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JSFK (Jurnal Sains Farmasi & Klinis)

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Published by Universitas Andalas

ISSN : 24077062 EISSN : 24425435 DOI : 10.25077

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Jurnal Sains Farmasi & Klinis (J Sains Farm Klin) adalah jurnal ilmiah di bidang kefarmasian yang diterbitkan oleh Fakultas Farmasi Universitas Andalas bekerjasama dengan lembaga profesi "Ikatan Apoteker Indonesia" (IAI) daerah Sumatera Barat sejak tahun 2014.

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Articles 509 Documents

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Kajian Toksisitas Serbuk Biji Mahoni terhadap Perkembangan Tingkah Laku, Histologi Hati serta Hematologi Anak Mencit Hilmarni Hilmarni; Almahdy Almahdy; Helmi Arifin
Jurnal Sains Farmasi & Klinis Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015
Publisher : Fakultas Farmasi Universitas Andalas

This study aims to determine the effect of seed powder mahogany (Swietenia macrophylla King) on the development of behavior, liver histology and hematology of pups mice. Experimental animals used were 45 female mice were divided randomly into 5 groups. Group 1 as a control group. Groups 2, 3, 4, and 5, respectively mahogany seed powder given at a dose of 5, 10, 15, and 20 mg/20g/day from fetal life until lactation is completed. Developmental toxicity test carried out by behavioral test battery, observation of histology and hematology profile. The results showed that the provision of mahogany seed powder causes abnormal in the conduct reflex test and motor test on post natal day of 8 and 10, as well as the vision test on post natal day of 14-18. While the observation of liver histology and hematology profile did not show any effect.

Audit Secara Prospektif terhadap Antimicrobial Stewardship Program pada Pasien Kanker Payudara di RSUP Dr. M. Djamil Padang Yelly Oktavia Sari; Rustini Rustini; Diva Diana; Telsa Dwiana Hapsari
Jurnal Sains Farmasi & Klinis Vol 4, No 1 (2017): J Sains Farm Klin 4(1), November 2017
Publisher : Fakultas Farmasi Universitas Andalas

Surgery has been used as part of the treatment of breast cancer, but surgery has a potential risk of infection due to the effect of normal flora on the body and air in the ward environment. The decrease of antibiotics effectiveness is caused by bacterial resistance to antibiotics. The purpose of this study was to find out the pattern of bacteria, antibiotic sensitivity patterns and patterns of antibiotic use among breast cancer patients in the surgery ward Hospital M. Djamil Padang. An observational prospective study design was performed in this study, whereby data was collected from the medical records of patients admitted to the surgery wards of Hospital Dr. M. Djamil Padang from April – September 2017. Results showed the bacterial identification in patients were Staphylococcus aureus and Klebsiella sp. while from the air were found Staphylococcus aureus, Staphylococcus epidermidis and Klebsiella sp. Based on the sensitivity pattern on surgical wounds during April-May 2017 reported amoxicillin/ clavulanic acid and meropenem were good (>80%) while on August-September 2017 was meropenem. Airborne sensitivity patterns result during April-May 2017 were not found, while on August-September 2017 gentamicin, ciprofloxacin and meropenem were good (>80%). Among 32 patients admitted during study period only 7 patients who fulfilled the inclusion criteria. The most common antibiotic used was ceftriaxone 7 (77,8%). The evaluation of the rationale use of antibiotics were 6 (66.7%) appropriate medication, 9 (100%) appropriate dosage, 7 (77.8%) appropriate time duration, 9 (100%) appropriate route, 7 (100%) appropriate patient, 4 (45,1%) appropriate indication and potentially drug interaction 1 (14,28%) as a minor potency.

Evaluasi Pengelolaan Obat pada Puskesmas di Kota Pariaman Syukriati Chaira; Erizal Zaini; Trisfa Augia
Jurnal Sains Farmasi & Klinis Vol 3, No 1 (2016): J Sains Farm Klin 3(1), November 2016
Publisher : Fakultas Farmasi Universitas Andalas

Drug Management at health centers need to be well, because exellent drugs management will ensure the continuity of availability and affordability of drugs that are efficient, effective and rational. This study aims to determine drugs management at seven community health centers in Pariaman, based indicators of drugs management stipulated by Ministry Health of Republic Indonesia. This research is descriptive-evaluative, with quantitative and qualitative methods, using retrospective data in 2013 and 2014. The results showed that suitability of drug provided by DOEN 64.70%-73.51%, accuracy of drug demand, 2:28%-24.47%, accuracy of drug distribution 4.66% -35.59%, percentage of drugs that are not prescribed, 5:00%-23.49%, percentage of prescribing generic drugs 97.27% -100%, percentage differences in recording of stock card with amount of physical drugs, 0.00%-13.13%, it can be concluded that drugs management at health centers in Pariaman is not good, because it is not accordance with established standards.

Penggunaan Obat Off-Label pada Anak di Apotek Kota Yogyakarta Ndaru Setyaningrum; Viara Gredynadita; Suci Gartina
Jurnal Sains Farmasi & Klinis Vol 4, No 1 (2017): J Sains Farm Klin 4(1), November 2017
Publisher : Fakultas Farmasi Universitas Andalas

Populasi anak sangat berisiko mendapatkan peresepan obat off-label disebabkan kekhususan kondisinya. Penelitian ini dilakukan untuk mengetahui bagaimana prevalensi penggunaan obat off-label pada anak di apotek kota Yogyakarta. Penelitian dilakukan secara retrospektif dengan pengambilan data berdasarkan rekam medis anak tahun 2014 – 2015. Subjek penelitian merupakan anak dengan batasan usia di bawah 12 tahun. Total peresepan anak selama periode penelitian sebanyak 828 rekam medis diantaranya sejumlah 268 peresepan memenuhi kriteria inklusi dengan kelengkapan data diagnosa pada catatan medis pasien. Total penggunaan obat dari 268 peresepan adalah 816 obat dengan 76 jenis obat. Berdasarkan review dari 268 peresepan, ditemukan sejumlah 57 (21%) peresepan off-label. Prevalensi penggunaan obat off-label diklasifikasikan sebagai off-label usia sejumlah 91 (11,1%) penggunaan, off-label indikasi sejumlah 7 (0,8%), dan tidak ditemukan off-label obat kategori dosis, rute pemberian dan kontraindikasi. Jenis obat paling dominan digunakan secara off-label antara lain pseudoefedrin sejumlah 47(5,7%), tripolidin 20 (2,4%) dan dekstrometorfan 14 (1,7%) dari total penggunaan obat. Berdasarkan hasil penelitian ini diketahui bahwa penggunaan obat off-label pada anak cukup tinggi (21%) sehingga pengawasan terkait risiko penggunaan obat perlu dilakukan.

Kesesuaian Dosis Vankomisin pada Pasien Penyakit Ginjal Kronik Stadium 3 dan 4 di Bangsal Penyakit Dalam RSUP Dr. M. Djamil Padang Muslim Suardi; Marissa Sofjan; Raveinal Raveinal
Jurnal Sains Farmasi & Klinis Vol 3, No 1 (2016): J Sains Farm Klin 3(1), November 2016
Publisher : Fakultas Farmasi Universitas Andalas

Vancomycin is a glycopeptide antibiotic which almost completely eliminated by renal unchanged in the urine (> 90%). Elimination of vancomycin is delayed in patients with renal insufficiency. The purposes of the research were to examine dosing adjustment and quantity individualized dose of vancomycin in patients with chronic kidney disease in Internal Ward of Dr. M. Djamil Padang Hospital based on pharmacokinetics dosing method. The study was designed by observational retrospective method conducted on patient’s medical record during January 2015 – March 2016. A number of 21 patients were treated using vancomycin with chronic kidney disease stage 3 and 4. Results showed that 19.05% patients received exceed dose based on pharmacokinetic dosing method calculation. Clearance of vancomycin in patients with chronic kidney disease on stage of 3 and 4 were 1.88 ± 0.28 and 0.88 ± 0.21L/h, respectively. The elimination half-life prolonged to patients with chronic kidney disease stage 3 and 4 were 14.11 ± 2.89 and 24.48 ± 5.44, respectively. While accumulation factor in patients with chronic kidney disease on stage of 3 and 4 were 0.50 ± 0.1 and 0.67 ± 0.09, respectively.

Pembuatan Dan Evaluasi Pati Talas (Colocasia esculenta Schoot) Termodifikasi dengan Bakteri Asam Laktat (Lactobacillus sp) Wira Noviana Suhery; Deni Anggraini; Novtafia Endri
Jurnal Sains Farmasi & Klinis Vol 1, No 2 (2015): J Sains Farm Klin 1(2), Mei 2015
Publisher : Fakultas Farmasi Universitas Andalas

Production and evaluation of modified taro (Colocasia esculenta Schott) starch by lactic acid bacteria (Lactobacillus sp) has been done. The purpose of this study was to observe the effect of lactic acid bacteria to the yield of taro starch and to evaluate physicochemical of starch. The evaluation which includes organoleptic, moisture content, pH, angle of repose, swelling power, gelatination temperature, amylose content, and examination of the surface shape of starch granules using SEM (Scanning Electron Microscope). The result showed that modified taro starch yield higher (19,12%) than native taro starch (11,79%). Modified taro starch of organoleptic examination showed better results where the smell was slighly reduced and the colour was white. Meanwhile, from the results of the evaluation of swelling power, gelatination temperature, and amylose content showed an increase. In addition, the modified taro starch granule were rougher due to some holes presented distinctively.

Pengaruh Kualitas Pelayanan dan Kepuasan Pasien Peserta BPJS Kesehatan sebagai Mediasi terhadap Loyalitas Pasien Rosiana Rizal; Muslim Suardi; Yulihasri Yulihasri
Jurnal Sains Farmasi & Klinis Vol 3, No 2 (2017): J Sains Farm Klin 3(2), Mei 2017
Publisher : Fakultas Farmasi Universitas Andalas

The formation of a positive perception of the patient is expected to bring satisfaction in pharmaceutical services, especially drug information services to improve patients’ loyalty to health care services they have used. The design of this research is probability sampling, with a population of patients in public hospitals in Padang city: Dr. M. Djamil Hospital; Dr. Rasidin Hospital; and Dr. Reksodiwiryo Hospital Padang who have used the service of National Health Insurance (BPJS) from January to June 2014. The sampling technique was simple random sampling (105 patients) by using a questionnaire. Data analysis was performed using Cronbach’s alpha analysis, Multiple Regression, R Square, t-test and path analysis. The results of this study indicated that the service quality affected patients’ satisfaction in the dimensions of responsiveness, assurance and direct evidence (p <0.05); toward the loyalty of patients in the direct evidence dimension (p<0.05); and towards patients’ loyalty mediated by patients’ satisfaction in the dimension of direct evidence (p <0.05).

Studi Sistem Dispersi Padat Klaritromisin – Eudragit L100 Yuska Noviyanty; Elfi Sahlan Ben; Erizal Zaini
Jurnal Sains Farmasi & Klinis Vol 2, No 2 (2016): J Sains Farm Klin 2(2), Mei 2016
Publisher : Fakultas Farmasi Universitas Andalas

Solid dispersion made with the weight ratio (b/b) using the dissolving method. DTA analysis of the solid dispersion obtained in Eudragit L 100 affects the position and sharpness of the peak. X-ray diffraction analysis showed that of clarithromycin - Eudragit L 100 is in amorphous form and did not produce a new crystalline phase. SEM analysis showed that crystalline of Eudragit L 100 is smaller (amorphous) and stick to the surface of the clarithromycin crystal. IR spectrophotometer analysis showed that there is no chemical interaction between clarithromycin and Eudragit L 100. Clarithromycin assay was done by HPLC method, using mobile phase methanol and 0.067 M KH2PO4 (13:7) plus fospat acid pH 4.0. The dissolution profile by the time of 60 minutes are clarithromycin 45.73%, CF (1:1) 49.86%, DP (1:1) 51.53%, DP (2:1) 55.87% and DP (1:2) 58.97% respectively. Solid dispersion 1:2 (w/w) have an increased dissolution rate compared to clarithromycin.

Studi Awal Sediaan Gel Ekstrak Etanol Kayu Angin (Usnea Sp) untuk Penyembuhan Luka Bakar Lili Fitriani; Fauzi Saputra; Melisa Melisa; Erizal Zaini
Jurnal Sains Farmasi & Klinis Vol 5, No 2 (2018): J Sains Farm Klin 5(2), Agustus 2018
Publisher : Fakultas Farmasi Universitas Andalas

Telah dilakukan studi awal formulasi dari ekstrak etanol kayu angin (Usnea sp) dalam bentuk sediaan gel dan uji efektivitas sediaan gel terhadap penyembuhan luka bakar pada mencit. Sediaan gel dibuat menggunakan hidroksipropil metilselulosa (HPMC) sebagai gelling agent. Gel dibuat dalam dua formula yaitu tanpa mengunakan ekstrak etanol Usnea sp (F1) dan mengunakan ekstrak etanol Usnea sp sebanyak 1% (F2). Evaluasi gel berupa organoleptis, homogenitas, pemeriksaan pH, uji daya sebar dan iritasi kulit. Uji aktivitas luka bakar dilakukan pada tiga kelompok hewan uji dimana masing-masing kelompok terdiri dari lima ekor mencit. Hasil penelitian menunjukkan bahwa ekstrak etanol kayu angin dapat dijadikan sebagai gel. Uji organoleptis gel ekstrak etanol kayu angin menunjukkan gel homogen dengan pH 5 - 5,5 dandaya sebar 5,6 – 6 cm2. Uji iritasi pada kulit menunjukkan hasil tidak terjadi iritasi pada kulit. Hasil uji aktivitas penyembuhan luka bakar menunjukkan bahwa kelompok hewan uji yang diberikan sediaan gel yang mengandung ekstrak etanol Usnea sp mampu menyembuhkan luka bakar lebih cepat dibandingkan dengan kelompok hewan uji yang diberikan sediaan gel tanpa ekstrak dan kelompok hewan uji tanpa perlakuan (kontrol). Hasil studi awal ini menunjukkan bahwa ekstak etanol Usnea sp dapat dibuat dalam bentuk gel dan dapat mempercepat proses penyembuhan luka bakar.

Pengaruh Dispersi Padat Irbesartan-Poloxamer 188 Terhadap Tekanan Darah dan Kadar Nitric Oxide (NO) Pada Tikus Putih Jantan Hipertensi Fifi Harmely; Ellyza Nasrul; Salman Umar; Erizal Zaini; Yufri Aldi
Jurnal Sains Farmasi & Klinis Vol 5, No 2 (2018): J Sains Farm Klin 5(2), Agustus 2018
Publisher : Fakultas Farmasi Universitas Andalas

A research on formulation of edible film from basil leaves extract as mouth freshener has been done. The extract of basil leaves were used in various concentrations which are 2.5%, 5% and 7.5%. The products were evaluated for some parameters such as organoleptic, friability, drying shrinkage, pH, thickness, flavonoid contents and respondents preference. The results of evaluation showed that edible filmsfrom basil leaves extract meet requirements as required by Standard Nasional Indonesia (SNI) and have such quality as product in the market. Statistical analysis using Kruskal Wallis test showed that respondents preferred for the F0 formulation in term of their appearance and taste while as mouth freshener, respondents preferred the F3 formulation.

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

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Contact Name Yori Yuliandra

Contact Email yoriyuliandra@gmail.com

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Journal Mail Official jsfkonline@gmail.com

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Location Kota padang, Sumatera barat INDONESIA

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Abstract

Contact Name
Yori Yuliandra

Contact Email
yoriyuliandra@gmail.com

Phone
-

Journal Mail Official
jsfkonline@gmail.com

Editorial Address
-

Location
Kota padang,

Sumatera barat

INDONESIA