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JPSCR : Journal of Pharmaceutical Science and Clinical Research
Published by Universitas Sebelas Maret
ISSN : -     EISSN : 2503331x     DOI : -
Core Subject : Health, Social,
Environmental Science Public Health
Journal of Pharmaceutical Science And Clinical Research (e-ISSN 2503-331x) offers a forum for publishing the original research articles, review articles from contributors, and the novel technology news related to pharmaceutical science and clinical research. Scientific articles dealing with natural products, pharmaceutical science-industry and clinical research, etc. are particularly welcome. The journal encompasses research articles, original research report, reviews, short communications and scientific commentaries pharmaceutical science and clinical research including: bioactive products, chemotaxonomy, chemistry, ecological biochemistry, metabolism, pharmacy management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, pharmaceutical social and pharmaceutical industry.
Arjuna Subject : -
Articles 100 Documents
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Therapeutic Potential of Bovine Lactoferrin to Reduce Brain Malondialdehyde Levels in Hyperlipidemia-Induced Sprague-Dawley Rats Telium, Havian Daulung; Djuartina, Tena; Notario, Dion; Hananta, Linawati
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 2 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i2.72048

Abstract

Hyperlipidemia is a medical condition that can trigger various diseases, one of which is a neurodegenerative or neurological disease. Lactoferrin is known to have multiple protective activities, one of which is antioxidant. This study aimed to determine the potential of lactoferrin bovine to decrease brain MDA levels in Sprague-Dawley (SD) rats induced by hyperlipidemia. This study was an in vivo experimental study using 24 male SD rats divided into six groups: normal, negative control, positive control, low-dose bovine lactoferrin (LLF), intermediate-dose bovine lactoferrin (ILF), and high-dose bovine lactoferrin (HLF). The diet in the normal group was the standard diet, and the other groups were induced by a high-fat diet (HFD). The intervention for the positive control group was simvastatin. In contrast, LLF, ILF, and HLF groups were given bovine lactoferrin doses of 100, 200, and 400 mg/kgBW, respectively. After seven weeks, all rats were necropsied, and their brains were taken to be tested for malondialdehyde (MDA) levels with an MDA assay kit using a spectrophotometer. Data was then analyzed using Shapiro-Wilk and Levene test and continued with one-way ANOVA and post-hoc Tukey test. There were significant differences (p<0.05) between the negative control group (269.99±13.50 nmol/g weight) and every bovine lactoferrin groups (219.92±22.99 nmol/g weight, 151.60±23.43 nmol/g weight, 158.16±12.33 nmol/g weight, respectively) in reducing brain MDA levels. In summary, all bovine lactoferrin groups (100, 200, and 400 mg/kgBW) significantly reduced brain MDA levels of SD rats in hyperlipidemia condition.
Optimasi Metode Ekstraksi Albumin Dari Ikan Gabus (Channa striata) Hidayatullah, Muhammad Haqqi; Munawwarah, Munawwarah; Suhendi, Andi
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 8, No 3 (2023)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v8i3.66952

Abstract

Ikan gabus (Channa striata) memiliki kadar protein yang tinggi dengan kandungan utamanya adalah albumin. Sehingga diperlukan metode dan kondisi ekstraksi yang sesuai agar mendapatkan rendemen dan kandungan albumin yang optimal. Penelitian ini bertujuan untuk mendapatkan metode ekstrkasi yang optimal antara perebusan biasa, microwave-assisted extraction (MAE) dan ultrasonic-assisted extraction (UAE) dengan parameter kadar albumin. Ekstraksi dilakukan dengan perbandingan daging ikan gabus dan akuades (1 : 1). Variasi waktu ekstraksi yaitu 5, 10 dan 15 menit. Kadar albumin ditetapkan dengan metode Lowry. Rendemen ekstrak yang dihasilkan dari 3 metode ekstraksi pada waktu ekstraksi 5 menit berurutan 2,419; 1,293 dan 1,575 %b/b. Kurva baku Albumin didapatkan persamaan regresi linier yaitu y = 3,38x + 0,7396 dengan nilai r = 0,997. Kadar albumin yang diperoleh dari 3 metode ekstraksi pada waktu ekstraksi 10 menit secara berurutan adalah 47,009 + 1,046; 44,792 + 5,372 dan 28,946 + 2,260 %b/b. Berdasarkan data tersebut, metode ekstraksi yang memberikan kadar albumin yang terbesar adalah metode perebusan dengan waktu 10 menit.
The Influence of Release Modifier Differences in Formulations on the Pharmacokinetic Profile of Ketoprofen in Rats: A Scoping Review Yugatama, Adi; SWM, Alyanis Mufid; Niruri, Rasmaya; Huang, Ya-Lin; Khoa, Nguyen Dang
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.80292

Abstract

The pharmacokinetic profile of drugs can be changed by genetic, environmental, and physiological variables such as age, sex, pregnancy, and different preparations and formulations. Ketoprofen is widely used in many different preparations and formulations. The various formulations can made by adding solubilizing and extending release agents. This study aimed to determine the influence of formulation differences on the pharmacokinetic profile of ketoprofen in rats. This research was a Literature Review. Articles were retrieved from the ScienceDirect and PubMed databases from 2011 to 2020. The inclusion criteria were the research article, the presence of ketoprofen was formulated with the addition of a solubilizing or extended-release agent, given orally and available in open access. The study resulted in differences in formulation, notably the addition of various dissolving agents or extended-release agents, which caused changes in the pharmacokinetic profile of ketoprofen. The highest increase in the pharmacokinetic parameters Cmax and AUC of ketoprofen was observed with poloxamer-188 as a release modifier agent. Therefore, the use of release modifier agents could have a significant effect on the drug's pharmacokinetic profile.
Formulasi, Uji Stabilitas Fisik, dan Efektifitas Sirup Antelmentik Ekstrak Bawang Putih (Allium sativum L.) Terhadap Cacing (Ascaris suum, Goeze) Zainal, Tuti Handayani; Aksa, Rahmad; Utami, Yuri Pratiwi; Heldawati, Heldawati
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 2 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i2.83298

Abstract

Umbi yang dapat digunakan untuk infeksi cacingan adalah bawang putih (Allium sativum L.). Kandungan bawang putih yaitu senyawa flavonoid dan saponin berkhasiat sebagai anthelmintik. Tujuan penelitian ini untuk mengetahui efektifitas ekstrak bawang putih sebagai antelmintik terhadap cacing gelang Ascaris suum, Goeze. serta memperoleh formula sirup yang stabil secara fisik. Penelitian ini meliputi persiapan hewan uji, persiapan sampel, pengolahan sampel, proses ekstraksi dengan metode maserasi, skrining fitokimia, uji bebas etanol, uji aktivitas antelmintik ekstrak bawang putih (Allium sativum L.), pembuatan sirup, dan evaluasi. Penelitian ini menggunakan 3 kelompok perlakuan yaitu, larutan NaCl 0.9% sebagai kontrol negatif, pirantel pamoat 1% (Combantrin®) sebagai kontrol positif, dan ekstrak bawang putih (Allium sativum L.) variasi konsentrasi 20% b/v, 25% b/v, dan 30% b/v. Hewan uji untuk setiap perlakuan adalah 6 ekor. Pengamatan kematian cacing dilakukan setiap jam dan selama 48 jam, Hasil perhitungan diperoleh nilai LC50 33,88% dan LC90 93,33% dan waktu kematian 100% cacing adalah 28 jam. Konsentrasi ekstrak yang digunakan dalam pembuatan formulasi yaitu sebesar 30%, dengan variasi konsentrasi sorbitol sebesar 20%, 25% dan 30%.   Formulasi sediaan sirup ekstrak bawang putih yang baik yaitu F3 dengan konsentrasi sorbitol 30% dengan hasil uji organoleptik berwarna coklat kehitaman, rasa manis, aroma strawberry, homogen dan jernih.  Evaluasi fisik pH 5,05, bobot jenis 1,23 g/mL, waktu tuang 2,93, volume terpindahkan 96% dan uji viskositas 8,40 cps. Hasil penelitian menunjukkan bahwa ekstrak bawang putih dapat dibuat sirup antelmintik dan efektif terhadap cacing Ascaris suum, Goeze.  
Antidiabetic Potential and Metabolite Profile of Leaf and Stem Extract of Castanopsis tungurrut (Blume) A.DC. Nabila, Bilqis Zahra; Surya, Muhammad Imam; Lailaty, Intani Quarta; Damayanti, Frisca; Nuringtyas, Tri Rini
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.74955

Abstract

Diabetes mellitus is a metabolic disorder caused by high blood sugar levels. One species in the Castanopsis genus is proven with a hypoglycemic effect. Therefore, the study aimed to discover the potential of Castanopsis tungurrut as an antidiabetic. Sample extraction, α-amylase inhibition, glucose diffusion analysis, GC-MS analysis, and molecular docking were applied in this study. Maceration of the leaf ethanol extract showed the highest yield value of 21.08%, while the stem extract was 14.04%. Leaf ethanol extract and stem ethyl acetate extract showed the highest inhibiting α-amylase activity with an inhibition value of 33.74%±1.54 and 34.45%±1.08 at 1 mg/mL concentration. The glucose entrapment assay showed that these two extracts could inhibit the diffusion of glucose in the dialysis bag. The final result was glucose concentration in dialysate for the two extracts of 0.114±0.001 mg/mL and 0.116±0.001 mg/mL which was lower than acarbose in 0.120±0.004 mg/mL. GC-MS analysis showed 6 metabolites in leaf ethanol extract and 22 metabolites in stems ethyl acetate extract from an alkane, salicylic, cinnamic, terpene, steroid, and fatty acid. Molecular docking resulting between the compounds with α-amylase enzymes complex showed γ-sitosterol and ß-bisabolene from C. tungurrut extract have the potential to be developed as an antidiabetic drug due to its good inhibitory activity with binding affinity values of -9.1 and -6.9 that considered better and quite close to acarbose as control of -7.7.
Cholecalciferol Effects on Lipid Profile of Experimental Animals: A Scoping Review Veonika, Dea Anenta; Wiboworini, Budiyanti; Muthmainah, Muthmainah
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.73400

Abstract

Vitamin D is an essential nutrient that has various beneficial effects on the human body. The results of cholecalciferol supplementation are varied, and there has yet to be a comprehensive review regarding its effect on animal models. Therefore, this scoping review aims to summarize the evidence regarding the effect of cholecalciferol (vitamin D3) supplementation on the lipid profiles of animal subjects. PubMed, Scopus, and DOAJ were searched for original research articles published until 2022. Studies were included if they were experimental studies, cholecalciferol was used as a supplement, and the changes in the lipid profile were analyzed. A total of 260 articles were collected, of which 250 articles were excluded, and 10 articles were included for qualitative synthesis. All studies used oral routes to supplement cholecalciferol with various doses and duration ranging from several weeks to several months. Most studies reported reduced lipid parameters in serum or organ-specific animals supplemented with cholecalciferol. As conclusion, cholecalciferol reduces lipid content in animal subjects and may have a beneficial effect on populations with metabolic diseases such as diabetes and dyslipidemia. Further research is required to explore the mechanism of how cholecalciferol affects the lipid profiles of experimental animals.
The Relationship of In Vitro Anti-Inflammatory and Antioxidant Activity with Total Phenolic and Flavonoids Content of Tithonia diversifolia Leaves Ethanolic Extract and Fractions Puspitasari, Endah; Nuri, Nuri; Muslichah, Siti; Triatmoko, Bawon; Dianasari, Dewi
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 2 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i2.83109

Abstract

A previous study showed that Tithonia diversifolia ethanolic extract has antiproliferative properties against HeLa cervical cancer cells. It has also shown anti-inflammatory properties in vivo, one of the approaches to cancer chemoprevention. This research aimed to determine the relation of in vitro anti-inflammatory and antioxidant activity of T. diversifolia leaves ethanolic extract and fractions with total phenolic and flavonoid content. The anti-inflammatory was evaluated in vitro using red blood cell (RBC) membrane stabilization and inhibition of protein denaturation method, while antioxidant activity was done using the DPPH method. Phytochemical screening was done using the TLC method. Total phenolic and flavonoid content were also counted using the colorimetry method. ANOVA followed by LSD post hoc, multiple regression analysis, and Pearson correlation were used to analyze the data. Compared to its fractions, the highest anti-inflammatory and antioxidant activity was obtained from T. diversifolia leaves ethanolic extract. The T. diversifolia leaves ethanolic extract contained terpenoids, alkaloids, polyphenols, and flavonoids. Overall, the antioxidant property contributed more to RBC membrane stabilization than protein denaturation inhibition. The phenolic and flavonoid content contributed most to antioxidant and red blood cell membrane stabilization rather than protein denaturation inhibition.
Identifikasi Kejadian Ikutan Pasca Imunisasi (KIPI) Vaksin Covid-19 pada Kelompok Komorbiditas di Desa Blaru Kecamatan Pati Kabupaten Pati Setyoningsih, Heni; Wicaksono, Terentia Zahrani; Palupi, Dian Arsanti
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 8, No 3 (2023)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v8i3.63744

Abstract

Kelompok komorbiditas diketahui menjadi kelompok yang rentan terinfeksi Covid-19. KIPI akibat vaksin Covid-19 dibedakan menjadi reaksi lokal dan reaksi sistemik. Tujuan penelitian ini adalah untuk mengidentifikasi KIPI akibat penggunaan vaksin Covid-19 pada kelompok komorbiditas di Desa Blaru Kecamatan Pati Kabupaten Pati. Metode yang digunakan dalam penelitian ini adalah analisis deskriptif dengan menggunakan pendekatan metode cross sectional. Jumlah total responden dalam penelitian sebanyak 92 orang masyarakat di Desa Blaru Kecamatan Pati Kabupaten Pati dan telah mendapatkan kedua dosis vaksin Covid-19. Vaksin Covid-19 yang digunakan diantaranya Sinovac, Astra Zeneca, Moderna, Pfizer, dan Biofarma. Berdasarkan karakteristik usia mayoritas 26-55 tahun sebanyak 59,8%; karakteristik jenis kelamin mayoritas wanita sebanyak 64,1%; karakteristik komorbid mayoritas hipertensi sebanyak 23,9%. Disamping itu, 68,5% responden tidak mengalami KIPI; 9,8% responden mengalami kelelahan; 6,5% responden mengalami demam; 5,4% responden mengalami nyeri di tempat suntik; 3,3 % responden mengalami pusing, nyeri sendi, dan kedinginan atau menggigil. Kesimpulan penelitian ini yaitu tidak terdapat hubungan antara penyakit penyerta dengan KIPI vaksinasi Covid-19 karena hasil p (value) ≥ 0,05.
Kualitas Hidup Pasien Kanker Payudara Menggunakan Kuesioner QLQ BR-23 di Rumah Sakit Kanker Dharmais Jakarta Barat Rusdi, Numlil Khaira; Iskandar, Iskandar; Maifitrianti, Maifitrianti; Nurhasnah, Nurhasnah; Sulistyaningsih, Endang; Safitri, Lia Desviana
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 2 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i2.84445

Abstract

Masalah utama pasien kanker payudara dalam jangka panjang berkaitan dengan masalah psikososial dan gejala fisik khususnya efek samping dari terapi adjuvant sistemik/ kemoterapi pada kualitas hidup. Penelitian ini bertujuan untuk menilai kualitas hidup pasien kanker payudara di instalasi rawat jalan Rumah Sakit Kanker Dharmais Jakarta Barat dan mengevaluasi faktor-faktor yang mempengaruhi kualitas hidup pasien. Desain penelitian menggunakan studi kohort. Kualitas hidup pasien kanker payudara dinilai menggunakan kuesioner EORTC QLQ-BR23 dengan kategori baik, sedang, dan buruk. Faktor-faktor yang mempengaruhi kualitas hidup dianalisis menggunakan regresi linear. Hasil penelitian menunjukkan, kualitas hidup berdasarkan skala fungsional; untuk domain citra tubuh terkategori baik, fungsi seksual terkategori buruk, kenikmatan seksual dan pandangan masa depan terkategori sedang. Kualitas hidup berdasarkan skala gejala; pada domain efek terapi, gejala pada payudara, gejala pada lengan, dan gejala pada rambut termasuk kategori baik. Faktor-faktor yang mempengaruhi kualitas hidup adalah usia 50 tahun keatas, postmenopause, mastektomi, dan stadium lanjut (p
Review: Cost-Effectiveness Analysis Metformin dan Dipeptidyl Peptidase-4 Inhibitor Dibandingkan dengan Metformin dan Sulfonilurea pada Pasien Diabetes Melitus Tipe 2 Kusumawati, Nuring Novita; Andayani, Tri Murti
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 2 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i2.91911

Abstract

Prevalensi diabetes melitus tipe 2 (DMT2) meningkat, sehingga manajemen terapi yang efektif dan cost-effective sangat penting. Kombinasi metformin dengan dipeptidyl peptidase-4 inhibitor (DPP-4 inhibitor) dan metformin dengan sulfonilurea (SU) merupakan terapi lini kedua pada pasien DMT2, masing-masing memiliki kelebihan dan kekurangan terkait biaya dan efektivitas. Review ini bertujuan untuk membandingkan hasil penelitian cost-effectiveness dari kedua kombinasi tersebut guna membantu praktisi kesehatan dalam membuat keputusan pemilihan terapi dalam pengelolaan DMT2. Review ini menganalisis temuan dari berbagai jurnal yang dipublikasikan secara online, menggunakan database SCOPUS dan PubMed serta mengikuti skema PRISMA dan PICO.  Penelitian yang memenuhi kriteria pencarian adalah 75 studi, 35 di antaranya berasal dari Scopus dan 40 PubMed. Terdapat beberapa artikel dikecualikan dan didapatkan 5 studi yang memenuhi kriteria akhir kemudian dilakukan penilaian kualitas berdasarkan standar CHEERS 2022. Analisis menunjukkan bahwa kombinasi DPP-4 inhibitor dan metformin lebih efektif dibandingkan kombinasi sulfonilurea dan metformin dalam mengelola diabetes melitus tipe 2, temuan ini didukung oleh pemelitian dari berbagai negara, menunjukkan pengurangan risiko hipoglikemia dan peningkatan kualitas hidup pasien. Tinjauan sistematis ini menunjukkan bahwa kombinasi DPP-4 inhibitor dengan metformin adalah terapi lini kedua yang cost effective dibandingkan dengan kombinasi sulfonilurea dan metformin untuk penderita diabetes melitus tipe 2.

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