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Jurnal Farmasi Sains dan Komunitas

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Published by Universitas Sanata Dharma

ISSN : 16935683 EISSN : 25277146 DOI : https://doi.org/10.24071/

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 247 Documents

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PEMBERIAN KOMBINASI VITAMIN B1, B6 DAN B12 SEBAGAI FAKTOR DETERMINAN PENURUNAN NILAI TOTAL GEJALA PADA PASIEN NEUROPATI PERIFER DIABETIK Ratna Sari Kusuma Dewi; Rizaldy Taslim Pinzon; Sapto Priatmo
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 13, No 2 (2016)
Publisher : Sanata Dharma University

Diabetic neuropathy is defined as symptoms of peripheral nerve dysfunction in people with diabetes after the exclusion of other causes. According to the earlier studies symptoms of neuropathy such as pain, burning, paresthesia/tingling and numbness can be reduced with neurotropic supplementation. The aim of the research is to determine vitamin B1, B6 and B12 as a determinant factor in the reduce total symptom score in patient with diabetic peripheral neuropathy. This research used case series studies and choose 43 sample with consecutive sampling method. We observed symptoms of diabetic peripheral neuropathy (pain, burning, tingling and numbness) measured as total symptoms score, among the patients treated with vitamin B1 (100mg), B6 (100mg) and B12 (5000mcg) for a month. Measurement of total symptoms score performed at first meeting, the second week later (day-14) and the fourth week later (day-30). The data were analyzed using univariate and bivariate statistics. The patients (n=43) consisted of 20 male (46.5 %) and 23 female (53.5 %). The symptoms of diabetic peripheral neuropathy (pain, burning, tingling and numbness) that measured by total symptoms score compared with first visit (4.70 1.83), second visit (2.99 1.61) and third (2:37 1.62). Bivariate analysis, showed a correlation between a reduction in total symptoms score after giving therapy of vitamin B1 (100mg), B6 (100mg) and B12 (5000mcg) with p = 0.00. Vitamin B1, B6 and B12 proved to be a determinant factor to reduce total symptoms score (pain, burning, tingling, and numbness) in patients with diabetic peripheral neuropathy.

SUATU KAJIAN MOLEKULER KETERGANTUNGAN NIKOTIN Agustina Setiawati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 10, No 2 (2013)
Publisher : Sanata Dharma University

Abstract: Nicotine, a simple chemical substance from tobacco, stimulates addiction byneuroadaptation inducing rewards system in human brain. Molecular mechanism of nicotineaddiction in rewards system are mediated by nicotinic acetylcholine receptor (nAChR) andactivate dopaminergic neuron. Thus, nicotine addiction are also induce other neurottransmitterand hormone release: norephinefrin, serotonin, opioid, glutamat and mono amine oxidase.Keywords: nicotine, addiction, rewards system.

IDENTIFICATION OF THE SPREAD OF BORAX USE IN MEATBALL SKEWERS IN BANTUL DISTRICT, SPECIAL REGION OF YOGYAKARTA Sabtanti Harimurti; Imelda Horirotul Bariroh; Asep Setiyawan; Ratna Indah Permatasari; Friccillia Dwi Putri; Leni Yasinta Fajriana
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 2 (2020)
Publisher : Sanata Dharma University

Borax is an additive that is often added to some foods such as meatball skewers. The government has banned this ingredient from being added to food because it is harmful to health when consumed for a long time. This study aims to identify the use of borax in Bakso Tusuk or meatball skewers sold in Bantul area. Samples were drawn from 17 sub-districts in Bantul, Special Region of Yogyakarta. Two samples were taken from each sub-district, so the number of total samples was 34. The speed of decay test was carried out by observing the appearance of fungus, maggots, and consistency of the surface of meatball skewers. The presence of borax in the meatball skewers was done by turmeric paper and flame test, while the quantitative analysis utilized the acid-base titration method. Based on the results of the study, all samples tested positive for borax with concentrations between 0.06% - 5.15%, and the decay rate test showed that the speed of decay was independent of the level of borax.

SINTESIS ASAM SINAMAT DARI BENZALDEHIDA DAN ASAM MALONAT DENGAN KATALIS DIETILAMINA Jeffry Julianus; Elvan Luckyvano
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 1 (2014)
Publisher : Sanata Dharma University

Abstract: Cinnamic acid is a natural compound that has known had activities as: antimicrobia; flavour in food; soap; cosmetic; and inhibitor proliferation of caco-2 cells. Cinammic acid compound commonly got by isolated kayu manis bark with yield 2.2%. There was a limitation amount of cinnamic acid that got by isolation so needed another effort to get much amount of cinnamic acid. There was an effort to get much amount of cinnamic acid that was by synthesized it. Synthesis process was carried out by reacted benzaldehyde 45 mmol (4.9 g) and malonic acid 45 mmol (4.5 ml) with catalyzed dietylamina for 7.5 hours at 80OC. Synthetic compound was carried out organoleptic test, solubility test, melting point test, gas chromatography, structure elucidation with ultraviolet spectrophotometry, infrared spectrophotometry, nuclear magnetic resonance spectroscopy (1H-NMR), mass spectroscopy; and amount of yield. Synthetic compound was white smooth crystal powder, and had a specific flavour with yield was4.68% and melting point was 132-133OC. Solubility test showed the synthetic compound dissolved in ethanol, methanol, chloroform, dimethyl sulfoxide, hot water, and acetone; very difficult soluble in water. Gas chromatography chromatogram showed one peak with retention time 13.321 minute. Based on structure elucidation conclude that synthetic compound was cinnamic acid.

THE EFFECT OF CANDESARTAN PRE-STROKE USE ON THE FUNCTIONAL OUTCOME OF POST ISCHEMIC STROKE PATIENTS IN BETHESDA HOSPITAL YOGYAKARTA Lise Insani Gulo; Rizaldy Taslim Pinzon; Esdras Ardi Pramudita
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 15, No 1 (2018)
Publisher : Sanata Dharma University

Stroke is a leading cause of death and disability, where the main risk factor is hypertension. Angiotensin Receptor Blocker (ARB) is the most common drug for stroke prevention in high-risk hypertensive patients. The purpose of this study was to see whether the candesartan pre-stroke use can improve the functional outcomes of post ischemic stroke patients. The data were obtained from 191 retrospective observational studies. Data were collected from Stroke Registry and medical record at Bethesda Hospital Yogyakarta in 2014-2016, then analyzed univariate, followed by bivariate analysis using chi-square test, independent t-test and fisher exact test for the variable which has actual count (F0), and logistic regression for multivariate analysis. One hundred and ninety one samples were systematically reviewed to evaluate the effect of candesartan pre-stroke use on functional outcomes of post ischemic stroke patients in Bethesda hospital Yogyakarta whose range of ages was mostly between 61 and 70 years (30.9%) and were mostly male patients (56.5%). Patients with good functional outcomes (2) were 79.6% and poor functional outcomes (?2) were 20.4%. The results of bivariate analysis showed that candesartan did not affect the improvement of clinical outcome (OR: 1.806, 95% CI: 0.591-5.519, p: 0.294), and also not better than other angiotensin receptor blocker (p=0.505, OR=1.472, 95% CI= 0.470-4.611). The multivariate analysis showed that sex (OR: 0.366, 95% CI: 0.156-0.858, p: 0.021), loss of consciousness (OR: 0.107, 95% CI: 0.021-0.549, p: 0.007), limb weakness (OR: 0.236, 95% CI: 0.067-0.834, p: 0.025), dyslipidemia comorbidity (OR: 2.750, 95% CI: 1.177-6.427, p: 0.019) and aphasia (OR: 0.342, 95% CI: 0.107-1.100, p: 0.072) affected the functional outcome. The candesartan pre-stroke use did not improve the functional outcome of post ischemic stroke patient.

UJI AKTIVITAS ANALGESIK ASAM 2-(3-(KLOROMETIL)BENZOILOKSI)BENZOAT DAN ASAM 2-(4-(KLOROMETIL)BENZOILOKSI)BENZOAT PADA TIKUS WISTAR JANTAN DENGAN METODE PLANTAR TEST Wahyu Dewi Tamayanti; Ratna Megawati Widharna; Caroline Caroline; Bambang Soekarjo
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 13, No 1 (2016)
Publisher : Sanata Dharma University

The new compounds of salicylic acid derivatives, 2- (3- (chloromethyl) benzoyloxy) benzoic acid and 2- (4- (chloromethyl) benzoyloxy) benzoic acid were synthesized to generate better analgesic activity and lesser stomach irritation of salicylic acid. The 2- (4- (chloromethyl) benzoyloxy) benzoic acid and 2- (3- (chloromethyl) benzoiloksi) benzoic acid were synthesized by Schotten-Baumann acylation process. In this study, analgesic activity was tested by plantar test method. The compounds were administered to the tested animals at 12.5; 25; 50; 100; and 200 mg / kg BW of doses. Analgesic activity was determined by the response time of rat to pain induced by infra red. The percentage of pain hindrance was calculated from the mean of response time to pain. Pain hindrance percentage were shown as: 74.28%; 105.58%; 110.58%; 115.29%; and 175.87% after administration of 2- (4- (chloromethyl) benzoyloxy) benzoic acid at doses of 12.5; 25; 50; 100; and 200 mg / kg. The pain hindrance percentage after administration of 2- (3- (chloromethyl) benzoyloxy) benzoaic acid, were 85.30%; 92.48%; 124.96%; 180.36%; and 208.01% respective to the doses of 12.5; 25; 50; 100; and 200 mg / kg. Five doses of acetyl salicylic acid ranged from 12.5 mg / kg to 200 mg / kg showed pain hindrance percentage as: 26%; 34.34%; 45.68%; 60.38%; and 114.12%. This study indicated that 2- (3- (chloromethyl) benzoyloxy) benzoic acid and 2- (4- (chloromethyl) benzoyloxy) benzoic acid generated higher analgesic activity than acetyl salicylic acid.

COST AND EFFECTIVENESS OF ATYPICAL-ATYPICAL ANTIPSYCHOTIC COMBINATIONS AND ATYPICAL-TYPICAL ANTIPSYCHOTIC COMBINATIONS IN PATIENTS OF PSYCHOTIC DISORDERS IN INSTALLATION OF EMERGENCY IN GRHASIA MENTAL HOSPITAL, YOGYAKARTA Arya Dibyo Adisaputra; Endang Darmawan; Arum Siwinarni
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 18, No 2 (2021)
Publisher : Sanata Dharma University

Psychotic disorders create a burden on the government, family, and society because of decreasing patient productivity. The use of atypical-atypical and atypical-typical antipsychotic combinations is one of the most commonly used combinations for patients with psychotic disorders. The study was conducted to determine the average total cost and effectiveness of the therapy measured by the difference in PANSS-EC pre-post scores during intensive care. The study was conducted prospectively to analyse the total cost and effectiveness of the therapy using combinations of antipsychotics in psychotic disorders patients. The measured costs include the cost of nursing classes, laboratory, medical treatment, doctor's visit, and antipsychotic. The effectiveness is measured by the difference in PANSS-EC pre-post scores. As many as 32 treated patients with psychotic disorders met the inclusion criteria. The average cost of atypical-typical antipsychotic combination group (Rp1,184,043) was higher than atypical atypical antipsychotic combination group (Rp1,115,829). The effectiveness of the therapy was represented by the value of the difference between the PANSS-EC pre and post scores, which in this research yielded a mean of 7,125 for atypical-atypical antipsychotic combinations and 8,375 for atypical-typical antipsychotic combinations. In conclusion, there is a difference in the total average cost and effectiveness of the therapy. There is a difference between PANSS-EC pre and post scores during the time period from intensive room to quiet room in atypical-typical antipsychotic combinations compared with atypical-atypical antipsychotic combinations.

REVIEW: PELUANG MAHKOTA DEWA SEBAGAI ANTIKANKER Phebe Hendra
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 9, No 2 (2012)
Publisher : Sanata Dharma University

Abstract: In order to be used in formal health care systems, medicinal plants have to be safe anddisplay promising pharmacological effects. Mahkota dewa is well known as a traditionalmedicine in Indonesia. In folk medicine, its fruits and leaves are used to relief cancer, impotency,hypoglycemic, hypotensive, antirheumatic, liver and kidney disorders and skin disorders.According to pharmacology and toxicology studies especially on cytotoxic effects, mahkota dewahas anticancer activity. However, further studies will be required to establish the cell target foranticancer treatment.Key words: mahkota dewa, anticancer, cytotoxic

PENGARUH PENGGUNAAN PARASETAMOL SELAMA KEHAMILAN TERHADAP PREEKLAMPSIA Dita Maria Virginia
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 10, No 2 (2013)
Publisher : Sanata Dharma University

Abstract: Preeclampsia is one of the causes of maternal death. The important factor ofpreeclampsia's pathophysiology is reduction of PGI2 as vasodilator. It causes vasoconstrictionwhich influences the formation of desidua. Paracetamol is the most widely used antipyretic in theworld. Mechanism of action of paracetamol may lead to preeclampsia. The aim of this researchwas to determine the relation between paracetamol used during pregnancy and preeclampsia inRS X Yogyakarta. The research was an analytical epidemiology with case control study design.Data were obtained from medical record and interview. Sample size was 137 maternal patients inOctober-December 2013 and 72 maternal have been followed up. Data were analyzed usingdescriptive statistics, Chi-square tests, and logistic regression. Preeclampsia patients weretaking paracetamol during pregnancy (71.8%), aged 30-40 years (84.6%), and hadpreeclampsia family history (28.2) than non preeclampsia patient. Chi-square test showed therelation between paracetamol used (p=0.010, OR= 3.46 (95%CI= 1.30 9.22), dose a day(p=0.010, OR= 3.18 (95%CI= 1.12 9.06), duration of paracetamol used (p=0.005, OR= 7.75(95%CI= 1.60 37.53), and used within first trimester (p=0.878, OR= 0.91 (95%CI= 0.26 3.12) to preeclampsia. Logistic regression analyses showed no correlation between variables topreeclampsia. Women who used paracetamol during pregnancy had an increased risk ofpreeclampsia.Key words: preeclampsia, paracetamol, pregnancy.

THE INFLUENCE OF B-CYCLODEXTRIN CONCENTRATIONS AS LIGANDS ON INCLUSION COMPLEXES TO INCREASE THE SOLUBILITY OF IBUPROFEN Rahmah Elfiyani; Anisa Amalia; Alvin Integra
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 1 (2020)
Publisher : Sanata Dharma University

Ibuprofen is a compound with low solubility but high permeability in water. One method to improve the ability of a substance to dissolve in water is through the formation of inclusion complexes. This study aims to obtain ratio between ibuprofen and b-cyclodextrin which results in inclusion complex with an optimal amount of dissolved ibuprofen. The inclusion complex was made using solvent evaporation method with molar ratio variations of 1: 1, 1: 2, 1: 3, 1: 4 and 1: 5. The results of the inclusion complex were characterized by X-ray diffraction, FTIR, SEM, and DTA. The solubility test was carried out using three different media; they are pH solution 7.4; pH solution 1.5; and distilled water. The solubility test results showed no increase on the ibuprofen solubility of the inclusion complex within medium solutions of pH 7.4 and pH 1.5 whereas in aquades medium there was an increase in the inclusion complex solubility compared to pure ibuprofen. Based on the results, it can be concluded that inclusion complex with molar ratio of 1: 1 shows optimal amount of dissolved ibuprofen compared to other ratio variations in aquadest medium.

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Florentinus Dika Octa Riswanto

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Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

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Daerah istimewa yogyakarta

INDONESIA