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All Journal Al Irsyad: Jurnal Studi Islam Journal of Computer Science Advancements Journal of Noesantara Islamic Studies Journal of Selvicoltura Asean Research of Scientia Naturalis Journal of Biomedical and Techno Nanomaterials Journal of Social Entrepreneurship and Creative Technology Journal of Multidisciplinary Sustainability Asean
Wong, Lucas
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Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Languange, Linguistic, Communication & Media Library & Information Science Physics Social Sciences Other

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MICROBIAL CONSORTIA ENGINEERING: BRIDGING ENVIRONMENTAL MICROBIOLOGY AND SYNTHETIC BIOLOGY Salim, Achmad Agus; Wong, Lucas; Muller, Johannes
Research of Scientia Naturalis Vol. 3 No. 1 (2026)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/scientia.v3i1.3342

Abstract

Natural ecosystems rely on complex microbial interactions that surpass the metabolic capabilities of isolated monocultures, yet engineering stable multi-species systems remains a significant challenge in biotechnology. This research addresses the unpredictability of interspecies social dynamics by integrating principles from environmental microbiology with the precision of synthetic biology. The study aims to evaluate a rational design framework for “obligate syntrophy” to maintain community stability and enhance metabolic throughput during the processing of complex feedstocks. Utilizing a “bottom-up” methodology, a synthetic consortium of Escherichia coli and Pseudomonas putida was engineered with cross-feeding circuits and quorum-sensing feedback loops for real-time population regulation. Results demonstrate that the engineered consortia achieved a stable co-existence for over 240 hours, representing a 45% increase in biomass yield and a 70% improvement in detoxification efficiency compared to non-engineered mixed cultures. Statistical analysis confirms that the division of metabolic labor significantly reduces individual cellular burden while increasing overall community resilience. This research concludes that bridging ecological wisdom with genetic circuit design provides a superior architecture for robust industrial bioprocessing. The findings offer a scalable blueprint for “programmable ecology,” asserting that engineered microbial consortia are essential for unlocking the full potential of the global circular bioeconomy.
Co-Authors Adinata, Uslan Chan, Rachel Chiristiaan, Pemy Dara, Ravi Fadhil, Fakhry Jiwon, Seo Johannes Muller, Johannes Joshi, Nikhil Koh, Megan Lailatul Qadariyah Lim, Sofia Muntasir, Muntasir Nugroho, Agung Yuliyanto Olsson, Ingrid Prasetio, Rachmat Rao, Ananya Riatmaja, Dodi Setiawan Salim, Achmad Agus Shodiq, MD Syahlan, Zainal Tan, Ethan Tan, Marcus Teo, Ryan