cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Kota bandung,
Jawa barat
INDONESIA
Chimica et Natura Acta
Published by Universitas Padjadjaran
ISSN : 23550864     EISSN : 25412574     DOI : -
Core Subject : Science, Agriculture, Social,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Materials Science & Nanotechnology
Chimica et Natura Acta diterbitkan oleh Departemen Kimia, FMIPA, Universitas Padjadjaran tiga kali setiap tahun pada bulan April, Agustus dan Desember. Artikel yang dimuat mencakup Kimia Analisis dan Pemisahan, Kimia Material, Kimia Energi dan Lingkungan, Kimia Organik Bahan Alam dan Sintesis, Biomolekular Pangan dan Kesehatan serta topik-topik lain yang berhubungan dengan ilmu Kimia.
Arjuna Subject : -
Articles 10 Documents
 1 
Search results for , issue "Vol 13, No 2 (2025)" : 10 Documents clear
Antibacterial Effect of Ethanol Extracts of Murraya paniculata Leaves, Smallanthus sonchifolius Leaves, Apis trigona Honey, and their Combination Against Staphylococcus epidermidis Kusuma, Sri Agung Fitri; Herawati, Irma Erika; Nugrahaningtiyas, Felika
Chimica et Natura Acta Vol 13, No 2 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n2.55483

Abstract

Several studies have reported that combining plant extracts may enhance their efficacy against specific bacterial infections. This study aimed to analyze the antibacterial interaction of ethanol extracts of Murraya paniculata leaves, Smallanthus sonchifolius leaves, Apis trigona honey, and their combinations against Staphylococcus epidermidis ATCC 12228, as each component has shown individual antibacterial activity against this bacterium. The antibacterial interactions of the test materials, both individually and in combination, were evaluated using the agar diffusion method with clindamycin phosphate as the standard antibiotic. The minimum inhibitory concentration (MIC) of the most potent extract was determined through the microdilution method according to the Clinical and Laboratory Standards Institute (CLSI) guidelines, while the minimum bactericidal concentration (MBC) was assessed via subculture on solid media. Among all tested substances, the S. sonchifolius leaf extract exhibited the highest antibacterial activity, with similar MIC and MBC values ranging from 15.625 to 31.25 mg/mL. Interaction tests revealed a significant difference, showing that the combination of all three agents had an antagonistic effect, whereas the combination of both leaf extracts produced a synergistic antibacterial effect. However, the inhibitory effect of the combination was not greater than that of the yacon extract alone. In conclusion, S. sonchifolius leaf extract demonstrates strong potential as a single antibacterial agent against S. epidermidis.
Synthesis of 1,2-Di(phenyl)ethan-1,2-dione through Oxidation of 2-Hydroxy-1,2-Dipheniletanone by using Copper(II) Citrate Seviani, Winda; Fadlan, Arif; Wirastuti, Vania
Chimica et Natura Acta Vol 13, No 2 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n2.50263

Abstract

1,2-Di(phenyl)-1,2-dione widely used in chemical and pharmaceutical industries and found as a framework in secondary metabolites can be obtained through oxidation of 2-hydroxy-1,2-diphenylethanone using strong acids, homogeneous, heterogeneous, and metal catalysts. However, these oxidation methods exhibit various drawbacks. This study reported the oxidation of 2-hydroxy-1,2-diphenylethanone by using copper(II) citrate to produce 1,2-di(phenyl)-1,2-dione. The oxidation performed with copper(II) citrate and ammonium nitrate in glacial acetic acid as solvent yielded 1,2-di(phenyl)-1,2-dione in 88% yield higher than the nitric acid method (79% yield). The FTIR, NMR spectriscopies, and mass analysis confirmed the structure of 1,2-di(phenyl)ethane-1,2-dione. The oxidation of 2-hydroxy-1,2-diphenylethanone using copper(II) citrate is proposed by the formation of Cu⁺ ions and a resonance-stabilized 2-hydroxy-1,2-diphenylethanone radical resulting in 1,2-di(phenyl)ethane-1,2-dione.
Effect of Fermentation on the Phsyco and Functional Properties of Red Sorghum Flour (Sorghum bicolor L.) Lembong, Elazmanawati; Wulandari, Endah; Harlina, Putri Widyanti; Tsalitsu, Syifa
Chimica et Natura Acta Vol 13, No 2 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n2.57757

Abstract

Modification of red sorghum flour by fermentation method can improve the physical, chemical, and functional properties of the resulting sorghum flour. The purpose of this study was to determine the fermentation time that can affect the physical and functional characteristics of red sorghum flour fermented spontaneous (TSS) and non-spontaneous (TTS). Results indicated that the best treatment was red sorghum flour fermented at 24 hours both spontaneous and non-spontaneous. TSS at 24 hours had a water absorption capacity of 1.04%, oil binding capacity of 1.04%, swelling volume of 7.47%, solubility of 7.57%, initial gelatinization temperature of 76.56oC, peak viscosity of 2855 cP, hot paste viscosity of 2214 cP, breakdown viscosity of 641 cP, cold paste viscosity of 3425 cP, and setback viscosity of 1211 cP. TTS at 24 hours had a water absorption capacity of 1.21%, oil binding capacity of 1.18%, swelling volume of 7.49%, solubility of 8.23%, initial gelatinization temperature of 75.81oC, peak viscosity of 3172 cP, hot paste viscosity of 2600 cP, breakdown viscosity of 572 cP, cold paste viscosity of 5107 cP, and setback viscosity of 2507 cP.
In-silico of Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) Inhibitors of Seven Bioactive Compounds from Sonneratia alba Latief, Madyawati; Melani, Fitria; Yusnaidar, Yusnaidar; Tarigan, Indra Lasmana
Chimica et Natura Acta Vol 13, No 2 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n2.59525

Abstract

Cancer is a disorder resulting from genetic changes, abnormal growth, and spread to other parts of the body. Cancer treatment is commonly administered through chemotherapy, which often results in adverse side effects. Therefore, research is essential to identify safer alternative cancer therapies. This study aims to identify potential bioactive compound ligand receptor targets from Sonneratia alba as anticancer candidates in silico by identifying VEGFR target proteins based on their pharmacophores and studying their interactions through the reverse docking method. Docking simulations between the native ligand (Tivozanib) and the receptor yielded promising results, with a free energy value of -12.76 kcal/mol and an inhibition constant of 440.70 μM. Among the seven bioactive compounds, Meperidine (C15H21NO2) exhibited favorable outcomes, showing a free energy value of -7.39 kcal/mol and an inhibition constant of 3.83 μM. Additionally, the meperidine and gibberellin A7 compounds formed three and four hydrogen bonds, respectively, including one with Ala866, and interacted with 15 and 18 amino acid residues, such as Glu917, Cys919, Glu885, and Asp1046. The presence of active sites on the ligand or test compounds that bind to the target receptor indicates a potential for comparable affinity in inhibiting VEGFR-2 receptor activity.
The Effect of Different Synthesis Solvents and Dialysis Processes on the Optical Properties of Carbon Dots from Spent Coffee Grounds using the Solvotermal Method Putri, Wahyuni Eka; Sjahriza, Ahmad; Sugiarti, Sri
Chimica et Natura Acta Vol 13, No 2 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n2.52599

Abstract

The distinctive optical properties of carbon dot (CD) make CD is one of the most widely developed carbon nanomaterials today. CD can be synthesized from materials that high in carbon content, such as spent coffee grounds. The optical properties of synthesized CD are influenced by several factors, including the solvent used to synthesize it and the purification method. The purification process that can be done is dialysis. However, this technique is not always used in several researches to purify CD. This study aims to synthesize CD from spent coffee grounds through solvothermal methods with three different solvents, which are water, 50% ethanol (v/v), and absolute ethanol that purified by dialysis and without dialysis and to characterize the differences in its optical properties. The results showed that CD was successfully synthesized with these three solvents, but the optical properties were different. All three solvents produce CD that emits blue light, but differ in intensity. The addition of ethanol can double the luminescence intensity of CD and CD synthesized with 50% ethanol produce the highest luminescence intensity. In addition, CD purified without dialysis produce twice as high luminescence intensity as CD purified by dialysis.
Maggot as a Bioconversion Agent of Cow Blood Waste and Date Pulp into Feed Raw Materials: A Chemical Profile Study Helmi, Imra Atun; Nufus, Hidayati; Ahdavia, Ikrima; Farid, Muhamad; Sjahriza, Ahmad
Chimica et Natura Acta Vol 13, No 2 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n2.55522

Abstract

Cow blood waste and date residue become environmental problems if not appropriately managed. So far, there has yet to be any special management to handle the waste. On the other hand, cow blood waste and date pulp can be efficiently decomposed by maggots. This research was carried out to utilize organic waste as maggot cultivation by producing animal feed materials high in protein and fat, and to determine the best composition in the feed medium. Maggot feed treatment consisted of household organic waste as P0, mixed feed as P1, the ratio of cow blood waste to date pulp P2 (1:1), P3 (1:2), and P4 (2:1). The maggot flour obtained was analyzed for its proximate, amino acid, and fatty acid content. The results showed the lowest moisture at P3 (2.26%), the highest ash content and fat content at P0 (8.27 and 36.62%), respectively, and the highest protein content at P3 (51.66%). Chemical profile analysis showed the highest amino acids, namely glutamic acid (6.05%) and lauric acid C13:0 as the highest fatty acid. The maggot content, which is rich in protein, can be used as a raw material for livestock feed.
Effectiveness of Magnetic Nanocomposites Modified with Reduced Graphene Oxide Derived from Spent Coffee Grounds for Pharmaceutical Waste Remediation Khairani, Raisya Fakhira; Nurqisthi, Faisha; Nuari, Sindhi Ika; Herwinta, Syifa Rahmalia; Rahma, Aqilla Irfa Muthia; Eddy, Diana Rakhmawaty
Chimica et Natura Acta Vol 13, No 2 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n2.57812

Abstract

The Covid-19 pandemic significantly inflluenced the growth of the pharmaceutical industry in Indonesia, leading to environmental challenges, particularly with the discharge of pharmaceutical wastewater. Traditional treatment methods, such as flocculation and coagulation, hav limitations as they produce large volumes of activated sludge. An alternative approach for remediating this wastewater is the use of magnetite nanocomposites modified with reduced graphene oxide. This material leverages the unique properties of reduced graphene oxide, enhancing the separation and transfer of electron-hole pairs generated in the photogeneration process and significantly reducing charge carrier recombination in the photocatalytic system. This study aims to determine the degradation precentage of pharmaceutical wastewater using magnetic nanocomposite materials synthesized via in-situ chemical co-precipitation. The degradation percentage achieved through photocatalytic testing was 38.34% in basic conditions, with a band gap value of 2.03 Ev, operating under visible light. The characterization techniques used in this research include XRD, TM-EDS, FTIR, and UV-vis-DRS.
Identification of Secondary Metabolites in Ethyl Acetate Extract of Ki Encok Plant Roots (Plumbago zeylanica Linn) and In Silico Cytotoxicity Activity Purwoko, Mitayani; Mundijo, Trisnawati; Astri, Yesi; Rohani, Siti
Chimica et Natura Acta Vol 13, No 2 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n2.50815

Abstract

The Ki Encok plant (Plumbago zeylanica Linn) has been extensively studied and is known to have cytotoxic activity. However, no research has yet investigated the compound content of the ethyl acetate extract from that plant. This study aims to identify the secondary metabolite content in the ethyl acetate extract of Plumbago zeylanica L. roots and to determine the potential of these secondary metabolites to bind with the Caspase-3 protein in silico. The ethyl acetate extract of Plumbago zeylanica roots was tested for its phytochemical properties and examined using GC-MS. The compounds found were then searched for their structures in Pubchem, tested in silico using the CB-Dock2 software, and evaluated for drug-likeness with SwissADME. Qualitative phytochemical tests indicate the presence of alkaloid and tannin compounds. The GC-MS test showed the presence of Plumbagin, Gamma sitosterol, and 4-ethoxybenzaldehyde. In the in silico test, docking between Gamma sitosterol, Plumbagin, and 4-ethoxybenzaldehyde with the target protein Caspase-3 has free binding energies of -8.5, -7.0, and -6.1. The Gamma sitosterol-Caspase-3 complex shows the best free-binding energy among the three ligands. Further in vitro or in vivo studies are needed to assess whether the interaction between Gamma sitosterol and Caspase-3 is inhibition or activation.
Antioxidant Potential and Active Compound Identification of Hylocereus costaricensis and Hylocereus undatus Peel Extracts using LC-MS/MS Mulyati, Ade Heri; Nurmayani, Reni; Widiastuti, Diana; Warnasih, Siti; Sinaga, Siska Elisahbet
Chimica et Natura Acta Vol 13, No 2 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n2.61186

Abstract

The object of this research was to determine the antioxidant potential and identify active compounds in the peel extracts of red dragon fruit (Hylocereus costaricensis) and white dragon fruit (Hylocereus undatus). Phytochemical tests were conducted to identify flavonoids, alkaloids, tannins, coumarins, and saponins. The antioxidant activity was assessed using the DPPH assay, while vitamin C content was quantified using UV-Vis spectrophotometry, and bioactive antioxidant compounds were identified through LC-MS/MS spectrophotometry. The results demonstrated that phytochemical screening revealed the presence of flavonoids and alkaloids in both extracts. Antioxidant activity assays indicated that the red dragon fruit peel extract exhibited an IC50 of 32.7 ppm (very active), while the white dragon fruit peel extract had an IC50 of 50.2 ppm (active), with the vitamin C control showing an IC50 of 11.90 ppm. The red dragon fruit peel extract had the highest vitamin C content (1.45%) compared to the white dragon fruit peel (1.04%). LC-MS/MS analysis identified several organic compounds, including the flavonoid isoliquiritigenin and alkaloid compounds such as aporphine, melosmine, 3-carbamoyl-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-4,5-dimethylpyridinium, and alkaloid group (6-Amino-5-{[2(diethylamino) ethyl]amino}-1-propyl -2,4(1H,3H)-pyrimidinedione). These findings suggest that both red and white dragon fruit peel extracts possess significant antioxidant potential, with red dragon fruit peel demonstrating superior activity. This study can be used for further research on food technology in producing food products that are rich in nutrients.
Cytotoxicity of Chromanone Acid from the Steam Bark of Calophyllum incrassatum against P-388 Leukemia Murine Cells Hasanah, Ulfatun; Andawiyah, Robi’atul; Taqiyah, Barrotut; Saputri, Ratih Dewi; Tjahtjandarie, Tjitjik Srie
Chimica et Natura Acta Vol 13, No 2 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n2.58510

Abstract

Calophyllum incrassatum is one of the plant species of the Calophylloceae family and is found endemic in Kalimantan and Sumatra. This study aims to isolate chromanone acid compounds from the stem bark of C. incrassatum and determine the relationship between structure and activity against murine Leukemia P-388 cells. The extraction method used was maceration using methanol solvent, partitioned with n-hexane and ethyl acetate solvents. Separation and purification of n-hexane and ethyl acetate extracts by vacuum liquid chromatography, pressed column, and radial. Two chromanone acids derivatives, isoapetalic acid (1), and methyl isoapetalic (2), have been successfully isolated from the stem bark of Calophyllum incrassatum. The structures of the two compounds were identified and elucidated using spectroscopic techniques such as UV, IR, and 1D and 2D NMR. The cytotoxic activity against murine leukemia P-388 cells of compounds 1-2 showed IC50 values of 8.51 and 1.47 µg/mL, respectively, and compound (2) exhibited high cytotoxic activity

Page 1 of 1 | Total Record : 10

 1 

Filter by Year

2025 2025


Reset
Filter By Issues
All Issue Vol 13, No 3 (2025) Vol 13, No 2 (2025) Vol 13, No 1 (2025) Vol 12, No 3 (2024) Vol 12, No 2 (2024) Vol 12, No 1 (2024) Vol 11, No 3 (2023) Vol 11, No 2 (2023) Vol 11, No 1 (2023) Vol 10, No 3 (2022) Vol 10, No 2 (2022) Vol 10, No 1 (2022) Vol 9, No 3 (2021) Vol 9, No 2 (2021) Vol 9, No 1 (2021) Vol 8, No 3 (2020) Vol 8, No 2 (2020) Vol 8, No 1 (2020) Vol 7, No 3 (2019) Vol 7, No 2 (2019) Vol 7, No 1 (2019) Vol 6, No 3 (2018) Vol 6, No 2 (2018) Vol 6, No 1 (2018) Vol 5, No 3 (2017) Vol 5, No 3 (2017) Vol 5, No 2 (2017) Vol 5, No 2 (2017) Vol 5, No 1 (2017) Vol 5, No 1 (2017) Vol 4, No 3 (2016) Vol 4, No 3 (2016) Vol 4, No 2 (2016) Vol 4, No 2 (2016) Vol 4, No 1 (2016) Vol 4, No 1 (2016) Vol 3, No 3 (2015) Vol 3, No 3 (2015) Vol 3, No 2 (2015) Vol 3, No 2 (2015) Vol 3, No 1 (2015) Vol 3, No 1 (2015) Vol 2, No 3 (2014) Vol 2, No 3 (2014) Vol 2, No 2 (2014) Vol 2, No 2 (2014) Vol 2, No 1 (2014) Vol 2, No 1 (2014) More Issue