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<![CDATA[Palpebral Non-Hodgkin Lymphoma with Non-specific Reactive Hepatitis ]]>
<![CDATA[Pradana Zaky Romadhon]]>;
<![CDATA[Bagus Aulia Mahdi]]>;
<![CDATA[Ugroseno Yudho Bintoro]]>
<![CDATA[ Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Surabaya ]]>
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DOI: 10.30651/jqm.v5i2.7550
<![CDATA[ABSTRACT Extranodal Non-Hodgkin Lymphoma (NHL) remains an odd issue and something to discuss. Clinical evidence and guidelines on the treatment have not yet been broadly published and accessible. Here, we present a case of a thirty-eight years old woman complaining of mass on both lower lids of the eyes. The CT Scan examination showed enhancing solid masses on right-sided and left-sided palpebra inferior that press bulb oculi, suspected as bilateral malignant masses of bilateral palpebra inferior. Laboratory data revealed the surge of liver function marker. The patient was eventually diagnosed with Non-Hodgkin Lymphoma (NHL) of palpebra inferior B cell type high-grade stadium II E. Although there are still ongoing research and development of definitive treatments, R-CHOP a regiment given to this patient has shown complete favorable result with dosage adjustment due to the surge of basal liver function. The regiment was considered safe since no adverse effects reportedKeywords: extranodal, lymphoma non-hodgkin, palpebra, liver function]]>
<![CDATA[Risk Factors for Diabetes Mellitus Patients Against Covid-19 ]]>
<![CDATA[Jasmin Ananda Wulan]]>;
<![CDATA[Afrita Amalia Laitupa]]>;
<![CDATA[Kartika Prahasanti]]>
<![CDATA[ Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Surabaya ]]>
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DOI: 10.30651/jqm.v5i2.4999
<![CDATA[ABSTRACTCovid-19 patients with Diabetes mellitus (DM) ranked third after hypertension and cardiovascular disease with an estimated 36% of all Covid-19 cases. These patients have a risk of experiencing a higher complication possibility since their metabolic disorder can cause hyperglycemia to the patient. It is showed that the number of deaths reached 7,3%, which is higher than non-diabetes. The increase of DM patients caused by stress factors may trigger the onset of glucose in blood sugar, and the glucose variability became abnormal. This circumstance may cause a glycemic increase that causes the predisposition intensification of susceptible affected by Covid-19. Good management is truly needed for DM patients affected by Covid-19. It is hoped to reduce the risk factor, such as preventing complications and increasing life quality by regular medical check to have a good prognosis. Some research showed that Covid-19 patients with DM are essential in ICU and need more treatment attention as they may experience Acute Respiratory Distress Syndrome (ARDS). Diabetes mellitus patients' treatment strategy is to manage the blood glucose level, especially in post-prandial glucose. This literature aims to know the degree of serious illness of Covid-19 patients by the comorbidity of DM in this pandemic event. Keywords: Covid-19, Sars-Cov-2, Diabetes Mellitus, risk factors,Correspondence: jasminananda@gmail.com]]>
<![CDATA[Relationship between modified Nutrition Risk in the Critically Ill (mNUTRIC) Score and nutrition intake with quadriceps femoris muscle thickness in critically ill patients ]]>
<![CDATA[Mahendra Dwi Aditya Lopulalan]]>;
<![CDATA[Prananda Surya Airlangga]]>;
<![CDATA[Arie Utariani]]>
<![CDATA[ Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Surabaya ]]>
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DOI: 10.30651/jqm.v5i2.6257
<![CDATA[Abstract Muscle wasting in critical illness is seen from inadequate nutrition intake and stress catabolism. Modified Nutrition Risk in the Critically Ill (NUTRIC) Score is a screening tool that measures starvation, inflammation, disease severity, and organ dysfunction. Relationship between muscle strength and muscle thickness causes the evaluation of muscle thickness is quite relevant. This study aimed to analyze the relationship between modified NUTRIC score and nutrition with muscle wasting in critically ill patients. The study was conducted on 30 patients in the ICU Dr Soetomo Hospital Surabaya. Nutritional intake and thickness of the quadriceps femoris muscle were monitored for one week. There was a relationship between mNUTRIC score with quadriceps femoris muscle thickness on days 3rd, 5th, and 7th. In the comparison between the low risk group and the high-risk group, it was found that there was a significant difference in the change in the percentage of muscle thickness difference on the 3rd, 5th and 7th day observation. There is a relationship between protein debt with quadriceps femoris muscle thickness (p = 0.008) with a positive correlation with moderate correlation strength (r = 0.477) on day 7. In conclusion, the modified NUTRIC Score had a moderate relationship with quadriceps femoris muscle thickness in critical patients from day 3rd until day 7th. The calorie intake not had a relationship with quadriceps femoris muscle thickness. Protein intake had a moderate relationship with quadriceps femoris muscle thickness only on day 7th measurement in critical patients. Keywords : Modified NUTRIC Score, Nutrition, Quadriceps Femoris muscleCorrespondence : mdr.lopulalan@gmail.com]]>
<![CDATA[Parental first concern according to age and type in children with Autism Spectrum Disorder ]]>
<![CDATA[Dian Dwi Sari]]>;
<![CDATA[Irwanto Irwanto]]>;
<![CDATA[Ahmad Suryawan]]>;
<![CDATA[Mira Irmawati]]>;
<![CDATA[Budi Utomo]]>
<![CDATA[ Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Surabaya ]]>
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DOI: 10.30651/jqm.v5i2.5738
<![CDATA[ Developmental problems concerned by parents are a further diagnostic step for children with Autism Spectrum Disorder (ASD). Research is needed to find a picture of the child's behavior complained of by parents. Investigations about first concerns among parents of children with ASD and comparisons of the same with children diagnosed with other developmental disorders are rare. We want to examine the type and age of parents ‘concern in children with ASD and other developmental disorders. A cross-sectional study was conducted in Child Developmental Centre in Surabaya Indonesia from August 1 to December 30, 2019. T-test and chi-square tests were used to analyze differences in subject variables and types of concern. Most parents of both children diagnosed with ASD and non-ASD indicated first concern were in communication, social skill, and behavior problem. The average age of parents’ first concern of ASD children is 30,14 months. Significant differences were found between ASD and non-ASD groups in communications, behavior, and sensory problem concerns. There is no specific difference between parental concerns of children with ASD and non-ASD children. The average age of first concern was significantly younger for children with an ASD diagnosis than other developmental disorders.Keywords :parent concern, autism, communication.Correspondence :dian_dwisary@yahoo,com]]>
<![CDATA[The Effect of Thespesia populnea Against Plasmodium falciparum Enoyl Acyl Carrier Protein Reductase Receptor by Study In Silico ]]>
<![CDATA[I Made Prasetya Kurniawan]]>;
<![CDATA[Prawesty Diah Utami]]>;
<![CDATA[Risma Risma]]>
<![CDATA[ Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Surabaya ]]>
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DOI: 10.30651/jqm.v5i2.5368
<![CDATA[Indonesia is a country that has abundant natural resources; one of them is the Baru laut plant which is the latest breakthrough because it has an active substance that can be used as an anti-malaria medicine. It is very beneficial because there has been a case of resistance of artemisinin derivatives in Indonesia. The purpose of this study was to determine the potential of active compounds in Baru laut plants (Thespesia populnea (L.) Soland ex. Correa) against the Plasmodium falciparum enoyl acyl carrier protein reductase receptor in P. falciparum through in silico studies. This research is purely experimental using the One-Shot Experimental Study research design method. Observations were only made once between the variables studied through three analyzes, namely prediction analysis of active compound content, prediction analysis of the mechanism of action of active compound content, and prediction analysis of ADME active compound. The study results show that there are three active compounds in Baru laut plants that have antimalarial potential. The three compounds include gossypol, linoleic acid, and beta-sitosterol, have their respective potential in becoming a malaria drug. This study concludes that Baru laut plants have potential as anti-malaria drugs.]]>
<![CDATA[Effect of positive end-expiratory pressure value on change in end-tidal carbon dioxide as a predictor of fluid responsiveness in Patients Undergoing Passive Leg Raising Maneuver ]]>
<![CDATA[Lutfi Nur Farid]]>;
<![CDATA[Hardiono Hardiono]]>;
<![CDATA[Pesta Parulian Maurid Edwar]]>
<![CDATA[ Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Surabaya ]]>
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DOI: 10.30651/jqm.v5i2.5458
<![CDATA[Abstract Identification of patients’ fluid status in the emergency room should be made before giving fluid therapy. This study aimed to determine the effect of positive end-expiratory pressure on change in end-tidal carbon dioxide during passive leg raising maneuver to predict fluid responsiveness. Thirty subjects aged 18-65 years in the resuscitation room, all on the ventilator, were divided into three groups according to their positive end-expiratory pressure value: low (0-5 cmH2O), moderate (6-10 cmH2O), and high (>10 cmH2O). Every subject underwent passive leg raising to simulate fluid administration. Values of blood pressure, heart rate, cardiac output, and end-tidal carbon dioxide were recorded before and after the maneuver. Analysis of the three groups found a significant correlation between change in end-tidal carbon dioxide with a cut-off value of 5% and 1 mmHg with fluid responsiveness of subjects in the low (p = 0.028) and moderate (p = 0.013) but not in the high positive end-expiratory pressure group (p = 0.333). In conclusion, change in end-tidal carbon dioxide in mechanically ventilated patients undergoing passive leg raising maneuvers can be used as a predictor of fluid responsiveness, but this method cannot be used on patients with high positive end-expiratory pressure (> 10 cmH2O) Keywords : change in end tidal carbon dioxide, fluid responsiveness, positive end-expiratory pressure, passive leg raising, cardiac output surrogateCorrespondence : lutfithe13th@gmail.com]]>
<![CDATA[Comparison of central vein pressure between distal, medial, and proximal lumens with water manometer method ]]>
<![CDATA[Cornellius Hendra Purnama Aria Sumantrie]]>;
<![CDATA[Bambang Pujo Semedi]]>;
<![CDATA[Bambang Purwanto]]>
<![CDATA[ Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Surabaya ]]>
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DOI: 10.30651/jqm.v5i2.5356
<![CDATA[ABSTRACT Catheter Vein Pressure in ward-cared patients is rarely measured and considered invalid. The two catheter vein pressure postulates contradict, making confusion among health workers. Dr Russo said the distal-medial-proximal Catheter Vein Pressure has no difference but were denied by Susan S. Scott. Proof of postulate is needed as a solution to inward care. Therefore, this study aimed to compare the central vein pressure between distal, medial, and proximal lumens with the water manometer method. Forty-nine samples retrospective study were taken from the distal - medial - proximal Catheter Vein Pressure of the "zero" until fifth days. The differences are analyzed with Statistical Paired t Test with p-Value < 0.05 from SPSS ver. 26 to prove the right postulate. 49 samples were concluded to represent of population. Catheter Vein Pressure from day "zero" becomes zero difference, the fifth day 91.8% are no difference while the rest have difference of 0.2 - 1.0 cm H2O and the conclusion are no significant difference with 95% CI. The correlation scale of 0.998 and 0.999 proves that the three lumens tend to produce no differences. In conclusion, the distal - medial - proximal Catheter Vein Pressure values in this study have no significant differences and consistent from "zero" until fifth days. This is formulated as P distal = P medial = P proximal (cm H2O).Keywords : Central Vein Pressure, Pressure, distal - medial - proximal, no differences, ward patient.Correspondence : sumantrie_medicalgp@yahoo.com]]>
<![CDATA[Expression of Brain-Derived Neurotrophic Factor in the Brain of Depressed Mice: Systematic Literature Review ]]>
<![CDATA[Nur Azizah AS]]>;
<![CDATA[Lysa Veterini]]>;
<![CDATA[Hafid Algristian]]>;
<![CDATA[Hotimah Masdan Salim]]>
<![CDATA[ Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Surabaya ]]>
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DOI: 10.30651/jqm.v5i2.6354
<![CDATA[Chronic stress exposure plays a role as a risk factor for depression. In chronic stress, there is prunning of nerve cell dendrites so that depression becomes irreversible. Depression is caused by low serotonin (5-HT2) neurotransmitters in the postsynaptic cleft. Recent findings in experimental animals indicate that serotonergic preparations are required to increase serotonin levels in the synapse opening, thereby triggering the formation of new dendrites to make depression reversible. The different results when these preparations create resistance in cases of chronic depression and actually increase the risk of uncomfortable and even fatal side effects with long-term use. This Systematic Literature Review uses the PubMed and Google Scholar databases for the period 2015-2020. A total of 322 articles at the beginning of identification and those that met the inclusion criteria in this study were six articles. The results of data extraction showed that the depression condition caused by various stressors resulted in BDNF levels in the hippocampus decreased significantly by p≤0.005. Based on the literature study, it was concluded that in depressive conditions, BDNF levels in the brain decreased.]]>
<![CDATA[Understanding Pacing-Induced Cardiomyopathy: a mini review ]]>
<![CDATA[Sidhi Laksono Purwowiyoto]]>;
<![CDATA[Reynaldo Halomoan Siregar]]>;
<![CDATA[Steven Philip Surya]]>
<![CDATA[ Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Surabaya ]]>
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DOI: 10.30651/jqm.v5i2.6036
<![CDATA[Patients with total atrioventricular block or sinus node dysfunction will need pacemaker implantation to improve the physiologic function of the heart. It is known that chronic pacing such as right ventricular pacing could deteriorate the cardiac function (decreased left ventricular ejection fraction) due to dyssynchrony. This condition is knows as pacing-induced cardiomyopathy (PICM). The incidence of PICM could reach 19.5% during 3 years follow-up. The right ventricle is one of the locations for implantation. Chronic right ventricular pacing may cause interventricular dyssynchrony and disrupt the contraction mechanism in the heart. These will lead to cardiac remodeling and eventually impair the left ventricular function. Therapy is needed in patients with PICM to improve the symptoms and maintain the cardiac function. This article will further highlight the definition, mechanism, risk factor, treatment and preventive strategy for patients with PICM.]]>
<![CDATA[Effectiveness factors analysis of near-miss incidence referral in obstetric complications at Waras Wiris Andong General Hospital on Boyolali District ]]>
<![CDATA[Edy Mustofa]]>;
<![CDATA[Widyasih Pritasari]]>;
<![CDATA[Arif Rahman Nurdianto]]>;
<![CDATA[Sunarjo Sunarjo]]>
<![CDATA[ Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Surabaya ]]>
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DOI: 10.30651/jqm.v5i2.7197
<![CDATA[AbstractMaternal mortality in Indonesia is still very high, and the biggest problem is obstetric complications. It is possible that the mother who has obstetric complications is safe and recovered (near miss) or died. This research was an observational analytic epidemiological study conducted to determine the effectiveness of near-miss incidence referral in obstetric complications using a cross-sectional approach. The sampling technique used was a random sampling system with 85 respondents. The effectiveness of referral affects near-miss incidence, meaning that mothers who get referral according to procedure only have a 0.107 times greater chance of not occurring near miss. Pregnant women who had a history of the disease had a risk of 0.157 times greater for the absence of near-miss than mothers who did not have a history. Pregnant women with high risk have 0.157 times no near-miss than those with low risk. Maternal antenatal examination affects the incidence of a near miss. It was found that the mother's history of illness, the risk of pregnancy owned by the mother and the effectiveness of referrals could affect the incidence of near miss in obstetric complications. In conclusion, there is an influence between the effectiveness of the referral and the near-miss incident at the Waras Wiris Andong Regional Hospital, Boyolali RegencyKeywords: referral, effectiveness, near-miss, obstetric complication]]>
