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Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan
Published by Universitas Pembangunan Nasional Veteran Jakarta
ISSN : 02163438     EISSN : 26211122     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Arjuna Subject : -
Articles 244 Documents
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RETN Gene Single Nucleotide Polymorphism Profile on Triglyceride-Glucose Index as Insulin Resistance Proxy Among Cohort Population of Non-Communicable Diseases in Bogor Frans Dany; Uly Alfi Nikmah; Ratih Rinendyaputri; Fitrah Ernawati; Dewi Kristanti; Fifi Retiaty
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2022): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v16i1.4342

Abstract

Genetic factors such as single nucleotide polymorphisms (SNPs) are thought to contribute to the increasing incidence of diabetes mellitus (DM) through insulin resistance.  SNPs in the RETN (resistin) gene encoding the resistin protein have been reported to play a role in causing abnormalities in blood glucose and lipid metabolism.  Still, studies related to this have rarely been explored in cohort population models.  This study aimed to evaluate the relationship of resistin gene SNPs to the trend of the triglyceride-glucose index (TyG) as a proxy for insulin resistance.  The data were obtained from the results of the biomedical laboratory examination among participants of a cohort study in the Kebon Kalapa subdistrict, Bogor, every odd year period between 2015-2021 and from RETN genotyping (rs3745367).  The generalized linear model (GLM) repeated measurement technique was used with the TyG index value as the dependent variable.  The results of the GLM analysis showed that although there was a significant difference in the trend of the TyG index between the observation periods [F(2,87, 1671,1)=41,10, p-value <0.001], that’s not the case for RETN gene SNP [F(5,73, 1671,1) = 1.09, p-value = 0.367]. However, the multivariate test results suggested the association of these SNPs with age and DM status [F(4, 583)=2.48, p-value = 0.043].  In conclusion, RETN gene SNPs may require interaction with other factors or genes to induce insulin resistance or act by indirect glucose–fatty acid metabolic cycle mechanisms.
Factors Associated with BCG Scar of Pediatric Tuberculosis Patients at Pisangan and East Ciputat Community Health Centers Farsida Farsida; Ayu Farah Syifa; Azka Zifa Tanama
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2022): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v16i1.4341

Abstract

Tuberculosis (TB) is the most common cause of death in children.  Prevention of TB through Bacille Calmette–Guérin (BCG) vaccination is an action to produce immunity against TB disease.  After vaccination, a scar forms from the boil, which indicates a successful vaccination.  This study aims to determine the factors associated with BCG Scar in pediatric TB patients.  A cross-sectional design was conducted at the Pisangan and East Ciputat Community Health Centers in January-September 2020.  Data collection using medical records and telephone interviews on 35 samples was taken using the probability sampling technique, simple random sampling.  With inclusion criteria for pediatric TB patients (0-18 years) and exclusion criteria that do not include telephone numbers and addresses.  Bivariate analysis was used with the chi-square test.  The results showed a significant relationship between contact history and BCG scars in pediatric TB patients.  Age, gender, nutritional status, exclusive breastfeeding, immunization, mother's education, parent's occupation, family income, and smoking history were not significantly related to BCG scar.  Contact history related to BCG scar.  Parents should pay more attention to and protect their children from the people around them to cut off the possibility of contact with TB sufferers even though the child has been vaccinated. 
Characteristic of Red Blood Cell Profile as a Predictor of 30-Day Clinical Outcome in Ischemic Stroke Patients Nathania Fadjarsugeng; Rizaldy Taslim Pinzon; Sugianto Sugianto
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2022): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v16i1.4055

Abstract

Ischemic stroke is the most common type of stroke in Indonesia. Measuring inflammatory biomarkers (IL-6) is a way to predict clinical outcomes in ischemic stroke patients. However, the laboratory test is very expensive, so it requires another test that can represent the inflammation, for instance, by measuring RDW and MCV value when hospitalized. Hence, this study aims to measure RDW and MCV value of ischemic stroke patients at admission with a 30-day clinical outcome (disability). This study is a retrospective cohort that used secondary data from medical records of ischemic stroke patients in Bethesda Hospital Yogyakarta and was conducted on 105 subjects. They are divided into two groups by their mRS score in 30-day after onset, (1) the independent group (mRS score of 0- 2), (2) the dependent group (mRS score of 3-6). After that, these two groups are analyzed by an independent t-test. High RDW and low MCV value at admission increased 30-day disability risk. There was a statistically significant RDW value and 30-day clinical outcome (p=0,008), but there was no statistically significant MCV value and 30-day clinical outcome (p=0,277). 30-day clinical outcome in ischemic stroke patients can be predicted by their characteristic of red blood cell profile at admission.
Ampicillin-Gentamycin Were Equivalent to Cefotaxime-Gentamycin Therapy Outcome on Neonatal Sepsis in Rural Area of West Borneo Amelia Handoko; Jeremy Tentra Elnusa; Ferryna Novianita
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2022): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v16i1.4429

Abstract

The limited facilities in rural areas, such as Ketapang, make it hard for clinicians in charge to provide the most effective treatment while also considering preventing irrational antibiotic usage at once for neonatal sepsis. This study aimed to compare the length of stay of neonatal sepsis patients given Ampicillin-Gentamycin and Cefotaxime-Gentamycin as empiric antibiotic therapy. This was a retrospective observational study of patients admitted to Fatima Hospital, Ketapang, West Borneo, from June 2020-June, to 2021, with neonatal sepsis diagnosis based on the clinical presentation and routine blood lab. Slovin formula was used to determine the minimum sample size. Data were analyzed using Mann-Whitney Test. From 105 samples collected, the most common symptoms of neonatal sepsis found were fever (32.4%), vomitus (29.5%), and breathing difficulty (26.7%). Routine blood lab mostly showed leukocytosis with a mean of 28.369, and the mean length of hospitalization in patients given the Ampicillin-Gentamycin combination was 6.35 days. In comparison, the Cefotaxime-Gentamycin combination was 4.68 days. There was an insignificant difference in hospitalization between the two groups (p=0.274). Therefore, administration of Ampicillin-Gentamycin as empiric therapy in neonatal sepsis showed a good outcome as with Cefotaxime-Gentamycin therapy.
Readiness of The Community-Based Organization in Improving Female Adolescents Iron Folate Status in a Rural Area Apriningsih Apriningsih; Muhammad Reihan Arianda; Widayani Wahyuningtyas; Feda Anisah Makkiyah
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2022): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v16i1.4268

Abstract

The iron deficiency anemia status of female adolescents needs attention because of its increasing prevalence and impact on adolescent health today and in the future, as well as the country's socio-economic status. Efforts to reduce cases of anemia in female adolescents need to involve multisectoral organizations, including community-based organizations (CBO). Karang-taruna and Posyandu cadres, as CBOs form in rural areas, have the potential to be involved in collaborative programs to improve the anemia status of female adolescents in rural areas. This study aims to identify CBO's readiness to prevent and control anemia in adolescent girls in Sirnagalih village, Bogor, West Java. This study uses a cross-sectional design with a mixed-method approach. The subjects of this study consisted of key resource persons consisting of a village head, three village officers, a head of Karang-taruna, a health-center staff, 6 Karang-taruna members, and 10 Posyandu cadres. The selection of these subjects is based on their role in the village as key persons who willingly participate. The results showed that most CBO members had less knowledge of female adolescents' anemia prevention programs (43.75%). But have a good attitude (56.25%) and self-efficacy (68.75%). The readiness of CBO at Sirnagalih village was at the first level, meaning that CBO members are not aware of the problem of anemia in young women in rural areas. It is necessary to make intervention efforts to increase the readiness of CBOs before further collaborative efforts are carried out.
Bowenoid Papulosis A Case Report Handelia Phinari; Ni Nyoman Ayu Sutrini
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2022): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v16i1.4387

Abstract

Bowenoid papulosis (BP) is a rare case of sexually transmitted disease caused by Human Papillomavirus 16 that affects the young, sexually active age group. A 39-years-old male complained of warts over the scrotum and left groin that gradually increased in number and size for one year duration. There was history of similar complaint. Dermatology status obtained multiple, small, well-defined, grey-brown papules on the scrotum and left groin. Dermoscopy examination revealed a pigmented papillomatous surface, brown-grey dots linearly arranged at the edges, and widespread dotted vessels. Histopathological examination confirmed Bowenoid Papulosis. Based on the clinical findings, Bowenoid papulosis cannot be distinguished from Condyloma Acuminata. Therefore, histopathological examination is necessary to confirm the diagnosis. The patient is treated with surgical excision and cauterization. Six months after the procedure, the patient had no complaints or new lesions. Since the development of BP is unpredictable, early diagnosis, adequate treatment, and routine examinations for recurrence and progression of the disease are required. 
Primary Giant Cell Tumor of Soft Tissue in The Female Breast Dody Novrial; Muhammad Yamsun
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2022): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v16i1.3204

Abstract

A giant cell tumor of soft tissue (GCT-ST) is a rare tumor composed of mononuclear and osteoclast-like multinucleated giant cells.  It is a low-grade malignant potential tumor morphologically analog to a giant cell tumor of bone.  The superficial and deep soft tissue of extremities is the most frequent site of this tumor which is cured by complete or radical resection.  GCT-ST as a primary tumor in the female Breast is exceedingly rare.  Presentation of osteoclast-like multinucleated giant cells in the breast tumor has been described in association with the variant of breast carcinoma.  We report a case of primary GCT-ST arising in the female Breast without a relationship with the epithelial component.  To the best of our knowledge, this is the fifth such case report, and only the second one occurred in a female under 50 years.
Profile of Unilateral Cataract in Children With Congenital Rubella Syndrome Dian Estu Yulia; Intan Datya Kirana; Diajeng Ayesha Soeharto
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2022): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v16i1.4283

Abstract

A congenital cataract is preventable blindness in children and is associated with intrauterine rubella infection known as congenital rubella syndrome (CRS), mostly found in developing countries. This study aims to describe the profile of unilateral cataracts in children with CRS, which are more difficult to manage than bilateral ones. As a retrospective study, we reviewed complete medical records of children with CRS and unilateral cataracts at Cipto Mangunkusumo hospital from 2017 to 2020. Fifteen patients were included, mostly male and from outside Jakarta.The mean age of onset was 2.9 months, while the average age at first presentation and surgery was 27.7 months and 29.1 months, respectively.No correlation was found between patients’ residential distance from the hospital towards duration between onset of symptoms and first presentation to the hospital. 100% and 66.7% of patients had leukocoria and microcornea as ocular manifestations. The majority of systemic manifestations are congenital heart disease.66.7% of children underwent cataract surgery without IOL implantation. Improvement of visual acuity postoperatively was observed in 13.3% of patients, and 66.7% of patients used contact lenses for visual rehabilitation. 60% of patients had posterior capsule opacity within six months of follow-up. The challenge of wearing contact lenses in children makes the risk of amblyopia even greater
Ferritin Level as Independent Predictor of Covid-19 : a Cross Sectional Study Nur Komariah; Salbiah Salbiah; Betha Ariesanthy Anggraini Nugroho; Suliati Suliati; Aninda Dinar Widiantari; Farida Murtiani
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2022): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v16i1.4183

Abstract

COVID-19 is an infectious disease caused by SARS-CoV-2. In severe cases of COVID-19, it is often accompanied by a syndrome known as cytokine storm or cytokine release syndrome (CRS). Serum ferritin levels, increase as the disease worsens. This study aims to see the relationship between ferritin levels and the degree of COVID-19 and evaluate ferritin levels as a predictor of severity in COVID-19 patients at RSPI Prof Dr Sulianti Saroso. This type of research is quantitative with a cross sectional approach. Data analysis using Kruskal Wallis test. Secondary data from medical records of confirmed COVID-19 patients based on the results of PCR examinations during March 2020 to December 2020 who examined ferrittin levels as many as 554 patients. The results showed that the average ferritin level was 164.78, moderate was 524.13, severe was 1377.52 and critical was 1592.46. The results of the analysis with the Kruskal Wallis test obtained P value = 0.000 < (0.05) so it can be explained that there are differences in ferritin levels of the four degrees of disease. This shows that there is an effect of the relationship between ferritin levels and the degree of disease in COVID-19 patients.
Amaurosis Fugax Preceeding Central Retinal Artery Occlusion : a Case Report Ade John Nursalim; Vera Sumual; Andrew Cietra; Elbetty Simanjuntak; Christian Maramis; Komaling Komaling; Stevanus Josafat Loho
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2022): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v16i1.4254

Abstract

Amaurosis fugax is a temporary condition characterized by transient visual loss which lasts several minutes or hours. This symptom can precede central retinal artery occlusion, which can cause permanent visual loss and bear several morbidity and mortality risks. We are reporting a case of a 59-year-old female with an unknown history related to risk factors who developed a painless vision loss in her right eye after experiencing similar symptoms for a short time. We describe the clinical features and other findings related to the diagnosis and discuss the further risk and management. Medical history, physical examination, and optical coherence tomography diagnosed acute central retinal artery occlusion. This includes a history of painless monocular vision loss, macular cherry-red spots, and papilledema. The diagnosis was confirmed by optical coherence tomography showing hyperreflectivity in the inner retinal layer, retinal edema, and hyperreflectivity in the outer retinal layer. Blood test including complete blood check, erythrocyte sedimentation rate (ESR), C reactive protein, lipid profile, and inflammatory markers within normal limit. The patient was then administered to further secondary vascular occlusion prevention, including a blood test, and referred to the neurology department for further examination. Early diagnosis and prompt treatment are necessary for this occlusive disease. A comprehensive examination to mitigate secondary vascular occlusion is needed to prevent morbidity and mortality.

Page 16 of 25 | Total Record : 244

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