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MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan

APKKM
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Published by Universitas Muhammadiyah Semarang

ISSN : 24070505 EISSN : - DOI : https://doi.org/10.26714/magnamed

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Magna Medica is a medical journal of APKKM contains papers and scientific articles created as a form of realization Tridharma college. The journal is published every six months, April and October of three articles in the form of: - Research article - Case report - Literature review The scope of this journal is all the field of medicine such as: -Internal medicine (including Pulmonary medicine and cardiovascular medicine) -Surgery (including urology, orthopaedic and traumatologic, plastic surgery, neurosurgery) -Anesthesia and Emergency Medicine -Neurology -Dermatology -Obstetric and Gynecologic -Forensic and Medicolegal -Clinical Pathology -Anatomical Pathology -Psychiatric -Ophthalmology -Otolaryngology -Pediatric -Radiology -Microbiology and parasitology -Basic Science of Medicine (including biochemistry, physiology, anatomy and Histology) -Public health and Health Management

Arjuna Subject : Kedokteran - Review dan Referensi, Kedokteran

Articles 222 Documents

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Faktor Risiko Timbulnya Kelainan Kongenital Purwoko, Mitayani
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 6, No 1 (2019): February
Publisher : Universitas Muhammadiyah Semarang

Risk Factors for Congenital AbnormalitiesThe life expectancy of a person can vary depending on where the person was raised. The gap in the health sector is especially felt in people with congenital disorders. Congenital abnormality is a condition of abnormal structure or function of the body that appears at birth. If the baby is born well, it can cause lifelong disability and cause negative effects on the family and the environment. Several risk factors that have an important role in the emergence of congenital abnormalities are nutrition, parental age, and environment. Inadequate nutritional consumption, drug consumption during pregnancy, maternal and paternal age at conception, and exposure to dust and cigarette smoke in the environment can cause congenital abnormalities. Usia harapan hidup seseorang dapat bervariasi tergantung di mana orang tersebut dibesarkan. Kesenjangan dalam bidang kesehatan terutama dirasakan pada penderita kelainan kongenital. Kelainan kongenital adalah suatu kondisi ketidaknormalan struktur atau fungsi tubuh yang muncul saat lahir. Apabila bayi terlahir dengan baik maka dapat menyebabkan disabilitas seumur hidup dan menyebabkan pengaruh negatif bagi keluarga dan lingkungan. Beberapa faktor risiko yang memiliki peranan penting dalam timbulnya kelainan kongenital adalah nutrisi, usia orang tua, dan lingkungan. Konsumsi nutrisi yang tidak adekuat, konsumsi obat-obatan selama kehamilan, usia ibu dan ayah saat terjadi pembuahan, serta adanya paparan debu dan asap rokok pada lingkungan dapat menyebabkan kelainan kongenital.

Hubungan Motivasi dengan Faktor-Faktor yang Mempengaruhi Wanita Usia Subur dalam Melakukan Pap Smear di Kecamatan Cipondoh, Kota Tangerang Tahun 2016 Rayhana, Rayhana; Izzati, Hatfina
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 4 (2017): February
Publisher : Universitas Muhammadiyah Semarang

Relationship between Motivation and Factors Affecting Women of Childbearing Age in Performing Pap Smears in Cipondoh District, Tangerang City in 2016Latar belakang: Kanker yang saat ini menjadi perhatian dunia dan megakibatkan tingginya angka kematian adalah kanker serviks. Data Globocan pada tahun 2013 menunjukkan prevalensi tertinggi kanker pada wanita di Indonesia adalah kanker serviks.Penyebabnyakarena kurangnya motivasi wanita untuk melakukan pemeriksaan Pap smear sehingga mengalami keterlambatan diagnosis yang mengakibatkan banyak wanita yang terdiagnosa kanker serviks dalam stadium lanjut. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang mempengaruhi motivasi untuk melakukan Pap smear pada Wanita Usia Subur (WUS) di Kecamatan Cipondoh.Metode: Metode pada penelitian ini adalah survey analitik dengan desain cross sectional. Sampel yang digunakan sebanyak 106 orang, dilaksanakan pada bulan Agustus sampai Oktober tahun 2016.I nstrumen yang digunakan adalah kuesioner.Hasil: Terdapat hubungan antara motivasi melakukan Pap smear pada Wanita Usia Subur (WUS) dengan status ekonomi keluarga (p=0,019), jarak dari rumah ke pelayanan kesehatan (p=0,001) dan paparan informasi (p=0,009); (p value< 0,05; α= 0,05).Motivasi untuk melakukan Pap smearsangat penting khususnya pada Wanita Usia Subur (WUS) untuk mencegah keterlambatan diagnosis sehingga dapat menurunkan angka kematian pada kanker serviks.Simpulan: Diperlukan penyuluhan tentang kanker serviks, pemeriksaan Pap smeargratis secara berkala oleh tenaga kesehatan untuk meningkatkan motivasi wanita melakukan Pap smear. Background: A disease that attracts world’s attention and result the high mortality rate is cervical cancer. According to Globocan in 2013 showed the highest prevalence of cancer in Indonesia is cervical cancer. One cause of the increased mortality rate is the lack of motivation of women to perform Pap smear so delayed diagnosis results in many women are diagnosed with cervical cancer in an advanced stage.This study investigates the factors that influence the motivation for Pap smears in productive age women in District of Cipondoh.Methods: The method in this research is analytic survey with cross sectional design. The samples used were 106 people, conducted in August and October 2016. The instrument used was a questionnaire research.Results: There was a relation between motivation to do Pap smears in productive age women with the economic status of the family (p=0,019), the distance from home to health services (p=0,001) and information exposure (p=0,009); (p value <0.05; α = 0.05). Motivation to perform Pap smear is very important, especially in productive age women to prevent delay in diagnosis that can reduce mortality incervical cancer.Conclusion: Required counseling about cervical cancer, Pap smear free regularly by health personnel to increase the motivati on in productive age women.

Analisis Letak Sumber Air Rumah Tangga Di Wilayah Kerja Puskesmas Mijen, Semarang Terhadap Bakteri Escherichia Coli Kanti Ratnaningrum; Merry Tiyas Anggraini; Pujangga P.Y. Dahlan
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 2 (2015): February
Publisher : Universitas Muhammadiyah Semarang

Analysis of the Location of Household Water Sources in the Working Area of Mijen Health Center, Semarang Against Escherichia Coli Bacteria Background: Case detection rate of diarrhea in Puskesmas Mijen, Semarang is still relatively high. One cause of diarrhea disease is a condition of polluted water sources such fouling proximity of water sources with a septic tank. Escherichia coli is a bacteria that may be found in contaminated water sources fouling. Coverage field of environmental health in terms of supervision and control of water quality in Puskesmas Mijen is still far from the achievement of the target, based on these data it is necessary to do research to analysis within a septic tank with a household water source for the presence of the bacterium Escherichia coli. Methods: This study is a cross-sectional study conducted in Puskesmas Mijen. The study methods using systematic random sampling method in 10 villages and the sample number were included with proportion estimate formula. Laboratory tests Escherichia coli bacteria levels in the water conducted in the laboratories of the Faculty of Medicine, Universitas Muhammadiyah Semarang. Data were analyzed using chi square test. Result: From the 36 samples of water, we get the result there is no significant relationship between the distance of a septic tank with a household water source for the presence of the bacterium Escherichia coli (P-value = 0.2). Conclusion: There is no related between the distance of the septic tank with a household water source within the findings of Escherichia coli bacteria in the household water in Puskesmas Mijen.

Perbandingan Pola Kuman dan Analisis Kualitas Bakteriologis pada Kolam Renang Jenis Learner Pool dan Standard Pool di Purwokerto Kusuma, Raden Maghfira Kurnia; Putri, Prima Maharani; Maulana, Andi Muh.
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 2, No 4 (2018): August
Publisher : Universitas Muhammadiyah Semarang

Comparison of Germ Patterns and Bacteriological Quality Analysis in Learner Pools and Standard Pools in PurwokertoLatar Belakang: Infeksi adalah penyakit yang disebabkan oleh agen infeksius tertentu yang dapat menyerang semua sistem tubuh manusia. Banyaknya kemunculan kembali re-emerging diseases dan new emerging diseases menjadi masalah kesehatan di Indonesia yang menjadikan penyakit menular memiliki kecenderungan mengalami peningkatan. Tempat umum seperti kolam renang dapat menjadi salah satu sumber dari transmisi agen infeksius dengan rute kontak langsung. Guideline WHO tahun 2006, telah mengatur indeks kebersihan dengan analisis kualitas bakteriologis dilihat dari pola kuman dan tinjauan kebersihan.Tujuan: mengetahui perbedaan pola kuman dan analisis kualitas bakteriologis pada kolam renang jenis learner pool dan standard pool di Purwokerto.Metode: Penelitian analitik observasional dengan pendekatan cross-sectional, melibatkan 4 sampel dengan total sampling, analisa data menggunakan Uji Fisher.Hasil: Hasil analisis kualitas bakteriologis pada kolam renang learner pool dan standard pool di keempat tempat yang diteliti adalah baik dan cukup serta tidak terdapat perbedaan yang signifikan (p= 0,757).Kesimpulan: Tidak terdapat perbedaan yang signifikan pola kuman dan analisis kualitas bakteriologis pada kolam renang learner pool dan standard pool di Purwokerto Background: Infectious diseases are caused by a infectious agent that is able to attack all human body systems. Large number of re-emerging diseases and new emerging diseases have became a health problem in Indonesia, as a result, the trend increases. Some area of public places such as swimming pools is one of the most frequent sources of transmission of infectious pathogens with direct contact. The WHO Guideline in 2006, has established a hygiene index with bacteriological quality analyzes seen from the microbial pattern and pool-related hygiene reviews. The aim to obserb the diversity of microbial pattern and bacteriological quality analysis at learner and standard swimming pools in Purwokerto.Method: The observational analytical research is conducted with a cross- sectional approach, involving 4 samples with total sampling, while data analysis uses a Fisher Test.Results: The results of bacteriological quality analysis in both learner and standard swimming pools in all four sites studied were good and sufficient based on WHO Guideline in 2006 and that there was no significant difference (p=0, 757).Conclusion: There is no significant difference of microbial pattern and bacteriological quality analysis at both learner and standard swimming pools in Purwokerto

The Relations Between Diabetes Mellitus Type 2 on The Incidence Cataract in Balai Kesehatan Mata Makassar in 2016 Amaliah, A. Nurul; Febriza, Ami
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 6, No 1 (2019): February
Publisher : Universitas Muhammadiyah Semarang

The aim of this research was to know about the correlation between cataract occurance with Diabetes Mellitus. This research was performed in Medical Record Departement of Balai Kesehatan Mata Masyarakat Makassar using medical record on the period of January 2016 to October 2016 with case control design, consist of 74 subjects which were divided into cataract as case, consist of 37 subjects and without cataract as control, consist of 37 subjects. Data of diabetes mellitus history were collected from patient medical record and analyzed by Chi Square with the significance’s degree was p<0.05. The result showed moderate correlation between cataract occurance and diabetes mellitus (p=0.002) with Odds Ratio (OR) 4,563 (IC :1,683 – 12,371)

Hubungan Kepatuhan Konsumsi Obat Antidiabetes dengan Kesehatan Jaringan Periodontal pada Pasien Prolanis Diabetes Melitus Tipe II: Studi Kasus di Puskesmas Mranggen III Hesti Widyawati; Sudibyo Sudibyo; Hayyu Failasufa
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 2, No 4 (2018): August
Publisher : Universitas Muhammadiyah Semarang

The Relationship between Compliance with Antidiabetic Drug Consumption and Periodontal Tissue Health in Patients with Type II Diabetes Mellitus: A Case Study at the Mranggen III Public Health CenterLatar belakang: Penyakit periodontal adalah keadaan patologis yang mengenai jaringan periodontal. Faktor penyebab penyakit periodontal dapat dikelompokkan menjadi dua, yaitu faktor lokal dan faktor sistemik. Diabetes dan periodontitis adalah penyakit yang saling berhubungan dan termasuk dalam penyakit kronis yang kompleks. Bukti bahwa kadar gula dalam darah yang tinggi pada penderita diabetes melitus dikaitkan dengan kesehatan jaringan periodontal yang buruk. Pencegahan komplikasi dengan cara menjaga kestabilan gula darah dengan pengobatan secara rutin seumur hidup. Hal tersebut karena diabetes melitus merupakan penyakit seumur hidup yang tidak bisa disembuhkan secara permanen sehingga banyak pasien yang jenuh dan tidak patuh dalam pengobatan. Ketidakpatuhan pasien dalam konsumsi obat antidiabetes meningkatkan resiko komplikasi dan bertambah parahnya penyakit yang diderita.Tujuan: mengetahui hubungan kepatuhan konsumsi obat antidiabetes dengan kesehatan jaringan periodontal pada pasien Prolanis DM tipe II di Puskesmas Mranggen III. Penelitian ini memeriksa kesehatan jaringan periodontal dengan indeks CPITN dan indeks gingiva serta menilai kepatuhan konsumsi obat antidiabetes dengan kuisioner Modified Morisky Scale.Metode: Metode penelitian adalah observasi analytic dengan desain cross-sectional. Pengambilan sampel menggunakan metode accidental sampling. Uji analisis data dengan uji korelasi Spearman Rho (ρ).Hasil: Jumlah sampel yang diperoleh 36 orang, dengan 86,2 % pasien patuh dan 13,8 % pasien tidak patuh dalam konsumsi obat antidiabetes. Pasien yang memiliki kesehatan periodontal yang sehat 33,3 %,sedang 52,8%, dan buruk 13,9 %. Terdapat korelasi antara kepatuhan konsumsi obat antidiabetes dengan kesehatan jaringan periodontal (nilai p=0,000; p<0,050).Simpulan: Terdapat hubungan antara kepatuhan konsumsi obat antidiabetes dengan kesehatan jaringan periodontal. Background: Periodontal disease is a pathologic condition on the periodontal tissue. Generally, the cause of this disease can be divided into two factors: local factor and systemic factor. Diabetes and periodontal are connected each other and are included as chronic and complex diseases. The evidence of the high sugar amount in the diabetics blood is related to the poor health condition of the periodontal tissue. The prevention of the complication can be done by keeping the stability of the blood sugar through routine medical treatment. This is needed because diabetes mellitus(DM) is a lifelong disease which cannot be cured permanently. Many patients are tired and not obedient towards the treatment. Disobedience of the patient in consuming antidiabetic medicine increases the risk of complications and the disease severity.Objective: this research was to know the relation between the obedience of antidiabetic medicine consumption and the health of periodontal tissue of Prolanis DM patients type II in a community health center called Pusat Kesehatan Masyarakat (Puskesmas) Mranggen III. This research examines the health of periodontal tissue using CPITN index and gingiva index and status ofobediencein consuming antidiabetic medicine using Modified Morisky Scale questionnaire. Method: The method of this research was analytic observation by using cross-sectional design. The samples were taken by using accidental sampling method. The test of the data analysis was done by using correlation test Spearman Rho (ρ).Result: The total of sample was 36; the percentage of obedient patient 86.2 % and non-obedient patient 13.8 %. Patients having healthy periodontalwas 33.3%, moderate 52.8%, and poor 13.9%. The correlation between the obedience of antidiabetic medicineconsumption and the health of periodontal tissue (p=0,000; p<0,050)Conclusion: There was relationship between the obedience of antidiabetic medicineconsumption and the health of periodontal tissue

Kehamilan Heterotropic Dengan Disertai Syok Hipovolumik Mochamad Ma'roef
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 2 (2015): February
Publisher : Universitas Muhammadiyah Semarang

Heterotropic Pregnancy With Accompanied Hypovolumic ShockBackground: Heterotopic pregnancy refers to a pregnancy that occurred simultaneously in two different implantation site. The majority occur in the fallopian tube. The exact cause s not clear, but the combination of multiple pregnancy with intrauterine and extrauterine pregnancy, a risk factor for all entities must be addressed.Case presentation: A female 34 year old 17 weeks pregnant, complaints of loss of consciousness, and before the patient complains of abdominal pain after a bowel movement. Experienced bleeding from vagina a week ago lasted for 4 days. Blood pressure 76/43 mmHg, heart rate 97 x / m, temperature 36.6 C, respiratory rate 24 x / m, SaO2 96% without O2. Loss of consciousness (delirium), looked anemic, distended abdomen, muscular defans +, tenderness +, pale, dry, and cold on the extrimities. Palpable lump in the labia majora dekstra. Laboratory tests obtained Hb 7, HCT 37, leukocytes: 10.400, Platelets 283,000, HBsAg negative, serum Cloride 105, 3.7 Serum Potassium, Sodium Serum 138, GDA 119, Diff count 4/1/80/11/4, LED 64 / 86.Discussion: A definitive diagnosis is heterotopic pregnancy. Management of the case was a laparotomy, with the condition of the intra-abdominal bleeding is massive enough. Report found that extrauterine and intrauterine pregnancy with differentgestational age. There was still a big question mark is how the intra and extra uterine pregnancy in differentgestational age.Conclusion: Diagnosis wasectopic pregnancy + G1 P0000 A000 19 weeks + IUFD + hypovolemic shock. Found the incidence of ruptured ectopic pregnancy occurs when the gestational age of 17 weeks, with the possibility that the gestational age between intra and ekstrauterine pregnancy is different.

Thyroid Status, Growth And Development Of Children Under 2 Years Of Age In Endemic Goiter Areas Of Srumbung Magelang Noor, Zulkhah; Susyanto, Bambang Edi; Praningwestri, Anindhita Mega; Rafiq, Aspar; Havis, Fajar Avivul; Soejono, Sri Kadarsih
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 6, No 1 (2019): February
Publisher : Universitas Muhammadiyah Semarang

Objective. To examine the relationship of Iodine urine, TSH and free T4 levels with the growth and development of children under 2 years of age in endemic areas of IDD in Srumbung District, MagelangSubjects. Respondents of this study were 43 respondents mother and her child under 2 years of age who are still breastfeeding. The study was conducted in March until June 2013.Method: observational and cross-sectional data retrieved. Mother urine iodine levels were measured in the laboratory GAKI Borobudur Magelang Indonesia. Levels of serum TSH and free T4 were measured by ELISA in the Clinical Laboratory AMC Yogyakarta with TSH ELISA reagents AIM and AIM fT4 ELISA TESTTEST (PT Intan Accurate Madya). Physical growth include weight, height, head circumference, and upper arm circumference. Weight measured in kilograms (kg), followed by calculation of BMI. Upper arm circumference were measured using standard Wolanski. Child development assessment performed using DDST-II (Denver Development Screening Test II). Data were analyzed with the Pearson correlation test for normal data and Spearman correlation for the data is not normal.Result. Ngargosoko Srumbung Magelang currently have adequate iodine intake with a median urinary iodine concentration of 296 ug / dL, mean blood levels of TSH and fT4 respectively is 1.7187 μIU / mL and 0.8545 ng / dL. But still obtained at 50.84% of respondents hypothyroidism.Conclutions. Free thyroxine blood levels determine body weight, body length and arm circumference, but did not determine the amount of head circumference, body mass index, the development of gross motor, fine motor, language and personal social. Child development needs to be measured with a measuring device better example with the Bayley Scale of Infant Development (BSID).

Peningkatan Ketrampilan Kader Posyandu Dalam Konseling Laktasi Sebagai Upaya Menggalakkan ASI Eksklusif Gita Sekar Prihanti; Muhammad Yasirto Fujaya; Thontowi Djauhari; Diah Hermayanti
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 2 (2015): February
Publisher : Universitas Muhammadiyah Semarang

Improving the Skills of Posyandu Cadres in Lactation Counseling as an Effort to Promote Exclusive Breastfeeding Background: During the 3 years of the achievement of exclusive breastfeeding in Puskesmas Kendal Kerep Malang has fluctuated, and only 1 out of 17 people related to the counseling of the breastfeeding who has been trained in breastfeeding counseling. Objective: To determine the effect of breastfeeding counseling training to support health workers in breastfeeding in Puskesmas Kendal Kerep Malang Methods: The study was quasi-experimental design with non-equivalent control group Results: There were differences in the support of health workers (pre-test and post-test) in the control and treatment groups (Wilcoxon test = 0.000 < á 0.05. There were differences in the support of health workers in breastfeeding (pre-test and post-test) in the control and treatment groups (Mann-Whitney = 0.000 < á 0.05). average ratings pre-test and post test both the control group and the treatment of the support of health workers had increased quite dramatically (9.167). Conclusions: There was a positive difference to the health workers support mothers in breastfeeding before and after breastfeeding counseling training. Breastfeeding counseling training was very effective to change the treatment of health workers in support of breastfeeding.

Efek Ekstrak Buah Kersen (Muntingia Calabura) terhadap Jumlah Sel Epitel Bersilia Bronkus pada Tikus Wistar yang Dipapar Asap Rokok. Afiana Rohmani; Ika Dyah Kurniati
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 2, No 4 (2018): August
Publisher : Universitas Muhammadiyah Semarang

Effect of Kersen Fruit Extract (Muntingia Calabura) on the Number of Bronchial Ciliated Epithelial Cells in Wistar Rats Exposed to Cigarette SmokeLatar Belakang: Asap rokok menyebabkan stress oksidatif dan memicu aktifitas Epidermal Growth Factor Receptor (EFGR)pada sel epitel bronkial, sehingga menyebabkan hiperplasia dan peningkatan jumlah sel epitel tersebut. Buah kersen (Muntingia Calabura) mempunyai aktifitas antioksidan yang kuat dan diharapkan dapat menurunkan jumlah oksidan yang ditimbulkan oleh paparan asap rokok.Tujuan penelitian: mengetahui efek ekstrak buah kersen terhadap jumlah sel epitel bersilia pada saluran nafas pada tikus wistar yang dipapar asap rokok.Metode: Tikus wistar berjumlah 24 ekor dibagi menjadi 4 kelompok : kelompok kontrol negatif (K-)diberikan plasebo saja, kelompok kontrol positif (K+) diberikan plasebo dan dipaparkan asap rokok, kelompok perlakuan 1 (P1) dan kelompok perlakuan 2 (P2) yang dipapar asap rokok dan diberi ekstrak buah kersen per oral dengan dosis 100 mg/kg BB /hari dan 200 mg/kgBB/hari. Pemaparan asap rokok dilakukan selama 30 menit setiap hari. Perlakuan ini dilakukan selama 20 hari , kemudian semua binatang coba diterminasi. Kemudian dilakukan analilsis sel epitel bronkial.Hasil: Melalui analisis Kruskal Wallis menunjukkan perbedaan yang signifikan (p=0,000) antara jumlah sel sepitel bersilia pada kelompok kontrol negatif (K-) dengan kelompok kontrol positif (K+). Terdapat perbedaan yang signifikan (p=0,001) jumlah epitel bersilia antara kelompok kontrol positif (K+) dengan kelompok perlakuan 1 (P1).Simpulan: Pemberian ekstrak buah kersen dengan dosis 100mg/kgBB/hari memberikan efek signifikan dalam hal menurunkan jumlah sel epitel bersilia bronkial pada tikus yang dipapar asap rokok. Background: Cigarette smoke causes oxidative stress and triggers the activity of Epidermal Growth Factor Receptor (EFGR) in epithellium bronchial cells that lead to hyperplasia and increasing the number of cells. Kersen fruit (Muntingia calabura Linn) has strong antioxidant activity, was expected to decrease the amount of oxidant caused by cigarette smoke exposure. The purpose of this study was to examine the effect of kersen fruit extract on the number of ciliated bronchial epithellium cells in wistar rats exposed to cigarette smoke.Methods: 24 rats were divided into 4 groups : Negative control group (C-) received a placebo, while the positive control group (C+) received a placebo and cigarrete smoke. Both treatment groups 1 (T1) and groups 2 (T2) exposed cigarrete smoke and received kersen extract by gavage at a dose of 100mg/kgBW/day and 200 mg/kgBW/day. The cigarrete smoke were exposed for 30 minutes in each day. These intervention were carried out for 20 days, and finally the animals were terminated. The differences in bronchial epithellium cells were then analyzed.Results: The Kruskal Wallis analysis showed significant differences (p = 0,000) in the ammount of ciliated epithelium cellsin negative control group (C-) compare with positive control group (C+). There were significant difference (p = 0.001) in the ammount of ciliated epithellium cells in positive control group (C+) compare with treatment group 1 (T1).Conclusion: Receiving kersen fruit extract 100mg / kgBW has significant effect on reducing the ammount of ciliated bronchial epithellium cells in rats exposed to cigarettes.

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FK UMS Kampus IV UMS Jl. Ahmad Yani, Gonilan, Kartasura, Gonilan, Kec. Kartasura, Kabupaten Sukoharjo, Jawa Tengah 57169. Telepon: (0271) 716844

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