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Buletin Farmatera
Published by Universitas Muhammadiyah Sumatera Utara
ISSN : 2528410X     EISSN : 2528410X     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Arjuna Subject : -
Articles 244 Documents
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The Correlation of Family Knowledge about Hypertension with Family Support for Stroke Patients at General Hospital Haji Medan Tapiheru, Jasmine Aulia Putri; Sari, Mila Trisna
Buletin Farmatera Vol 9, No 2 (2024)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v9i2.21199

Abstract

Abstract: Hypertension is called a silent killer because it does not show symptoms when high blood pressure continues for a long period so it will cause complications such as stroke. Stroke can cause disability and death so it becomes a serious problem for families and patients. Family support is an important aspect of patient treatment and can help the patient's recovery and treatment. This research aims to analyses the relationship between family knowledge about hypertension and family support in stroke patients at the General Haji HospitalMedan. This study is a descriptive study with a cross-sectional design to determine the level of knowledge about hypertension and family support in stroke patients. This study uses a bivariate test using the Spearman Rho test. The results of this research bivariate test with the Spearman Rho test showed a correlation between family knowledge of patients regarding hypertension and family support in stroke patients (r value 0.001 a = 0.05) with a correlation coefficient of 0.763. It can be concluded that family knowledge is significant and strongly with family support which indicates a relationship between family knowledge about hypertension and good family support in stroke patients at the General Haji Hospital Medan. 
Relationship Between Necrosis, Neovascularization, and Lymphocyte Reaction in Histopathological Types of Cervical Cancer Jamilah, Qurratu Kasturi; Lubis, Humairah Medina Liza
Buletin Farmatera Vol 9, No 2 (2024)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v9i2.21947

Abstract

Abstract: Cervical cancer is a malignant tumour that grows on the cervix, more than 90% of which are caused by HPV 16 and 18. lymphocytes are one of the immune systems that play a role in immunosurveillance against cancer cells. However, cervical cancer will cause necrosis and activate Hypoxia-Inducible Factor-1 (HIF-1) which plays a role in the formation of neovascularization. Based on histopathological findings, cervical cancer types are classified into squamous cell carcinoma (SCC) and adenocarcinoma (ADC). This study aimed to determine the relationship between necrosis, neovascularization, and lymphocyte reaction in various histopathological types of cervical cancer. This research is observational analysis using medical records and histopathological slides of patients diagnosed with cervical cancer. There were 26 cases of cervical cancer consisting of 16 types of SCC and 12 types of ADC. Based on the highest percentage, more necrosis was found in ADC 81.8% (p-value 0.014), neovascularization in SCC 73.3% (p-value 0.014), and lymphocyte reaction in SCC 86.7% (p-value 0.973). This means that there was a significant relationship between necrosis and lymphocyte reaction in various histopathological types of cervical cancer, however, there is no significant relationship between neovascularization in various histopathological types of cervical cancer.
Effect Of Low Doses of Acetylsalicylic Acid (ASA) On the Histopathological Features of Fibroblasts in The Amniotic Membrane Mourisa, Cut; Suryani, Des
Buletin Farmatera Vol 9, No 3 (2024)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v9i3.19907

Abstract

Abstract: Acetylsalicylic acid (ASA) is a drug with several indications such as analgesic, antipyretic, and antithrombotic/antiplatelet. ASA is efficacious as antithrombotic at low doses and used for thrombosis therapy in stroke, antiphospholipid syndrome (APS), pre-eclampsia and eclampsia. However, the administration of ASA made pharmacokinetic interactions that cause a vitamin C deficiency condition. This study aims to determine the effect of low doses of Acetylsalicylic acid (ASA) on the histopathological appearance of fibroblasts on fetal membranes. This study used a cross-sectional design using 54 paraffin membrane blocks as samples processed into histopathological preparations. The case group received low-dose ASA and the control group did not receive low-dose ASA. Histopathological preparations were observed using a microscope to see images / count the number of fibroblast cells. The results showed that there were significant differences between the number of fibroblasts in the case group and the control group with p = 0.001 or p 0.05
Molecular Mechanisms and Effectiveness of Sports On Hypertension Treatment Nasution, Sharlini Desfika; Rahmi, Rahmi
Buletin Farmatera Vol 9, No 3 (2024)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v9i3.23362

Abstract

Abstract: Hypertension is a serious global health problem. Exercise is an effective non-pharmacological intervention in the management of hypertension through several molecular mechanisms, including vascular endothelial regulation, oxidative stress modulation, and anti-inflammatory effects. This literature study aims to increase readers' knowledge about the molecular mechanism and effectiveness of exercise in the treatment of hypertension by conducting literature searches in national and international journals published in the last 5 years. The main pathological changes in hypertension are changes in the structure and function of arterial vessels, which are characterized by increased peripheral vascular resistance due to vascular remodelling. Regular aerobic exercise has been shown to increase the activity of antioxidant enzymes, including superoxide dismutase (SOD), which plays an important role in protecting cells from oxidative damage. The frequency and duration of exercise play a key role in the effectiveness of exercise programs to lower blood pressure in hypertensive patients.
Potensi Habbatussauda ( Nigella Sativa ) Terhadap Pencegahan Demensia Alzheimer Arifin, Hasanul
Buletin Farmatera Vol 9, No 3 (2024)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v9i3.23405

Abstract

Abstract: Dementia is a progressive and degenerative clinical syndrome, that affects memory, thinking ability, behaviour, emotions and personality that interfere with daily life activities. The aetiology of dementia is linked to the involvement of vascular, inflammatory, oxidative stress and neurotoxicity that causes neurodegenerative brain pathologies that can contribute to cognitive impairment and dementia. Multidomain interventions targeting multiple risk factors for effective prevention including dietary supplements from traditional plants. Nigella sativa (NS) is a traditional plant native to the Mediterranean Area and Southwest Asia that has long been used to maintain human health. Nigella Sativa has a significant content of thymoquinone (TQ) as a bioactive element of 30-48% of the total NS compounds. Several in vitro and in vivo preclinical studies and clinical trials that are still limited to non-dementia humans show that TQ has a positive effect on cognitive impairment through oxidative stress control mechanisms, vascular health, anti-inflammatory, maintenance of nerve cell integrity and improvement of neurotrophic regulatory factors which are promising in preventing cognitive decline. Nigella sativa serves as a potential dietary supplement to prevent the progression of Alzheimer's disease but requires long-term investigation and follow-up research to test safety and toxicity and compare its effectiveness at different stages of dementia such as Alzheimer's disease.
Prevalence of Allergies Due to Paracetamol Use in Children: A Literature Study Hariaji, Ilham
Buletin Farmatera Vol 9, No 3 (2024)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v9i3.23436

Abstract

Abstract: Paracetamol is an antipyretic and analgesic drug that is often used to relieve fever and pain in children. Although considered safe, the use of paracetamol in children can cause allergic reactions. This study aims to assess the prevalence of allergies due to the use of paracetamol in children. This Literature Review identifies and analyzes articles published in the last five years, using databases such as PubMed, Scopus, and Google Scholar. The included studies were studies with cohort, cross-sectional, and case-control designs that assessed the association between paracetamol use and allergic reactions in children. Of the 23 articles that met the inclusion criteria, it was found that the prevalence of allergies due to paracetamol use in children varied between 0.1% and 6.5%. Some of the factors that play a role in increasing the risk of allergies are the history of allergies in the family and the influence of environmental factors. In addition, frequently reported types of allergies include urticaria, eczema, and anaphylactic reactions. The results of this review suggest that although the prevalence of paracetamol allergy in children is relatively low, special attention is still needed, especially in children with a history of allergies or certain medical conditions. Proper management and further understanding of the pathogenesis of paracetamol allergy in children need to be done. Allergies due to paracetamol use in children, although rare, should remain a medical concern. Further research is needed to identify clearer risk factors and to develop guidelines for the use of paracetamol in children who have allergic predispositions.
The Relationship between the Intensity of Tahajud Prayer and the Stress Level of Grade IX Students of Istiqomah Sambas Sambas Boarding School Purbalingga Novitri, Ersa Agriana; Fuad, Wijayanti; Basuki, Rochman
Buletin Farmatera Vol 10, No 1 (2025)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v10i1.23713

Abstract

Abstract: Stress can affect mental states in adolescents, especially students. Stress in Purbalingga Regency has a prevalence of 62.5%. This condition can be affected by a variety of factors. Islam provides one of the solutions to relieve stress, namely by getting closer to Allah, one of which is by performing tahajud prayers. Most studies have looked more at stress in college students than in college students. This study aims to analyze the relationship between the intensity of tahajud prayer and the stress level of grade IX students of Istiqomah Sambas Boarding School Purbalingga. The method used was observational analytics with a cross-sectional approach. The technique in the study was a total sampling with a total of 118 respondents and 92 respondents were included in the inclusion and exclusion criteria. The intensity of tahajud prayer was measured by a questionnaire on the intensity of tahajud prayer and the level of stress with a DASS scale of 42. Relationship analysis using the Spearman rank test. The intensity of tahajud prayer was mostly included in the good category, which was 36 students (39.1%) and the stress level of the majority of students was included in the normal category, which was 30 students (32.6%). The Spearman rank test showed a p-value of 0.000 and a correlation coefficient value of -0.743. There is a significant relationship between the intensity of tahajud prayer and the level of stress with the direction of a negative correlation, which means that the higher the intensity of tahajud prayer, the lower the student's stress level. 
Vitamin C Consumption Affects the Treatment Period of Covid-19 Patients at Dr. Pirngadi Regional General Hospital Mahardika, Virani; Syafina, Ikhfana; Hapsah, Hapsah; Arbaningsih, Sri Rezeki
Buletin Farmatera Vol 10, No 1 (2025)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v10i1.23946

Abstract

Abstract: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) or what we now know as Coronavirus disease (COVID-19) is a viral infection that has hit the world in the last three years. The management of patients confirmed with COVID-19 continues to be researched. Vitamin C is one of the therapies that can be given to COVID-19 patients from mild to severe or critical degrees. Vitamin C is an antioxidant whose function can reduce oxidative inflammation and greatly affect the human immune system. The dose of vitamin C administration in COVID-19 patients can be given up to high doses. Due to the protective properties of vitamin C, it can affect the treatment period of COVID-19 patients. This study aims to determine the relationship between vitamin C consumption and the length of treatment of COVID-19 patients at DR Pirngadi General Hospital. This study is an observational analytical study with a cross-sectional design. A total of 66 samples were obtained divided into low and high doses of vitamin C which were then analyzed using Chi Square. The results of the study found that there was a significant result (P=0.039) in the relationship between vitamin C consumption and the treatment period of COVID-19 patients. Vitamin C consumption affects the treatment period. 
The Relationship Between Service Quality and Patients' Revisit Interest at Beutong Public Health Centre, Beutong Subdistrict, Nagan Raya District Susanti, Lia; Hasnur, Hanifah; Akbar, Fahrisal
Buletin Farmatera Vol 10, No 1 (2025)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v10i1.22766

Abstract

Abstract: The significant decline in the number of patient visits at Beutong Public Health Centre, Beutong Subdistrict, Nagan Raya District, which reached 73% between 2021 and 2022, serves as a critical backdrop for this study. This research aims to analyse the factors influencing healthcare service quality and patients' revisit interest by focusing on five key service dimensions: reliability, responsiveness, assurance, empathy, and tangibles. The study is descriptive-analytical and was conducted at the Beutong Public Health Centre from March to April 2024. The sample consisted of 100 respondents selected using purposive sampling based on inclusion criteria. Data were collected through questionnaires and secondary data from the health centre and analysed using SPSS version 24. The results showed that all five dimensions of healthcare service—reliability, responsiveness, assurance, empathy, and tangibles—influence patients' revisit interest. Specifically, the assurance variable had the most significant impact, with 77% of respondents indicating positive revisit interest. Reliability influenced 69% of respondents, empathy 68%, tangibles 63%, and responsiveness 53%. However, statistical analysis revealed that only assurance had a statistically significant effect (p 0.05), while reliability, responsiveness, empathy, and tangibles did not show significant influence (p 0.05). Based on these findings, it is recommended that Beutong Public Health Centre improve healthcare service quality by focusing on enhancing staff reliability through regular training, strengthening responsive communication channels to address patient complaints, improving staff credibility and professionalism through certification and continuous training, and upgrading the physical facilities of the health centre. 
Hubungan Kecukupan Kalori dan Protein dengan Status Malnutrisi pada Pasien Hemodialisis di Klinik Ginjal Lestari Semarang Khairunnisa, Khalifia; Widiasih, Esti; Rohmani, Afiana; Riani, Risky Ika
Buletin Farmatera Vol 10, No 2 (2025)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v10i2.24544

Abstract

Abstract: Hemodialysis patients have several side effects from treatment, including possible malnutrition due to their decreased nutritional status.  Malnutrition in hemodialysis patients can occur due to increased protein catabolism, loss of nutrients during the dialysis process, and impaired food intake due to anorexia, nausea, and vomiting. The purpose of this study was to determine the relationship between calorie and protein adequacy and malnutrition status in hemodialysis patients at the Lestari Kidney Clinic Semarang. This study uses a quantitative design of observational analytics with a cross-sectional approach. The research sample of 47 hemodialysis patients at the Lestari Kidney Clinic Semarang in 2025 was selected using a purposive sampling method that met the inclusion and exclusion criteria. Calorie and protein adequacy measurements were carried out using the 3x24-hour food recall method, while malnutrition status was assessed using the Dialysis Malnutrition Score (DMS). Data analysis was carried out with the Spearman Rank test to see the relationship between calorie and protein adequacy and malnutrition status. The analysis showed a significant relationship between calorie adequacy and malnutrition status (p = 0.034, r = -0.310) and protein adequacy with malnutrition status (p = 0.020, r = -0.338). The association showed a negative correlation with weak correlation strength, meaning the higher the calorie and protein adequacy, the lower the patient's malnutrition score. There was a relationship between calorie and protein adequacy and malnutrition status in hemodialysis patients at the Lestari Kidney Clinic.

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