cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Laila Susanti
Contact Email
laila.susanti@utb.ac.id
Phone
-
Journal Mail Official
laila.susanti@utb.ac.id
Editorial Address
-
Location
Kota bandar lampung,
Lampung
INDONESIA
JFL : Jurnal Farmasi Lampung
Published by Universitas Tulang Bawang
ISSN : 23552506     EISSN : 25984896     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health
The focus of JFL is to become a media for the publication of articles on Pharmaceutical and related practice-oriented subjects in the pharmaceutical sciences, natural medicine and clinic community. The scope of the journal is Pharmaceutical sciences, its research and its application.
Arjuna Subject : -
Articles 145 Documents
 5   6   7   8   9 
APAKAH RITME SIRKADIAN BERPENGARUH TERHADAP ANTIBIOTIKA : STUDI LITERATUR Ilham alifiar; Nur Rahayuningsih; Lalu Muhammad Irham; Chita Widia
JFL : Jurnal Farmasi Lampung Vol. 11 No. 1 (2022): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v11i1.674

Abstract

Antibiotics are one of the most widely used drugs in the world, therefore research on the use of antibiotics has been carried out, including research on the use of antibiotics associated with circadian rhythms for 24 hours. This literature study aims to explore research related to the effects of circadian rhythms on antibiotic drug levels. We conducted a search on two electronic databases, namely PubMed and Cochrane Library to search for articles related to the influence of circadian rhythms on antibiotics. This study does not limit the year, but the focus of this study is research conducted on humans and is a clinical study or randomized controlled clinical study. From the search, 28 articles were obtained from PubMed and 19 articles from the Cochrane Library. Of the total articles, six articles fall into the criteria of this study. One article is a test on levofloxacin, one article is a test on cefrozil, one article is a test on flomoxef, one article is a test on ciprofloxacin, and two articles are tests on tobramycin. From this study, it was found that the human body's circadian rhythm has an effect on antibiotics, either affecting the pharmacokinetic profile of the drug, or affecting the potential therapeutic effect of the antibiotic itself. Keywords: antibiotics, chronopharmacology, circadian rhythm
EVALUASI PENGGUNAAN ANTIBIOTIK PADA PASIEN PNEUMONIA DI RSUD DR. ADNAAN WD PAYAKUMBUH TAHUN 2019 Lola Azyenela; Ringga Novelni
JFL : Jurnal Farmasi Lampung Vol. 10 No. 2 (2021): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v10i2.701

Abstract

Abstrac Pneumonia is an inflammation of the lung parenchyma caused by bacteria, viruses, fungi, and parasites, but pneumonia can also be caused by chemicals or due to physical exposure such as temperature or radiation. The main therapy given to patients with pneumonia caused by bacteria is antibiotics. WHO recommends ATC (Anatomical Therapeutic Chemical) and DDD (Defined Daily Dose) as global standards for the study of drug use, one of which is antibiotics. The purpose of this study was to see an overview of the use of antibiotics using the ATC/DDD and DU 90% methods at Dr. Adnaan WD Payakumbuh Hospital in 2019. This study was a descriptive analytic study with a cross sectional design that was carried out retrospectively using data obtained from patient medical records. . Samples were taken by purposive sampling technique. The results showed that the quantity of antibiotic use from 111 patients in medical records obtained a total of 101.04 grams of DDD/100 days of hospitalization. The most widely used antibiotic was ceftriaxone and the least was cefoperazone. Antibiotics that fall into the 90% segment are Ceftriaxone (36.57%), Levofloxacin (28.39%), Cefotaxime (7.83%), Ciprofloxacin (7.40%), Cefixime (7.11%),Ceftazidime ( 6.24%) DDD/100 patient-days. Keywords: ATC/DDD, DU90%, evaluation of antibiotic use, pneumonia
POTENSI INTERAKSI OBAT PADA PASIEN GASTRITIS DI PUSKESMAS RAWAT INAP WAY KANDIS BANDAR LAMPUNG TAHUN 2020 Lilik Koernia Wahidah; Novita Tri Wahyuni; Cahya Rizky Amaliana
JFL : Jurnal Farmasi Lampung Vol. 10 No. 2 (2021): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v10i2.702

Abstract

ABSTRACT Gastritis is an inflammatory process in the mucous and sub-mucous layers of the stomach. The use of several drugs simultaneously facilitates the occurrence of drug interactions that are part of the Drug Related Problem (DRPs). This study aims to determine the potential for drug interactions in gastritis patients at the Puskesmas Rawat Inap Way Kandis Bandar Lampung in 2020. The research method carried out is observational research with a descriptive design taken retrospectively. The results of the study based on gender showed that there were 34 male patients (40.5%) and 50 female patients (59.5%). Then, based on the age group of 17-25 years, there were 26 patients (31%), aged 26-35 years as many as 16 patients (19%), aged 36-45 as many as 19 patients (22.6%), aged 46-55 as many as 13 patients (15.5%), aged 56-65 as many as 5 patients (6%), and aged >65 years as many as 5 patients (6%). The most use of gastritis drugs are antacids (92.8%), omeprazole (21.4%), ranitidine (15.1%). Drug interactions based on pharmacokinetic mechanisms were 20 cases (58.8%), and pharmacodynamic mechanisms were 14 cases (41.1%). Severity, 18 cases (52.9%) minor, 14 cases (41.1%) moderate, and 2 cases (5.8%) major. It was concluded that the potential drug interactions that experienced the incidence of drug interactions were 27 samples (32.1%) and 57 samples (67.8%) did not experience drug interactions.  Keywords : Antacids, DRPs, Drug Interactions, Gastritis, Omeprazole, Ranitidine
UJI EFEK STIMULAN FRAKSI N-HEKSAN DAUN PEGAGAN (Centella asiatica (L.)Urban) Nurma Suri; Subur Widodo; Mega Intan Yulianti
JFL : Jurnal Farmasi Lampung Vol. 10 No. 2 (2021): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v10i2.703

Abstract

Abstract Current condition related to fulfilling stimulating in the societies is by energy drinks and vitamins which have side effects restless, nervous, tremor, and seizures. Alternative stimulant can derived from herbs. One of the plants has potention of stimulant is Centella asiatica. This study was to examine the effect of stimulant on fraction n-hexane of C.asiatica leaves. The simplisia of C.asiatica leaves was extracted with ethanol 70% using a maceration method. Thereafter, extract was fractionated using n-hexane. Phytochemical screening was carried out to determine the content of secondary metabolites in order to find out the potential utilization by testing the active compounds. Stimulant effect was evaluated using induced sleeping time, swimming endurance time, hanging time, and rotarod method with the dose 2.59 mg/KgBW, 5.185mg/KgBW, 10.37 mg/KgBW, and 15.55 mg/KgBW, caffeine as the positive control, and Na-CMC as the negative control. The phytochemical screening showed positive results for triterpenoids and alcaloid. All of the dose fraction n-hexane had effect stimulant however dose 5.185 mg/KgBW and 10.37 mg/KgBW had as same stimulant effect as positive control and dose15.55 mg/BW had higher stimulant effect. N-hexane fractionation of C.asiatica leaves demonstrated the presence of secondary metabolites with potential biological activities as stimulant. Keywords: Alkaloids, C. asiatica, Triterpenoids, Stimulants test
AKTIVITAS ANTIFUNGI MINYAK ATSIRI DAUN KEMANGI (Ocimum x africamum Lour.) TERHADAPTrichophyton rubrum dan Trichophyton mentagrophytes Annisa Mulia Anasis; Mashuri Yusuf; Sigit Prayoga
JFL : Jurnal Farmasi Lampung Vol. 10 No. 2 (2021): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v10i2.704

Abstract

Abstract Traditional medicine using natural because it has small side effects and more economical than the synthetic drugs. One of the medicinal plants that for traditional medicine is basil (Ocimum x africamum Lour.).Basil plants contain active compounds such as alkaloids, saponins, flavonoids, triterpenoids, steroids, tannins, eugenol, phenols and essential oils that act as antifungals. Sweet basil essential oil can damage fungal cell membranes so that fungal cell molecules lyse which results in fungal cell death. The purpose of this study was to prove the antifungal activity of sweet basil essential oil as antifungal against T. rubrum and T. mentagrophytes. The essential oil from sweet basil leaves was obtained as much as 18 ml using the steam distillation method. Testing for antifungal activity was carried out using the agar dilution method/well method. The concentrations used in this study were 10%, 20%, 30%, 40%, 100%, positive control using ketoconazole and negative control using aquades with media Potato Dextrose Agar (PDA).Based on the results of research that has been carrier out, basil leaves essential oil has antifungal activity against with the largest inhibition greatest at 100% concentration with an inhibition zone diameter of 15,05 mm for T. rubrum and 19,11 mm for T. mentagrophytes Key words : antifungal, essential oil of sweet basil leaves, Trichophyton rubrum, Trichophyton mentagrophytes
AKTIVITAS ANTIPIRETIK KOMBINASI EKSTRAK ETANOLMENIRAN (Phyllanthus niruriL) DAN DAUN BELIMBING WULUH (Avverhoabillimbi) PADA TIKUS PUTIH JANTAN YANG DIINDUKSI VAKSIN DPT-Hb Yuli Wahyu Tri Mulyani; Annisa Mulia Anasis; Vatiyah Hari Utami
JFL : Jurnal Farmasi Lampung Vol. 11 No. 1 (2022): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v11i1.705

Abstract

Abstract Fever is defined as a change in the body's temperature regulation mechanism which results in an increase in body temperature above normal above 32.7ºC. Antipyretics are drugs used to reduce fever, one of which is paracetamol, but the use of paracetamol in large doses and for a long time has the potential to cause damage to the kidneys, brain, liver (hepatotoxic), disorders of the digestive system, respiratory system and hematological effects. These unwanted effects can be minimized using the active ingredients of meniran (Phylantus niruri L) and wuluh (Avverhoa bilimbi) plants. The purpose of this study was to prove the antipyretic activity of the combination of meniran leaf extract (Phylantus niruri L) and wuluh starfruit leaf (Avverhoa bilimbi) in male white rats (Rattus norvegicus L) induced by the DPT-Hb vaccine. The principle of this research is laboratory experimental research. This study included a combination of samples of meniran leaves and starfruit leaves, making thick extracts of meniran leaves and starfruit leaves, and testing the effect of antipyretics on the test animals. This study used the DPT–Hb (fever) vaccine induction method and the SPSS analysis method. The results showed that ethanol extract of meniran leaves 200mg/200grBB, ethanol extract of belimbing wuluh leaves 7.2mg/200grBB and a combination of ethanolic extract of meniran leaves with starfruit at doses of 200mg/200grBB and 7.2mg/200grBB, 100mg/200grBB and 3.6mg/ 200grBW, 200mg/200grBW and 3.6mg/200grBW, 100mg/200grBW, and 7.2mg/200grBW had antipyretic effects on male white rats. Keywords: antipyretic, starfruit, meniran
UJI DAYA HAMBAT ANTIBAKTERI KOMBINASI EKSTRAK DAUN PEPAYA ( Carica papaya L. ) DENGAN DAUN SIRIH ( Piper betle L. ) TERHADAP BAKTERI Staphylococcus aureus Amy Siska Zulyani; Samsuar Samsuar; Yuli Wahyu Tri Mulyani; Muti Dianda Sari
JFL : Jurnal Farmasi Lampung Vol. 11 No. 1 (2022): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v11i1.714

Abstract

Infection is a disease that is often found in Indonesia. Infectious diseases can be caused by one of the gram-positive bacteria, staphylococcus aureus bacteria. How to prevent infectious diseases is to inhibit the growth of Staphylococcus aureus bacteria. Papaya leaf plant (Carica papaya L.) and betel leaf plant (Piper betle L.) is a plant that has long been used by the community as a traditional medicine that can cure diseases, one of which is as an antibacterial. This study aims to find out the antibacterial bland power of the combination of papaya leaf extract with betel leaves in inhibiting Staphylococcus aureus bacteria. The method used is an experimental method of combining the concentration of papaya leaf extract with betel leaves, namely K1 (100%+0%), K2 (30%+70%), K3 (40%+60%), K4 (50%+50%), K5 (60%+40%), K6 (70%+30%), K7 (0%+100%), K (-) Aquadest, K(+) Chloramfenikol, which then concentrates on testing Staphylococcus aureus bacteria with the welling method. The variables measured in this study are the diameter of the bland zone. The observations were analyzed using one away anova with a sig (0.00) < A value (0.05) continued with Tukey that showed all treatments were different. This study can be concluded that the combination of papaya leaf extract with betel leaf proved to have a bland force of antibacterial activity against Staphylococcus aureus bacteria with the largest bland zone in K2 (papaya leaf extract 30% + 70% betel leaf extract) with an average diameter of 12.17 mm. Keywords: papaya leaves, betel leaves, infections, Staphylococcus aureus, bland zone.
IDENTIFIKASI DRUG RELATED PROBLEMS (DRPs) PENGGUNAAN ANTIHIPERTENSI PASIEN HIPERTENSI DI RSU AZZAHRA KALIREJO LAMPUNG TENGAH Lilik Koernia Wahidah; Novita Tri Wahyuni; Desiamti Ughfiroh
JFL : Jurnal Farmasi Lampung Vol. 11 No. 1 (2022): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v11i1.715

Abstract

A person is diagnosed with hypertension if there is an increase in systolic blood 140 mmHg and diastolic blood pressure 90 mmHg. Treatment of hypertension aims to reduce morbidity and mortality. Hypertensive patients receiving polypharmacy pharmacological therapy are at risk of developing DRPs. The purpose of this study was to identify the incidence of Drug Related Problems (DRPs) in the use of antihypertensives in hypertensive patients at Azzahra Kalirejo General Hospital, Central Lampung in 2021. This study was non-experimental with a retrospective descriptive design, then identified using the classification of DRPs according to Robert J. Cipolle EL. Pharmaceutical Care Practice and Medscape and Drug Interaction Chacker applications to identify drug interactions, and use the Medication Possession Ratio (MPR) formula to identify patient non-compliance. Based on the results of research at Azzahra Kalirejo General Hospital, Central Lampung, of the 135 samples that met the inclusion criteria, 80% of the samples experienced DRPs. Based on gender characteristics, there were 50.37% male and 49.62% female with 0% of patients aged <25 years, age 26-45 years 30.3%, age 46-65 years 57.8% and age > 65 years 11.8%. The most widely prescribed antihypertensive drug was furosemide as much as 42.2%, the most antihypertensive combination was a combination of two drugs as much as 57%. The most use of non antihypertensive drugs is PPI and analgesics as much as 12.8%. Cases of DRPs requiring additional therapy were 1.9%, drug therapy was not necessary 7.4% cases, inappropriate drugs 4.6% cases, doses too low and high in 0% cases, drug interactions were 77.8% with major severity 11.7%, minor 34.5% cases and moderate as many as 53.7%, patient non-compliance with DRPs occurred in 51.9% cases.  Keywords:  Antihipertensive, DRPs, Furosemide, Hypertension
POTENSI INTERAKSI OBAT PADA PERESEPAN PASIEN GERIATRI RAWAT JALAN DI PUSKESMAS SATELIT BANDAR LAMPUNG TAHUN 2021 Hijrah Hijrah; Lilik Koernia Wahidah; Ayu Herawati; Adityo Adityo
JFL : Jurnal Farmasi Lampung Vol. 11 No. 1 (2022): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v11i1.741

Abstract

Drug interaction is the modification of the effect of a drug due to a drug being given alongside food, drinks or other drugs so that the effectiveness or toxicity of a drug changes. Some of the drugs prescribed in geriatric patients need to be considered so that no adverse drug interactions occur. This study aims to determine the potential for drug interactions in the prescribing of outpatient geriatric patients at the Bandar Lampung City Satellite Health Center in the 2021 period. This study is a non-experimental type with a descriptive design taken retrospectively. Sampling using purposive sampling method. The instruments in this study were medical records and prescriptions of geriatric patients, using the Drugs.com and Medscape applications. The results of this study showed that out of 256 prescriptions for geriatric patients there were 138 prescriptions (53.9%) who experienced drug interactions, with 120 male sex patients (46.9%) and female sex as many as 136 patients (53,1%). Based on the age category of 56-65 there were 110 patients (43%), aged 66-75 there were 120 patients (47%), and aged 76-90 there were 26 patients (10%). Drug interaction levels were minor category 51 patients (24.1%), moderate 140 patients (66.0%), and major 21 patients (9.9%). Based on the mechanism of pharmacodynamic interactions of 183 (86.3%) and pharmacokinetic interactions of 28 (13.7%). The conclusions of this study prove drugs administered to geriatric patients can cause drug interactions. Keywords : Drug Interactions, Geriatric, Prescription
AKTIVITAS ANTIBAKTERI KOMBINASI EKSTRAK DAUN JAMBU BIJI (Psidium guajava L.)DENGAN DAUN SIRSAK ( Annona muricata L.) TERHADAP Escherichia coli Samsuar Samsuar; Yuli Wahyu Tri Mulyani; Brigitta Saniscara R.H
JFL : Jurnal Farmasi Lampung Vol. 11 No. 2 (2022): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v11i2.806

Abstract

Infection is a type of disease that is often found in developing countries, including Indonesia. Escherichia coli is one of the most common causes of infection in society. The most common clinical symptoms in cases of this infection include watery diarrhea, abdominal cramps, low-grade fever, nausea, and malaise. Guava plants (Psidium guajava L.) and soursop plants (Annona muricata L.) are medicinal plants that are easy to find in Indonesia. Guava leaves and soursop leaves can be used as antibacterials. This study aims to determine the antibacterial activity of a combination of guava leaf extract (Psidium guajava L.) and soursop leaves (Annona muricata L.) against Escherichia coli bacteria. The method used is an experimental method of combining the concentrations of guava leaf extract and soursop leaves, namely K1 (100% + 0%), K2 (80% + 20%), K3 (60% + 40%), K4 (50% + 50% ), K5 (40%+60%), K6 (20%+80%), K7 (0%+100%), K(-) aquadest, K(+) Ciprofloxacin which was then followed by testing for Escherichia coli bacteria using the hole or well method. The variable measured in this study was the diameter of the inhibition zone formed in the combination of extracts. The results of observations were analyzed using One Way Annova with a sig value (0.000) <p value (0.050) followed by a follow-up tukey test which showed K1, K2, K3, K4, K5, K6, K7, K(-) and K(+) real different. It can be concluded from this study that the largest inhibition zone of combined extracts was found in K2 (80% guava leaf extract + 20% soursop leaf extract) with an average inhibition zone of 11.89 mm which belonged to the strong category. Inhibits the growth of E.coli bacteria. Keywords : guava leaves, soursop leaves, Escherichia coli, inhibition zone

Page 7 of 15 | Total Record : 145

 5   6   7   8   9 

Filter by Year

2017 2025


Reset
Filter By Issues
All Issue Vol. 14 No. 2 (2025): JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung Vol. 13 No. 2 (2024): JFL : Jurnal Farmasi Lampung Vol. 13 No. 1 (2024): JFL : Jurnal Farmasi Lampung Vol. 12 No. 2 (2023): JFL : Jurnal Farmasi Lampung Vol. 12 No. 1 (2023): JFL : Jurnal Farmasi Lampung Vol. 11 No. 2 (2022): JFL : Jurnal Farmasi Lampung Vol. 11 No. 1 (2022): JFL : Jurnal Farmasi Lampung Vol. 10 No. 2 (2021): JFL : Jurnal Farmasi Lampung Vol. 10 No. 1 (2021): JFL : Jurnal Farmasi Lampung Vol. 9 No. 2 (2020): JFL: Jurnal Farmasi Lampung Vol. 9 No. 1 (2020): JFL: Jurnal Farmasi Lampung Vol. 8 No. 2 (2019): JFL: Jurnal Farmasi Lampung Vol. 8 No. 1 (2019): JFL: Jurnal Farmasi Lampung Vol. 7 No. 2 (2018): JFL: Jurnal Farmasi Lampung Vol. 7 No. 1 (2018): JFL: Jurnal Farmasi Lampung Vol. 6 No. 2 (2017): JFL: Jurnal Farmasi Lampung More Issue