Garuda - Garba Rujukan Digital

All

MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan

APKKM
Website

Published by Universitas Muhammadiyah Semarang

ISSN : 24070505 EISSN : - DOI : https://doi.org/10.26714/magnamed

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Magna Medica is a medical journal of APKKM contains papers and scientific articles created as a form of realization Tridharma college. The journal is published every six months, April and October of three articles in the form of: - Research article - Case report - Literature review The scope of this journal is all the field of medicine such as: -Internal medicine (including Pulmonary medicine and cardiovascular medicine) -Surgery (including urology, orthopaedic and traumatologic, plastic surgery, neurosurgery) -Anesthesia and Emergency Medicine -Neurology -Dermatology -Obstetric and Gynecologic -Forensic and Medicolegal -Clinical Pathology -Anatomical Pathology -Psychiatric -Ophthalmology -Otolaryngology -Pediatric -Radiology -Microbiology and parasitology -Basic Science of Medicine (including biochemistry, physiology, anatomy and Histology) -Public health and Health Management

Arjuna Subject : Kedokteran - Review dan Referensi, Kedokteran

Articles 222 Documents

5 6 7 8 9

Determinan Biologi Maternal Dan Sosial Ekonomi Apakah Yang Berhubungan Dengan Persalinan Tindakan SC Pada Ibu Bersalin Di RSU Wiradadi Husada Riyanto, Refni
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 2 (2015): February
Publisher : Universitas Muhammadiyah Semarang

Maternal Biological And Socio-Economic Determinants Are Associated With Delivery of SC Actions in Maternal Maternity at Wiradadi Husada General Hospital Background: Prevalence of maternal mortality in Indonesia on 2010 was 228/100.000 live births. Childbirth complication was a risk factor of prevalence of maternal mortality. Number of childbirth complication was estimated 31%. Theincidence of complications of childbirth labor requires action to improve maternal morbidity . However , delivery to the action has the risk of maternal morbidity and mortality is higher than the persalianan without action or normal delivery . The high number of deliveries through the action section is Cesaria ( SC ) in Wiradadi Husada Hospital due to several factors including maternal factors biological and socio-economic factors that accompany the birth mothers. Objective: The objective of the study to identified determinant of maternal biology ang economic social whether related to childbirth sectio caesarea action on women giving birth in public hospitals Wiradadi Husada Method: The study was an analitic observational study using case control design. The population of the study was 144 subjects, consists of two groups, namely case group and control group, with 1:1 comparison. Sampling method using purposive sampling. Data was a secondrary data and was collected by observation sheet. Data analysis using univariat analysis, bivariat analysis through pearson chi square and multivariat analysis. Result: There are three maternal biological factors related to labor actions in RSU Wiradadi SC Husada ie maternal age (p value 0.002 <0.05) , nutritional status (p value 0.024 < 0.05) , and a history of birth complications (p value 0,000 <0 , 05). There are two socio-economic factors associated with labor action in RSU Wiradadi SC Husada, namely economic status (p value 0.03 <0.05) and geographic groups (p value 0.012 <0.05). Conclussion: Based on the results of the study showed that variables history of birth complications are the most dominant veriabel related to childbirth sectio caesarea action on women giving birth in Public Hospitals Wiradadi Husada.

Analisis Lokasi Rumah Sakit Gigi dan Mulut Universitas Muhammadiyah Semarang di Wilayah Kedungmundu terhadap Perspektif Pelanggan Arti, Dwi Windu Kinanti
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 4 (2017): February
Publisher : Universitas Muhammadiyah Semarang

Analysis of the Location Dental and Oral Hospital of the University of Muhammadiyah Semarang in the Kedungmundu Region from the Customer PerspectiveLatar Belakang: Rumah Sakit Gigi da Mulut (RSGM)Pendidikan berfungsi menyelenggarakan pelayanan kesehatan gigi dan mulut, sekaligus sebagai sarana proses pembelajaran, pendidikan dan penelitian bagi profesi tenaga kesehatan kedokteran gigi, dan terikat melalui kerjasama dengan Fakultas Kedokteran Gigi.Keberadaan RSGM ini menjadi penting seiring dengan meningkatnya kesadaran masyarakat terhadap kesehatan gigi dan mulut. Perawatan gigi dan mulut bukan hanya ditujukan untuk fungsi kesehatan namun juga fungsi estetis, yang kini dikenal dengan sebutan dental aesthetic. Penelitian ini bertujuan untuk menganalisis daya dukung terhadap lokasi Rumah Sakit Gigi dan Mulut di lingkungan Fakultas Kedokteran Gigi daerah Kedungmundu SemarangMetode: Penelitian ini merupakan penelitian deskriptif dengan jenis kualitatif. Data primer menggunakan wawancara secara open ended dengan dokumentasi, wawancara, FGD dan data sekunder diperoleh dari dokumen penelitian. diantaranya: dokumen penelitian. Analisis data dilakukan secara diskriptif kualitatifHasil: Berdasarkan perspektif pelanggan pengguna RSGM terdekat adalah mahasiswa FKG, warga Muhammadiyah di wilayah Semarang serta masyarakat sekitar RSGM, Warga Muhamamdiyah yang tersebar di berbagai lingkungan seperti sekolah dan organisasi masyarakat. Dimana masyarakat disekitarnya sangat membutuhkan layanan tambahan dalam bidang kesehatan gigi dan mulut.Kesimpulan: Hasil penelitian ini adalah dilihat dari daya dukung perspektif pelanggan dimana pengguna RSGMP terdiri dari dosen, mahasiswa FKG, masyarakat sekitar Semarang, dan warga Muhammadiyah. Background: Dental Hospital School have a function to as a tools to organize a dental services, education for intern dentist, and a place of research facility for the dentist which having a cooperation with the faculty of dentistry. Dental Hospital School it self being important as same as people awareness of the dental health. Nowadays, dentistry is growing up rapidly, the handling system become more up to date which is the facility has to be integrated and complete. Dental care is not for the dental health only but it can reach the esthetic health care or nowadays we can call it Dental aesthetic.Method: This Research using a qualitative descriptive method. The primer data have been collected by an interview which is gathered directly from the interviewees by open ended with documentary, interview, FGD (Focus Group Discussion) and the secondary data have been collected from the document which have a related with the research (research document). analized with qualitative description.Result: Base on customer perspective which is the user of Dental Hospital School is the college student, the people of university and the local communities whom need the extra services of dental health care.Conclusion: From carrying capacity of costumer which is from lecture, student of dentistry faculty, and people around the dental hospital

Kleptomania: Manifestasi Klinis dan Pilihan Terapi Levani, Yelvi; Prastya, Aldo Dwi; Ramadhani, Safira Nur
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 6, No 1 (2019): February
Publisher : Universitas Muhammadiyah Semarang

Kleptomania: Clinical Manifestations and Treatment OptionsKleptomania (pathological stealing) is a form of mental disorder characterized by repeated stealing. This behavior is accompanied by a strong desire that is difficult to control. Kleptomania can be associated with psychiatric disorders such as depression, alcoholism, anxiety disorders and obsessive compulsive disorder. Kleptomania has symptoms in common with addiction such as strong pressure before the desire is achieved, decreased desire immediately after the action is carried out, there is a time lag (hours, days or weeks) for the emergence of the desire to commit repeated theft, and there is a feeling of pleasure after doing the action Kleptomania It can also be related to mood changes. Diagnostic criteria for kleptomania based on the American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders include the behavior of stealing items repeatedly where the patient is unable to control the desire. Stolen items are usually not needed by the patient and are not for sale. There are several tools for establishing the diagnosis of kleptomania, including the Yale Brown Obsessive Compulsive Scale Modified for Kleptomania (K-YBOCS) and the Kleptomania Symptom Assessment Scale (K-SAS). K-YBOSC is a tool to measure the severity of kleptomania symptoms. For pharmacological therapy, including Selective serotonin reuptake inhibitors (SSRI) which is a class of antidepressants that work by increasing serotonin levels in the brain and naltrexone is a medical therapy for alcohol addiction. , systemic desensitization and aversion therapy. This psychotherapy aims to change the sufferer's perception of the act of stealing and divert interest to other things. Kleptomania (curi patologis) merupakan salah satu bentuk gangguan kejiawaan yang ditandai dengan mencuri berulang. Perilaku tersebut disertai dengan keinginan kuat yang sulit dikendalikan. Kleptomania dapat berhubungan dengan gangguan kejiwaan seperti depresi, kecanduan alcohol, gangguan kecemasan dan gangguan obsesif kompulsif. Kleptomania memiliki kesamaan gejala dengan adiksi seperti adanya tekanan yang kuat sebelum keinginan tersebut dicapai, penurunan keinginan segera sesaat setelah aksi dilakukan, adanya jeda waktu (jam, hari atau minggu) terhadap munculnya keinginan melakukan aksi pencurian berulang, serta terdapat perasaan senang setelah melakukan aksinya Kleptomania juga dapat berkaitan dengan perubahan mood. Kriteria diagnostik untuk kleptomania berdasarkan American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders diantaranya adalah prilaku mencuri barang berulang dimana penderita tidak mampu untuk mengendalikan keinginan tersebut. Barang yang dicuri biasanya tidak diperlukan oleh pasien dan bukan untuk dijual. Terdapat beberapa alat bantu untuk penegakkan diagnosis kleptomania diantaranya adalah Yale Brown Obsessive Compulsive Scale Modified for Kleptomania (K-YBOCS) dan Kleptomania Symptom Asessment Scale (K-SAS). K-YBOSC merupakan alat ukur keparahan gejala kleptomania. Untuk terapi farmakologi diantaranya Selective serotonin reuptake inhibitors (SSRI) merupakan golongan antidepresan yang bekerja dengan meningkatkan level serotonin di otak dan naltrexon merupakan terapi medikasi terhadap adiksi alcohol selain itu beberapa psikoterapi yang banyak dilakukan untuk penderita kleptomania adalah Cognitive Behavioral Therapy (CBT), psikoterapi kognitif, desensitisasi sistemik dan terapi aversi. Psikoterapi ini bertujuan untuk mengubah persepsi penderita terhadap tindakan mencuri dan mengalihkan minat ke hal lain.

Mekanisme Regenerasi Hati secara Endogen pada Fibrosis Hati Safithri, Fathiyah
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 2, No 4 (2018): August
Publisher : Universitas Muhammadiyah Semarang

Mechanism of Endogenous Liver Regeneration in Liver Fibrosis Hati merupakan organ unik yang mempunyai kemampuan regenerasi yang luar biasa. Kemampuan regenerasi ini terjadi sepanjang usia manusia. Terapi fibrosis hati yang berkembang saat ini lebih banyak terfokus pada bagaimana mengobati sel/ jaringan yang sakit berdasarkan patogenesis dan melupakan potensi sel-sel sehat. Sel sehat ini masih mempunyai potensi untuk regenerasi dan memperbaiki daerah yang sakit. Bila kedua hal ini dapat dilakukan bersama-sama maka akan mempercepat proses regenerasi hati. Artikel ini akan mengeksplorasi kontribusi hepatosit, sel stelata, sel punca endogen, sel Kupfer, dan enzim proteolitik pada proses homeostasis dan perbaikan hati khususnya pada kondisi fibrosis. The liver is a unique organ that has remarkable capacity for regeneration. This regenerative potential occurs throughout human life. Currenly treatment of liver fibrosis focuses more on how to treat diseased cells / tissues based on pathogenesis and forget the potential of healthy cell. These healthy cell still havecapability to regenerate and repair the affected areas. If both things are done done together it will accelerate the process of liver regeneration. This article will explore the contributions of hepatocytes, stellate cells, endogenous stem cells, Kupfer cells, and proteolytic enzymes in homeostasis and liver repair processes, especially in conditions of fibrosis

Analisis Kepatuhan Perawat Dalam Melaksanakan Standar Prosedur Operasional Pemasangan Ventilator Di Rumah Sakit PKU Muhammadiyah Yogyakarta Ulfa, Maria; Adhyaksafitri, Fiqih
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 2 (2015): February
Publisher : Universitas Muhammadiyah Semarang

Analysis of Nurse Compliance in Implementing Standard Operating Procedures for Installing Ventilators at PKU Muhammadiyah Hospital YogyakartaBackground: The application of standard operating procedures (SOPs) for installing ventilators is one of the efforts to prevent and control infection. Implementation of SOPs depends on nurse compliance which can varybecause it is influenced by internal factors (gender, knowledge, and attitudes) and external factors (group and job characteristics).Objectives: To determine the level of nurse compliance, as well as the relationship and influence of internal and external factors on nurse compliance in implementing SOP for ventilator installation at PKU Muhammadiyah HospitalYogyakarta.Methods: This research is an observational analytic with a cross-sectional approach. The results are presented descriptively followed by bivariate analysis and multivariate analysis. The research subjects were ICU nurses at PKU Muhammadiyah Hospital Yogyakarta. The research instrument is a questionnaire andObservation checklist which was also matched with the interview sheet.Results: Attitudes, knowledge, and external factors contribute to nurse compliance by 34.4% and attitude is a factor that influences nurse compliance.Conclusion: Some nurses still do not fully comply with the SOP, the recommendation that needs to be done is to increase nurse compliance by increasing monitoring, providing training and motivation of nurses in complying with the SOP on ventilator installation.Latar belakang: Penerapan standar prosedur operasional (SPO) pemasangan ventilator adalah salah satu upaya pencegahan dan pengendalian infeksi. Pelaksanaan SPO bergantung pada kepatuhan perawat yang dapat bervariasi karena dipengaruhi oleh seperti faktor internal (jenis kelamin, pengetahuan, dan sikap) serta faktor eksternal (karakteristik kelompok dan pekerjaan). Tujuan Penelitian: Untuk mengetahui tingkat kepatuhan perawat, serta hubungan dan pengaruh faktor internal dan faktor eksternal terhadap kepatuhan perawat dalam melaksanakan SPO pemasangan ventilator di RS PKU Muhammadiyah Yogyakarta.Metode: Penelitian ini adalah analitik observasional dengan pendekatan cross-sectional yang hasilnya disajikan secara deskriptif dilanjutkan analisis bivariat dan analisis multivariat. Subjek penelitian adalah perawat ruang ICU RS PKU Muhammadiyah Yogyakarta. Instrumen penelitian ini adalah kuesioner dan checklist observasi yang juga dicocokkan dengan lembar wawancara.Hasil dan Pembahasan: Sikap, pengetahuan, dan faktor eksternal memberikan kontribusi terhadap kepatuhan perawat sebesar 34,4% dan sikap merupakan faktor yang berpengaruh terhadap kepatuhan perawat.Kesimpulan: Beberapa perawat masih tidak mematuhi SPO sepenuhnya, rekomendasi yang perlu dilakukan adalah meningkatkan kepatuhan perawat dengan cara meningkatkan monitoring, memberikan pelatihan dan motivasi perawat dalam mematuhi SPO pemasangan ventilator.

Pemanasan Fisik Menurunkan Kejadian Kram Otot Triceps Surae pada Atlet Renang Baskoro, Firza Yoga; Moerjono, Sigit; Anggraheny, Hema Dewi
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 2, No 4 (2018): August
Publisher : Universitas Muhammadiyah Semarang

Physical Warming Reduces Triceps Surae Muscle Cramps in Swimming AthletesLatar Belakang: Olah raga renang melibatkan sebagian besar anggota gerak. Berenang tanpa persiapan sebelumnya dapat mengakibatkan kram otot. Pemanasan fisik yang kurang optimal dan gaya berenang merupakan risiko dari kram otot.. Penelitian ini bertujuan menganalisis hubungan pemanasan fisik awal dan gaya berenang terhadap kejadian kram otot pada atlet renang di Semarang. Metode: Penelitian ini merupakan studi observasional analitik dengan pendekatan cross sectional yang di analisis dengan uji chi square. Sampel adalah atlet renang di Semarang, yang berjumlah 42 orang. Teknikpengambilan sampel menggunakan total sampling. Waktu pelaksanaan bulan September – Oktober 2016.Hasil: Terdapat hubungan antara pemanasan fisik dengan kram otot triceps surae (p value = 0,012 ;OR=0,190, 95%CI 0,05-0,72). Tidak terdapat hubungan antara gaya berenang dengan kram otot tricepssurae (p value = 0,429).Simpulan: Pemanasan fisik berperan dalam mencegah kram otot triceps surae pada olah raga renang Background: Swimming sport involves most members of the motion. Swimming without prior preparation can lead to muscle cramps. Less optimal physical heating and swimming style is a risk of muscle cramps. This study aims to analyze the relationship of physical warming and the style of swimming to the occurrence of muscle cramps in swimming athletes in Semarang.Method: This was an analytic observational study with cross sectional approach which was analyzed by chi square test. The sample is a swimming athlete in Semarang, which amounts to 42 people. The sampling technique uses total sampling. The execution time of September-October 2016..Results: There was a relationship between physical heating with triceps surae muscle cramps (p value =0.012; OR = 0.190, 95% CI 0.05-0.72). There was no association betwee n swimming forces with triceps surae muscle cramps (p value = 0.429).Conclusion: Physical heating plays a role in preventing triceps surae muscle cramps in swimming sport

Analisis Faktor Kunjungan Ibu Nifas Di Wilayah Kerja Puskesmas Poned X Prihanti, Gita Sekar; Rayhana, Juwita; Wahyuningtias, Widya; Carolina, Anastasyia; Hidiana, Amalia
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 6, No 1 (2019): February
Publisher : Universitas Muhammadiyah Semarang

Factor Analysis of Postpartum Mothers' Visits in the Work Area of the Poned X Health CenterLatarBelakang: Salah satu sasaran global Sustainable Development Goals (SDGs) pada tahun 2030 adalah mengurangi rasio angka kematian ibu hingga kurang dari 70 per 100.000 kelahiran hidup. Kunjungan ibu nifas dapat membantu mengurangi angka kematian ibu. Melalui kunjungan ibu nifas diharapkan dapat terjadi deteksi dini komplikasi persalinan atau pelayanan kesehatan ibu nifas yang paripurna.Tujuan: Menganalisis faktor-faktor yang mempengaruhi kunjungan ibu nifas di wilayah kerja Puskesmas Poned X. Metode: Desain cross sectional. Pengambilan sampel dengan teknik simple random sampling. Jumlah sampel 159 orang.Hasil Penelitian: Hasil uji multivariate terdapat empat variabel yang dapat mempengaruhi jumlah kunjungan ibu nifas, yaitu pendidikan (p=0.001), sikap (p=0.003), dukungan keluarga (p=0.025) dan asuransi (p=0.026). Nilai Nagelkerke R Square menunjukkan nilai sebesar 0,729 atau 73%. Artinya, pendidikan, sikap, dukungan keluarga, asuransi mempengaruhi kunjungan ibu nifas secara serentak pada kisaran 73%, sedangkan 27% lainnya dipengaruhi atau dijelaskan oleh variablevariabel yang tidak dimasukkan dalam penelitian ini. Sedangkan faktor yang paling dominan berpengaruh terhadap kunjungan ibu nifas yaitu variabel yang ditunjukkan oleh nilai β tertinggi, yaitu pendidikan (β = 13.941).Kesimpulan: Faktor yang mempengaruhi kunjungan ibu nifas adalah pendidikan, sikap, dukungan keluarga dan asuransi. Background: One of the global target s of Sustainable Development Goals (SDGs) by 2030 is reduces the ratio of maternal mortality to less than 70 per 100,000 live births. Postnatal care visit could reduce the maternal mortality rate. Through postnatal care visit, it could detect birth complication earlier and give comprehensive care for postpartum woman.Purpose: To analyse the factors that influence postnatal care visit in the primary public health center basic emergency neonatal obstetric services.Method: Cross sectional design. Sampling with simple random sampling technique. Number of sample 159 people.Result: Multivariate test results showed that there are four variables that have a significant influence on the visiting of postnatal care, mother education (p=0.001), attitude (p=0.003), support from families (p=0.025) dan assurance (p =0.026). Based on the value of Nagelkerke R square of 0,729 (73%), it means that education, attitude, support from families, and assurance influence the visiting of postnatal care, and 27% can be explained by other variables hasn’t been studied. While the most dominant factor influence the visiting of postnatal care, variable indicated by highest value of β, that is education (β =13.941).Conclusion: Postnatal care visit affected by mother education,attitude , support from families and assurance.

Kajian Tentang Efek Pemberian Nutrisi Kedelai (Glicine max) Terhadap Penurunan Kadar Kolesterol Total Pada Menopause Setyawan, Febri Endra Budi
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 4 (2017): February
Publisher : Universitas Muhammadiyah Semarang

A Study on the Effects of Nutrition Soybeans (Glicine max) on Reducing Total Cholesterol Levels in MenopauseLatar belakang: Kadar kolesterol darah yang meningkat merupakan resiko terjadinya arterosklerosis pada penyakit pada jantung koroner. Wanita menopause mempunyai kadar estrogen yang sangat rendah, sehingga menyebabkan peningkatan faktor resiko profil lipid. Kedelai memiliki kadar protein yang tinggi, yaitu rata-rata 35%, bahkan pada varietas unggul dapat mencapai 40-44%. Protein kedelai memiliki susunan asam amino esensial lengkap, serta daya cerna yang sangat baik. Kandungan asam amino pada kedelai terutama adalah metionin dan sistein, sedangkan kandungan lisin dan treonin sangat tinggi. Lemak kedelai mengandung asam lemak esensial yang cukup, yaitu asam linoleat (omega-6) serta asam linolenat (omega-3) sehingga memberikan pengaruh yang sangat berarti bagi kesehatan, khususnya dalam kaitannya dengan pengendalian kolesterol dan penyakit kolesterol dan penyakit kardiovaskuler. Mekanisme penurunan kolesterol oleh kedelai disebabkan oleh isoflavon yang mempunyai sifat estrogenik, sehingga terjadi penurunan LDL, TG dan kenaikan dari HDL dan akhirnnya terjadi penurunan kadar kolesterol total dalam darah. Ada berbagai macam faktor yang mempengaruhi asupan kedelai terhadap penurunan kolesterol total. Faktor-faktor yang mempengaruhi asupan kedelai dalam penurunan kolesterol total adalah bentuk dan jenis isoflavon, kadar asupan isoflavon, waktu penelitian, gender dari subjek, kadar lipid serta status dari menopause. Background: Increased blood cholesterol levels are a risk of arterosclerosis in coronary heart disease. Menopausal women have very low estrogen levels, thus leading to an increase in lipid profile risk factors. Soybean has high protein content, which is average 35%, even at high yielding varieties can reach 40-44%. Soy protein has a complete array of essential amino acids, as well as excellent digestibility. Amino acid content in soybean is mainly methionine and cysteine, while the lysine and threonine content is very high. Soy fat contains sufficient essential fatty acids, linoleic acid (omega-6) and linolenic acid (omega-3) to give a significant effect on health, especially in relation to cholesterol control and cholesterol disease and cardiovascular disease. The mechanism of lowering cholesterol by soybeans is caused by isoflavones that have estrogenic properties, resulting in a decrease in LDL, TG and an increase in HDL and ultimately a decrease in total cholesterol levels in the blood. There are various factors that affect the intake of soybean to decrease total cholesterol. Factors affecting soy intake in total cholesterol reduction are the form and type of isoflavones, isoflavone intake levels, research time, gender of the subject, lipid levels and status of menopause

Pengaruh Pemberian Formalin Peroral Terhadap Mukosa Lambung Tikus Putih Strain Wistar (Rattus Norvegicus Strain Wistar) Romdhoni, Muhammad Fadhol
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 2 (2015): February
Publisher : Universitas Muhammadiyah Semarang

The Effect of Oral Formalin on Gastric Mucosa of Wistar Strain White Rats (Rattus Norvegicus Wistar Strain) Background: Gastritis represent one of more disease in clinic, on 2001 prevalention of cronic gastritis in Indonesia 4.3% of 100.000 population and caused additive like formaldehyde. Formaldehyde was misused especially in food industry, if consumed can cause organ’s disparity. Intention of this research is prove the Effect of Formaldehyde peroral subacute on the stomach mucosal of White Rat Strain Wistar (Rattus Norvegicus strain wistar)Method : The design of the study was pure experimental which usingThe Posttest Control Group Design. Sample were white mice which divided into 4 groups. Group I is as a control, without formaldehyde, and another groups were given with formaldehyde doses 20 ppm, 40 ppm, and 80 ppm. Result: The results should that formaldehyde can cause hyperplasia, hypertrophic, atopic, chafe (ANOVA p=0.000). The mechanism of action possibility as DNA cross-linked by protein than gene expression anormal. Conclusions: The study concluded that formaldehyde can cause hyperplasia, hypertrophic, atopic, and chafe on the mucosal stomach of white rat strain wistar and further study was needed to know minimum doses than can change of stomach mucosal and than mecahanism of action about them.

Efek Ekstrak Kulit Manggis Terhadap Gambaran Histopatologi Hepar Tikus Wistar Yang Diinduksi Formalin Rohmani, Afiana; Rakhmawatie, Maya Dian
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 2 (2015): February
Publisher : Universitas Muhammadiyah Semarang

Effects of Mangosteen Peel Extract on Histopathological Appearance of Wistar Rats Induced by FormalinBackground: Formalin chemical idamage can stimulate the formation of reactive oxygen species (ROS) compounds that can cause cellular damage to the body. Mangosteen rind is known as a natural antioxidant due to its xanton content.Objective: To determine the effect of mangosteen peel extract on liver histopathology in Wistar rats induced by formalin solution.Methods: 24 rats were divided into 4 groups. The first group is a negative control group (K-), only given a placebo until the termination period. The second group was a positive control group (K+) which was induced by oral formalin for 21 days, then was given a placebo for 7 days. The third group as Treatment group 1 (P1) were induced by oral formalin for 21 days and then given mangosteen peel extract 200mg/kg BW/day for 7 days. The fourth group as Treatment group 2 (P2) were induced by oral formalin for 21 days and then given mangosteen peel extract 400mg/kg BW/day for 7 days. After that, the rats were terminated and their livers were taken to make histopathological preparations.Results: There was a significant difference (p=0.008) in the histopathological picture of liver tissue in the group of rats given mangosteen peel extract 400mg/kg BW/day (P2) and the positive control group (P2). K+). There was no significant difference (p=0.715) in the histopathological picture of liver tissue in the group of rats given mangosteen peel extract 200mg/kg BW/day (P1) and the positive control group (K+). There was a significant difference (0.00) in the histopathological picture of the liver tissue of the negative control group (K-) with the three groups that were induced by formalin, either given mangosteen peel extract (P1 and P2) or not (K+). Latar Belakang : Jejas kimia formalin dapat memacu terbentuknya senyawa reactive oxygen species (ROS) yang dapat menyebabkan kerusakan seluler jtubuh. Kulit manggis dikenal sebagai antioksidan alamiah dari kandungan xanton di dalamnya. Tujuan: mengetahui efek pemberian ekstrak kulit manggis terhadap gambaran histopatologi hepar pada tikus wistar yang diinduksi larutan formalin. Metode Penelitian: 24 ekor tikus dibagi menjadi 4 kelompok . Kelompok pertama merupakan kelompok kontrol negatif (K-), hanya diberi placebo saja hingga masa terminasi. Kelompok kedua merupakan kelompok kontrol positif (K+) yang diinduksi formalin peroral selama 21 hari, kemudian diberi placebo selama 7 hari. Kelompok ketiga sebagai kelompok Perlakuan 1 (P1) yang diinduksi formalin peroral selama 21 hari kemudian diberi ekstrak kulit manggis 200mg/kg BB/hari selama 7 hari. Kelompok keempat sebagai kelompok Perlakuan 2 (P2) yang diinduksi formalin peroral selama 21 hari kemudian diberi ekstrak kulit manggis 400mg/kg BB/hari selama 7 hari. Setelah itu tikus diterminasi dan diambil organ heparnya untuk dibuat preparat histopatologi. Hasil: Terdapat perbedaan yang signifikan (p=0,008) gambaran histopatologi jaringan hepar pada kelompok tikus yang diberi ekstrak kulit manggis 400mg/kg BB/hari (P2) dengan kelompok kontrol positif (K+). Tidak terdapat perbedaanyang signifikan (p=0,715) gambaran histopatologi jaringan hepar pada kelompok tikus yang diberi ekstrak kulit manggis 200mg/kg BB/hari (P1) dengan kelompok kontrol positif (K+). Terdapat perbedaan yang signifikan (0,00) gambaran histopatologi jaringan hepar kelompok kontrol negatif (K-) dengan ketiga kelompok yang diinduksi formalin, baik diberi ekstrak kulit manggis (P1 dan P2) maupun yang tidak (K+)

Page 7 of 23 | Total Record : 222

5 6 7 8 9

Filter by Year

2015 2026

Filter By Issues

All Issue Vol 13, No 1 (2026): FEBRUARY Vol 12, No 2 (2025): AUGUST Vol 12, No 1 (2025): FEBRUARY Vol 11, No 2 (2024): August Vol 11, No 1 (2024): February Vol 10, No 2 (2023): August Vol 10, No 1 (2023): February Vol 9, No 2 (2022): August Vol 9, No 1 (2022): February Vol 8, No 2 (2021): August Vol 8, No 1 (2021): February Vol 7, No 2 (2020): August Vol 7, No 1 (2020): February Vol 6, No 2 (2019): August Vol 6, No 1 (2019): February Vol 2, No 4 (2018): MAGNA MEDICA Vol 2, No 4 (2018): MAGNA MEDICA Vol 2, No 4 (2018): August Vol 1, No 5 (2018): MAGNA MEDICA Vol 1, No 5 (2018): February Vol 1, No 4 (2017): February Vol 1, No 4 (2017): MAGNA MEDICA Vol 1, No 3 (2016): August Vol 1, No 2 (2015): MAGNA MEDICA Vol 1, No 2 (2015): February More Issue

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Muhammad Anas

Contact Email
magnamedica21@gmail.com

Phone
+62271-716844

Journal Mail Official
magnamedica21@gmail.com

Editorial Address
FK UMS Kampus IV UMS Jl. Ahmad Yani, Gonilan, Kartasura, Gonilan, Kec. Kartasura, Kabupaten Sukoharjo, Jawa Tengah 57169. Telepon: (0271) 716844

Location
Kota semarang,

Jawa tengah

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Muhammad Anas

Contact Email magnamedica21@gmail.com

Phone +62271-716844

Journal Mail Official magnamedica21@gmail.com

Editorial Address FK UMS Kampus IV UMS Jl. Ahmad Yani, Gonilan, Kartasura, Gonilan, Kec. Kartasura, Kabupaten Sukoharjo, Jawa Tengah 57169. Telepon: (0271) 716844

Location Kota semarang, Jawa tengah INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Muhammad Anas

Contact Email
magnamedica21@gmail.com

Phone
+62271-716844

Journal Mail Official
magnamedica21@gmail.com

Editorial Address
FK UMS Kampus IV UMS Jl. Ahmad Yani, Gonilan, Kartasura, Gonilan, Kec. Kartasura, Kabupaten Sukoharjo, Jawa Tengah 57169. Telepon: (0271) 716844

Location
Kota semarang,

Jawa tengah

INDONESIA