cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Florentinus Dika Octa Riswanto
Contact Email
editorial.jpsc@usd.ac.id
Phone
-
Journal Mail Official
editorial.jpsc@usd.ac.id
Editorial Address
Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia
Location
Kab. sleman,
Daerah istimewa yogyakarta
INDONESIA
Jurnal Farmasi Sains dan Komunitas
Published by Universitas Sanata Dharma
ISSN : 16935683     EISSN : 25277146     DOI : https://doi.org/10.24071/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 247 Documents
 18   19   20   21   22 
The Immunomodulator Effects of Biosynthetic Nanosilver Based on Immunoglobulin G Level of Mice Induced by Measles Vaccine Compared with Immunostimulant Agent Ermawati, Dian Eka; Nuraini, Putri Indah; Anjani, Niki Putri
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005834

Abstract

Inulin is a carbohydrate class contained in gembili tuber (Dioscorea esculenta (Lour.) Burkill) as a source of prebiotics to maintain immunity. Inulin can be used as a nanosilver bioreductor and increase the solubility of gembili's inulin. This study aims to determine the effectiveness of gembili's inulin nanosilver as an immunomodulator based on IgG levels of vaccine-induced Mice. Nanosilver at doses of 2 mg/KgBW, 4 mg/KgBW, 8 mg/KgBW, and 12 mg/KgBW was compared with synthetic immunostimulants to observe the type of immunomodulatory activity. This research was conducted in several stages, including the biosynthesis process, characterization, determination of nanosilver dose, animal conditioning, animal treatments, taking blood from retro-orbital sinuses, and ELISA reader. Blood serum obtained from the animals was analyzed for IgG levels using Mice IgG ELISA Kit and Spectrophotometer UV-VIS. The pH variation test was also conducted in this study which aims to determine the stability of the nanosilver solution at pH 8, 10, and 12. The results of the ELISA reader showed that the dose of 4 mg/KgBW. had the highest Optical Density value compared to other doses. Then, the comparison with synthetic immunostimulants produces p values of 0.13 0.05, which is not significantly different. Nanosilver inulin at 4 mg/KgBW. is the chosen dose as an immunomodulator with immunostimulant activity. The stability results showed that increasing pH changes do not affect the pH change of gembili's inulin nanosilver solution. It is because nanosilver's pH control and adjustment are still in the alkaline range.
The Effect of Adherence to Antihypertensive Therapy and Cardiovascular Risk Among Hypertensive Patients in Purworejo Regency Arwinda, Prili; Virginia, Dita Maria; Hendra, Phebe
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007334

Abstract

Uncontrolled hypertension will increase mortality and morbidity rates. The adherence is an important factor in controlling blood pressure. Uncontrolled blood pressure will affect cardiovascular risk. Therefore, hypertensive patients must comply with taking medication to control blood pressure and cardiovascular risk. This study was an analytical observational study with a cross-sectional design. A total of 85 respondents who met the inclusion criteria were measured for adherence using the MPR (Medication Possession Ratio) method and the MARS-5 (Medication Adherence Report Scale-5) questionnaire.  A patient who had blood pressure 140/90 mmHg was categorized as controlled hypertension. The cardiovascular risk was measured using the ACC/AHA criteria method. Data were analyzed using chi-square tests and odds ratio (OR) with 95% confidence interval (CI) and p0.05 considered significant. This study showed that there was a significant association between adherence to antihypertensive therapy to controlled blood pressure, either according to MPR (OR=18.262; 95%CI=5.259-63.412; p=0.000) and MARS-5 (OR=31.607; 95%CI=8.170-122.277; p=0.000). A significant association was found between antihypertensive adherence and cardiovascular risk, either according to MPR (OR=3.733; 95%CI=1.269-10.983; p=0.020) and MARS-5 (OR=9.000; 95%CI=2.702-29.983; p=0.000). Therefore, this study concludes a significant relationship between antihypertensive adherence to controlled blood pressure and cardiovascular risk in Purworejo Regency.
Cost-Effectiveness of Antithrombotic Agents for STEMI Zulpadly, M Fiqri; Thobari, Jarir At; Dinarti, Lucia Kris
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006073

Abstract

In Indonesia, the prevalence of Acute Coronary Syndrome (ACS) continues to rise annually and remains high. Aspirin and adenosine diphosphate receptor inhibitors are recommended as part of the dual antiplatelet therapy that is recommended by the standard guidelines for managing ACS. Ticagrelor, a new treatment option for ACS, has been made available during the current period of Indonesia's National Health Insurance. Ticagrelor is more effective, but it costs more. Objective: In patients with ST-Elevation Myocardial Infarction (STEMI), the goal of this study was to compare how much ticagrelor and clopidogrel cost when compared to one another with relative ratio (RR) analysis and 95% confidence interval (CI) with p
Nanoemulgel Formulation of Eleutherine palmifolia Onion Bulb Extract and Its Effectiveness in Wound Healing Faisal, Muhammad; Chabib, Lutfi; Dewi, Melynia Sintha; Gani, Michael Raharja; Dwiastuti, Rini
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007454

Abstract

Eleutherine palmifolia onion, an indigenous medicinal plant from Borneo, is empirically applied to treat wound healing. The objective of this study is to formulate its extract and assess its in vivo wound healing activity. Eleutherine palmifolia onion was extracted with a 96% ethanol solvent. The extract of the Dayak onion bulb was then formulated into a nanoemulsion by applying the DOE method of 2-level factorial design. Four nanoemulsion formulations were further analyzed to obtain the optimal formulation. The particle size analysis and % transmittance was performed using a particle size analyzer and an ultraviolet-visible spectrophotometer. Furthermore, the data were analyzed using the Minitab 19 application with the DOE factorial design method. The three nanoemulgel formulations containing 2.5, 5.0, and 7.5% extract were further investigated for wound healing efficacy in rats. The duration of wound closure was analyzed using paired t-tests. The best nanoemulsion formulation was made with 22.5 mL of Tween 80 and 2 mL of isopropyl myristate oil. This produced particles that were 12.13 nm in size and a 99.12% transmittance rate. Wound length measurements were taken daily for 15 days. The statistical test results of p0.05 indicate that the nanoemulgel of the extract has significant activity in wound healing. The optimal nanoemulsion formula is formula A, and the effective dose of Dayak onion extract nanoemulgel is 5% and 7.5% concentrations, with a wound healing time of 13 days.
Analysis on the Acceptance of COVID-19 Vaccine Administration for Children in Indonesia Based on the Theory of Planned Behavior Hasymi, Liana Fitriani; Mardiati, Nurul; Kusuma Dewi, Ratih Puspita; Rizal, Rizal; Jayanto, Imam; Nurmansyah, Dian
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006160

Abstract

The administration of COVID-19 vaccine in children aims to control the spread of this disease in Indonesia. Parents make the decision whether to vaccinate their children against COVID-19 or not. This study was conducted to analyze parents’ acceptance of the COVID-19 vaccination for children in Indonesia based on the Theory Planned Behavior (TPB). The research design used a cross-sectional survey involving 400 parents of children aged 6-11 years in Indonesia in 34 provinces. Samples were purposively selected based on inclusion criteria: parents are older than 18 years, parents of children aged 6-11 years and live in Indonesia. The exclusion criteria were parents of children who recovered from COVID-19 less than 3 months and children with COVID-19 contraindications. The chi-squared test was conducted to determine the correlation between parents’ acceptance and TPB constructs that include attitudes, subjective norms and behavioral control. A multivariate logistic regression analysis was employed to analyze the TPB construct with the largest contribution on parents’ acceptance of the COVID-19 vaccination. The results showed high acceptance toward COVID-19 vaccination for children aged 6-11 years (98.5%). Positive subjective norms and positive behavioral control also contributed to the parental acceptance of the COVID-19 vaccine for children in Indonesia (p-value = 0.000), in which subjective norms had the largest influence (sig. 0.096 value with Exp B value of 6.203). TPB is a useful framework in developing proper interventions to raise the vaccination acceptance of parents in Indonesia.
Evaluation of Antibiotics Used in Pediatric Outpatients with Acute Respiratory Infection at a Private Hospital in Yogyakarta Kurniasari, Margaretha Wulan; Hartayu, Titien Siwi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007707

Abstract

Ensuring patient safety and optimal health outcomes in the healthcare system requires appropriate and rational use of medicines. One of the prescription issues noted in the pediatric clinic at a private hospital is the high use of antibiotics for acute respiratory infections. This study aimed to improve antibiotics used in outpatient pediatric clinic. This study was a descriptive analysis with a cross-sectional study design, combining quantitative and qualitative methods. The population was all prescriptions in January - March 2023. By using a purposive sampling method, there were 340 prescriptions obtained. The instruments of the study were data collection sheets and in-depth interview guidelines. Data were analyzed using the triangulation method. The antibiotic prescription rate was 64% (n=340). There were patients with Azithromycin and Erythromycin who received antibiotics below the dosing recommendations. Observation of patients’ treatment process showed that prescribers did not always suggest the laboratory examinations. Based on in-depth interviews of prescribers, they prescribed antibiotics based on the patient’s clinical examination. Based on in-depth interviews with the hospital managers, there was a tendency to choose a strategy which was a combination of educational and managerial strategies. The strategies to improve the quality of the antibiotics used include conducting training programs for the prescribers and developing standard treatment guidelines.
The Formulation of Effervescent Granules with Oxalis dehradunensis Raizada Ethanol Extract as an Antioxidant Mahyuni, Eka Lestari; Harahap, Urip
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004492

Abstract

Antioxidants and their health implications are widely studied related to their benefits in reducing free radical exposure. Oxalis dehradunensisRaizada is a type of wild mountain clover containing flavonoids and polyphenols. These contents allow the leaves to be consumed in a more practical, effective, and efficient way by processing the extract into effervescent granules. This experimental study used samples of Oxalis dehradunensisRaizadaethanol extract formulated in the form of effervescent granules. The content included citric acid, tartrate acid, lactose and sodium bicarbonate. The antioxidant activity assays were conducted by DPPH methods including testing the total phenol and flavonoid contents for the extracts and forms of effervescent granules. The total phenol content analysis used the Folin-Ciocalteu method while the total flavonoid content used the colorimetry method. The results identified the extract as the hygroscopic extract which had increasing IC50 for upgraded content of the formula but looked wet and was not stable. The experiment for the formula of effervescent granules was fulfilled by adding povidone, aspartame and polyethylene glycol. It required angle of repose which was 200-400 with a flow time not exceeding 10 seconds. The tap density also fulfilled the requirements, with the smaller the granule tap density, the greater the compression volume. The extract has a good antioxidant with IC50 value which reached near moderate to high levels. Although the formula 4 of effervescent granules was the best, it did not have the best antioxidant activity. Based on the results from the antioxidant activity assays, the extract has good antioxidant activity but it decreased when made into effervescent granules. 
Preparation and Characterization of Binahong (Anredera cordifolia) Leaf Extract Transfersome Wound-Healing Gel Immanuel, Handika; Yuliani, Sri Hartati; Dwiastuti, Rini; Nugraha, Alvin Arya; Limianty, Angela; Annabel, Evangeline Keisha; Lu, Felisha; Lestari, Fajar Sri; Branitasandini, Regina Epiphania
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007311

Abstract

Burn injuries are a significant global health concern due to their profound impact on morbidity and mortality rates. Immediate medical care is essential given the potential for bacterial infections to complicated burn injuries. Binahong leaves (Anredera cordifolia (Ten.) Steenis) contain vitexin compounds that demonstrate wound healing and antibacterial potential. However, vitexin has low solubility, prompting the use of ethanol for extraction and the introduction of nanoparticle technology to enhance solubility, namely transfersomes. The present study explored the development of a gel using binahong extract transfersomes with the composition of carbopol 940 and Na-CMC to determine the effect of carbopol 940, Na-CMC, and the interaction of the two on the gel’s physical properties and stability as well as obtain the optimum composition of the two. This study demonstrates positive results in terms of gel physical properties, including pH, spreadability, and viscosity. A Factorial design method is used for optimization. The results showed that Na-CMC had the most effect on increasing viscosity, while carbopol 940 had the most effect on reducing spreadability. The optimal formula obtained in this research was to use 0.653 grams of Na-CMC and 4.391 grams of Carbopol as gelling agents. 
Corrective and Preventive Actions of Pharmacist Preceptor in Guiding Pharmacy Internship at Public Health Center during the COVID-19 Pandemic Nirma Atin Shintia; Yosef Wijoyo
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 2 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006316

Abstract

During the COVID-19 pandemic, a pharmacy internship at the Public Health Centers (PHC) was carried out by complying with the implementation of health protocols. There were risks for students to be exposed to COVID-19 when a pharmacy internship was carried out directly at the PHC, and some pharmacy internship materials could not be applied easily due to the pandemic. This study aimed to identify the corrective and preventive actions of the preceptor in guiding the pharmacy internship at the PHC during the COVID-19 pandemic. This descriptive study was conducted using the in-depth interview method and examined using qualitative data analysis. The results of interviews were categorized into six issues, namely: 1) roles and abilities as preceptors; 2) pharmacy college institution support; 3) pharmacy internship mentoring methods; 4) corrective and preventive actions to overcome problems in pharmacy internships during pandemics; 5) pharmacy internship modules; and 6) barriers and factors supporting the role of preceptors. Preventive action taken by the preceptor was generally in relation to government policies during the pandemic and infection prevention and control programs in PHC. Concurrently, the corrective actions were modifying learning methods and using information technology to support pharmacy internship learning outcomes during the pandemic and post-pandemic.
Antibacterial Activity of Extract Combination Gel of Cherry Leaf (Muntingia calabura L.) and Beluntas Leaf (Pluchea indica L.) againts Staphylococcus aureus Nanik Sulistyani; Tegar Prasetya Budi; Aprilia Kusbandari
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 2 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005267

Abstract

Staphylococcus aureus (S. aureus) infection is a critical problem, in health care because there are S. aureus found that are resistant to antibiotics. Some alternative treatments of infection include herbal plants such as cherry (Muntingia calabura L.) and beluntas (Pluchea indica L.) leaves since they contain antibacterial compounds. Cherry and beluntas leaves are formulated in gel form since they are easy to use. This study aims to determine the physical properties, microbial contamination and antibacterial activity of the gel preparation. Combination of cherry leaf extract and beluntas leaf extract with a concentration ratio of 2.5: 0.5 was formulated in gel preparations with concentrations of 3%, 6% and 12%. The gel was later tested for physical properties including tests for organoleptic, pH, spreadity diameter, adhesity, and viscosity. The gel was also tested for the number of yeasts and antibacterial activity by the agar well diffusion method. The results were analyzed with SPSS 20.0.0 with One-way ANOVA. The results of the physical properties test for the gel preparation for viscosity were: (5666.18; 6369.23; and 8540.11) cps, the pH value was (7.58; 7.11; and 6.45), the scattering diameter was ( 6.16; 5.88; and 5.00) cm, the value of adhesity (74.66; 80.99; and 98.18) seconds, respectively. The test results of the yeast mold number  obtained 3x102 CFU/mL. The results of the inhibition zone diameters were (6.00; 7.90; and 10.00) mm, respectively. Based on these research findings, the difference in extract concentration affects the physical properties of the gel. The gel formula with a 12% concentration has physical properties reaching the requirements, meets the requirements for the value of yeast mold numbers, and provides the most optimal antibacterial activity.

Page 20 of 25 | Total Record : 247

 18   19   20   21   22 

Filter by Year

2012 2025


Reset
Filter By Issues
All Issue Vol 22, No 2 (2025) Vol 22, No 1 (2025) Vol 21, No 2 (2024) Vol 21, No 1 (2024) Vol 20, No 2 (2023) Vol 20, No 1 (2023) Vol 19, No 2 (2022) Vol 19, No 1 (2022) Vol 18, No 2 (2021) Vol 18, No 1 (2021) Vol 17, No 2 (2020) Vol 17, No 1 (2020) Vol 16, No 2 (2019) Vol 16, No 1 (2019) Vol 15, No 2 (2018) Vol 15, No 1 (2018) Vol 14, No 2 (2017) Vol 14, No 1 (2017) Vol 13, No 2 (2016) Vol 13, No 1 (2016) Vol 12, No 2 (2015) Vol 12, No 1 (2015) Vol 11, No 2 (2014) Vol 11, No 1 (2014) Vol 10, No 2 (2013) Vol 10, No 1 (2013) Vol 9, No 2 (2012) More Issue