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Muhammad Sulaiman Zubair
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Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)
Published by Universitas Tadulako
ISSN : 24427284     EISSN : 24428744     DOI : https://doi.org/10.22487/j24428744
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (E-ISSN: 2442-8744) (p-ISSN: 2442-7284), is an open access journal (print and e-journal) focusing on the scientific works in the field of Pharmacy and Pharmaceutical Science. The articles of this journal are published every six months, that is March and October (2 issues per year). This journal is developed by Department of Pharmacy, Faculty of Mathematics and Natural Science, Tadulako University and has been identified in Crossref with the DOI Number : 10.22487/j24428744. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) has been accredited by Kemenristekdikti as Sinta 3 starting from Volume 5 No 1 2019.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 8 Documents
 1 
Search results for , issue "Vol. 7 No. 1 (2021): (March 2021)" : 8 Documents clear
Analysis of Potential Drug-drug Interactions in Liver Cirrhosis Patients: Analisis Interaksi Obat-obat Potensial pada Pasien Sirosis Hati Muti, Annisa Farida; Anindya, Chanica
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 1 (2021): (March 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i1.15148

Abstract

Background: Patients with liver cirrhosis are at a high risk of drug interactions due to the use of multi-drug combination regimens. Objectives: This study analyzed potential drug-drug interactions in the liver cirrhosis patients at Gatot Soebroto Army Hospital, Jakarta in 2016. Material and Methods: This study employed an observational-cross sectional design with retrospective data collection of liver cirrhosis patients' medical records. The data of potential drug-drug interactions were identified using Drug Interaction Facts 2012 including the mechanism type, the severity and the onset of drug interactions. Results: As many as 88% of the liver cirrhosis patients experienced potential drug-drug interactions with a total of 35 cases. The highest proportions of the cases were found in the pharmacokinetic mechanism by approximately 25 cases (71.43%), minor severity comprising 29 cases (82.86%) and rapid onset by 19 cases (54.29%). The highest potential drug-drug interactions were furosemide-propranolol combination in 16 cases (45.72%). Conclusions: The high incidence of potential drug interactions in patients with liver cirrhosis requires high vigilance and close monitoring of all health professionals in achieving optimal therapeutic outcomes for the patients.
Burns Wound Healing Activity of Extract Gel Formula of Lidah Buaya (Aloe vera) and Senggani Leaf (Melastoma polyanthum): Aktivitas Penyembuhan Luka Bakar Formula Gel Ekstrak Lidah Buaya (Aloe vera) dan Daun Senggani (Melastoma polyanthum) Wahyuningsih, Sri; Syamsu, A. Suparlan Isya; Awaluddin, Nurhikma; Andriawan, Riki
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 1 (2021): (March 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i1.15251

Abstract

Aloe vera and senggani leaf can accelerate tissue regeneration, re-epithelialization, fibroblast stimulation, and collagen formation in the skin for burns wound healing. Burns wound can cause damage in the capillaries of the skin, then Aloe vera and senggani leaf were formulated into the gel formula for burns wound healing. The gel has the advantage of high water content; then it will hydrate the epidermis layer, increasing the penetration of the active substances. This study aims to formulate a gel of extract Aloe vera and senggani leaf (Melastoma polyanthum) and to evaluate the burns wound healing activity. The gel was formulated by composition of Aloe vera : senggani leaf with concentrations (0.5%: 1%); (0.5% : 3%); and (0.5% : 5%). Burns wound healing activity was observed by the diameter of the burn wound. The result showed that the gel with a concentration of (0.5%: 5%) gave a significance value of 0.692 (p >0.05) against positive control, then it was the formula that effective for burns wound healing.
Screening Bioactivity of Kersen Fruits (Muntingia calabura L.) as a Sunscreens Candidate: Skrining Bioaktivitas dari Buah Kersen (Muntingia calabura L.) sebagai Kandidat Bahan Tabir Surya Nur, Syamsu; Nursamsiar, Nursamsiar; Aswad, Muhammad; Tumigolung, Aprilia Ester Eunike; Risfah Yulianti; Burhan, Asril
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 1 (2021): (March 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i1.15257

Abstract

Kersen (Muntingia calabura L) fruits have the potential to be used as an active ingredient in sunscreens because of phenolic and flavonoid content that can absorb UV rays. This study aims to determine the percentage of erythema/pigmentation transmission and SPF value as parameters for sunscreen activity. Kersen fruits were extracted by maceration using 96% ethanol. The ethanol extract of Kersen Fruits was also fractionated to separate the components of the active compounds based on the polarity level using n-hexane, ethyl acetate, and ethanol as solvents. The test was carried out using the in vitro method by measuring the ability of the material to absorb ultraviolet light at a wavelength of 292.5-372.5 nm. This research was conducted at concentrations of 100, 200, 400, 600, and 800 µg/mL for ethanol, lyophilisate, n-hexane, and ethanol fractions, while the ethyl acetate fraction concentrations are 50, 100, 150, 200, 250 µg/mL. The results showed the best value at the ethyl acetate fraction concentration of 250 µg/mL with % Te of 5.28 and % Tp of 28.65 and the SPF value of 16.54. Based on the % Te and Tp, the ethyl acetate fraction exhibited protection against erythema and pigmentation with the category of extra protection and based on the SPF value with the category of ultra protection.
The Encapsulation Effect on Viability of Mesenchymal Stem Cells: Pengaruh Enkapsulasi Terhadap Viabilitas Sel Punca Mesenkimal Siburian, Marsudi; Sismindari; Rilianawati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 1 (2021): (March 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i1.15258

Abstract

Stem cells are potentially used as a regenerative therapy agent. Cell encapsulation is one of the developed methods to utilize Mesenchymal Stem Cells (MSCs) for therapy. This research aimed to study the effect of encapsulation using alginate-CaCl2 towards the viability of hAdMSCs during in vitro culture. Encapsulation of hAdMSCs with alginate-CaCl2 was done using the extrusion method. The viability of hAdMSCs was analyzed with Live/Dead Assay and MTT assay. The results indicated that cultured hAdMSCs within alginate remain alive for 7 days culture period. However, the viability was lower than the reference culture. The absorbances from MTT assay of encapsulated MSCs were lower than the conventional hAdMSCs culture. This result indicated lower metabolic activity of hAdMSCs when cultured in alginate beads.
Review of Impact and Handling of Potential Antihypertensive Drug Interactions in Chronic Kidney Disease Patients: Review Dampak dan Penanganan Potensi Interaksi Obat Golongan Antihipertensi pada Pasien Penyakit Ginjal Kronis Ni Made Susilawati; Eli Halimah; Siti Saidah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 1 (2021): (March 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i1.15332

Abstract

Drug interaction is a type of Drug-Related Problems (DRPs) that caneventually increase morbidity and mortality rates. CKD patients have asignificant risk of developing polypharmacy due to comorbid diseases andpharmacokinetics' alteration. The literature review was conducted byexploring all of the articles related to the drug interaction using druginteraction analysis program in CKD patients, which obtained from threedatabases, namely Google Scholar, PubMed, and Science Direct, usingseveral keywords combination. Based on the comprehensive reviewsconducted, it is known that the most common effects of antihypertensivedrug interactions in CKD patients are decreasing effects of antihypertensivedrugs, hypotension, and hyperkalemia. Handling management used for theemergence of potential drug interactions is based on the severity of the druginteractions and complete knowledge of the patients' clinical condition. Themanagement of drug interaction by monitoring blood pressure, diuresis, andpotassium levels; Monitor the related effect symptoms; Monitor the fluidand body weight; Monitor the kidney and heart function. On the conditionwhere the handling management of potential drug interactions is not carriedout, elevated morbidity and mortality rates are the risks of complicationsarising from the drug interactions.
Exploration of Types and Consumption Behaviour of Usada-based Herbal Galactagogue on Lactating Mothers in Bali : Explorasi Jenis dan Perilaku Konsumsi Galaktagogue Herbal berbasis Usada pada Ibu menyusui di Bali Monika, Ni Luh Gde Mona; Yunita, Ella
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 1 (2021): (March 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i1.15342

Abstract

Breastfeeding is essential for the health of newborn infants and mothers. Basic health research in 2018 showed that exclusive breastfeeding in Bali has not reached the national target. High rates of cesarean section delay breastfeeding initiation, the important predictor of continued breastfeeding. Main concern for breastfeeding mothers about medications increased the use of herbal galactagogue to aid lactation. The use of traditional medicinal plant in Bali is 40% higher than national average and its existence is strengthened by the issuance of Bali Governor Regulation No. 55/2019 concerning Traditional Balinese Health Services. Despite increasing popularity of traditional medicine, there are currently limited data available on the plant list and pattern of use herbal galactagogue. This study aims to explore the galactagogue plants, pattern of use, perceived effectiveness of herbal galactagogues during breastfeeding among breastfeeding mother’s in Bali. This study was conducted using a questionnaires and in-depth interviews. The questionnaire and interview guideline were validated by lactation consultants and traditional health practitioners in Bali. The study was approved by Human Research Ethic Committee of Bina Usada Bali. The use of herbal galaktagogue is mostly practiced by highly educated mothers, mother’s occupation as health workers and primiparous. There are 26 types of plants that are often used by lactating mothers in Bali. Majority of respondent begin to use herbal galactagogue after giving birth (82%) for approximately less than 1 month. Majority of lactating mothers in Bali perceived effectiveness of herbal galactagogue usage based on breastfeeding adequacy indicators. About 95% respondents feel confidence and have self-empowerment after using herbal galactagogue, possessing psychological benefits. The use of herbal galactagogue is common amongst breastfeeding mothers in Bali, while information about efficacy and safety is lacking. Further research is needed to give evidence-based information to support exclusive breastfeeding
Studies of Wound Healing Activity and Irritation Test of Chili (Capsicum frutescens L.) Leaves Gel on Rats (Rattus novergicus): (Studi Aktivitas Penyembuhan Luka Dan Uji Iritasi Gel Daun Cabai Rawit (Capsicum frutescens L.) Pada Tikus (Rattus novergicus) Lebang, Julianri Sari; Siampa, Jainer Pasca; Nurmiati, Nurmiati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 1 (2021): (March 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i1.15430

Abstract

Chili pepper (Capsicum frutescens L.) leaves have been used empirically as wound healing caused by sharp objects. Several studies showed that it has antibacterial and wound healing activities. This study aims to formulate gel from chili leaves extract, then determine wound healing activity and irritating properties on rat’s skin. Gel was formulated by using various types and concentrations of gelling agents, consisted of Carbopol 0.5%, 0.75%, 1% and hydroxy propyl methyl cellulose at 2.5%, 5% and 7.5% respectively. Cycling test was conducted to determine the physical stabilities. The results showed that all formula has no altered on organoleptic properties and pH value. Gel of 0.5% Carbopol (F2) and 7.5% of HMPC (F5) has no change in spreadability and adhesion properties. Based on statistical analysis using paired t-test and one-way ANOVA, it concludes that F2 and F5 were physically stable and further evaluated as wound healer. Wound healer evaluation showed that the healing time (days) of Carbopol based gel (F2) was 10.2±1.26 and HPMC based gel was 8±0.82. The length of incision wound (cm) at 8th day was 0.5±0.183 for F2 and 0.06±0.071 for F5. Statistical analysis of healing time showed p<0.01 and wound length showed p<0.05 indicated that F5 (contained 5% HPMC) was significantly different compared to negative control. The results of the irritation test showed that gel formulas were not causing erythema and edema on rat’s skin. It can be concluded that gel of chili leaves extract that formulated with 5% of HPMC has wound healing activity and safety to be used.
Formulation and Antioxidant Activity of Clay Mask of Tomato (Solanum lycopersicum L.) Lycopene Extract with Variation of Concentration of Kaoline and Bentonite Bases): Formulasi dan Aktivitas Antioksidan Masker Clay Ekstrak Likopen Tomat (Solanum lycopersicum L.) dengan Variasi Konsentrasi Basis Kaolin dan Bentonit Syamsidi, Armini; Syamsuddin, Alifah Magfirah; Sulastri, Evi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 1 (2021): (March 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i1.15462

Abstract

Free radicals can cause damage to human skin, so antioxidants are needed to counteract the negative effects of these free radicals, for example preparations in the form of face masks. Tomatoes (Solanum lycopersicum L.) contains nutritious substances, namely lycopene which can be useful as an antioxidant for the skin. This study aims to determine the effect of variations in kaolin and bentonite bases on physical characteristics and antioxidant activity of tomato lycopene extract clay mask, and to determine the best formula. Tomato lycopene extract was modified into a microemulsion preparation to maintain the stability of antioxidant activity. Kaolin and bentonite used as bases had various concentrations in each formula, namely F1: 15% and 2%, F2: 20% and 1.5%, F3: 25% and 1%, F4: 30% and 0.5%. The results showed that the four clay mask preparations were homogeneous and no change in color, shape and aroma. The pH test on the four formulas was F1: 4.33 ± 0.35, F2: 5.58 ± 0.24, F3: 6.48 ± 0.22, and F4: 7.34 ± 0.08. The viscosity test on the four formulas was F1 : 20213.3 ± 140.4, F2: 24133.3 ± 83.26, F3 29080 ± 105.83, F4 33293.3 ± 378.06. The spreadability test was F1 6.59 ± 0.24, F2 5.59 ± 0.16, F3 4.85 ± 0.11, F4 7.84 ± 0.05. The test time for the preparation to dry was F1 19.02 ± 0.36, F2 15.33 ± 0.54, F3 11.27 ± 0.42, F4 8.24 ± 0.50. F1 and F2 are very easy to clean. Meanwhile, F3 and F4 are easy to clean. The best formula for clay masks is the F3 preparation where the concentration of kaolin is 25% and bentonite is 1%. It also showed the lower antioxidant activity (741.34 µg/mL) than other formulas.

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