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INDONESIA
Buletin Farmatera
Published by Universitas Muhammadiyah Sumatera Utara
ISSN : 2528410X     EISSN : 2528410X     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Arjuna Subject : -
Articles 244 Documents
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Cholesterol Levels in Angiotensin Converting Enzyme Gene Polymorphisms in Schizophrenia Patients Isra Thristy; Nanda Sari Nuralita; Debby Mirani Lubis
Buletin Farmatera Vol 8, No 2 (2023)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v8i2.8330

Abstract

Abstract: Angiotensin-converting enzyme (ACE) is widely distributed on the surface of endothelial and epithelial cells. The renin-angiotensin system in the brain has implications for various functions, including cerebral blood circulation and brain protection, stress, depression, and the aetiology of schizophrenia. ACEs and angiotensin receptors can be found on dopaminergic neurons in the basal ganglia. Elevated levels of triglycerides and cholesterol can also be found in schizophrenic patients related to treatment and duration of the course of the disease. The purpose of this study was to determine the relationship between ACE gene polymorphism and cholesterol levels in schizophrenia patients. The design of this study was observational analytic with a cross-sectional approach. The sample in this study was schizophrenia patients who sought treatment at Madani Medan Hospital with a total of 42 people. The data obtained is then processed with the ANOVA one-way test. The results of the study were obtained from 42 samples, the most types of ACE gene polymorphisms were type II (76.2%), followed by the type of DD polymorphism (19%) and the least was the type of ID polymorphism (4.8%). The average value of cholesterol levels of the sample was 235.40 mg/dl with a standard deviation value of 47.618. Statistical test results of ACE gene polymorphism with cholesterol levels with p = 0.770 (p 0.05). It can be concluded that there is no relationship between the polymorphism of the ACE gene and the cholesterol levels of schizophrenic patients.
Antipyretic Activity of Some Plant Species of The Genus Hibiscus And Genus Citrus: Review Articles Asman Sadino; Suwendar Suwendar; Lani Husni Awaliah
Buletin Farmatera Vol 8, No 2 (2023)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v8i2.11745

Abstract

Abstract: Traditional medicine is one of the great benefits for the community in building health, for example, such as using medicinal plants as an alternative to traditional treatment, one of which is reducing fever. This review aims to find and evaluate the scientific literature on plants with antipyretic effects of the genera Hibiscus and Citrus. The research approach used in this article review is a literature review based on journals published in the last ten years (2012-2022) collected from national and international journals and conducted online using Google scholar, Pubmed, and NCBI search engines. The results of the review related to plants that have antpyretic activity from the Hibiscus Genus and Citrus Genus as many as 8 plant species,  namely Hibiscus rosa sinensis, Hibiscus tiliaceus L, Hibiscus sabdariffa, Hibiscus schizopetalus (MAST.) HOOK, Citrus aurantifolia (Christm) Swing, Citrus hystrix, Citrus  x aurantium L and Citrus assamensis.
Nutrition Knowledge Improves Capabilities Educational Information Communication Service (EIC) Practice Community Pharmacist Health Supplement Rizki Siti Nurfitria; Tiara Ismadewi Hastuty; Ni Nyoman Sri Mas Hartini
Buletin Farmatera Vol 8, No 2 (2023)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v8i2.12684

Abstract

Abstract: Community pharmacists as the spearhead of pharmacy services may be asked to provide advice on the use of health supplements through Information Communication and Education services (EIC) such as counselling and drug information. Knowledge of nutrition and health supplements is very important to prevent misuse in consuming these products. The purpose of the study was to determine the extent of the relationship between nutritional knowledge and community pharmacist practice in EIC health supplements. The method used is observational analytic with a cross-sectional approach in Purwakarta Regency in March – April 2022. Data was taken using questionnaires on 59 community pharmacists and then processed qualitatively and quantitatively through the Spearman Rank correlation test using SPSS version 25.0. The results showed that all community pharmacists routinely conduct EIC (100%), most have positions as the first pharmacist practice license (SIPA) (88.6%) and practice in pharmacies (50%). The level of knowledge of nutritional counselling and community pharmacist practice in EIC health supplements falls into the good category (85.8% and 81.32%). The level of knowledge of nutritional counselling and community pharmacist practice in EIC health supplements falls into the good category (85.8% and 81.32%). There was a significant positive relationship between nutritional knowledge and community pharmacist practice in the EIC of health supplements at a significance value of 0.000 (p0.05) and a correlation coefficient value of 0.769 indicating that the relationship is strong.
Analysis of Medicine Procurement Planning using FIFO and FEFO Methods at West Pasaman Regional Hospital Daulay, Ayu Sasmita; Girsang, Ermi; Ramadhani Nasution, Sri Lestari
Buletin Farmatera Vol 9, No 2 (2024)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v9i2.20849

Abstract

Abstract: Planning in medicine procurement is carried out because inefficiency can harm the smooth procurement of drugs for pharmaceutical service activities in the provision of overall health services, both medical, social and economic. Therefore, careful planning and medicine procurement management is needed. Stock-outs and stagnation that occur can also be influenced by drug storage methods that do not apply the First Expired First Out (FEFO) and First In First Out (FIFO) principles. This research aims to analyze medicine procurement planning using the FIFO and FEFO methods at the West Pasaman Regional Hospital using a descriptive research design through a qualitative approach. The results of this research conclude that the human resources, budget, facilities and infrastructure as well as procedures included in the input picture for drug procurement planning using the FIFO and FEFO methods at the West Pasaman District Hospital are under need, as are the human resources that have been met, the available budget and the facilities and infrastructure that has been fulfilled. However, several things must be evaluated regarding facilities and infrastructure, namely in the warehouse section, where the West Pasaman Regional Hospital still has a warehouse that is not conducive to procuring medicines.
Differences in Sleep Quality of Schizophrenia Patients Based on Gender at Madani Hospital Medan, North Sumatra Zulhilmi, Zulhilmi; Nuralita, Nanda Sari; Rizaldi, Aril; Asfur, Robitah
Buletin Farmatera Vol 9, No 2 (2024)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v9i2.16340

Abstract

Abstract: Schizophrenia is a severe mental disorder, this disorder is characterized by delusions, hallucinations, thought disorder, restlessness, strange or hostile behaviour, feeling (affect) dull or flat, interest away from social interactions, little emotional contact (quiet, difficult to talk to), passive, apathetic or indifferent, difficult to think abstractly and lose of motivation. Sleep disturbances have been assessed in various studies in patients with schizophrenia, using subjective (ie daily interviews, sleep diaries) and objective (ie, polysomnography and actigraphy) parameters. Compared with healthy controls, patients with schizophrenia exhibit longer sleep onset latency, decreased sleep efficiency, more nighttime awakenings, increased daytime dysfunction due to sleep deprivation, poorer overall sleep quality, and a higher proportion of sleep disturbances. Previous studies have suggested that poor sleep quality is associated with female gender in schizophrenic patients. This study aims to determine the difference in sleep quality of schizophrenia patients based on gender at Madani Hospital Medan, North Sumatra. This study is an analytical descriptive with a cross-sectional study approach, sampling method using a purposive sampling technique. The data of this study were obtained from primary data using questionnaire instruments and patient medical records. Data analysis using Chi-Square test. The results showed that the sleep quality of male research respondents with disturbed sleep quality was found in 18 people (51.4%), and undisturbed sleep quality was found in 17 people (48.6%). Of female research respondents, 22 people (62.9%) had disturbed sleep quality and 13 people (37.1%). The p-value was found to be 0.334 (p0.05), which means that there was no significant difference in the sleep quality of schizophrenic patients based on gender at Madani Hospital Medan, North Sumatra. There was no significant difference in the sleep quality of schizophrenic patients based on gender at Madani Hospital Medan, North Sumatra.
Access to Health Services Affects the Level of Adherence to Taking Medication for Hypertensive Patients At Puskesmas Medan Area Selatan Year 2024 dinillah, Izzah; Siregar, Pinta Pudiyanti
Buletin Farmatera Vol 9, No 2 (2024)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v9i2.21011

Abstract

Abstract: Hypertension is known as a silent disease. Compliance of patients with hypertension is essential because hypertension must always be controlled. Access to healthcare is one of the reasons for this non-compliance. This study aims to determine the influence of access to health services on the level of medication adherence of hypertensive patients in Puskesmas Medan Area Selatan. This type of research is descriptive analytics with a cross-sectional design. The research subjects used were 98 hypertension patients in Puskesmas Medan Area Selatan who met the inclusion and exclusion criteria. Sampling is based on purposive sampling and is carried out by Chi-Square Test. The results of the Chi-Square Test obtained a value of P value = 0.001 (P0.05) which means that access to health services has a significant influence on the level of medication adherence of hypertension patients in Puskesmas Medan Area Selatan. Access to health services has a significant influence on the level of medication adherence in hypertensive patients, where the easier it is to access health services, the more compliant patients will be to take medication.
The Association Between the Physical Fitness Index and the Grade Point Average in Faculty of Medicine UMSU Students Lubis, Debby Mirani; Asfur, Robitah
Buletin Farmatera Vol 6, No 1 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i1.3333

Abstract

The GPA (Grade Point Average) is the passing score for each course a student gets every semester which is currently often used as a requirement for further study students (Masters or Specialists) or applying for jobs so that the GPA is considered important to describe student intelligence during taking the educational process. Many things affect student intelligence, one of which will be discussed and proven in this study is the value of the Physical Fitness Index. This study aims to determine the relationship between the Physical Fitness Index and the GPA score of FK UMSU students. This research is an analytical study using a cross-sectional approach. The research site was conducted at the Faculty of Medicine UMSU from April to June 2020. A total of 94 subjects with male gender totaled 25 people (26.6%), women totaled 69 people (73.4%). Based on the measurement of the Physical Fitness Index which was carried out using the Harvard Step Test method, the mean value of all 2018 students was 49.57. The average GPA of all 2018 students was 3.00. Based on the results of the statistical test, the relationship between the Faculty of Medicine UMSU student body fitness index and the cumulative grade point average is p = 0.87. Therefore, it can be concluded that there is no significant association between the Faculty of Medicine UMSU student body fitness index and the grade point average.
Comparison of the Incidence of Nausea and Vomiting in the Administration of Tramadol 100 mg Suppositories with Intravenous Post-Spinal Anesthesia for Lower Extremity Surgery Putra, Adhi Setia
Buletin Farmatera Vol 6, No 1 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i1.6516

Abstract

Pendahuluan :Post operative nausea vomiting (PONV) pasca pemberian tramadolPostoperative nausea vomiting (PONV) after intravenous administration of tramadol has a high incidence rate, so it needs alternative drug administration to overcome this problem. This study aims to compare the incidence of postoperative nausea and vomiting in the intravenous administration of tramadol suppositories. A double-blind analytical experimental study, involving 36 subjects divided into tramadol suppositories and intravenous tramadol post-extremity surgery with spinal anesthesia at Haji Adam Malik Hospital and Network Hospital in 2013. The incidence of PONV in tramadol suppository subjects was much lower than in intravenous tramadol subjects.
Prevention and Control of Nosocomial Infections Through Implementation of Precaution Standards at Royal Prima Hospital Medan Pesta Ria, Anna Maria; Ginting, Chrismis Novalinda; Nasution, Sri Wahyuni
Buletin Farmatera Vol 9, No 2 (2024)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v9i2.20243

Abstract

Abstract: Nosocomial infections (Health Care-Associated Infections/HAIs) are infections that occur in sufferers, health workers, and also everyone who comes to the hospital. There are six types of nosocomial infections, namely: HAP/VAP infections, Phlebitis, urinary tract infections (UTI), surgical wound infections, primary bloodstream infections, and decubitus ulcers. Efforts to prevent nosocomial infections are carried out through the Infection Prevention and Control (IPC) program by implementing Standard Precautions in health facilities, including hospitals. One of the implementations of standard precautions is maintaining hand hygiene. This research is a type of quantitative research with a case-control design conducted at the Royal Prima Medan Hospital on IPC officers with a sample size of 50 respondents who used a questionnaire as a research instrument consisting of three types, namely: Knowledge, Attitude, and Practice adapted from the WHO Hand Hygiene Knowledge Questionnaire for Health Care Workers. Validity tests and reliability tests on the three types of questionnaires show that all questions are valid and reliable. The analysis carried out in this research included three forms, namely: univariate, bivariate and multivariate analysis, using the IBM SPSS version 29 program.
Effectiveness Test of The Use of Nigella Sativa Oil Compared with Sodium Docusate as A Therapy for Cerumen Impaction on Children at Puteri Aisyiyah Medan Orphanage in Vitro Siregar, Anandya Annisa Amri; Syahputra Nasution, Muhammad Edy
Buletin Farmatera Vol 9, No 2 (2024)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v9i2.21255

Abstract

Abstract: Introduction: Cerumen Impaction is a hearing problem that most often results in decreased hearing function and ear pain. Treatment using natural ingredients is widely practised. One of them is the use of Nigella sativa Oil. The purpose of this study was to analyze the effectiveness of using Nigella sativa Oil and sodium docusate as a treatment for impaction of cerumen in children at the Puteri Aisyiyah Orphanage in Medan City in vitro at 5,10,15and 30 minutes. This type of research was a eksperimental study in vitro which in practice uses a probability sampling technique, namely simple random sampling on existing groups. Significance value of 0.000(p 0.05).So it can be stated that the use of the Nigella Sativa Oil solution and the Docusate Sodium solution have different effectiveness, while this difference can be seen from the Mean ± Deviation Standard value in each group, where the Nigella Sativa Oil solution has a higher Mean ± Deviation Standard value (0.788 ± 0.144) compared to sodium docusate solution (0.145 ± 0.125). The conclusion is that the use of Nigella Sativa Oil has significant effectiveness for the treatment of impaction of cerumen and the use of Sodium Docusate does not have significant effectiveness for the treatment of impaction of cerumen in children.

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