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Jurnal Farmasi Sains dan Komunitas
Published by Universitas Sanata Dharma
ISSN : 16935683     EISSN : 25277146     DOI : https://doi.org/10.24071/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 247 Documents
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Stability Evaluation of Candlenut Oil Capsule: Disintegration, Iodine Value, Omega Content, and Drug Kinetics Hery Sutanto; Wulan Sutardiman; Silvya Yusri
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 2 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004982

Abstract

Candlenut oil, known for its high omega-3 fatty acid content (up to 90%), shows great promise as a valuable source of omega. However, its rich unsaturated fatty acid composition makes it susceptible to oxidation and quality degradation. To address this, candlenut oil is encapsulated for use as a food supplement product. This research aims to investigate the stability of omega oil content in capsulated candlenut oil as well as the physical and chemical properties of gelatin and seaweed-based hard capsules used for encapsulation. Additionally, the study explores the optimal capsule material, opacity, and storage conditions for preserving the quality of candlenut oil products. Three key factors were considered: capsule material (gelatin and seaweed-based), capsule opacity (colored and transparent), and storage temperature (cool temperature with relative humidity of 33% and ±8°C, or room temperature with relative humidity of 65% and ±28°C). The evaluation of the best capsule material and optimum storing temperature of candlenut oil capsules was based on disintegration time, iodine value analysis, and omega content analysis. The results indicate that the disintegration times for gelatin and seaweed capsules were 5.80 and 5.78 minutes, respectively. Transparent gelatin capsules demonstrated the best performance in preventing oil quality degradation, as confirmed by the iodine value analysis. Both gelatin and seaweed capsules exhibited the ability to prevent the degradation of omega oil when stored at cool temperatures, with an estimated kinetic shelf life of 2.92 years.
Effectiveness of the Combination of Spirulina platensis and Stichopus variegatus on Prevention of Caspase-3 Gene Expression of Dementia Rat Models Safira, Rizka; Botutihe, Lisa Agustina; Yuliani, Sapto; Kintoko, Kintoko
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006051

Abstract

The death of cells in the brain, especially the hippocampus, manifests in a decrease in memory, language, and behavior. Golden sea cucumber (Stichopus variegatus) andblue-green algae (Spirulina platensis) are reported to have high antioxidant content which has the potential to prevent cell death in the brain due to oxidative stress thereby preventing memory decline.This study aimed to investigate the effect of the combination of Stichopus variegatus and Spirulina platensis on preventing caspase 3 gene expression in pyramidal hippocampal cells in a rat model of trimethlytin-induced dementia (TMT). This study used Sprague Dawley rats, about 2 months old, weighing 180-200 g, divided into 6 treatment groups, with each group consisting of 8 rats. The hippocampus was taken from the right cerebral hemisphere for histological observations of pyramidal caspase-3 gene expression in the CA1 and CA2-CA3 regions.The combination of Spirulina platensis and Stichopus variegatus with a dose 200 mg/kg BB can prevent the expression of caspase-3 in the CA1 and CA2-CA3 areas of the hippocampus. Conclusion: The combination of spirulina and golden sea cucumber extracts has the potential to prevent caspase 3 gene expression in pyramidal cells of TMT-induced dementia rat models. 
Synthesis and Characterization of Ethanolic Extract of Red Betel Leaf as an Antiseptic Gel Harimurti, Sabtanti; Hidayaturahmah, Rizky; Arsito, Puguh Novi; Febriansah, Rifki; Widada, Hari
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006555

Abstract

Hand hygiene is one way to maintain health. There are several ways to clean hands, namely by washing hands and applying a hand sanitizer. The use of hand sanitizer is increasing due to its practical nature. Utilizing natural materials for preparing hand sanitizer widely available around us will be beneficial, one of which is red betel leaf which some people of Indonesia empirically use for antiseptic. This study aims to develop antiseptic gel preparations with ethanolic extracts from red betel leaves. The extraction was done using maceration with 70% ethanol solvent. The formula for choosing a carbomer as a gelling agent with the red betel leaf extract concentration was 0%, 2.5%, 5%, 10%, and 15%. The assessments of the gel were physical and antiseptic evaluations. The physical evaluations included an organoleptic, pH, viscosity, adhesion, and dispersion tests. The antiseptic activity was determined by a replica method. The physical evaluation results of red betel gel revealed that the higher the red betel leaf extract levels are, the darker the green color will be, and the lower the pH and viscosity will be. Furthermore, the antiseptic activity showed that red betel extract gel effectively reduced the number of bacterial colonies. 
A Network Pharmacology Analysis of Secondary Metabolites of Noni (Morinda citrifolia) as Immunomodulators Helmi, M.; Jamil, Ahmad Shobrun; Muchlisin, M. Artabah; Almuhtarihan, Irsan Fahmi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006183

Abstract

Immunomodulators are substances or compounds that can modulate or help increase the activity and function of the immune system. The medicinal use of herbal plants is now increasing again among Indonesian people. Noni (Morinda citrifolia) is a plant commonly found in Indonesia that has long been known to have many benefits for treating and preventing various diseases and the secondary metabolites have potential as immunomodulators. This study aimed to determine the protein network associated with the body's immune system, which was activated by the administration of noni. The explorative descriptive research was conducted with in silico analysis using a computational model with software, including KNApSAck, Dr. Duke, Pubchem, Swiss ADME, Swiss Target Prediction, Gene Cards, Venny, STRING, and KEGG. Based on the results of pharmacological network analysis, noni contains 128 secondary metabolites, and 83 of them have high bioavailability. Based on pharmacological network analysis, (z,z,z)-8,11,14-eicosatrienoic-acid and 1-5-6-trihydroxy-anthraquinone are important compounds that play a role in the immune system because they are expected to interact with five crucial pathways related to immunomodulators.
Antioxidant and Antiaging Activity of Ethanolic Extract of Red Beetroot (Beta vulgaris L.): An In Vitro Study Winanta, Aji; Saffriza, Maitsa Via
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004722

Abstract

Aging is a process of gradual changes in the skin caused by intrinsic and extrinsic factors. Intrinsic and extrinsic aging is the effect of increasing the reactive oxygen species (ROS) produced by cells resulting in cell damage. The use of natural materials has expanded for skin damage therapy, one of which is the utilization of red beetroot (Beta vulgaris L.). This study aims to discover the antioxidant and antiaging activity of Beta vulgaris L. in vitro. The process begins with the extraction of the maceration method using 70% ethanol as a solvent followed by identification of secondary metabolite compounds by phytochemical screening. Antioxidant activity test used the DPPH method with quercetin as a comparison. Antiaging activity testing was conducted in vitro with cell viability test using Human Dermal Fibroblast adult (HDF-a) by MTT Assay and the inhibitory effect of skin degradation enzymes (antiaging) was carried out with elastase using Human Neutrophil Elastase (HNE). The result of phytochemical screening tests showed Beta vulgaris L. contains alkaloids, saponins, and triterpenoid compounds. Red beetroot extract has weak antioxidant activity with IC50 of 3284.42 μg/mL. Antiaging activity testing showed that the extract can maintain cell viability and has the inhibitory activity of the enzyme elastase. This study concludes that red beetroot extract (Beta vulgaris L.) has potential as a cosmetic active ingredient for antiaging.
Stability Model Prediction Using the Response Surface Approach to Assess the Outcomes of Vitamin B12 Injection Post-Market Sampling Yulia, Yulia; Yuliani, Sri Hartati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007779

Abstract

B12 injections are one of the most widely used vitamins in Indonesia. The nature of vitamin B12, which is easily degraded by environmental factors, has been widely reported. This research aimed to determine the effect of stability optimization model predictions with post-market sampling of vitamin B12 injection preparations by considering the variables of temperature, humidity, and distribution time. Factorial design was used to determine the stability optimization model. Validation of the analysis method using ultraviolet (UV) spectrophotometry showed valid results for testing. Stable product outcomes were seen during the research period based on the results of post-market sampling, optimization of stability conditions by evaluating pH parameters, and content determination. Post-market sampling data showed a pH decrease of 3.46% in the Palembang distribution area and an increase in pH of 4.54% and 5.33% in the Cirebon and Denpasar distribution areas. In the Palembang distribution area, the content of cyanocobalamin decreased by 0.90%, while in the Cirebon distribution area, it decreased by 0.94%. A paired t test for statistical analysis was used to determine the significance of the model. The results obtained show that there was no significant difference between the prediction model and the results of post-market sampling (p-values of 0.065 and 0.491) or H0 received
Gastroprotective Potential of Hantap Leaves (Sterculia coccinea Jack) Extract in Stress-Induced Gastric Ulcers of Male White Rats Yuliet, Yuliet -; Khaerati, Khildah; Lokong, Gladies Melinda
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006398

Abstract

Stomach ulcer is a prevalent digestive problem that can lead to serious complications such as bleeding in the digestive tract, perforation, recurrence, cancer, and even death. One of its potential remedies lies in the antioxidant compounds contained in hantap leaves. Accordingly, this study aimed to investigate the anti-gastric ulcer effects of hantap leaf extract in white male rats induced by water immersion and cold-resistant stress methods. Hantap leaf extract (EEDH) was obtained by maceration using 96% ethanol, resulting in a yield of 7.8%. The results of gastric macroscopic observations based on percentage of ulcer inhibition showed that EEDH doses of 50, 100, and 200 mg/kg BW did not have a significant difference (p0.05) with ranitidine, exhibiting the same gastroprotective effects. An increase in the dose does not lead to a corresponding rise in the gastroprotective effect. Therefore, 50 mg/kg BW of EEDH was considered to be the optimum dose.
Antihyperlipidemic Effectivity of Sweet Orange Peel Extract (Citrus sinensis) on Triglyceride Levels in Male Mice (Mus musculus) Induced by High Cholesterol Lumbantoruan, Ellya Catharine Romanna Aprilya; Zakiah, Mistika; Fahrurroji, Andhi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005944

Abstract

Hyperlipidemia is a significant risk factor for atherosclerosis in arteries and cardiovascular disease, especially coronary heart disease (CHD), the leading cause of global mortality. Treatment of hyperlipidemia can be done through chemical treatment. However, statins have potentially dangerous side effects such as myopathy and rhabdomyolysis, so a therapeutic solution with minimal toxicity is needed. One of the potential treatments is Citrus sinensis orange peel, which contains antihyperlipidemic bioactive compounds, namely hesperidin, and naringenin. The aim of this research is to determine the effectivity of sweet orange peel extract (Citrus sinensis) on high cholesterol-induced male mice (Mus musculus) triglyceride levels. Citrus sinensis orange peel was extracted by maceration method using 50% ethanol as solvent. Lipid profile measurements were performed three times using the GPO-PAP method. The concentration of orange peel extract in the treatment group (P1, P2, P3) was 10%, 5%, and 1%. The positive control received 40 mg atorvastatin treatment, the negative control received 1% CMC Na, and the control received abnormal treatment. Antihyperlipidemic therapy with Citrus sinensis sweet orange peel extract has a strong relationship/influence on triglyceride levels in mice. Sweet orange peel extract (Citrus sinensis) has antihyperlipidemic effectiveness in reducing blood triglyceride levels in mice (Mus musculus) induced by high cholesterol. The effective dose is 1% dose.
Exposure of Histone Deacetylase-2 Inhibitor Curcumin and Its Analogues in Self-Nano Emulsifying Drug Delivery System Change Memory and Cognitive Function, Anxiety, and Social Interaction Behavior in Mouse Yuniarti, Nunung; Wulandari, Febri; Azizah, Ulfah Laily; Anas, Yance; Murwanti, Retno
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.009660

Abstract

Class 1 and 2 histone deacetylase inhibitors (HDACI) have been reported as novel therapeutic approaches to treat neurodegenerative disorders, depression, anxiety, and cognitive deficits. HDACI ameliorated deficits in cognition and stress-related behaviors in a wide range of neurologic and psychiatric disorders. Preclinically, behavioral bioassay can be used to predict the influence of new compounds for treatment of these illnesses. Curcumin and its new analogues PGV-0 and PGV-1 have been reported to inhibit HDAC2. However, reports regarding the effect of curcumin and its analogues on memory and cognitive function, anxiety, and social interaction behavior are as yet to be examined. Mice were divided into control and treated groups. Brain disorder was induced by oral administration of 10% ethanol in sodium-CMC for 7 days. Curcumin, PGV-0, PGV-1, and sodium butyrate (as positive control) were then given orally once a day for 21 days. The behavior tests of social interaction, open field, radial 8-arm-maze, and passive avoidance were performed on day 29. To increase dissolution and bioavailability of the compounds, they were formulated in a self-nano emulsifying drug delivery system (SNEDDS). Brains were isolated and analyzed using PCR to investigate the expression of genes related to neurobehavioral disorders hdac2, trkB, and bdnf. In different doses, curcumin, PGV-0, and PGV-1 increased social interaction capability, declined anxiety level, and improved long-term memory and cognitive function. The mechanism proposed is: HDACI curcumin and its analogues (PGV-0 and PGV-1) that keep the histone protein in acetylation state increase bdnf expression. The increased trkB expression is increasing the activation of the bdnf gene because trkB is the primary receptor of bdnf that supports the survival of existing neurons and encourages the growth and differentiation of new neurons and synapses. Thus, those mechanisms could improve long-term memory and cognitive function, increase social interaction, and reduce anxiety in ethanol-induced mice with brain disorders.
Nanostructured Lipid Carrier (NLC) as a Topical Drug Delivery System : A Review Latifah, Luluk; Hendradi, Esti; Isadiartuti, Dewi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006789

Abstract

Nanostructured Lipid Carrier (NLC) appears as the next generation of lipid nanoparticles which overcomes the weaknesses of Solid Lipid Nanoparticles (SLN). NLC is a delivery system that offers several advantages, such as significantly improved entrapment efficiency, reduced drug expulsion during long-term storage, and increased contact between the drug and the stratum corneum, thereby enhancing drug penetration. The methods used to manufacture NLC have high energy-required such as high-pressure homogenization and high shear homogenization, low energy-required such as microemulsification and phase inversion, and very low or no energy-required such as solvent evaporation and solvent injection. The basic components of an NLC are solid lipids, liquid lipids, and surfactants or mixtures of surfactants. This narrative review refers to several previously published databases on the types, preparation methods, and physical properties of NLC. This review focuses on descriptions related to the NLC as a topical drug delivery system.

Page 19 of 25 | Total Record : 247

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