yan Pratama, Aldian Arie Prihatiningsih, Riska Dwi Putri, Valerinna Yogibuana S. rahmah, shofi nur Restalia, Fianda Rismaina Putri Sanarto Santoso Simanjuntak, Roganda Siskanita Nur Fitriana Sri Andarini Sudarwantono, Johannes Suseno, Daniel Alexander Sutrisno Sutrisno Sutrisno Sutrisno Tantular, Rezki Utomo, Rudi Priyo Wardani, Arti Wardani, Diadjeng Setya Widowati, Ayu Rizky Windari, Era Nurisa Wirawati Amin Wiyasa, I Wayan Arsana