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INDONESIA
Akta Kimia Indonesia
Published by Institut Teknologi Sepuluh Nopember Surabaya
ISSN : 18584586     EISSN : 25493736     DOI : -
Core Subject : Science,
Chemistry
Akta Kimia Indoneisa publishes peer-reviewed open access articles in all areas of chemistry, including: Analytical Chemistry Physical Chemistry Organic Chemistry Inorganic Chemistry Biological Chemistry To submit an article, you need to register first. Please click register in the menus above.
Arjuna Subject : -
Articles 6 Documents
 1 
Search results for , issue "Vol 9, No 1 (2024)" : 6 Documents clear
Antiinflamasi Ekstrak Daun Trembesi (Samanea saman (Jacq.)Merr.) Terhadap Ekspresi Enzim Siklooksigenase-2 (COX-2) Sa'adah, Nikmatus; Lukis, Prima Agusti; Asri, Arilis Larasati Ode; Istiati, Istiati; Asmarani, Yolanda Kartika; Moelok, Iqbal Moch; Adriansyah, Agus Aan; Setianto, Budhi
Akta Kimia Indonesia Vol 9, No 1 (2024)
Publisher : LPPM, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j25493736.v9i1.20950

Abstract

Background: The cyclooxygenase-2 (COX-2) enzyme is the main source of prostanoids in inflammation and has various effects on nerve endings, blood vessels, and cells involved in inflammation. Trembesi leaves (Samanea summons (Jacq.) Merr.) are one of the herbal plants that have anti-inflammatory properties because it contains steroid compounds with high antioxidant capacity, active compounds of flavonoids, and tannins. With antioxidant activity and high flavonoid, trembesi leaf extract can act as an anti-inflammatory and influence the COX-2 enzymes and can cause pro-inflammatory effects. Objective : To discover the effect of trembesi leaf extract as an anti-inflammatory on COX-2 enzyme levels. Laboratory experimental method live with 30 (Rattus norvegicus) with 3 sample groups: the negative control group was CMC NA, and the treatment group was given trembesi leaf extract 100 mg/KgBW and a dose of 200 mg/KgBW. COX-2 expression was examined using the immunohistochemical staining method. Then do data analysis with normality test, homogeneity test, test Kruskal-Wallis, and test Mann Whitney. Results : Trembesi leaf extract at a dose of 100 mg/KgBW with a concentration of 12% had the effect of inhibiting COX-2 enzyme expression compared to the negative control group and the extract group at a dose of 200 mg/KgBW at a concentration of 12%. Conclusion : Trembesi leaf extract has an effect on reducing inflammation of the cyclooxygenase-2 (COX-2) enzyme.
Kualitas Asap Cair Kayu Pelawan dan Tempurung Kelapa dengan Pemurnian Destilasi Sederhana Mariyamah, Mariyamah; Wijayanti, Fitria; Oktasari, Ade
Akta Kimia Indonesia Vol 9, No 1 (2024)
Publisher : LPPM, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j25493736.v9i1.15066

Abstract

Pelawan is a unique tree because all parts of its body, starting from the roots and stems to the tips of the branches, are red. Pelawan wood which is used by the community as firewood turns out to produce a liquid which is believed to be used for health. On the other hand, coconut shells are very abundant and are only used as charcoal. Pelawan wood and coconut shells are processed through pyrolysis at 450 °C to produce liquid smoke. The liquid smoke that has been obtained is subjected to a purification process. This study compares the quality of liquid smoke to SNI 8985:2021 and Japanese standards. The results show that the yield of liquid smoke from pelawan wood is 35% and coconut shell is 56.67%. Following the analysis of the chemical content of coconut shell liquid smoke, it has a bright yellow colour, no floating material, pH 3, specific gravity 1.0090 gr/cm3, 5.562% acid content and 0.014% phenolic content. Meanwhile, the chemical content of Pelawan Wood liquid smoke has colour, no floating matter, pH 2, specific gravity of 1.0096 gr/cm3, an acid content of 4.586% and a phenol content of 0.013%. The results of the analysis of the chemical content of the resulting liquid smoke meet SNI and Japanese standards.
Crystal Growth Study of CoZnPO-HEX (CZP) Synthesised using Solvent-Free Method and Its Crystal Growth Simulation Farida, Nani; Ningtyas, Anggraini Widya; Pertiwi, Elva Oktavianti; Wijaya, Husni Wahyu; Danar, Danar; Sari, Meyga Evi Ferama
Akta Kimia Indonesia Vol 9, No 1 (2024)
Publisher : LPPM, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j25493736.v9i1.20989

Abstract

Zinco-phosphate having CZP structure (CoZnPO-HEX) has a potential as a catalyst in Knoevenagel condensation of benzaldehyde with activated methylenic compounds or the Michael addition of nitroethane to olefin. The potency is led by the physicochemical properties of the material, which depend on its crystal habits. Understanding the crystal growth of materials is important to be able to design and control their crystal habits.  Therefore, the crystal growth study of CoZnPO-HEX is crucial for its crystal habit modification as well as for optimization and expansion of the material’s functions. Several parameters of crystal growth, such as nucleation time, gel supersaturation, and crystal size changes during the synthesis process can be analysed by observing the material’s crystallisation profile. In this study, crystallisation analysis was performed on CoZnPO-HEX, synthesised using solvent-free method, from its crystallinity curve based on Powder-XRD data supported by SEM data. As a comparison, crystal growth simulation was performed using CrystalGrower program to determine the morphology, surface topography, and theoretical crystal growth mechanisms. From this study, we found that the nucleation time of the CoZnPO-HEX crystals prepared using a solvent-free method took place during the precursor grinding process at room temperature. The crystal morphology of the as-prepared materials agrees well with the simulation’s one. Moreover, the CrystalGrower simulation proved that the smallest t-czp-1 tile started the nucleation on the crystal surface because of its low free energy.
Analisis Fitokimia Dan Uji Aktivitas Antioksidan Ekstrak Pelarut Kulit Batang Tumbuhan “At Anonse” (Annona reticulata L.) Obenu, Noviana Mery; Bria, Emilia Juliyanti; Kolo, Maria Magdalena; Mere, Jenrigo Klaumegio; Tse, Anastasia
Akta Kimia Indonesia Vol 9, No 1 (2024)
Publisher : LPPM, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j25493736.v9i1.17399

Abstract

Antioksidan adalah senyawa yang berfungsi untuk melawan radikal bebas dan melindungi sel dari efek toksik yang dihasilkan. Sumber antioksidan dapat berasal dari dalam dan luar tubuh. Antioksidan yang berasal dari luar tubuh dapat diperoleh dari tanaman yang mengandung senyawa metabolit sekunder seperti senyawa fenolik, flavonoid, alkaloid, tanin, steroid dan terpenoid. Berdasarkan hasil eksplorasi dan identifikasi tumbuhan Annona reticulata L. juga dimanfaatkan sebagai tumbuhan obat. Penelitian ini dilakukan dengan tujuan untuk mengetahui senyawa metabolit sekunder dalam ekstrak tumbuhan dan aktivitas antioksidannya. Ekstraksi dilakukan dengan metode maserasi menggunakan pelarut etil asetat dan metanol sedangkan uji aktivitas antioksidan di lakukan dengan metode DPPH (1,1-difenil-2-pikrilhidrazil). Hasil analisis fitokimia menunjukkan bahwa golongan senyawa yang terkandung dalam ekstrak etil asetat dan metanol adalah golongan triterpenoid, tanin, saponin, fenolik, flavonoid, dan alkaloid. Aktivitas antiosidan kedua ekstrak pelarut tersebut tergolong dalam kategori sedang dengan nilai IC50 ekstrak etil asetat sebesar 177,1325 μg/mL dan metanol sebesar 235,4198 μg/mL.
PRODUKSI PIGMEN JINGGA Penicillium sp. LBKURCC27 PADA MEDIA CAIR DENGAN VARIASI pH DAN SUMBER NITROGEN, SERTA POTENSINYA SEBAGAI PEWARNA TEKSTIL Gaol, Fuji Randa Lumban; Ramadhan, Gilang; Sakinah, Alifia Andra; Fitri, Nur Annisa; Gurning, Esther Angelita; Nugroho, Titania Tjandrawati
Akta Kimia Indonesia Vol 9, No 1 (2024)
Publisher : LPPM, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j25493736.v9i1.20626

Abstract

Penggunaan pigmen warna sintetis yang marak di industri tekstil, dikhawatirkan akan menimbulkan dampak lingkungan selama produksi maupun pengaplikasiannya. Limbah yang dihasilkan dari pigmen warna sintesis sulit didegradasi dan cenderung bersifat karsinogenik. Pigmen warna alami yang dihasilkan jamur Penicillium dapat menjadi solusi alternatif untuk mengatasi dampak lingkungan yang dihasilkan dari penggunaan pigmen warna sintesis tersebut. Penelitian ini bertujuan untuk menggali potensi isolat lokal Penicillium sp. LBKURCC27 sebagai sumber pigmen warna jingga alami dengan variasi pH media dan sumber nitrogennya. Penelitian dilakukan dengan memproduksi pigmen menggunakan isolat lokal Penicillium sp. LBKURCC27 pada media PDB dengan variasi pH (pH 4,5 hingga 7,5) dan variasi sumber nitrogennya (urea, tepung kedelai dan ekstrak ragi) pada suasana gelap dan statis selama 40 hari.  Hasil penelitian menunjukkan bahwa media produksi pada pH 5,5 menghasilkan jumlah pigmen yang secara signifikan (p<0,05) lebih tinggi dibandingkan dengan pH lainnya. Sumber Nitrogen berupa urea akan menghasilkan jumlah pigmen yang secara signifikan (p<0,05) lebih tinggi bila dibandingkan dengan sumber nitrogen berupa ekstrak ragi dan tepung kedelai. Hasil ekstraksi diuji menggunakan spektrofotometri UV-Vis untuk mengetahui panjang gelombang optimumnya sehingga diperoleh panjang gelombang 511 nm sebagai panjang gelombang optimum. Uji pewarnaan dilakukan dengan metode mordanting menggunakan mordant besi sulfat dan tawas yang menghasilkan kain berwarna coklat hingga jingga. Analisis kolorimetri juga dilakukan pada kain yang telah diwarnai sehingga diperoleh koordinat kromatis primer berupa RGB. Hasil pewarnaan kain dengan mordant besi sulfat memiliki warna yang lebih merata. Kain sutra memiliki warna yang lebih gelap dan lebih merata dibandingkan pewarnaan pada kain katun.
PENGARUH JENIS PELARUT TERHADAP KADAR SENYAWA METABOLIT SEKUNDER DAN AKTIVITAS ANTIOKSIDAN EKSTRAK KULIT BATANG LINO (Grewia koordersiana Burret) Pote, Lodowik Landi; Taek, Maximus M; Nadut, Anggelinus; Latumakulita, Gertreda
Akta Kimia Indonesia Vol 9, No 1 (2024)
Publisher : LPPM, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j25493736.v9i1.20177

Abstract

Abstract: The process of extracting secondary metabolite compounds from plants through extraction. One of factor that influences the success of extraction is the type of solvent used. This study aims to determine the effect of solvent type on the contents of secondary metabolite compounds and the antioxidant activity of Lino (G. koordersiana Burret) bark extract. This research began with taking lino bark samples, extraction, phytochemical screening, content analysis and antioxidant activity tests. The research results showed that the yields for ethanol, methanol, ethyl acetate and n-hexane extracts were 42.15%, 41.65%, 0.98% and 0.62%, respectively. The phytochemical test results of ethanol and methanol extracts contain alkaloids, flavonoids, phenolics, triterpenoids, saponins and tannins. Meanwhile, ethyl acetate extract contains phenolics, triterpenoids and tannins and n-hexane extract contains triterpenoids. The results of analysis of secondary metabolite on the contents for ethanol, methanol, ethyl acetate and n-hexane extracts showed different results. Antioxidant activity test results for each ethanol, methanol, ethyl acetate and n-hexane extract with different IC50 values. Antioxidant activity of ethanol, methanol and ethyl acetate extracts has antioxidant activity in the very strong category. Meanwhile, n-hexane extract has antioxidant activity in the inactive category. The results showed that the type of solvent affected the levels and antioxidant activity of secondary metabolite compounds from Lino (G. koordersiana Burret) extract.

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