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Jurnal Farmasi Sains dan Komunitas

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Published by Universitas Sanata Dharma

ISSN : 16935683 EISSN : 25277146 DOI : https://doi.org/10.24071/

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 247 Documents

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CORRELATION ANALYSIS BETWEEN THE SERVICE QUALITY, CUSTOMER SATISFACTION, AND CUSTOMER LOYALTY OF VIVA GENERIK PHARMACY IN SEMARANG Eva Monica; Basu Swastha Dharmmesta; Suci Paramitasari Syahlani
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 14, No 2 (2017)
Publisher : Sanata Dharma University

Today, pharmacy service has become more developed along with the enhancement of society awareness of the importance of health. Therefore, as one of the health service facilities, pharmacy is required not only to give priority on product prices and varieties but also to provide qualified service for the patients. Viva Generik pharmacy as a new comer should have the ability to understand the situation and should have the competitive advantage. This study used a survey method. Data were collected with a purposive sampling method using the instrument of closed questionnaires. The questionnaires were tested for the validity and the reliability to 40 respondents who were the consumers of Viva Generik pharmacy. Questionnaires were given to 150 respondents, then were analyzed using qualitative descriptive statistics to identify the respondents characteristic. Quantitative analysis was used to identify the quality of the service and to see the correlation between service quality, satisfaction, and customer loyalty of Viva Generik pharmacy. As a result, Viva Generik pharmacys consumers tended to agree that the quality of service given by Viva Generik pharmacy was good. Simultaneously, service quality variables gave a positive impact to the customer satisfaction and the customer loyalty. It was just the tangible dimension that gave the significant impact on the customer satisfaction and customer loyalty. It was also disclosed that the customer satisfaction brought a significant impact on the customer loyalty to Viva Generik pharmacy.

ANTIOXIDANT ACTIVITY, TOTAL PHENOLIC, AND FLAVONOID CONTENTS OF THE EXTRACT OF ENDOPHYTIC FUNGI DERIVED FROM TURMERIC (Curcuma longa) LEAVES Eris Septiana; Siti Irma Rahmawati; Fauzia Nurul Izzati; Partomuan Simanjuntak
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 2 (2019)
Publisher : Sanata Dharma University

Air pollution can increase free radicals that may worsen some diseases. Antioxidants such as phenol and flavonoid compounds are known to counteract these free radicals. Long term use of synthetic antioxidants is known to cause bad effects on the body. Therefore, the necessity to search for natural antioxidants from plants and its endophytic microbes continues with the hope to obtain potential natural antioxidants with minimum side effects. The purpose of this study was to determine the antioxidant activity, total phenolic, and flavonoid contents of the extract of endophytic fungi which were derived from the Bogor-originated turmeric leaves via in vitro isolation. DPPH free radical scavenging method was used to determine in vitro antioxidant activity. The total phenolic and flavonoid contents assays were based on the Follin-Ciocalteu and aluminium chloride reagents, respectively. The extract of endophytic fungi of Bo.Ci.Cl.D1 and Bo.Ci.Cl.D2 showed antioxidant activity with IC50 value at 24.04 and 96.08 mg/L, respectively. Total phenolic content of Bo.Ci.Cl.D1 and Bo.Ci.Cl.D2 extracts were 113.47 and 81.83 mg gallic acid equivalent/g extract respectively. Total flavonoid content of Bo.Cl.D1 and Bo.Ci.Cl.D2 extracts were 41.79 and 38.50 mg quercetin equivalent/g extract, respectively. Based on these assays, it could be concluded that the extract of Bo.Ci.Cl.D1 has better antioxidant activities than Bo.Ci.Cl.D2.

PENGARUH PEMBERIAN ANGKAK TERHADAP KENAIKAN JUMLAH TROMBOSIT TIKUS JANTAN Christianus Heru Setiawan
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 12, No 1 (2015)
Publisher : Sanata Dharma University

Abstract: The research has purpose to get information about the effect of water-boiled red yeast rice for raising the platelet levels so that it can be used as a supplement for patients of Dengue Hemorrhagic Fever (DHF). The research was pure experimental with direct sampling design. The research used Wistar male rats, age 2-3 months, and weight + 150-250 grams. Rats randomly divided into five treatment groups. First group (negative control) given CMC Na 1% 0.72 g/KgBW for 7 days followed by 2.5 mL of distilled water for 5 days. Second group (positive control) given chloramphenicol 0.72 g/KgBW for 7 days followed by distilled water for 5 days. Fourth-fifth group (treatment) given chloramphenicol dose 0.72 g/KgBW for 7 days followed by water-boiled red yeast rice dose 2; 1; and 0.5 g/KgBW orally for 5 days. Blood sampling taken on day 0 and day 12, blood taken from the sinus orbitalis eyes for measuring levels of platelet count. Platelet concentration data that got were analyzed by Shapiro-Wilk test to see the distribution of data. If data are normally distributed then continue the analysis with paired-samples t test analysis, if data is not normal distributed then followed by Wilcoxon test analysis to know the difference levels of platelets experiment by treatment and duration of the test. The results of this research showed that water-boiled red yeast rice has effect to increase platelet levels in male rats induced by chloramphenicol at a dose of 2; 1; and 0.5 g/KgBW and gived platelet levels increasing effect at rate of 18.78, 14.02, and 5.45%. Keywords : red yeast rice, platelets, chloramphenicol

STUDY OF CORONAVIRUS DISEASE 2019 (COVID-19) VACCINATION IN INDONESIA: A LITERATURE REVIEW Theresia Lidia; Aris Widayati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 18, No 2 (2021)
Publisher : Sanata Dharma University

Research and development of the COVID-19 vaccine give hope to all people to stop the COVID-19 pandemic in the world. This literature review explores the safety and efficacy of the COVID-19 vaccine used in Indonesia and discusses Indonesia's current vaccination process. The primary databases for the reviewed articles were PubMed and Mendeley. Others are official websites, such as World Health Organization (WHO); COVID-19 and National Economic Recovery Committee in Indonesia (KPCPEN); the National Agency of Drug and Food Control (NA-DFC–in Bahasa Indonesia: BPOM) of the Republic of Indonesia; the US Food and Drug Administration (FDA), Clinical Trials.gov, COVID-19 vaccine Tracker, the Indonesian regulations, and guidelines regarding COVID-19. The inclusion criteria of the searched articles were those published from December 2019 to April 30, 2021, and those which discussed vaccines' types, efficacy, and safety. Acceptance of the COVID-19 vaccination is quite high (65%). Refusal was related to vaccine safety (30%); effectiveness (22%); distrust of vaccines (13%); fear of side effects (12%); and religious reasons (8%). The COVID-19 vaccines planned by the Indonesia Government have gone through clinical trials phases I to III. The Coronavac vaccine efficacy showed seroconversion that occurred was 92.4% to 97.4%, and no severe side effects have been reported. The ChAdOx1 nCoV-19 efficacy was 66.7% to 76.0%, and none of the tested participants was hospitalized, serious side effects were very small (0.9% to 1.1%). The mRNA-1273 efficacy was 94.1%, and its reactogenicity was mild to moderate. The BNT162b2 efficacy was ≥ 92%, and no severe or specific safety concerns have occurred. The efficacy of the BBIBPCorV vaccine has not been established. Ongoing phase I, II, and III clinical trials will provide more information on safety and immunogenicity for the BBIBP-CorV. Three of the six vaccines have obtained EUA from BPOM and approval from the Indonesian Ulema Council (MUI). A health promotion program about the safety, efficacy, and the 'halal' of the COVID-19 vaccine; acceleration and ensuring access to the COVID-19 vaccination program are urgent to end this pandemic immediately.

PEMAHAMAN MASYARAKAT DESA PERERENAN, KECAMATAN MENGWI, KABUPATEN BADUNG, BALI TENTANG BOREH-ANGET Titien Siwi Hartayu; Ketut Ary Widiasih
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 9, No 2 (2012)
Publisher : Sanata Dharma University

Abstract : Boreh-anget is one of Bali traditional medicines used by the ancient people ofBali to warm their body and it is believed that Boreh-anget could be used for pain relieves,improving blood circulation reduces rheumatic pain, and fever. This study is aimed to identifyknowledge of recent generation in Bali about Boreh-anget, including what are the ingredientsof it, how to make it, how to use it, and what benefit by using it. This study was conducted atPererenan village, Mengwi, Badung Bali where is most all of people there using Boreh-anget.This study is non-experimental, descriptive qualitative approach, using purposive sampling.There are 78 participants with age ranging form 26 60 years old involve in this study. Dataare collected using questionnaires and supported by in-depth interview among a viewparticipants, and then the data are analyzed using enumerative methods. Results of the studyshow that 76.3% of participants knew about the ingredients of Boreh-anget, 92.6% ofparticipants knew how to make Boreh Anget, 80.3% of participants knew how to use Borehanget and 78.0% of participants knew the benefit of using Boreh-anget. Conclusions of thisstudy is that recent generation in Pererenan, Mengwi, Badung, Bali still have a high level ofknowledge about Boreh-anget.Keyword: Boreh-anget, tradisional-medicines, Bali, traditional ingredient

PREVENTION EFFECTS OF METHANOLIC EXTRACT OF Eurycoma longifolia ROOTS ON CARBON TETRACHLORIDE-INDUCED HEPATOTOXICY IN RATS Phebe Hendra; Eustachia Diajeng Wandansari; Elni Meilianti; Bella Anggelina; Damiana Sapta Candrasari; Fenty Fenty
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 1 (2019)
Publisher : Sanata Dharma University

The objective of this study was to investigate preventive effects of methanolic extract of Eurycoma longifolia roots (MEEL) against carbon tetrachloride-induced hepatotoxicity in rats. A total of 25 rats were randomly divided into five groups (n=5). Group I was treated with Sodium CMC 1% w/v (peroral, 6 days), and group II was treated with single dose of CCl4 in olive oil (1:1) 2 mL/kg (intraperitoneal injection). Groups III-V received 75, 150, and 300 mg/kg BW of MEEL (peroral, 6 days), respectively, and administration of CCl4 in olive oil (1:1) 2 mL/kg (intraperitoneal injection) on the seventh day. The hepatoprotective potential was estimated by measuring serum activity of biochemical parameters. Further, liver weight ratio and histopathological changes were determined. The serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) were significantly (p0.05) increased and albumin decreased significantly (p0.05) in the CCl4 treated group, but treatment with MEEL 75 mg/kg significantly (p0.05) prevented the elevation of ALT, AST, and LDH. Histopathological changes also indicated hepatic protection of the MEEL at 75 mg/kg. This finding suggested that methanolic extract of Eurycoma longifolia roots at 75 mg/kg was enough to give a protective effect against CCl4-induced hepatotoxicity

PEMBUATAN DAN UJI AKTIVITAS SEDIAAN UNGUENTA SCARLESS WOUND DENGAN EKSTRAK BINAHONG DAN ZAT AKTIF ASPIRIN Maria Faustina Sari; Sri Hartati Yuliani
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 12, No 2 (2015)
Publisher : Sanata Dharma University

Wound is a defect of skin caused by physical or thermal damage. The inflammatory phase in the wound healing usually causes scars. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that has the ability to inhibit the activity of cyclooxygenase (COX) leading to reduced prostaglandin amount. Binahong (Anredera cordifolia) is one of the plants that is used as a wound healer. Binahong contains ascorbic acid which has an important role in collagen formation phase. In this study, binahong leaf extract ointment will be combined with aspirin to produce scarless wound ointment. The method used is a purely experimental method. The test method used is histopathology tests then processed by the method of calculating the area of collagen. The data are analyzed using T-test. The addition of aspirin in the preparation of wound healing ointment cant reduce scar formation allegedly with an incision method of white mice (Mus musculus) Swiss Webster. Statistically, the results showed that binahong ointment (UB) produces the least scar than ointment base (B), followed binahong-aspirin ointment (UBA), and aspirin ointment (UA).

PENGARUH PEMBERIAN EKSTRAK METANOL-AIR DAUN Macaranga tanarius L. TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA TIKUS YANG TERBEBANI GLUKOSA Martina Tri Handayani; Phebe Hendra
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 10, No 1 (2013)
Publisher : Sanata Dharma University

Abstract: This research aim to find out the effect of M. tanarius leaf methanol-water extract(MTME) whether it can lowering blood glucose levels. This research was experimental studywith one way-complete-random design using 25 male rats which divided into five groups. Therats in group I were given CMC 1% (negative control). The group II rats were given 0.45 g/kg BWdose of Glibenclamide (positive control). In group III, IV and V, the rats were given 0.43; 1.28;3.84 g/kg BW doses of MTME orally. The hypoglycemic effect of MTME was tested by using theOral Glucose Tolerance Test (OGTT) method. The blood-glucose contents were measured at the0, 15, 30, 60, 90, 180, and 240 after the OGTT and treatment. The AUC were statisticallyanalyzed using one way ANOVA and Scheffe test with 95 % convidence level. The result show thatMTME at dose 0.43; 1.28; and 3.84 g/kg BW was effective in improving oral glucose tolerance.Keywords : Blood glucose, Methanol-water extract, Macaranga tanarius

MOLECULAR DYNAMICS STUDIES OF FULL HUMAN MATRIX METALLOPROTEINASE 9 LIGANDED WITH N-HYDROXY-2-[(4-PHENYLPHENYL) SULFONYL-PROPAN-2-YLOXYAMINO] ACETAMIDE Roy Gunawan Wicaksono; Maywan Hariono; Enade Perdana Istyastono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 1 (2020)
Publisher : Sanata Dharma University

The research presented in this article aimed to provide a full quarternary structure of human matrix metalloproteinase 9 (MMP9) enzyme with a ligand in the catalytic site for structure-based virtual screening. The enzyme plays an important role in wound healing of diabetic foot ulcer. By employing the primary structure of the enzyme obtained from UniProt database (UniProt:P14780), the theoretical structure of full apoenzyme of the human MMP9 (PDB:1LKG), the crystal structures of the catalytic domain (PDB:4H3X) and the hemopexin domain (PDB:1ITV) of the human MMP9, homology modeling studies have been performed. The ligand N-2-(biphenyl-4-yl-sulfonyl)-N-2-(isopropyloxy)-acetohydroxamic acid (CC27) or N-hydroxy-2-[(4-phenylphenyl)sulfonyl-propan-2-yloxyamino]acetamide (IUPAC version) from PDB:4H3X was embedded in the catalytic site of the enzyme. The modeling made use of the modules of homology modeling in YASARA structure. Subsequently, molecular dynamics (MD) simulations in YASARA structure were performed to examine the stability of the enzyme. The homology model was found stable after 5.05 ns and the lowest energy of the model was found at the 6.40 ns of the MD production run. This lowest energy snapshot was then energetically minimized and analyzed for its applicability for virtual screening. This optimized model was then stored in Mendeley Data (DOI: 10.17632/4gsb4p75gz.1).

FORMULASI SEDIAAN ORALLY DISINTEGRATING TABLET ATENOLOL DENGAN SODIUM STARCH GLYCOLATE SEBAGAI SUPERDISINTEGRAN Karina Citra Rani; Nani Parfati; Jessica Wangsa Putri
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 14, No 1 (2017)
Publisher : Sanata Dharma University

Atenolol, a competitive beta (1)-selective adrenergic antagonists, has been widely used in hypertension therapy. Administration of conventional tablets of atenolol has limitation due to patient compliance in geriatric patients. Formulation of atenolol as orally disintegrating tablet (ODT) can improve the effectiveness of the drug and patient compliance in hypertension therapy. The objective of this study was to formulate orally disintegrating tablet of atenolol using sodium starch glycolate as superdisintegrant in two different concentrations (10% and 20%). Orally disintegrating tablets (ODT) of atenolol without superdisintegrant were used as a control in this study. It was found that orally disintegrating tablets (ODT) of atenolol which used 10% sodium starch glycolate have better wetting time (9.330.58 seconds), disintegration time (15.481.16 seconds), in vitro dispersion time (24.001.00 seconds), and dissolution efficiency (95.230.14 %) than orally disintegrating tablet (ODT) which used 20% sodium starch glycolate.

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Florentinus Dika Octa Riswanto

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editorial.jpsc@usd.ac.id

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editorial.jpsc@usd.ac.id

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Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

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Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA