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Nurul Mutiah Aminuddin
Universitas Negeri Makassar, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Nursing Physics Public Health Social Sciences Veterinary Other

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AREDS2 sebagai Strategi Perlindungan Retina Terhadap Penuaan: Tinjauan Pustaka dari Perspektif Gerosains: Tinjauan Pustaka Wilaksono, Bhirau; Elfandari, Enno; Ichsan, Rayhani; Alfiandari, Dhini; Damry, Nurul Muf'idah; Chairul, Andi Makkawaru; Aminuddin, Nurul Mutiah; Nurdin, Novi Safitri; Chandrawati, Aida Ayu; Hammado, Nurussyariah
Cermin Dunia Kedokteran Vol 53 No 08 (2026): Agustus 2026
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i08.2130

Abstract

Introduction: Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss among the elderly population. The Age-Related Eye Disease Study 2 (AREDS2) supplementation was developed as an evidence-based nutraceutical strategy to slow the progression of AMD. This review aims to evaluate the clinical evidence and potential application of AREDS2 as a geroprotective retinal intervention within the framework of precision geromedicine. Methods: A narrative review of recent AREDS and AREDS2 studies was conducted, integrating concepts from geroscience related to retinal aging. Results: The AREDS2 formulation, which replaced beta-carotene with lutein and zeaxanthin, demonstrated an 18% reduction in AMD progression risk without increasing lung cancer risk among smokers. AREDS2 components target key aging pathways, including oxidative stress, mitochondrial dysfunction, chronic inflammation, and dysregulated autophagy. In addition, potential modulation of mTOR and AMPK signaling suggests a role in extending retinal healthspan. Conclusion: AREDS2 represents a promising nutraceutical approach as a retinal gerotherapy within the paradigm of precision geromedicine. Its clinical implications include preventing AMD progression, optimizing visual function in older adults, and enabling integration into precision-based ophthalmologic practice. Further research is warranted to validate the molecular mechanisms and assess the cross-population effectiveness, thereby strengthening its role in broader age-related ocular health interventions.
Co-Authors A. Dhini Alfiandari Aida Ayu Chandrawati Aida Ayu Chandrawati Alfiandari, A. Dhini Alfiandari, Dhini Amir Hamzah Basir Bhirau Wilaksono Bhirau Wilaksono Bhirau Wilaksono Budahu, Muhammad Abdi Sabri I Chairul, Andi Makkawaru Chandrawati, Aida Ayu Damry, Nurul Muf'idah Dewi Yusuf Dhini Alfiandari Elfandari, Enno Hammado, Nurussyariah Kusnadi Umar Lulu Ichsan Moh Sulfikar Suling Muhammad Ichsan Ali Nurdin, Novi Safitri Nurul Azizah Nurul Mufidah Damry Nurul Muf’idah Damry Nurussyariah Hammado Okto Sofyan Paramita, Diah Astini Rayhani Ichsan Tuan Afero Harahap Wilaksono, Bhirau