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Jurnal Farmasi Sains dan Komunitas
Published by Universitas Sanata Dharma
ISSN : 16935683     EISSN : 25277146     DOI : https://doi.org/10.24071/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 247 Documents
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Computational Studies of Donepezil and Acetylcholinesterase Dynamics Interactions Windah, Axl Laurens Lukas; Istyastono, Enade Perdana
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006967

Abstract

Donepezil is an acetylcholinesterase (AChE) inhibitor commonly used as an anti-dementia medication for patients with Alzheimer's Disease. This research aims to determine the stability of each enantiomer R and S of donepezil as an AChE inhibitor using molecular dynamics (MD) simulations. The MD simulations were performed on a Cloud Protein Simulator (CPS) with YASARA-Structure as the main software and PyPLIF HIPPOS as the software to identify protein-ligand interactions. The MD simulations were performed in three replications of 50 ns for each enantiomer complexed to AChE. The stabilities of the AChE-donepezil complexes were analyzed by assessing the root-mean-squared deviation (RMSD) values of the AChE backbone atoms (RMSDBb) and the ligand (RMSDLigMov) during the last 5 ns of simulation time. The dynamics of the protein-ligand interactions were also analyzed during the last 5 ns. The results of these MD simulations indicate that the S-donepezil serves as a better AChE inhibitor compared to the R-donepezil. 
Antibacterial Activity Test of Noni Leaves (Morinda citrifolia L.) Ethanol Extract Ointment Against Staphylococcus aureus Bacteria Arifin, Arfiani; Djide, Natsir; Muhtar, Mardiyana
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005763

Abstract

Noni leaves (MorindacitrifoliaL.) are known to provide antibacterial properties and can be used in ointment formulations to prevent or eliminate germs that might cause infections, such as Staphylococcus aureus. This research aimedto formulate an ointment containing noni leaf ethanol extract that fulfills the physical quality test standards and to determine the antibacterial activity of various concentrations of ethanol extract of noni leaves in ointment preparations against Staphylococcus aureus bacteria. The extraction technique employed was maceration with 96% ethanol. The extracted substance was formulated into ointments with concentrations of 2.5%, 5%, and 10%. The antibacterial activity of the ointment was evaluated using the agar diffusion method with wells. Organoleptic, homogeneity, pH, spreadability, and adhesion tests demonstrated that the ointment at the three concentrations of 2.5%, 5%, and 10% satisfied the physical quality test standards. The antibacterial activity test revealed that a 96% ethanol extract of noni leaves inhibited the growth of Staphylococcus aureus bacteria with the maximum diameter of the inhibition zone at a concentration of 10% (15.26 mm) and was classified as strong. 
Physical Properties Investigation on Sunscreens with Red Dragon Fruit Peel Extract Ruth Febriana Kesuma; Rokiy Alfanaar; Markus Angkawijaya
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 2 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004537

Abstract

Red dragon fruit peel extract is reported as an active ingredient in sunscreen because of its ability to protect the skin. UV exposure to the skin can cause reddish skin to develop skin cancer. This study aimed to determine the characteristics of the cream made from ZnO and red dragon fruit peel extracts (Hylocereus costaricensis), such as sun protection factor (SPF), pH, stability, viscosity, spreadability, and adhesion. Red dragon fruit peel extract was obtained by maceration using methanol, and DPPH-scavenging activity resulted in an IC50 of 0.96 μg/mL. Measurement of diffuse UV-vis reflectance shows that ZnO has absorption at λex 385 nm, which correlates with a bandgap energy of 3.22 eV. F1 formulation cream (red dragon fruit peel extract and ZnO ratio of 0:1) has the highest SPF value of 17. The Kruskal-Wallis test shows that there is a significant difference in adhesion between the F1 formulation cream with F2 (p-value = 0.002) and F4 (p-value = 0.03).
Molecular Dynamics Simulation of Serotonin Transport Protein Complex with 6-Hydroxy-1-Methyl-1,2,3,4-Tetrahydro-β-Carboline Ligand from Chocolate (Theobroma cacao L.) Isolate Farach Khanifah; Enade Perdana Istyastono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 2 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005939

Abstract

6-hydroxy-1-methyl1,2,3,4-tetrahydro-β-carboline (6OHMTHβC) is a chocolate derivate that has antidepressant potency. It can increase dopamine and serotonin secretion, which leads to mood improvement. This method was carried out using computational molecular docking simulations (in silico). The research design was computational-based exploratory descriptive. The results of molecular docking showed the lowest energy score and the backbone RMSD value ≤2Å. The procedure performed was 6AWP receptor docking without ligand, with native ligand (6OHMTHβC), and with reference ligand (fluvoxamine). This study also performed molecular docking simulations of 6OHMTHβC towards 6AWP to find compounds in the receptor binding pocket. This study also performed dynamics simulations and identified the molecular determinants using PyPLIF-HIPPOS and YASARA Structure software 20.1.24.10 with the Windows 10 operating system. This study succeeded in determining the stability of the dynamics simulation of the serotonin transport protein complex with the reference ligand 6OHMTHβC for 50 ns, and this result corresponds to the RMSD value and binding energy. The determination of binding energy (BE) was calculated from the BE calculation available at YASARA and Ubuntu. The binding energy value of the original ligand was -11.6590 kJ/mol, and the reference ligand was -83880 kJ/mol. The highest RMSD value of the original ligand was 1.39292Å, while the RMSD value of the reference ligand was 1.71072Å. The essential amino acid carried out was 438Ser with hydrogen bond interactions, so 6OHMTHβC was considered a competent antidepressant candidate.
Isolation and Protein Profile of Chicken, Pork and Processed Products Nugget with Sodium Dodecyl Sulphate Polyacrylamide Gel Electrophoresis (SDS-PAGE) Method Orbayinah, Salmah; Widada, Hari; Anindita, Nosa Septiana; Mohdar, Adhe Filiyahtri
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007099

Abstract

Chicken nuggets are known as a nutritious processed meat food ingredient and are widely available in supermarkets and are very popular with consumers. Nugget is made by mixing it with various other additives, so that it raises a bit of concern about the ingredients used in terms of halal. The purpose of this study was to determine and analyze the protein profile of chicken, pork, nugget references, and nugget commercials. The method used in this study is an experimental laboratory analysis of variables using SDS-PAGE (Sodium Dodecyl Sulphate Polyacrylamide Gel Electrophoresis). The data were obtained from observing the description of protein bands, calculations were carried out using linear regression, and descriptive analysis was carried out. The results of this study showed 4 protein bands in pork that were not found in chicken meat with a molecular weight of 62.95 kDa, 41.86 kDa, 31.28 kDa and 17.46 kDa. Based on the protein fraction, the protein referred to as BM 31.28 kDa is Tropomyosin and BM 17.46 kDa is Troponin C. Nugget reference shows similarities to the protein bands found in pork, whereas nugget commercially did not show specific similarity. 
The Effect of Combination of Porang Tuber Starch (Amorphophallus muelleri Blume) with Lactose on the Physical Properties of Bajakah Root (Spatholobus littoralis Hassk) Water Extract’s Tablet Ermawati, Dian Eka; Tambunan, Rido Rohana; Darojati, Ulfa Afrinurfadhilah
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005765

Abstract

Kalimantan's people drink bajakah roots as a traditional medicine to restore stamina and treat various diseases. The infusion is less practical and unstable, so it was developed into a tablet. Porang is a local tuber that contains amylum and amylopectin. The combination of starch-lactose has been widely used as a tablet filler and produces tablets with good physical properties. This study aimed to determine the effect of the combination of porang starch-lactose on the granules and tablets' physical properties. Bajakah roots were infused and dried using a freeze-dryer. The antioxidant activity was measured using the DPPH method. Tablets of bajakah root water extract were made with a 1:1 porang tuber starch-lactose ratio using the dry granulation. Physical evaluations of granules and tablets were conducted, including flow rate, angle of repose of granules, and weight uniformity, hardness, friability, and disintegration time of tablets. Porang tubers-lactose with a ratio of 1:1 produced tablets with good evaluation results with a granule flow rate of 9.70±0.92 g/s and an angle of repose of 26.15±1.79°. Uniformity of tablet weight met acceptance value, with hardness of 5.38±0.90 Kg, friability of 0.26±0.05%, and disintegration of 10.60±1.33 min. Porang tuber fulfills the requirements of a good tablet filler and can be developed as a tablet filler.  
Secondary Metabolites Production of Bacillus spp. Isolated from Sea Cucumbers (Holothuria scabra) and their Activity against Mycobacterium smegmatis Maya Dian Rakhmawatie; Aida Zakiyatul Fikriyah; Ika Dyah Kurniati; Nanik Marfu'ati; Stalis Norma Ethica
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 2 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004843

Abstract

New anti-tuberculosis agents are very important due to Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis problems. Mycobacterium smegmatis can be used to replace Mycobacterium tuberculosis as bacteria test to increase the velocity of anti-tuberculosis screening. To answer the need for new drugs, exploration of secondary metabolites from Bacillus spp. can be conducted. Bacillus spp. are known to produce antimicrobials, including discovery of iturins, fengycins, and pumilacidins. This study explored the Bacillus spp. isolated from fermented intestines of Holothuria scabra. The production of Bacillus sp. Holothuria scabra Fermented Intestine (HSFI) secondary metabolites was done using culture media containing starch as a carbon source, as well as yeast and peptone as a nitrogen source. Production capacity of secondary metabolites of Bacillus sp. HSFI was calculated, to determine its potential as an antibacterial producer. Inhibition testing of secondary metabolites of Bacillus sp. HSFI against M. smegmatis was performed using the Kirby-Bauer disk diffusion method. Based on the results of the inhibition test, it was concluded that Bacillus sp. HSFI-9 has the greatest potential to inhibit the growth of M. smegmatis, with a moderate inhibition (7.67 mm). Production of secondary metabolites from Bacillus sp. HSFI-9 is exceptionally good with an extract production capacity of 24.6 mg/L.
Optimization of Naringenin Self-Nano Emulsifying Drug Delivery System (SNEDDS) Formula with D-optimal Mixture Design Method Yudanti, Gendis Purno; Kuncahyo, Ilham; Ikasari, Endang Diyah
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004319

Abstract

This study aimed to optimize and formulate the poorly water-soluble naringenin in the Self-Nano Emulsifying Drug Delivery System (SNEDDS) using D-optimal mixture design. D-optimal mixture design was used to optimize SNEDDS loading naringenin by selecting SNEDDS composition as an independent factor and SNEDDS characterization as a response. SNEDDS in the optimal formula were characterized, including transmittance, particle size, emulsification time, and drug loading. Triacetin, Tween 80, and transcutol p were respectively the selected oil, surfactant, and co-surfactant phases for their greatest ability to dissolve naringenin. The optimization results showed that the optimal formula was that using 10% triacetin, 70% of Tween 80, and 20% of transcutol p. SNEDDS loading naringenin produced nanoemulsion with 88.74±2.27 % of transmittance, 14.8 nm of particle size, 51.13 ± 4.53 mg/L of drug loading, and 18.58 ± 0.62 second of emulsification time. This study concludes that the D-optimal mixture design can be used to optimize and prepare the SNEDDS loading poorly-water soluble naringenin.  
Why Does the Poor Glycemic Control Among Type 2 Diabetes Mellitus Patients Remain High in Southeast Asia? Maria Lisa Nova; Dita Maria Virginia
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 2 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006214

Abstract

Presently, as well, 55% of the world’s diabetic population is Asian, with an estimated 230 million. The International Diabetes Federation (IDF) shows that the number of people with diabetes in the Southeast Asia (SEA) Region is 16.8% of all people with diabetes worldwide. To manage a patient’s blood glucose level, consider minimizing the worst effects of diabetes mellitus. Glycemic control using HbA1c levels is one of the important factors in the risk of diabetes that is associated with complications and mortality. A PubMed and Google Scholar databases were searched using the following: We only screened original-type articles for relevance and considered them further. Type 2 diabetes mellitus patients in Southeast Asia mostly experience uncontrolled blood glucose. More than 50% of research subjects show poor glycemic control. The influencing factors of poor glycemic control in Southeast Asia were age, BMI, hypertension, smoking activity, education, physical activity, and dyslipidemia. The awareness of glycemic control must be improved in type 2 diabetes mellitus patients.
Evaluation of Diabetic Wound Healing Activity of Novel Quercetin Topical Preparations Nastiti, Christofori Maria Ratna Rini; Michelina, Ellisia; Wijayanti, Fabiola Rani; Gani, Michael Raharja
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007288

Abstract

Diabetic wound needs effective pharmacotherapy in order to accelerate the wound healing process and to prevent further infection. Quercetin (QUE) is one of flavonols which ispotential as an active ingredient for diabetic wound therapy, due to its anti-inflammatory and antioxidant activities.  This current study evidenced wound healing activity of QUE topical preparations on the open wound of diabetic-induced subjects preclinically. The investigation focused on topical administration of QUE nanoemulgels and QUE micellar gels (0.2% w/w of QUE) on groups of diabetic-induced male Wistar rats. The quality of preparations in terms of organoleptic performance, pH, viscosity and spread-ability was physically characterized prior to topical administration to the wound. Punch biopsy (5mm) was applied to create the open wound. The visual observation of wound contraction area (in mm2) was carried out every three days. On the day 12th, after sacrificing the subjects, the wounded tissues were removed, fixed in 10% formalin and prepared for histology examination-hematoxylin and eosin staining. The results showed that the QUE nanoemulgels and QUE micellar gels were relatively comparable onthe physical quality as well as the wound healing activity. Their wound healing activities were remarkably faster compared to the untreated control group and it was showed fromthe histology study that the QUE nanoemulgels and QUE micellar gels successfully accelerate the wound healing process to the proliferation step if it was compared the untreated. In conclusion, QUE nanoemulgels and QUE micellar gels were potential to develop to accelerate the diabetic wound healing process.    

Page 18 of 25 | Total Record : 247

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