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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
Arjuna Subject : -
Articles 459 Documents
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Importance of piperidone moiety in pharmaceutical chemistry: a review De, Sourav; Banerjee, Suhasis; Babu, M. Niranjan; Keerithi, C. Navaya
Journal of Applied Pharmaceutical Research Vol 3 No 2 (2015)
Publisher : Creative Pharma Assent

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Abstract

Piperidone heterocycle have gained a considerable attention in the field of drug discovery. The wide range of its therapeutic application paved the way to the researchers to insert the nucleus every now and then in diversified pharmacophore, so as to generate novel therapeutic profile. In this review, we have tried to present various therapeutic applications, which have already been demystified by the researchers. The study may prompt the researcher to generate scaffolds of highest therapeutic efficacy considering the importance of 4- Piperidone nucleus.
A short glimpse on promising pharmacological effects of Begenia ciliata Pokhrel, Priyanka; Parajuli, Rishi Ram; Tiwari, Amish Kumar; Banerjee, Janmajoy
Journal of Applied Pharmaceutical Research Vol 2 No 1 (2014)
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Abstract

Bergenia ciliata is a potent indigenous folk medicine that has been proved fruitful in the treatment of various adverse conditions of the body. The major chemical constituents of plant include tannic acid, gallic acid, glucose, metarbin, albumen, bergenin, (+)-catechin, gallicin. Bergenia ciliata was subjected to bioactivity analysis. The plant has antitussive, antiulcer, antioxidant, antibacterial, hypoglycemic, toxicological activity. It was observed that root and leaves extract were promising as antifungal agent. The root and leaves extract were effective against Microsporum canis, Pleuroetus oustreatus and Candida albicans.   All the extracts except chloroform extract of root and leaves of Bergenia ciliata were found to possess hypoglycemic activity in Streptozotocin (STZ) treated rats. The methanolic extract exhibited significant anti-tussive activity in a dose-dependent manner. B. ciliata bear potent anti-neoplastic activities that may have prospective clinical use as precursor for preventive medicine. Methanolic and aqueous B. ciliata rhizome extracts were found to possess antioxidant activity, including reducing power, free radical scavenging activity and lipid peroxidation inhibition potential. Bergenia ciliata extracts exhibit a narrow spectrum antibacterial activity. The results obtained thus suggest that extracts of B. ciliata have promising therapeutic potential and could be considered as potential source for drug development by pharmaceutical industries.
Ligand conjugated liposomal drug delivery system for enhanced brain uptake of ampicillin Lala, Rita; Nandvikar, N; Agnihotri, S
Journal of Applied Pharmaceutical Research Vol 4 No 4 (2016)
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Abstract

Targeting of antimicrobial agents by means of liposomes may be of great value in the treatment of intra or extracellular infections compare to conventional forms of antimicrobial therapy. In the present study Ampicillin loaded non-targeted Polyethylene glycolated liposomes and targeted Glutathione Polyethylene glycollated liposomes of about 132.14 nm size were prepared with 80 % of drug entrapment. Prepared liposomes were evaluated for in vitro, in vivo release profile and brain uptake studies. Results of these studies revealed more absorption of drug than standard Ampicillin solution and non targeted liposomes (Auc0-6h 1858.908 µg h/ml) and 3.5 times increase in brain uptake. Incorporation of polyethylene glycol in the liposomes increased the drug concentration and circulation time in plasma as well as in the extracellular fluid of brain thus improved therapeutic availability of Ampicillin trihydrate. 
Formulation and evaluation of enteric coated microcapsules of diclofenac sodium for modified release by combination of wet granulation and thermal change method Roy, Amit; Saha, Suman; Choudhury, Ananta; Bahadur, Sanjib; Baghel, Pragya; Chanda, Ranabir
Journal of Applied Pharmaceutical Research Vol 2 No 4 (2014)
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Abstract

The purpose of the present work was to develop optimized novel enteric microcapsules containing diclofenac sodium, a non steroidal anti inflammatory drug (NSAID) used for rheumatoid arthritis, for improved delivery and to diminish its adverse effect after oral administration. The microcapsule was prepared by using different polymers and the enteric coating was provided by using an innovative technique combining wet granulation method and thermal change method. This work also investigated different levels of enteric polymers like cellulose acetate phthalate (CAP) (X1) and ethyl cellulose (EC) (X2) and the stirring speed during coating ethyl cellulose (X3), by using 23 full factorial design. The dependent variables assessed were % yield (Y1), Q8 (% drug released after 8 hour) (Y2), n (Diffusion coefficient) (Y3), DEE (Drug entrapment efficiency) (Y4). The main effect and interaction terms were quantitatively evaluated using a mathematical model. The prepared microcapsules were evaluated for percentage drug dissolved, scanning electron microscopy, drug excipient interaction, angle of repose, particle size. Mean dissolution time (MDT) was used to compare dissolution patterns obtained. The results showed that X1 and X2 significantly affected the release properties. 
Cucumis sativus (cucumber): a review on its pharmacological activity Sahu, Tripti; Sahu, Jyoti
Journal of Applied Pharmaceutical Research Vol 3 No 1 (2015)
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Abstract

Medicinal plants have been used for centuries, and numerous cultures still rely on plants for their primary health care needs. In the recent past there has been a tremendous increase in the use of plant based health products in developing as well as developed countries resulting in an exponential growth of herbal products globally. The present article gives an account of such a medicinally important of Cucumis sativus belonging to family Cucurbitaceae which comprise both wild and cultivated species and is consumed in different ways like vegetable and salads, but less is known about its medicinal importance. Phytochemical analysis of these plants confirms the presence of various phytochemicals like tannins, cardiac glycosides, terpenoides, carbohydrates, resins, Saponins and phytosterols. While other phtochemicals like alkaloids, flavonoids, glycosides, steroidal terpenes and phylobatamins were found to be cucumber fruits. The plant exhibits various pharmacological activities such as anti-bacterial activity, antifungal activity, cytotoxic activity, Antacid & Carminative activity,  Activity against ulcerative colitis ,Hepetoprotective activity, Hypoglycemic and Hypolipidemic activity, Wound healing activity   etc. A study on safety profile suggests the plant to be safe for its therapeutic uses.
Standardization of herbal medicines – an overview Bhairam, Monika; Roy, Amit; Bahadur, Sanjib; Banafar, Alisha; Turkane, Dhanushram
Journal of Applied Pharmaceutical Research Vol 1 No 1 (2013)
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Abstract

In the few decades, there has been exponentional growth in the field of herbal medicines. Most of the traditional systems of medicine are effective due to lack of standardization. So there is a need to develop a standardization technique. Standardization of herbal formulation is essential in order to assess the quality, purity, safety and efficacy of the drug. There is increasing awareness and general acceptability of the use herbal drugs in today’s medical practice. The world population depends on herbal medicines and product for healthy living. This rise in the use of herbal product has also given rise to various forms of adulteration of the products, which leading to consumers’ and manufacturers’ disappointment and in some instances fatal consequences. The challenge is innumerable and enormous, to fulfill the need of global herbal market. The standardization of this formulations like the organoleptic characters, physical properties, the various physic-chemical properties such as moisture content, ash values, extractive values need to be carried out along with Thin layer chromatography and heavy metal content study should also carried out to ascertain the quality, purity and safety of this herbal formulation.
Phytochemical and antipyretic potential of ethanolic leaf extract of Heliotropium indicum L. Basak, Mrinmoy; Dey, Biplab Kr.
Journal of Applied Pharmaceutical Research Vol 4 No 2 (2016)
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Abstract

In the present study, the ethanolic leaf extract of Heliotropium indicum L (H. indicum L) was investigated for phytochemical screening and antipyretic activity in rats using Brewers yeast induced Pyrexia. The leaves of H. indicum were collected from different part of Assam and cut into small pieces and shade dried. The dried powdered leaves (100 gm) were extracted in a Soxhlet apparatus by using 95% ethanol. Phytochemical screening has been done by standard procedure and showed the presence of alkaloids, glycoside, carbohydrate, phytosterol, flavonoids and saponins and absence of fixed oil and gums-mucilage. Albino rats weighing (200-250g) were taken for the experiment divided into four groups of six animals each. Group 1 received 3% aqueous suspension of gum Acacia (1ml/200g) as vehicle orally, group 2 and group 3 received ethanolic leaf extract of H. indicum 250 and 500 mg/kg with 3% aqueous suspension of gum Acacia orally and the group 4 served as standard received paracetamol 25 mg/kg with 3% aqueous suspension of gum Acacia orally. The subcutaneous injection of yeast suspension markedly elevated the rectal temperature after 18h of administration. Treatment with H. indicum extract at a dose of 250, 500 mg/kg decreased the rectal temperature of the rats in dose dependent manner. This effect was maximal at dose of 500 mg/kg and it caused significant lowering of body temperature (P< 0.01) up to 4 hour after its administration. The antipyretic effect started as early as 1h and the effect was maintained for 4h, after its administration. Both the standard drug paracetamol 25mg/kg and tested drug H. indicum extract were significantly reduced the yeast elevated rectal temperature, at 2nd, 3rd and 4th hour compared to control group.
Comparative study of hexane extract for volatile and non volatile components of leaves and rhizomes of acorus calamus linn. using high performance thin layer chromatography (HPTLC) Bisht, A S; Chauhan, Monika; Joshi, A; Joshi, Y; Singh, V; Juyal, D
Journal of Applied Pharmaceutical Research Vol 2 No 2 (2014)
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Abstract

The present communication attempts to evaluate the comparative study of leaves and rhizomes of Acorus calamus Linn. (Family; Araceae) using High Performance Thin Layer Chromatography (HPTLC). Since the plant contains various volatile and non-volatile components so paper advocates the quantitative study using hexane extract. Acorus calamus Linn. is a well known medicinal plant in traditional medical systems  having various ethno-pharmacological uses. As the official source of the plant is roots and rhizomes, but here study had been done comparatively with leaves. Previously leaves of Acorus calamus were not regarded as useful part of plant, but recently there is growing interest in leaves of the said plant. The leaves are considered to possess various activities such as an insect repellent, when cut up and kept with grain storage; anti-hyperlipidemic; anti-diabetic; antipsychotic; anti-inflammatory and analgesic. As there is no detailed work reported in leaf constituents of the plant, therefore the study revealed specific quantitative HPTLC data for the plant for future standardization work. HPTLC analysis of both leaves and rhizomes showed the presence of Asarone, ?- sitosterol, lupeol and Ursolic acid when matched with marker compounds. 
Chemometric – assisted uv spectrophotometric method for determination of antihyperlipidemic agents in pharmaceutical formulation Gandhi, Santosh V; Mutha, Amit S.
Journal of Applied Pharmaceutical Research Vol 5 No 2 (2017)
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Abstract

This presented work is based on application of two multivariate calibration methods for simultaneous UV-VIS spectrophotometric determination of active substances in combined pharmaceutical formulation composed of Atorvastatin calcium (ATV) and Ezetimibe (EZT). The methods used were Principal Component Regression (PCR) and Partial Least Square (PLS). The Spectra of ATV and EZT were recorded at concentrations within their linear range 5.0-30.0 μg/ml for both drugs. 28 set of mixtures were used for calibration and 08 set of mixtures were used for validation in the wavelength range of 230 to 260 nm with the wavelength intervals λ= 0.5 nm in methanol. The methods were validated as per International Conference on HarmonizationQ2 (R1) (ICH) guidelines. These methods were successfully applied for determination of drugs in pharmaceutical formulation (tablet) with no interference of the excipient as indicated by the recovery study results. The proposed methods are simple, rapid and can be easily used as an alternative analysis tool in the quality control as well as in process control of drugs and formulation.
Formulation and characterization of chewable tablets of paracetamol and metoclopramide hydrochloride Kumar, D; Goswami, D S; Tomar, P; Kaur, S
Journal of Applied Pharmaceutical Research Vol 2 No 3 (2014)
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Abstract

The present study was aimed to formulate and characterized chewable tablets of Paracetamol and Metoclopramide hydrochloride. Paracetamol and Metoclopramide hydrochloride is an oral fixed dose combination for the preparation of chewable tablets used to treat the symptoms of migraine as it comply with physicochemical properties require to improve the effectiveness of therapeutic agent, better bioavailability, improved patient acceptance (especially pediatrics) through pleasant taste, patient convenience; need no water for swallowing, fasten the absorption of drug and for rapid onset of action. The investigation was carried out to study the effect of different proportion of Avicel 101, Avicel 102 and moringa gum, which are superdisintegrating agents. The chewable tablets of Paracetamol and Metoclopramide hydrochloride were prepared by wet granulation method. Several physicochemical parameters like thickness, diameter, hardness, %weight variation, %loss in weight, drug content, disintegration time, in vitro dissolution studies, kinetics of drug release and stability studies for all the formulations were studied and were found within the acceptance limits. Formulation F7 (containing moringa gum 1%) showed the best cumulative drug release and disintegration time of 56 secs.

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