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Jurnal Farmasi Sains dan Komunitas

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Published by Universitas Sanata Dharma

ISSN : 16935683 EISSN : 25277146 DOI : https://doi.org/10.24071/

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 247 Documents

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HUBUNGAN PROCALSITONIN DAN GAMBARAN MORFOLOGI LEUKOSIT PADA INFEKSI BAKTERIAL Fenty Fenty; Dita Maria Virginia
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 2 (2014)
Publisher : Sanata Dharma University

Abstract: Bacterial sepsis increases morbidity and mortality in all ages. Early detection has been shownto be crucial for the improved outcome of patients with sepsis. Till now there is no routine test forscreening. Procalcitonin and morphology of leukocytes are biomarkers of bacterial sepsis. The aim of thisstudy was to determine the relationship between procalcitonin and morphology of leukocytes as marker inbacterial infection. This study was analytical observational with cross sectional design and data collectedprospectively.This study measured simultaneously the value of procalcitonin and morphology of leukocytesexamination in patients with suspected bacterial infection in hospital X of Yogyakarta. Data were analysedby statistics. The results showed immature granulocytes and vacuolization of neutrophils in the leucocytesmorphology has a significant correlation with level of procalcitonin.Keywords: bacterial infection, procalcitonin, morphology of leukocytes

PHARMACEUTICAL CARE PRACTICE IN THE COMMUNITY PHARMACY BY UTILIZING PROBLEM-BASED LEARNING IN REFLECTIVE PEDAGOGY PARADIGM METHOD Titien Siwi Hartayu; Yosef Wijoyo; Maria Wisnu Donowati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 18, No 1 (2021)
Publisher : Sanata Dharma University

This study follows the previous study entitle Problem-based Learning (PBL) in reflective pedagogy paradigm (RPP): Innovative learning in pharmaceutical care, which identified the learning material as complicated. This study aimed to provide an appropriate method for performing pharmacy management and pharmaceutical care in Community Pharmacy. Data collection was done using an assessment instrument to identify student’s achievement. The previous study encompasses preceptors and students in developing learning material, which cause it more valid and reliable to be implemented. The study was conducted in Yogyakarta, Surakarta, and Semarang city. The effectiveness of the learning material was shown by the grade of student’s achievement in learning outcome and the clear state with confidence in the expression of reflection and action-plan. Most of the students in the 3 cities achieved an excellent grade both in the problem-solving field, and presentation of the assignment. The students reflected that the learning material is simple and suitable in practicing pharmaceutical care and pharmacy management, moreover, they can state their plan to work as a Community Pharmacist with confidence. Therefore, PBL in the RPP method is ready to be used in practicing pharmaceutical care in the Community Pharmacy.

PENGARUH WAKTU PROTEKSI INFUSA BIJI Persea americana Mill. TERHADAP HEPAR DAN GINJAL TIKUS TERINDUKSI KARBONTETRAKLORIDA Lydia Setiawan; Inneke Devi Permatasari; Phebe Hendra
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 1 (2014)
Publisher : Sanata Dharma University

Abstract: The aim of this research is to investigate the protective activity of the infusion of seed ofPersea americana Mill. (IBPA) against carbon tetrachloride-induced hepatotoxicity andnephrotoxicity in rats. Healthy rats were weighed and randomly divided into 6 groups of 5animals in each. Group 1 were treated with olive oil (2ml/kg, i.p) as negative control. Group 2received carbon tetrachloride (2 ml/kg, i.p.). Group 3 received IBPA 360.7 mg/kg once daily for 6hours (control of dose IBPA). Group 4-6 received IBPA at doses 360.7 mg/kg orally once for 1, 4and 6 hours respectively received treated carbon tetrachloride. Blood sample from all groupswas obtained by sinus orbitalis for the estimation serum transaminase and creatinine. Thepretreatment 1,4 and 6 hours of infusion of seed of Persea americana Mill. has a potent protectiveactivity upon carbon tetrachloride-induced hepatic and nephron damage in rats.Keywords: Persea americana Mill., infusion, protective, carbon tetrachloride

STANDARDIZATION OF EXTRACT AND CHARACTERIZATION OF EMULGEL FORMULA OF LENGKUAS (Alpinia galanga (L.) Willd) RHIZOME EXTRACT Widyasari Putranti; Novia Ariani Dewi; Lina Widiyastuti
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 15, No 2 (2018)
Publisher : Sanata Dharma University

The lengkuas rhizome has an antifungal activity. The non-specific parameters for extracts of lengkuas rhizome need to be standardized to obtain the extracts with consistent good quality. The lengkuas rhizome extract emulgel topical preparations are easily mixed with active substances that are hydrophobic or hydrophilic. This study aims to obtain a lengkuas rhizome extract emulgel formula that has good quality and good physical properties. Extraction of lengkuas rhizome was obtained using a maceration method with 96% ethanol solvent. The extract is standardized by non-specific parameters. After that, the extract was formulated in the form of emulgel preparation with 10% concentration. The physical properties of emulgel were evaluated. The results of the study showed that the extract yield is of (14.660.056)%; powder drying shrinkage (8.630.134)%; extract water rate (50)%; powder total ash rate (3.240.017)%; and extract (1.300.035)%; acid-insoluble ash rate powder (2.660.10)%; and extract (0.870.031)%; extract type weight 1.01; and the physical properties of emulgel preparations were homogeneous emulgel, semisolid form, light brown color, distinctive smell of lengkuas rhizome extract, stable at 5oC and 25oC for 24 hours; pH 7; spreadability (2.450.03) g.cm.s-1; stickiness (8.800.72) seconds; o/w emulsion type; and viscosity (1.370.22) Pa.s. This study obtained extracts of lengkuas rhizomes that meet the requirements of non-specific parameter standardization in general and the formulation of lengkuas rhizome extract emulgel had good physical properties.

PEMBUATAN DAN UJI AKTIVITAS SEDIAAN GEL SCARLESS WOUND DENGAN EKSTRAK BINAHONG DAN ZAT AKTIF IBUPROFEN Prita Patricia; Sri Hartati Yuliani
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 12, No 2 (2015)
Publisher : Sanata Dharma University

Wound is a condition where the tissue was damaged. The body will repair this damage by wound healing mechanism which often leads to the formation of scar. The scar is caused by the inflammation phase of wound healing mechanism. Ibuprofen is one of the antiinflammatory agent that can inhibit or shorten the inflammatory phase by inhibit cyclooxygenase enzyme in prostaglandin synthesize. Prostaglandin has an important role on the formation of inflammatory phase. Binahong (Anredera cordifolia (Ten.) Steenis.) has a potential activity as a wound healing agent. Binahong contains ascorbic acid which is impotant for the activation of prolyl-hydroxygenase enzyme that support hydroxylation phase in the process of collagen formation, so that the wound healing process can be acceletared. In this research, a gel preparation with binahong extract was combined with ibuprofen to form a scarless wound gel. This research was purely experimental. The test method used is a histopahological test which continued with a calculation of collagen area and a physical properties test. The collagen area calculation data were analyzed by independent sample t-test with 95% confidence interval. In this research, the addition of ibuprofen was expected to reduce the scar formation on incisional wound of white Swiss Webster mice. The result showed that the gel preparation with binahong extract and ibuprofen formed statistically less scar when compared to the gel preparation with binahong extract only.

VALIDATION OF ANTIBODY RAPID TEST FOR SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS-2 INFECTION IN BETHESDA HOSPITAL YOGYAKARTA Fenty Fenty; Ivan Lim; Frida E. W.; Kristiani D.; Rizaldi Pinzon
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 18, No 2 (2021)
Publisher : Sanata Dharma University

Since March 2020, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection has been around in Indonesia with a case fatality rate was 4.7% on August, 1th 2020. So far, the Real-Time Polymerase Chain Reaction (RT-PCR) method is the gold standard for the SARS-CoV-2 infection diagnosis. This method, however, has some limitations where it has a longturnaround time, complicated operations, and high prices. Hence, the rapid test kits are now readily available to identify the SARS-CoV-2 patients. The purpose of this study is to measure the diagnostic performance, including sensitivity, specificity, positive and negative predictive value, likelihood ratio or LR of antibody rapid test if compared with RT-PCR for the SARS-CoV-2 suspected patients in Bethesda Hospital Yogyakarta. This research was analytical observational research with a cross-sectional design approach, in which data were collected retrospectively. The instruments used in this study included e-medical record (ERM), Laboratory Information System (LIS) data from patients with suspected SARS-CoV-2 infection in Bethesda Hospital Yogyakarta. We collected demographic data of patients, RT-PCR results, antibody rapid test results using Standard Q COVID-19 IgM/IgG Combo. The data were obtained from 50 patients. The results showed that the Rapid test kit has a 100% sensitivity value, 74.4% specificity value, 38.9% positive and 100% negative predictive value, 3906 positive likelihood ratio compared with the RT-PCR results.

OPTIMIZATION OF CARBOPOL 940 AND PROPYLENE GLYCOL CONCENTRATION ON THE CHARACTERISTIC AND INHIBITORY EFFECT OF ETHANOL EXTRACT GEL OF PAPAYA (Carica papaya L.) SEEDS AGAINST Staphylococcus aureus Octavianus Yandri; Wahyuning Setyani
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 18, No 1 (2021)
Publisher : Sanata Dharma University

Papaya (Carica papaya L.) seeds contain alkaloids, flavonoids, tannins, phenolic compounds and saponins have been proven its synergistic effect in inhibiting the growth of Staphylococcus aureus. In this research, ethanol extract of papaya seeds was formulated in gel preparations. Optimization of the composition of the gelling agent and humectant was carried out to obtain the gel preparation of papaya seed ethanol extract with good physical properties and stability. The parameters used to determine the stability of the preparation are Physical properties which include viscosity, spreadability, and percentage of viscosity shift. Data analysis was performed using Design-Expert software version 12 and SPSS. The inhibitory activity test was carried out by the disk-diffusion agar method with Staphylococcus aureus ATCC 25923 as the test bacteria. The results of the inhibitory activity test of papaya seed ethanol extract at a concentration of 20% had moderate activity and at concentrations of 40%, 60%, 80% and 100% classified as strong against the Staphylococcus aureus. Carbopol 940 is dominant factor in influencing the response of viscosity (92.504%) and spreadability (59.539%). Preparations with good physical properties and stability were obtained on the use of carbopol 940 and propylene glycol as much as 1.06604 grams and 13.2146 grams respectively.

FORMULATION AND CARACTERIZATION OF QUERCETIN NIOSOME WITH CONCENTRATION VARIATIONS OF SPAN 20 SURFACTANT Weka Sidha Bhagawan; Rahmi Annisa; Atiza Fajrin Maulidya
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 18, No 2 (2021)
Publisher : Sanata Dharma University

Quercetin has low solubility, absorption and bioavailability which limits its practical use as a drug or supplement. Therefore, it is important to formulate a quercetin niosome system with various concentrations of span 20 as a surfactant. This investigation aimed to formulate and analyse a quercetin niosome preparation with span 20 variations to provide optimal quercetin solubility. Niosomes were prepared using various concentrations of span 20. In the present study, the quercetin niosome used the reverse phase evaporation (RPE) method. Quercetin niosome is characterised by its organoleptic properties, pH value, particle morphology comprising the particle shape and size, and encapsulation efficiency. Organoleptic observations of the quercetin niosome included a yellow colour, distinctive quercetin odour and thick consistency for all formulas. The pH remained within the physiological pH range of skin. Quercetin niosome morphology was close to spherical while the niosome particle size results were 2.13 µm (F1), 2.99 µm (F2) and 3.31 µm (F3). The quercetin niosome encapsulation efficiency results were 81.86 ± 0.47% (F1), 84.02 ± 0.26% (F2) and 88.24 ± 0.10% (F3). Quercetin niosome were successfully prepared using multiple span 20 concentrations below the cholesterol concentration characterised by the measurement results of organoleptic, pH, particle morphology and encapsulation efficiency.

IN VITRO ANTIBACTERIAL ACTIVITY OF CEFADROXIL CAPSULES CONSUMED BY PATIENTS IN THE HOSPITAL Mahfudz Mahfudz; Suharjono Suharjono; Isnaeni Isnaeni; Primadi Avianto
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 18, No 2 (2021)
Publisher : Sanata Dharma University

Clinical use of cefadroxil, particularly in Bangka Tengah Hospital, is proven beneficial to overcome mild to moderate infections which especially occur in soft tissues such as skin, upper respiratory tract, pharyngitis, tonsillitis and urinary tract. For this reason, it is necessary to procure cefadroxil to be available enough for the treatment of cases of these diseases. The cefadroxil used by the Central Bangka Hospital was obtained from several pharmaceutical industries with different prices and distributions, due to the possibility that the active raw materials and ingredients had different origins, so there was concern that the microbiological quality would be different. Drug procurement is carried out using the e-catalog or non-e catalog method. This study aimed to examine the microbiological quality of six preparations (A, B, C, D, E, and F) in terms of their inhibitory activities against Gram-positive and Gram-negative bacteria. The bioassay was carried out by diffusion agar method using Escherichia coli ATCC 29522 and Staphylococcus aureus ATCC 29523 as the bacterial test, and nutrient agar as the test medium. The inhibitory activities were compared to cefadroxil standard for measuring the ratio potency. The results showed that all samples fulfilled USP 41 requirements with potential ratio of 90% to 120% and minimum inhibitory concentration of ≤ 8 ppm and ≤ 2 ppm against Escherichia coli and Staphylococcus aureus respectively. The potency ratios to cefadroxil standard were 95.9%, 99.1%, 100.0%, 96.7%, 96.2% and 98.2% against Staphylococcus aureus while the potency ratios of 95.6%, 99.3%, 103.8%, 97.1%, 95.7% and 100.4% were achieved against Escherichia coli for A, B, C, D, E, and F samples, respectively.

Inhibitory Activity of Parsea americana Mill. Peels Extract and Fraction Containing Phenolic Compound Against Staphylococcus aureus ATCC 25923 Nanik Sulistyani; Lola Angelita; Nurkhasanah Nurkhasanah
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 19, No 1 (2022)
Publisher : Sanata Dharma University

Parsea americana Mill. is a natural resource that has been studied for its antibacterial properties. The pulp, peel, and seed of Parsea americana Mill. have potential as an antibacterial agent. This study aimed to determine the inhibitory activity and phenolic content of Parsea americana Mill. peels extract and fraction against Staphylococcus aureus ATCC 25923. Parsea americana Mill. was macerated with 96% ethanol and then fractionated with n-hexane, ethyl acetate, and methanol solvent. Determination of the fraction that has the greatest antibacterial activity against S. aureus was carried out using the Kirby Bauer method. The total phenolic content in the extract and fraction was calculated as gallic acid equivalent (GAE) using the Folin-Ciocalteu method spectrometrically. Antibacterial activity test of the 96% ethanol extract, ethyl acetate fractions, and methanol fractions at a concentration of 10% w/v showed activity with a measurable inhibition zone. On the other hand, the n-hexane fraction showed no inhibition zone. The highest inhibition zone was the ethyl acetate fraction with approximately 8.33 ± 0.58 mm. The ethyl acetate fraction of Parsea americana Mill. resulted in 536.26 ± 14.29 mg GAE/g fraction. The conclusion was that the ethyl acetate fraction had the highest total phenolic content and was the most active fraction in inhibiting the growth of Staphylococcus aureus.

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Florentinus Dika Octa Riswanto

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editorial.jpsc@usd.ac.id

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Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

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Daerah istimewa yogyakarta

INDONESIA