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JPSCR : Journal of Pharmaceutical Science and Clinical Research
Published by Universitas Sebelas Maret
ISSN : -     EISSN : 2503331x     DOI : -
Core Subject : Health, Social,
Environmental Science Public Health
Journal of Pharmaceutical Science And Clinical Research (e-ISSN 2503-331x) offers a forum for publishing the original research articles, review articles from contributors, and the novel technology news related to pharmaceutical science and clinical research. Scientific articles dealing with natural products, pharmaceutical science-industry and clinical research, etc. are particularly welcome. The journal encompasses research articles, original research report, reviews, short communications and scientific commentaries pharmaceutical science and clinical research including: bioactive products, chemotaxonomy, chemistry, ecological biochemistry, metabolism, pharmacy management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, pharmaceutical social and pharmaceutical industry.
Arjuna Subject : -
Articles 105 Documents
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The Effect of Flaxseed (Linum usitatissimum) Ethanol Extract on LDL Cholesterol Levels and Foam Cell Number in the Aorta of Male Wistar Rats (Rattus norvegicus) Fed A High-Fat and High-Fructose Diet Marzha Marcella; Desak Made Wihandani; I Gusti Ayu Artini; I Wayan Juli Sumadi; I Made Pande Dwipayana; Ni Putu Sriwidyani
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 3 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i3.100142

Abstract

A diet high in saturated fat and fructose leads to dyslipidemia, increasing atherosclerosis risk. Although lipid-lowering medications are available, they have certain limitations. Flaxseed, rich in ALA, lignans, and phytosterols, may improve lipid profiles and act as an antioxidant. This study evaluated the effectiveness of flaxseed in preventing LDL cholesterol elevation and aortic foam cell formation in male Wistar rats fed a high-fat, high-fructose (HFHF) diet.This actual experimental study used a post-test-only control group design for 35 days. Twenty-five male Wistar rats were randomly assigned to five groups: N (normal control, standard diet), K (negative control, HFHF diet), and three treatment groups (P1, P2, P3, HFHF diet) receiving flaxseed ethanol extract at doses of 200, 400, and 800 mg/kgBW/day. LDL cholesterol levels (mg/dL) and aortic foam cell counts (cells/HPF) were measured. Data were analyzed using Shapiro-Wilk and Levene tests for normality and homogeneity, followed by one-way ANOVA, Kruskal-Wallis, and Tukey-HSD post hoc tests. LDL cholesterol levels in groups N, P1, P2, and P3 were significantly lower than in group K (p = 0.007), with P2 showing the most significant inhibition (p = 0.035). Foam cell counts were lower in treatment groups than in group K (p = 0.257), but no significant differences were found among them. Flaxseed (Linum usitatissimum) ethanol extract at 400 mg/kgBW/day was the most effective in preventing an increase in LDL cholesterol. However, the extract at all three doses was ineffective in preventing an increase in aortic foam cells in male Wistar rats (Rattus norvegicus) fed an HFHF diet.
Evaluasi Rasionalitas Pengobatan Pasien Dengue Hemorrhagic Fever dengan Komplikasi dan Komorbiditas di Rumah Sakit “X” Provinsi Bali Rr Asih Juanita; Herleeyana Meriyani; Dwi Arymbhi Sanjaya; Nyoman Budiartha Siada; Nyoman Ayu Prascitasari
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 2 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i2.92941

Abstract

Penggunaan obat pada pasien Dengue Hemorrhagic Fever (DHF) dengan komplikasi dan komorbiditas perlu mendapat perhatian khusus untuk menghindari kejadian Drug Related Problems (DRPs) yang dapat memengaruhi luaran klinis. Penelitian ini bertujuan untuk mengevaluasi rasionalitas pengobatan pada pasien DHF dengan komplikasi dan komorbiditas di Rumah Sakit “X” Provinsi Bali. Jenis penelitian yang digunakan adalah observasional dengan rancangan cross-sectional. Data rekam medis pasien dikumpulkan secara retrospektif tahun 2020-2021. Penilaian rasionalitas pengobatan dilakukan dengan analisis DRPs menggunakan instrumen Pharmaceutical Care Network Europe Association (PCNE) versi 9.1. Luaran klinis dianalisis berdasarkan nilai trombosit, hematokrit, leukosit, dan hemoglobin. Analisis hubungan rasionalitas pengobatan terhadap luaran klinis dilakukan menggunakan uji Chi-square. Dari total 115 pasien yang memenuhi kriteria penelitian, terjadi DRPs pada 33% pasien dan 67% tidak terjadi DRPs. DRPs yang terjadi yaitu P3.2 Unclear problem/complaint (51%); P1.2 Effect of drug treatment not optimal (28%); P1.3 Untreated symptoms or indication (13%); serta P3.1 Unnecessary drug-treatment (8%). Rasionalitas pengobatan tidak berhubungan dengan luaran klinis pasien DHF dengan komplikasi dan komorbiditas di Rumah Sakit “X” Provinsi Bali (p>0,05).
Korelasi antara Aspek Sosiodemografi dan Tingkat Pengetahuan Orang Tua terhadap Rasionalitas Swamedikasi Parasetamol dalam Pengobatan Demam Anak Gita Larasanti; Valentina Yurina; Ema Pristi Yunita
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 3 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i3.91407

Abstract

Swamedikasi menggunakan obat bebas seperti parasetamol umum dilakukan oleh orang tua untuk mengatasi demam pada anak, namun penggunaan yang tidak tepat dapat menimbulkan efek samping serius. Penelitian ini bertujuan untuk menilai rasionalitas swamedikasi parasetamol dalam penanganan demam anak serta menganalisis pengaruh faktor sosiodemografi dan tingkat pengetahuan orang tua. Penelitian ini menggunakan desain potong lintang dengan teknik purposive sampling dan dilakukan di beberapa apotek Kota Malang pada Mei–Juni 2024 dengan melibatkan 92 responden. Analisis data menggunakan uji korelasi Lambda dan Somers’d untuk menilai kekuatan korelasi antara faktor sosiodemografi dan tingkat pengetahuan dengan rasionalitas swamedikasi parasetamol. Mayoritas responden adalah perempuan (70,65%) dan berusia 18–28 tahun (46,74%). Sebagian besar memiliki tingkat pengetahuan baik (46,74%) dan melakukan swamedikasi secara rasional (56,52%). Faktor yang berhubungan signifikan dengan rasionalitas swamedikasi adalah tingkat pendidikan (p = 0,002; r = 0,339) dan tingkat pengetahuan orang tua (p < 0,001; r = 0,411). Semakin tinggi pendidikan dan pengetahuan orang tua, semakin rasional praktik swamedikasi parasetamol dalam mengobati demam pada anak.
Unveiling the Anticancer Efficacy of Kaempferol from Moringa oleifera Against Breast Cancer: Insights from an In Silico Investigation Maharani Retna Duhita; Vina Virlana Azhar
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 11, No 1 (2026)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v11i1.94156

Abstract

Breast cancer is a significant global health problem that is often encountered in women. Kaempferol from Moringa is known to control breast cancer cells. This study explores the in silico potential of kaempferol compounds derived from Moringa oleifera as breast cancer drug candidates. The results showed that kaempferol compounds have anticarcinogenic potential, with a high Pa value of 0.715, via the target proteins CYP1B1 and HSD17B2. The prediction of physicochemical properties indicates that kaempferol is a viable oral medication candidate, as it adheres to Lipinski's rule of five. However, it is dangerous if swallowed because it is classified as toxicity class 5. Molecular docking analysis indicates that kaempferol has high affinity for the target proteins CYP1B1 and HSD17B2. It can significantly contribute to breast cancer progression, with binding energies of -7.1 kcal/mol and -6.8 kcal/mol, respectively. Hydrogen bonds and hydrophobic interactions predominated the molecular interactions between kaempferol and the target proteins. These findings suggest that kaempferol from Moringa oleifera is a promising lead compound for the development of breast cancer treatments. Despite its potential, further studies are required to mitigate its toxicity risks, as indicated by the pharmacokinetics, drug-likeness, and toxicity assessments.
Formulation of Small Quantity Lipid-based Nutrient Supplement (SQ-LNS) Tablet from Soybean: A Preventive Approach on Stunted Birth for Pregnant and Breastfeeding Women Virginia Heaven Mariboto Siagian; Johnessa Cung; Spica Diani Anandawijaya; Sandya Amelia Febriliani; Avika Widyapuspita; Iyan Sopyan
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 2 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i2.91338

Abstract

The prevalence of stunting in Indonesia, which has not met the requirements of the WHO, makes stunting a national problem. In line with the nutritional intervention in 2020-2030, UNICEF developed SQ-LNS products as a food paste. As an effort to prevent stunting as well as improve product stability, the formulation of Small-Quantity Lipid-based Nutrient Supplements (SQ-LNS) from soybeans (Glycine max (L.) Merr) in tablet form is proposed to be a solution for pregnant and breastfeeding women. Microencapsulation technology is used to entrap soybean oil as the lipid source of this supplement. This study aims to obtain the best concentration of maltodextrin, soy protein isolate, and carboxymethyl cellulose as a soybean oil coating for felting into SQ-LNS tablet preparation. The best microcapsule is produced from a 40% formula with a percent yield of 28%, encapsulation efficiency of 79.83%, PSD microcapsule of 1.003 μm, and round agglomerated particles with a smooth surface without any residual oil seen under the SEM, and obtained the best formulation and evaluation of SQ-LNS tablets so that they meet the quality standards of good stunting supplement tablets.

Page 11 of 11 | Total Record : 105

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