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Jurnal Farmasi Sains dan Komunitas

JFSK
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Published by Universitas Sanata Dharma

ISSN : 16935683 EISSN : 25277146 DOI : https://doi.org/10.24071/

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 247 Documents

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Drug Utilization 90% Profile of Antibiotics Use during the Period of 2013 – 2017 at a Private Teaching Hospital in Yogyakarta Saepudin Saepudin; Cinthia Sendysagita; Endang Yuniarti
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 19, No 1 (2022)
Publisher : Sanata Dharma University

Evaluation of antibiotics use plays an important role in antimicrobial stewardship programs to support the rational use of antibiotics at all healthcare facilities. This study aimed to describe the profile of drug utilization 90% (DU90%) of antibiotics use for hospitalized patients at a private teaching hospital in Yogyakarta over period of 2013 – 2017. Aggregate data of all systemic antibiotics having an anatomic therapeutic chemical (ATC) code and used for hospitalized patients during 2013 – 2017 were included in this study. Quantity of antibiotics use was expressed in defined daily dose (DDD) and final quantity was expressed in DDD/100 bed days. DU90% profile was obtained by calculating the cumulative use of antibiotics from the highest to the lowest percentage. There were 44 antibiotic agents used each year over the period of 2013 – 2017. However, there were only 10 – 12 agents within the DU90% segment. Cephalosporins group was identified as the most used antibiotics consistently over the period and the top three antibiotics that were consistently prescribed were: ceftriaxone, levofloxacin, and cefixime. It can be concluded that only about a quarter of the total antibiotic agents used in hospitals are within the DU90% segment and those antibiotic agents are relatively consistent, especially for the top three of the highest used antibiotics.

Users’ Views Regarding Electronic Prescribing Implementation: A Qualitative Case Study in A Private Hospital of Magelang City, Indonesia Eulalia Puji Febri Kurniawati; Aris Widayati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 19, No 1 (2022)
Publisher : Sanata Dharma University

The use of the Internet and digital system in a hospital named the Hospital Information System (HIS) has grown rapidly and remarkably, including in Indonesia. One of the HIS components is electronic prescribing (e-prescribing). Although the Indonesian government has mandated HIS in hospitals since 2011, successful implementation is not without challenges. Therefore, this study aimed to explore users' views regarding e-prescribing implementation through a case study in a private hospital in Magelang City, Indonesia. This study applied a qualitative approach. Participants were e-prescribing users who were selected purposively. Data were gathered using interviews. The Capability, Opportunity, Motivation, and Behavior (COM-B) model was used to structure the interview guideline. Data were transcribed verbatim and analyzed using a thematic approach. Twenty participants were interviewed. Five themes emerged through the interviews: self-reflection, perceived advantages, policy, capacity building, and quality assurance. The themes express optimism in implementing e-prescribing. Users are central to e-prescribing system acceptance, as is explained in the self-reflection and perceived advantages themes. Furthermore, top management plays a pivotal role in improving the capacity and ensuring system implementation quality. This study’s findings imply that the user, system, and organization play crucial roles in enhancing health care service quality through e-prescribing.

Systematic Review: Anti-Osteoporosis Potential Activities Of Phytoestrogen Compounds In Chrysophyllum cainito L., Elaeis guineensis Jacq., Lannea acida Rich., Marsilea crenata Presl., and Medicago sativa L. Burhan Ma'arif; Suryanto Suryanto; Faisal Akhmal Muslikh; Arief Suryadinata; Begum Fauziyah
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 19, No 1 (2022)
Publisher : Sanata Dharma University

Phytoestrogens are compounds from plants that have a structure and function similar to estrogen (17β-estradiol). Phytoestrogens can be found in Chrysophyllum cainito L., Elaeis guineensis Jacq., Lannea acida Rich., Marsilea crenata Presl., and Medicago sativa L. This systematic review aimed to prove that all of these five plants have phytoestrogens which were observed with several instruments, and to assess activities and bone forming mechanisms from these five plants in the female mice (Mus musculus) and female rats (Rattus norvegicus). This systematic review was done by identifying articles in several databases (Google Scholar, PubMed, and Science Direct). The process of selecting the articles used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to create a flowchart with inclusion and exclusion study criteria. Meta-synthesis was done to analyze, identify, and interpret all of the data in the articles systematically. 31 articles in total were obtained from the selection process, with 27 articles containing a discussion about chemical compound content and 4 articles describing research results for in vivo testing of the plants that were reviewed. The results showed that these five plants have phytoestrogens and by in vivo testing have the activity in increasing trabecular bone density in the experimental animals.

Profile of The Use of Traditional Medicines Among Adolescents in SMK Farmasi Teladan Demak Barnabas Bagus Aditya Abadi; Aris Widayati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 19, No 2 (2022)
Publisher : Sanata Dharma University

The use of traditional/herbal medicines is prevalent among Indonesians. However, the description of such use among adolescents is scarce. This study aimed to describe the profile of traditional medicine used by adolescents. This study conducted a descriptive survey as a preliminary study of a proposed research to explore adolescent intentions and behavior in the use of traditional medicines. Respondents were students of SMK Farmasi Teladan Demak. Data were obtained from 78 respondents using a structured interview guideline in Google Forms. Data were analyzed descriptively. The results of this preliminary study show the profiles of traditional medicines usage among adolescents, as follows: 1) 35% of respondents use traditional medicine once a month, 2) 44% of the respondents said the traditional medicine is more harmless than conventional medicine, 3) 96% of respondents showed an interest in "jamu gendong", 4) 86% of the respondent preferred "jamu beras kencur", 5) 79% of respondents use branded traditional medicine for the common cold, 6) 51% of respondents cited the Internet as a source of information about branded traditional medicines, and 7) 78% of respondents purchased branded traditional medicines at pharmacies. This preliminary study identified particular beliefs regarding traditional medicines among adolescents, such as it is safer, natural and practical. The Internet becomes the primary source of information about traditional medicines. The adolescents found it is easy to use traditional medicines, as they can be quickly obtained from a pharmacy. Further research is needed to explore the factors that influence the behavior of using traditional medicine among adolescents.

Identification Bioactive Compound of Ethanol-Water Fraction of Coleus atropurpureus for Anti-rheumatic Rheumatism in CFA-induced Rats Ipang Djunarko; Nanang Fakhrudin; Arief Nurrochmad; Subagus Wahyuono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 19, No 2 (2022)
Publisher : Sanata Dharma University

Nonsteroidal anti-inflammatory drugs are used for pain and to slow the progression of rheumatoid arthritis. Accordingly, the discovery of rheumatoid arthritis active compounds from the ethanol-water fraction Coleus atropurpureus (EWC) was conducted to characterize the isolated compounds as well as the anti-rheumatic effects of the EWC induced Complete Freund's Adjuvant (CFA). We conducted in vivo study in rats which were randomly divided into 5 groups. Group 1 was only given CFA as a negative control. Group 2 as positive control was orally exposed to diclofenac potassium (9 mg/BW). Three groups were given different EWCs orally as follows: 11.25 mg/BW, 22.5 mg/BW, and 45 mg/BW, respectively. Rheumatism rates were then compared with positive controls using a visual arthritic scoring system. The compounds identified by isolation of the EWC of Coleus atropurpureus predicted forskolin. The ethanol-water fraction Coleus atropurpureus did not act as an anti-rheumatic arthritis agent in CFA-induced rats.

Preparation of a Questionnaire for Clean and Healthy Behavior and Multivitamins to Measure Knowledge, Attitudes and Behavior as Prevention Efforts During the COVID-19 Pandemic Sisilia Christina Ari Widiastuti; Yosef Wijoyo; Nunung Priyatni
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 19, No 2 (2022)
Publisher : Sanata Dharma University

Clean and Healthy Behavior (PHBS) is a movement that aims to improve the quality of the life and health of a person and society. One way to prevent the spread of COVID-19 is to live a clean and healthy lifestyle and increasing a person’s endurance can be done by taking multivitamins. This study aims to develop a PHBS and Multivitamins questionnaire that can be used to evaluate the knowledge, attitudes and behavior of Pelita Bangsa Health Vocational School students. This quantitative research was conducted in two stages. The first stage aimed to develop the PHBS and Multivitamin questionnaire’s framework, and the second stage was to test the validity and reliability. The questionnaire was made in three parts, including knowledge, attitude and behavior. The knowledge parts used the Guttman scale, while the attitude and behavior parts used a Likert scale. Questionnaire statements were considered valid by experts’ judgment. From the results of the validity and reliability tests of the questionnaire using Cronbach's alpha analysis, the results of the questionnaire were declared valid and reliable with a value above 0.60. The resulting questionnaire consists of 25 statements of knowledge, 20 statements of attitude and 20 statements of behavior. This research instrument can be used to measure students’ knowledge, attitudes and behavior in Pelita Bangsa Health Vocational School.

High Frequency of CYP2A6*4, CYP2A6*7, and CYP2A6*9 Alleles Detected Among Patients with Type 2 Diabetic: Genetic Study in The Private Hospital in Yogyakarta Christine Patramurti; Dita Maria Virginia; Fenty Fenty; Christianus Heru Setiawan; Jeffry Julianus; Phebe Hendra; Nicholas Adi Perdana Susanto
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 19, No 2 (2022)
Publisher : Sanata Dharma University

Smoking is a risk factor for type 2 diabetic (T2DM), since the nicotine in cigarettes can cause insulin resistance and increase lipolysis. Both of these can worsen the condition of patients with T2DM and increase treatment failure. Nicotine is metabolized to cotinine by the CYP2A6 enzyme encoded by the CYP2A6 gene. This gene is highly polymorphic, with several inactive alleles, which are CYP2A6 *4, CYP2A6 *7, and CYP2A6 *9. Someone who has an inactive gene will experience being a slow or poor metabolizer. Therefore, the nicotine metabolism will decrease, nicotine blood levels will increase, causing therapy failure among patients with T2DM. This study aims to determine the distribution of CYP2A6*4, CYP2A6*7, and CYP2A6*9 among patients with T2DM who have been routinely treated using oral antidiabetics. We also investigated whether HbA1c levels is a predictor for the success of the treatment. This observational study was conducted with a cross-sectional design. Polymerase chain reaction was used to analyze the three inactive alleles with specific primers. Based on our study, there is a high frequency of the inactive alleles, i.e., CYP2A6*4, CYP2A6*7, and CYP2A6*9, among the patients with T2DM. The presence of these inactive alleles will worsen and reduce the effectiveness of the therapy. Smoking cessation programs are needed to increase the effectiveness of the anti-diabetic therapy.

Optimization of Nanosilver Synthesis Process with Bioreductor of Binahong Leaf Extract (Anredera cordifolia (Ten.) Steenis) Rini Dwiastuti; Elsa Irnandari; Michael Raharja Gani; Sri Hartati Yuliani; Christofori Maria Ratna Rini Nastiti
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 19, No 2 (2022)
Publisher : Sanata Dharma University

Nanosilver is a type of metallic silver nanoparticles and has a particle size of 1-100 nm. The method used in the synthesis of nanosilver is a chemical reduction method with silver metal precursor AgNO3 and a bioreductant of binahong leaf extract containing flavonoid compounds. This study aims to obtain the duration, temperature and optimum point in the synthesis of nanosilver with the bioreductant of binahong leaf extract using the sonication method. This type of research is purely experimental with a 2x2 factorial design. The nanosilver characterization was conducted by determining the optimum wavelength and the transmittance value of the nanosilver formed. The effect of temperature and duration of sonication on the wavelength and % transmittance of the synthesized nanosilver in this study were analyzed by ANOVA statistical test using the Minitab 19 application with a 95% confidence level. In this study, the temperature and duration of sonication as well as their interactions have an effect on the transmittance response. The statistical results of the model have a significant effect on the % transmittance response only with p-value 0.05. The optimum point was found in the synthesis of nanosilver with the bioreductant of binahong leaf extract (Anredera cordifolia (Ten.) Steenis) using a 2x2 factorial design, namely at a sonication temperature of 80°C for 10 minutes, a sonication temperature of 70oC for 15 minutes and a sonication temperature of 80oC for 15 minutes.

The Epigenetic Impact of Vegetables-Derived Dietary Compounds in Neurodegenerative Conditions : A Review Vania Amanda Samor; Yurida Ni'ma Annisa; Muthi Ikawati; Nunung Yuniarti
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 19, No 2 (2022)
Publisher : Sanata Dharma University

Dietary compounds from the foods we eat on a daily basis offer several benefits; they help prevent disease and preserve health. The epigenetic advantages of the vegetables we eat every day are one of the benefits that have not been well-reported. Epigenetic pathways involving histone modification, DNA methylation, and alterations caused by miRNAs are extensively engaged in signal transmission, cell development, and death in various disease states, including brain cells. Through this narrative review collected from multiple studies available on reputable online databases until March 2022 shows the epigenetic advantages of various vegetables' content such as gallic acid, quercetin, kaempferol, apigenin, luteolin, resveratrol, genistein, sulforaphane, and diallyl disulfide in neurodegenerative conditions are summarized. However, in-depth investigations are still required to clarify these epigenetic mechanisms before these compounds are ready to be used in the future, as several studies still provide contradictory results

The Effect of Ethanol Extract of Marsilea crenata Presl. Leaves on Rotenone-Induced Zebrafish Locomotor Activity Ma'arif, Burhan; Muslikh, Faisal Akhmal; Fihuda, Destiya Argo Pamuji; Khotimah, Husnul; Taek, Maximus M.; Agil, Mangestuti
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 19, No 2 (2022)
Publisher : Sanata Dharma University

Neurodegenerative diseases are mostly experienced by postmenopausal women and are often caused by estrogen deficiency, so it is necessary to replace the hormone estrogen in the form of phytoestrogens. One of the plants that contain phytoestrogens is Marsilea crenata. The objective of this study is to see if giving rotenone-induced zebrafish a 96% ethanol extract of M. crenata leaves increases locomotor activity. This research was conducted by inducing 5 µg/L rotenone as a compound that will interfere with the locomotor activity of zebrafish. Next, treatment was given with 96% ethanol extract of clover in each group with a dose of 2.5; 5; 10; and 20 mg/mL to determine the effect of the extract on increasing locomotor activity of rotenone-induced zebrafish. Observations were made by looking at the quantity of zebrafish swimming every five minutes until day 28. The treatment of 96% ethanol extract of M. crenata leaves could significantly increase zebrafish motility at the optimum dose of 2.5 mg/mL, because every week the zebrafish locomotor activity increased compared to the negative control. M. crenata leaves extract is proven to prevent neurodegenerative diseases. However, further research needs to be done on the degenerative effects of rotenone every week.

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Home Page

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Contact Name Florentinus Dika Octa Riswanto

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Editorial Address Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

Location Kab. sleman, Daerah istimewa yogyakarta INDONESIA

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Contact Name
Florentinus Dika Octa Riswanto

Contact Email
editorial.jpsc@usd.ac.id

Phone
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Journal Mail Official
editorial.jpsc@usd.ac.id

Editorial Address
Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA