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INDONESIA
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia)
Published by Universitas Muhammadiyah Purwokerto
ISSN : 16933591     EISSN : 2579910X     DOI : -
Core Subject : Science,
Materials Science & Nanotechnology
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) is a scientific journal publishing original articles research in pharmaceutical science such as Pharmaceutical Technology, Pharmacology and Toxicology, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Herbal Medicines, Pharmaceutics, Pharmaceutical Microbiology and Biotechnology, Community and Clinical Pharmacy, and Pharmaceutical Care.
Arjuna Subject : -
Articles 538 Documents
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Validitas dan Reliabilitas Kuesioner Pengetahuan, Sikap, dan Perilaku Apoteker terhadap Pharmaceutical Care Ulviani Yulia Husna; Burhannudin Ichsan
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 20 No. 02 Desember 2023
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v0i0.13953

Abstract

Pharmaceutical care didefinisikan sebagai pelayanan yang bertanggung jawab terhadap terapi obat dengan tujuan untuk mendapatkan hasil yang pasti serta  meningkatkan kualitas pasien. Pharmaceutical care menggambarkan tujuan dari farmasi klinik apabila dilihat dari praktek pofesional kefarmasian. Pharmaceutical care melibatkan peran Apoteker untuk mengembangkan rencana terapeutik yang akan menghasilkan hasil terapeutik yang spesifik untuk pasien. Tujuan dari penelitian ini adalah untuk membuat kuesioner standar siap pakai untuk penelitian tentang pengetahuan, sikap, dan perilaku apoteker tentang pharmaceutical care. Tiga puluh apoteker yang diberikan kuesioner untuk diisi menjadi sampel dalam penelitian ini. Sebuah teknik digunakan untuk mengevaluasi validitas kuesioner secara expert judgement sedangkan pada uji reliabilitas digunakan dengan melihat nilai korelasi item-total. Pengujian validitas instrument dengan expert judgment dihasilkan ada beberapa item pernyataan yang mengalami perbaikan kalimat. Sedangkan uji reliabilitas, item pernyataan pengetahuan ada 7 item yang memiliki nilai korelasi item-total > 0,20, pada item pernyataan sikap ada 22 item yang memiliki nilai korelasi item total > 0,20 dan pada item pernyataan perilaku ada 14 item yang memiliki nilai koralasi item total > 0,20. Hasil uji validitas dan reliabilitas instrumen dapat diterima untuk digunakan dalam menilai pengetahuan, sikap, dan perilaku apoteker terhadap pharmaceutical care.
Effectiveness of Papaya (Carica papaya L.) Seed Extract and Alum on Aedes aegypti Larvae Death Rini Ambarwati; Sara Nurmala; Nuning Anggraini
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 21 No. 01 Juli 2024
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v21i1.14358

Abstract

People generally use larvicide to kill mosquito larvae. Synthetic chemical larvicides leave residues that have a negative impact on the environment. Therefore, research on natural larvicides has been developed to suppress the negative effects of chemical larvicides. Microparticle preparations can speed up the compound delivery system so that it will be effective in its use as a larvicide. The important composition in making microparticle preparations is polymer. The polymer used in this research is chitosan. The formulation of papaya seed extract and alum microparticles using chitosan polymer with the spray drying method was made into three formulas with different concentrations of extract and alum, namely formula 1 (0.1% : 0.05%), formula 2 (0.15% : 0.075%). %), and formula 3 (0.2% : 0.1%). The results obtained show that formula 3 with a concentration of 0.2% papaya seed extract and 0.1% alum has the best quality characteristics based on the polydispersity index parameters, namely 0.181, particle size 1233.67 nm, zeta potential value 72.6 mV. The number of samples was 500 test larvae consisting of 5 treatment groups. Each group contained 25 larvae and 4 replicates. The test larvae were observed after 24 hours and then analyzed. The test analysis carried out was the Probit test. The LC50 value obtained in this study was 95.5 ppm. These results indicate that the microparticle powder preparation has larvicidal efficacy against third/IV instar Aedes aegypti larvae.
Physical Interaction between Curcumin and Paracetamol in the Binary Mixture and Its Impact on the Solubility of Curcumin Fikri Alatas; Susi Sunarty Sigalingging; Citra Permata Sari; Fahrauk Faramayuda; Sundani Nurono Soewandhi
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 21 No. 01 Juli 2024
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v0i0.15170

Abstract

Curcumin, found in turmeric (Curcuma longa L.), is a pharmacologically active component with hepatoprotective properties. In addition to alleviating pain, the synergistic effects of paracetamol protect the liver from harm. Oral solid dose formulations of curcumin have low bioavailability due to its low solubility. This study aims to characterize the physical interactions that occur in the binary mixture of curcumin and paracetamol and to determine its impact on the solubility of curcumin. The curcumin-paracetamol binary mixture with a 1:1 stoichiometric ratio was prepared by a wet grinding method with the addition of a small amount of ethanol. The characterization of the physical interactions in the wet milling result was carried out using a powder X-ray diffractometer (PXRD) and a differential scanning calorimeter (DSC). Evaluation of physicochemical properties was carried out by testing its solubility in water and its dissolution rate in 40% v/v ethanol. The PXRD pattern of the curcumin-paracetamol milling result did not show any new peaks that were different from the typical peaks of the two components (curcumin form I and paracetamol form 1). The thermogram DSC of the binary mixture curcumin-paracetamol (1:1) only showed one wide endothermic transition at 151.2°C which is below the melting point of curcumin and paracetamol which is thought to be the melting point of the eutectic mixture of curcumin-paracetamol (1:1). The solubility of curcumin from the curcumin-paracetamol (1:1) milled binary mixture was 8.3-folds higher than that of pure curcumin. The dissolution rate of curcumin from the wet milling of the curcumin-paracetamol binary mixture (1:1) was also faster than that of pure curcumin. The research results can be concluded that wet milling of the binary mixture of curcumin-paracetamol (1:1) with a little ethanol shows a physical interaction with the formation of a simple eutectic mixture between the two substances which has an impact on increasing the solubility and dissolution rate of curcumin.
GC-MS Profile of Antioxidant Secondary Metabolites of Red Ginger from Batu Malang with Hepatoprotector Effect on Wistar Rats Exposed to Ethanol Linia Nitrika; Nanik Marfu'ati; Maya Dian Rakhmawatie
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 20 No. 02 Desember 2023
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v0i0.15337

Abstract

The liver is the organ most susceptible to the adverse effects of alcohol use. Decreased superoxide dismutase can be used as an indicator of liver cell damage due to excessive alcohol consumption. Red ginger (Zingiber officinale var. Rubrum) is known to have a hepatoprotective effect through antioxidant and anti-inflammatory mechanisms. This study was to prove the effect of red ginger extract from Batu Malang, Indonesia to restore normal levels of superoxide dismutase in the liver of Wistar rats induced by ethanol. Gas Chromatography-Mass Spectroscopy (GC-MS) metabolite profiling analysis of the red ginger ethanol extract was also carried out to ensure the presence of antioxidant compounds. Male Wistar rats were divided into 5 groups with 6 rats each, including negative control (C-) which was only given standard feed, positive control (C+) which was only given 1.8 mL/200g body weight of 40% ethanol orally, and treatment group which were given 40% ethanol as much as 1.8 mL/200 g body weight and red ginger extract at a dose of 250 (T1), 500 (T2), and 750 (T3) mg/kg body weight. Liver organs were taken to examine superoxide dismutase levels after 14 days of treatment in all groups. This research shows that ethanol with a concentration of 40% can reduce superoxide dismutase levels in the liver of rats significantly (p<0.05). All treatment groups that were given red ginger extract had higher superoxide dismutase levels than the positive control (C+) group (p <0.05), but the optimal dose to increase superoxide dismutase levels in Wistar rats induced by oral administration of 40% ethanol is 250 mg/kg body weight. Based on the results of metabolite profiling using GC-MS, found three dominant compounds thought to act as antioxidants, including Zingiberene, Gingerol, and 6-shogaol. Furthermore, further research is needed to evaluate the safety of using red ginger extract.
The Effect of Squid (Loligo sp.) Bone Chitosan Powder on Total Cholesterol Levels of Rats (Rattus norvegicus) Indah Indah; Muhammad Asri; Suryanita Suryanita; Astika Irianti
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 21 No. 01 Juli 2024
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v0i0.15666

Abstract

Bones in squid (Loligo sp.) can be used as a source of medicinal ingredients, one of which is chitosan. The polymer in chitosan contains amino and hydroxyl groups per residue, giving chitosan many biological activities, such as anti-inflammatory, antimicrobial, hypoglycemic, hypocholesterolemic, and immunostimulatory effects. This study aims to determine the antioxidant activity and the effect of chitosan squid bone powder on the total cholesterol levels of rats (Rattus norvegicus). This type of research used an experimental method with a one-group pre-test and post-test design, in which 12 male white rats, body weight 150 g, were divided into four groups. Group 1 was a negative control of 1% Na-CMC, group II chitosan 50 mg/kg, group III chitosan 100 mg/kg, and group IV positive control of simvastatin 10 mg, which each group was given orally; the treatment was carried out for two weeks. The results showed a decrease in the mean after treatment in the treatment group with chitosan powder, but there was no significant difference compared to the control group (P>0.005). This shows that squid bone chitosan powder reduced total cholesterol levels in rats.
Formulasi dan Uji Aktivitas Sediaan Gel Anti Jerawat Ekstrak Etanol Bunga Telang (Clitoria ternatea L) Elisabeth Oriana Jawa La; Repining Tiyas Sawiji
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 21 No. 01 Juli 2024
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v21i1.15680

Abstract

Acne vulgaris merupakan masalah kulit yang multifaktorial, salah satu penyebabnya adalah bakteri Propionibacterium acnes. Bunga telang (Clitoria ternatea L.) disinyalir memiliki aktivitas sebagai antibakteri. Kandungan senyawa aktifnya diduga mampu menghambat perkembangan Propionibacterium acnes. Sediaan gel lebih sering digunakan untuk penggunaan topikal pada penderita jerawat dengan tipe kulit berminyak. Tujuan penelitian untuk mengevaluasi stabilitas fisik sediaan gel dan menguji aktivitas antibakteri Propionibacterium acnes dari sediaan gel. Ekstraksi menggunakan metode maserasi dengan pelarut etanol, dilanjutkan dengan skrining fitokimia dan pembuatan formula gel antiacne bunga telang dengan berbagai formula yaitu FI (5%), FII (10%) dan FIII (15%), kontrol positif dan kontrol negatif. Uji aktivitas bakteri menggunakan metode difusi cakram. Hasil berupa zona bening yang terbentuk disekitar cakram diukur sebagai zona hambat dilanjutkan analisis statistik. Gel ekstrak etanol bunga telang telah memenuhi syarat mutu sediaan gel dari organoleptis, homogenitas, pH dan viskositas.  Pengujian aktivitas bakteri menunjukkan semua formula memberikan daya hambat bakteri Propionibacterium acnes dengan adanya zona hambat yang muncul disetiap formula serta kontrol positif.
Evaluation of the use of Favipiravir on the Hematology value of COVID-19 patients at Anna Bekasi Hospital in 2021 Feri Setiadi; Ardy Tanfil T; Widyastuti Widyastuti
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 20 No. 02 Desember 2023
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v0i0.15776

Abstract

The COVID-19 pandemic caused by the SARS-CoV-2 virus occurred in Indonesia in early 2020. Favipiravir was used as an antiviral for the disease due to an emergency. The results of routine hematological examinations of inpatients can be used as a parameter to predict the patient's risk of severity and the effect of using favipiravir antiviral. This study aimed to determine the effect of using favipiravir on hematological values in COVID-19 patients. The method used in this research is cross-sectional. The data collection method was carried out retrospectively with the data source in the form of medical records at Anna Bekasi Selatan Hospital in 2021. The total sample that included the inclusion criteria in this study was 83 patients. The results of the study between before and after the use of favipiravir in patients without comorbidities were significant differences in the values of the Neutrophil Lymphocyte Ratio (p: 0.003), Lymphocytes (p: 0.000), Platelets (p: 0.009) while in the value of hematocrit (p: 0.185) ) and hemoglobin (p:0.069) did not experience a significant difference. Patients with comorbid comorbidities using favipiravir had significant differences in hematological values, namely hemoglobin (p: 0.007), hematocrit (p: 0.004), platelets (p: 0.000) while the value of the Neutrophil Lymphocyte Ratio (p: 0.260) and lymphocytes (p: 0.234) did not experience a significant difference. Favipiravir is known to have a positive correlation with hematological values, in patients with COVID-19 infection without comorbidities using favipiravir it is known that the Neutrophil Lymphocyte Ratio value has decreased while the Lymphocyte and Platelet values have increased. However, it is known that the hemoglobin and hematocrit values did not experience a significant difference before consuming favipiravir and after consuming favipiravir.
Penentuan Kandungan Fenolik Total dan Model Klasifikasi Serbuk Rimpang Jahe Emprit (Zingiber officinale var. Amarum Roscoe) di Dataran Sedang dan Tinggi Harinditha Pramana Putra; Evi Umayah Ulfa; Lestyo Wulandari
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 20 No. 02 Desember 2023
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v0i0.16275

Abstract

Jahe emprit (Zingiber officinale var. Amarum Roscoe) merupakan salah satu varietas jahe di Indonesia yang dimanfaatkan sebagai obat anti inflamasi, obat nyeri sendi, tonikum, serta obat batuk. Salah satu senyawa yang mempengaruhi khasiat dari jahe emprit adalah senyawa golongan fenol. Penelitian ini bertujuan menentukan kandungan fenolik total dan menentukan model klasifikasi menggunakan spketroskopi NIR dan kemometrik pada jahe emprit yang di tanam di dataran sedang dan dataran tinggi. Penentuan model klasifikasi menggunakan analisis multivariat LDA (Linear Discriminant Analysis), SVM (Support Vector Machines), dan SIMCA (Soft Independent ModeIIing of CIass AnaIyze), dan SVM (Support Vector Machines). Selanjutnya dilakukan validasi LOOCV (Leave-one-out cross-vaIidation) dan validasi eksternal. Penentuan fenolik total menggunakan spektroskopi uv-vis dengan reagen folin. Hasil rata-rata dari kandungan fenolik total pada dataran sedang adalah (23,592 ± 6,705) mg GAE/g serbuk, dan pada dataran tinggi adalah (13,382 ± 1,2700) mg GAE/g serbuk. Model klasifikasi LDA, SVM, dan SIMCA menghasilkan %akurasi sebesar 100%. Hasil validasi LOOCV model LDA dan SIMCA adalah 100%, dan SVM sebesar 60%. Hasil validasi eksternal model LDA dan SIMCA memiliki akurasi sebesar 100%. Setelah itu aplikasi pada sampel nyata pada model LDA dan SIMCA masing-masing memiliki akurasi sebesar 100%.
Aktivitas Penghambatan Radikal Bebas Jamu Modifikasi Beras Kencur dan Pengaruhnya terhadap Ketahanan Fisik Mencit Nina Herlina; Cyntia Wahyuningrum; Almasyhur Almasyhur; Nhadira Nheistricia; Teddy Aryudha; Dea Ananda Safira; Eka Herlina
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 20 No. 02 Desember 2023
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v0i0.16691

Abstract

Jamu Beras Kencur (JBK) adalah ramuan khas Indonesia yang secara tradisional dikenal sebagai jamu. Setiap komponen dari beras kencur telah dilaporkan memiliki kekuatan antioksidan yang berperan dalam meningkatkan kekebalan tubuh. Penelitian ini bertujuan untuk mengetahui aktivitas penghambatan radikal bebas dari JBK dengan metode ekstraksi infusa dan rebusan serta pengaruhnya terhadap peningkatan daya tahan tubuh. Penelitian ini menggunakan bahan beras, rimpang kunyit dan kencur, serta jeruk nipis. Bahan tersebut diserbuk dan diekstraksi dengan metode ekstraksi infundasi dan dekok dengan air sebagai pelarut. Uji aktivitas penghambatan radikal bebas menggunakan metode DPPH dan pengaruhnya terhadap daya tahan tubuh yang diuji mengacu pada uji Natatory exhaustion (metode berenang) dengan menggunakan mencit jantan. Tiga puluh ekor mencit jantan dibagi menjadi enam kelompok. Mencit diberi akuades 0,5 ml (kontrol negatif), kafein dengan dosis 1,82 mg/20gBB (kontrol positif), JBK (156 mg/20gBB, 312 mg/20gBB, dan 468 mg/20gBB), dan perasan kencur (78 mg/20gBB) per oral selama 6 hari. Hasil penelitian menunjukkan bahwa JBK memiliki aktivitas pengambahtan radikal bebas (IC50) untuk metode infus sebesar 45,699 ppm dan 77,68 ppm untuk metode dekok. JBK memperpanjang waktu berenang dan mengurangi peningkatan kadar laktat darah.
Effects of the RH-40 Cremophor Concentration on the Formulation of the Vaccinium varingiifolium (Blume) Miq leaf Extract Nanoemulsion Yulius Evan Christian; Deni Rahmat; Yunahara Farida
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 20 No. 02 Desember 2023
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v0i0.16795

Abstract

Cantigi (Vaccinium varingiaefolium (Blume) Miq.) contains anthocyanins, chlorophyll, phenols, saponins, steroids, tannins, triterpenoids, flavonoids, and antioxidant activity. This study aimed to obtain the concentration of cremophor RH-40 as an optimal and stable surfactant during storage in Cantigi leaf extract nanoemulsion formulation process. Cantigi leaf extract was made by kinetic maceration in stages with n-hexane, ethyl acetate, and 96% ethanol as solvent, then evaporated with an evaporator. The extract was tested for solubility using various solvents before making the nanoemulsion. Nanoemulsions were prepared by varying the amount of cremophor RH-40 in three formulas (5%, 7.5%, and 10%) with stirring at 400 rpm at 40 °C. The nanoemulsions were characterized by particle size, zeta potential, and storage for 5 days. The evaluation results of Formula 1, 2, and 3 have an average particle size of 224.7, 226.5, and 198.3 nm, with a polydispersity index of 0.565, 0.237, and 0.223. The zeta potential values are - 43.7, - 39.2, and - 42.3 mV, respectively. The results of the storage of nanoemulsions for 5 days showed that in formulas 1 and 2 a precipitate formed, while in formula 3, there was no precipitate. Based on the optimization results obtained, cremophor RH-40 10% obtained a stable nanoemulsion that does not occur with no observed sedimentation/precipitation during storage.

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