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INDONESIA
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia)
Published by Universitas Muhammadiyah Purwokerto
ISSN : 16933591     EISSN : 2579910X     DOI : -
Core Subject : Science,
Materials Science & Nanotechnology
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) is a scientific journal publishing original articles research in pharmaceutical science such as Pharmaceutical Technology, Pharmacology and Toxicology, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Herbal Medicines, Pharmaceutics, Pharmaceutical Microbiology and Biotechnology, Community and Clinical Pharmacy, and Pharmaceutical Care.
Arjuna Subject : -
Articles 555 Documents
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Efficacy of Additional Vitamin D 1000 IU on Diabetic Neuropathy Peripheral for Sleep Quality, Moods, and Daily Activity Tillandsia Filli Folia Primastuti; Rizaldy Taslim Pinzon; Sugaianto Adisaputro
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 21 No. 01 Juli 2024
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v21i1.17199

Abstract

Diabetic neuropathy is one of the most common long-term microvascular complications in diabetes mellitus, in which diabetic neuropathic pain is the most frequent symptom. Diabetic neuropathic pain mostly gets worse at night leading to sleep disturbances. Prolonged pain that does not improve can be stressful and decrease quality of life, symptomatic therapy has not been able to reduce the pain completely. This study aims to investigate the efficacy of additional therapy with 1000 IU of vitamin D on sleep quality, mood, and daily activity in patients with diabetic neuropathy. This study was a randomized controlled trial comparing the experimental group which was given symptomatic therapy and 1000 IU of vitamin D supplementary therapy and the control group which was only given symptomatic therapy, both of them were given 3 months of therapy and the pain impact was checked with the Brief Pain Inventory (BPI). Sampling was conducted in February 2021 using consecutive sampling through a computerized block randomization technique. Data analysis was conducted univariately, and bivariate used Mann-Whitney. Based on the Mann-Whitney test, it was found that the administration of 1000 IU of vitamin D to the experimental group showed a significantly superior improvement in sleep quality (p = 0.004), mood (p = 0.002), and daily activities (p =0.003) in the experimental group compared to the control group after 3 months intervention. Additional therapy of 1000 IU of vitamin D improves sleep quality, mood, and daily activity abilities in patients with diabetic neuropathic pain.
Quality Analysis, Phenolic and Flavonoid Content, and Antimicrobial Activity of Stingless Bees Honey (Heterotrigona itama) Misrahanum Misrahanum; Haya Aqilah; Murniana Murniana
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 20 No. 02 Desember 2023
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v0i0.17205

Abstract

Stingless bee (Heterotrigona itama) honey has been utilized as a therapeutic ingredient for treating infectious illnesses. This study aims to investigate the quality of stingless honey, total phenolic and flavonoid content, and antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans. Honey quality parameters evaluated included organoleptic tests, diastase enzyme activity values, hydroxymethylfurfural (HMF) content, water content, reducing sugar content, honey acidity, and lead (Pb) contamination with test procedures based on the Indonesian National Standard (SNI) 8664: 2018 on honey. The antimicrobial activity test uses the well diffusion method at various concentrations, i.e., 5, 10, 15, 20, and 30%. The results showed four honey quality parameters, i.e., organoleptic, HMF content (0.0054 mg/kg), water content (27.41%), and lead metal contamination levels (0.001198 mg/kg). Honey contained total phenolic content of 6.56 ± 0.03 mg GAE/g and total flavonoid levels of 5.80 ± 0.03 mg QE/g. The stingless honey could stop the growth of Staphylococcus aureus and Escherichia coli at the lowest concentration of 5%, with inhibition zone diameters of 14.7 and 9.3 mm diameters. Stingless bee honey did not affect Candida albicans growth.
Peningkatan Performa Self Nanoemulsifying Drug Delivery System Daun Kelor (Moringa oleifera Lam) Menggunakan Metode Emulsifikasi Ultrasonic Esri Rusminingsih; Hardhono Susanto; Diana Nur Afifah; Ronny Martien; Yance Anas
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 20 No. 02 Desember 2023
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v0i0.17415

Abstract

Daun kelor (Moringa oleifera Lam) diketahui mengandung polifenol yang tinggi berupa asam fenolat, flavonoid, dan glukosinolat yang telah terbukti memiliki aktivitas hipoglikemik. Studi menunjukkan bahwa 40% senyawa alami memiliki kelarutan yang rendah dalam air, yang memengaruhi bioavailabilitas senyawa alami dalam tubuh. Self Nanoemulsifying Drug Delivery System (SNEDDS) merupakan sistem penghantaran obat yang dapat meningkatkan kelarutan dan bioavailabilitas obat. Penelitian ini bertujuan untuk meningkatkan kinerja formulasi SNEDDS ekstrak daun kelor. Metode: Penelitian ini terdiri dari 3 tahap yaitu preparasi ekstrak, preparasi SNEDDS, dan karakterisasi nanoemulsi. SNEDDS dibuat menggunakan metode emulsifikasi ultrasonik. Bahan formulasi SNEDDS adalah asam oleat: Tween 20: polietilen glikol (PEG) 400 dengan perbandingan 1:8:1. Ada tiga konsentrasi ekstrak daun kelor berbeda yang digunakan dalam penelitian ini yaitu 75 mg, 100 mg, dan 125 mg per 3 ml dalam formula dasar SNEDDS. Formula dihomogenkan menggunakan hotplate magnetic stirrer pada suhu 400C selama 30 menit, kemudian disonikasi selama 15 menit pada suhu 400C. Hasil penelitian menunjukkan rata-rata ukuran partikel pada konsentrasi 75 mg, 100 mg dan 125 mg adalah 14,40 nm, 22,99 nm dan 86,48 nm dengan polidispersitas (Pdi) masing-masing 0,41; 0,67; 0,20. Meskipun konsentrasi 125 mg memiliki rata-rata ukuran partikel terbesar yaitu 86,48 nm, namun memiliki konsentrasi ekstrak daun kelor tertinggi, Pdi terbaik dan zeta potensial -32,6 mV. Formula SNEDDS ekstrak daun kelor terbaik terdapat pada dosis 125 mg/3ml telah memenuhi parameter nanoemulsi yang dapat dikembangkan sebagai terapi komplementer dari bahan alam.
Analisis Faktor Risiko Kejadian Adverse Drug Reaction Obat Anti Inflamasi Non Steroid Pada Pasien Gout Amaliyah Permata; Rizki Nur Azmi
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 21 No. 01 Juli 2024
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v0i0.17533

Abstract

Gout artritis adalah bentuk radang sendi parah yang disebabkan oleh penumpukan kristal di persendian akibat kadar asam urat yang berlebihan di dalam tubuh. Menurut Riset Kesehatan Dasar, prevalensi artritis gout di Indonesia adalah 11,9% pada tahun 2013, dan meningkat menjadi 18,9% pada tahun 2018. Obat antiinflamasi nonsteroid dapat meredakan gejala gout artritis. Penggunaan obat ini dalam jangka panjang dapat menimbulkan efek samping berupa nyeri gastrointestinal. Penelitian ini bertujuan untuk mengetahui profil kejadian adverse drug reaction penggunaan obat antiinflamasi non steroid pada pasien gout dan mengetahui faktor risiko kejadian adverse drug reaction penggunaan obat antiinflamasi non steroid pada pasien gout. Metode yang digunakan adalah observasional dan cross-sectional dengan pengumpulan data secara prospektif menggunakan formulir monitoring efek samping obat dan juga algoritma naranjo yang dikumpulkan melalui wawancara pasien. Data dianalisis dengan menggunakan SPSS uji Fisher. Hasil penelitian menunjukan bahwa profil kejadian adverse drug reaction penggunaan obat antiinflamasi non steroid pada pasien gout didapatkan Jenis obat yang paling banyak menyebabkan adverse drug reaction yaitu natrium diklofenak sebanyak 70% dan asam mefenamat sebanyak 30%. Kejadian adverse drug reaction yang paling sering dikeluhkan yaitu perih pada perut sebanyak 56,3%. Berdasarkan hasil uji fisher’s, jenis kelamin dan Riwayat penyakit lambung memiliki nilai P<0,05 hasil tersebut menunjukan bahwa jenis kelamin dan riwayat penyakit lambung merupakan faktor risiko kejadian Adverse Drug Reaction penggunaan obat anti inflamasi non steroid.
Analisis Rasionalitas Peresepan Antibiotik Pada Pasien Infeksi Saluran Kemih Dengan Metode Gyssens di Rumah Sakit X Samarinda Muh. Irham Bakhtiar; Rismayanti Rismayanti
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 21 No. 01 Juli 2024
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v21i1.17582

Abstract

Infeksi saluran kemih disebabkan oleh perkembangbiakan mikroba yang terjadi di sepanjang sistem saluran kemih, termasuk ginjal. Memberikan gambaran profil peresepan pasien infeksi saluran kemih di Rumah Sakit X Kota Samarinda dan menilai rasionalitas peresepan antibiotik untuk pasien infeksi saluran kemih di Rumah Sakit X Kota Samarinda. Desain penelitian ini menggunakan observasional deskriptif analitik dengan desain Cohort retrospektif. Pengambilan sampel menggunakan Teknik purposive sampling. Subyek penelitian ini adalah semua pasien ISK Yang memenuhi kriteria inklusi dan eksklusi penelitian yang dirawat di RS X Kota Samarinda selama periode Januari 2020-Agustus 2022. Pasien ISK di Rumah Sakit X Kota Samarinda tahun Januari 2020 - Agustus 2022 sebanyak 55 pasien (rekam medis).Berdasarkan temuan penelitian ini, antibiotik  Ceftriaxone merupakan antibiotik paling banyak digunakan sebanyak 53,37%, diikuti Levofloxacin (10,44%), Terfacef (5,97%), Ciprofloxacin (5,97%), Cefixime (2,98%), Cefoperazone Sulbactam (2,98%), Baguinor (1,49%), Ceftazidime (1,49%), Gentamisin (1,49%), Meropenem (1,49%), Urotractin dan Azithromycin (1,49%). Semua berjumlah 67 regimen ditemukan memiliki ketidakrasionalan dengan rincian adalah kategori IIB sebanyak 68,65% (46 regimen) kategori IIA sebanyak 64,17% (43 regimen), kategori IIIB sebanyak 62,68% (42 regimen), Kategori V sebanyak 4,47% (3 regimen), kategori IIIA sebanyak 1,49% (2 regimen) dan IIC sebanyak 1,49% (2 regimen).
Medication Adherence among Acute Coronary Syndrome Outpatients at Sardjito Hospital in 2019 M Fiqri Zulpadly; Dian Eka Ermawati; Heru Sasongko
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 21 No. 01 Juli 2024
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v21i1.17807

Abstract

Worldwide, heart disease accounts for the majority of deaths. One of the indications of coronary illness is Acute Coronary Syndrom (ACS) STEMI. With a prevalence rate of 7.2%, Indonesia still has the highest ACS incidence, and it continues to rise annually. Several factors are involved in reducing the mortality rate of ACS, namely by controlling several risk factors that can reduce the incidence and improve treatment. This study aims to determine the level of adherence to drug use in patients who are registered with new STEMI and outpatients at Sardjito Hospital Yogyakarta. The research method used in this study was non-experimental analytic observational with a retrospective cohort design. Measurement using the Medication Possession Ratio (MPR) method. The study population was patients who were registered for the first ACS diagnosis since January 2017 and followed the course of their treatment until the patient stopped using the drug or the end of observation (31 December 2018). The number of samples obtained according to the inclusion criteria was 495 patients. Adherence to the use of antithrombotic drugs was greater in female patients (82.4%), age < 60 years (88.4%), and patients using combination antithrombotic therapy regimens (81.4%). Statistical significance was shown in the category of gender (Log Rank = 0.046) and treatment regimen (Log Rank = 0.005). However, the age category did not show statistical significance (Log Rank = 0.289). The conclusion of this study is that adherence to the use of antithrombotic drugs in STEMI patients is influenced by gender and therapeutic regimen.
Characterization of Ethanolic Extract of Saluang belum (Luvunga sarmentosa Kurz) Root Gusti Rizaldi; Helmina Wati; Rahmi Muthia; Selvi Amadia; Farida Hayati; Pinus Jumaryatno
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 21 No. 01 Juli 2024
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v0i0.17955

Abstract

Saluang belum (Luvunga sarmentosa Kurz) is a member of the endemic plants of Central Kalimantan, which the local community has traditionally used as a traditional medicine to cure several kinds of diseases. Characterization of the ethanolic extract of Saluang belum root is needed to facilitate the consistency of safety and quality. Therefore, this research needs to be carried out to complete the data on the characterization of the ethanolic extract of Saluang belum root. The material used is Saluang belum root collected from Palangkaraya, Central Kalimantan, Indonesia. There is no standard for Saluang belum extract. The results showed that name of the extract was Sarmentosa radix extractum; Indonesian name was Saluang belum; Latin name was Luvunga sarmentosa Kurz; part that used was root; reddish dark brown colour; typical smell; bitter flavour; contains carbohydrate, allylic alcohol and terpenoid compounds; density 0,82 g/ml; water content 4,865%; total ash content 1,74%; acid insoluble ash content 0,31%, negative residual solvent; Pb contamination 3,206 mg/kg; Cd contamination <0,001 mg/kg; total plate count 1,0 x 102 colonies/g; mold contamination 1,0 x 102 colonies/g; yeast contamination < 1,0 x 100 colonies/g.
Profil Ekstrak Rimpang Lengkuas (Alpinia galanga (L.) Willd.) dari Lokasi Tanam dengan perbedaan Letak Ketinggian Geografis Missya Putri Kurnia Pradani; Mamik Ponco Rahayu; Reslely Harjanti; Perdana Priya Haresmita
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 21 No. 01 Juli 2024
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v0i0.18646

Abstract

Rimpang lengkuas (Alpinia galanga (L.) Willd.) merupakan bahan tanaman obat sebagai bahan baku obat bahan alam yang harus berkualitas sehingga menjamin keamanan, dan manfaatnya. Lokasi geografis tanam menjadi salah satu faktor eksternal yang dapat mempengaruhi kualitas mutu simplisia, ekstrak dan kandungan metabolit sekunder yang dihasilkan. Penelitian ini bertujuan untuk mengetahui apakah perbedaan ketinggian lokasi tanam berpengaruh terhadap kualitas dan profil metabolit sekunder pada rimpang lengkuas. Sampel diperoleh dari Kecamatan Jaten, Jumantono dan Jenawi sebagai lokasi dengan perbedaan ketinggian geografis, yaitu dataran tinggi, sedang, dan rendah. Karakter mutu serta profil metabolit sekunder yang dari simplisia tersebut diidentifikasi menggunakan metode High Performance Thin Layer Chromatography (HPTLC) menggunakan pembanding eugenol selanjutnya dianalisis menggunakan hierarchical cluster analysis (HCA). Hasil penelitian menunjukkan bahwa ketinggian letak geografis tanam lengkuas yang berbeda menunjukkan profil susut pengeringan, kadar air, kadar sari larut air, dan kadar sari larut etanol yang berbeda. Profil HPTLC menunjukkan bahwa metabolit sekunder rimpang lengkuas dari Jenawi berbeda dengan sampel dari Jaten dan Jumantono dengan nilai similarity 61,49% pada analisis HCA.
Knowledge, Attitudes, and Practices of Health Workers in Medical Waste Management During the COVID-19 Pandemic I Gede Dedik Antara; I Gusti Ayu Rai Widowati; I Made Dharmadi; Putu Eka
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 21 No. 02 Desember 2024
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v0i0.19009

Abstract

Medical waste (MW) has the potential to be hazardous due to the presence of dangerous microbes. During the COVID-19 pandemic, MW had exploded, particularly in healthcare facilities. The lack of knowledge, attitudes, and practices related to medical waste management (MWM) among health workers will have a substantial influence on public health and environmental health concerns. The objective of this research is to evaluate health workers' knowledge, attitudes, and practices encompassing MWM at the health center during the Covid-10 pandemic. This cross-sectional study was done from March to May 2023, involving direct interviews with healthcare workers at the Manggis I Karangasem Health Center. A total of 36 participants responded (100% response rate). The results demonstrate that the respondent's knowledge (n=34 [68.0%]) and attitude (n=44 [88.0%]) were considered good. Solid MWM practices in the emergency room (ER) were suitable (64.0%); liquid MWM in the ER were suitable (66.5%); solid MWM in polyclinic were suitable (64.0%); liquid MWM in polyclinic were suitable (83.0%); solid MWM in pharmacy were suitable (67.5%); liquid MWM in pharmacy were suitable(50.0%). In general, health workers' knowledge, attitudes, and practices in MWM were beneficial. Statutory requirements require periodic examinations of the necessity of handling medical waste in health facilities.
Formulasi Sirup Ekstrak Etanol Citrus amblycarpa Ochse dan Aktivitas Antidiare Ekstrak dan Sirup pada Mencit yang Diinduksi Castor Oil Dina Yuspita Sari; Rini Fajaria; Ika Selvia; Jevi Asmitha Dewi; Ratna Widyasari
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 21 No. 01 Juli 2024
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v21i1.19183

Abstract

Kulit jeruk sambal (Citrus amblycarpa Ochse) mengandung tanin dan flavonoid yang diduga memiliki aktivitas sebagai antidiare. Penelitian ini bertujuan untuk mengetahui aktivitas antidiare ekstrak etanol kulit buah jeruk sambal (EELP), membuat formula sirup, serta menentukan aktivitas sirup ekstrak etanol kulit jeruk sambal (sirup EELP) terhadap mencit putih jantan. Simplisia kulit jeruk sambal dimaserasi menggunakan etanol 96%. Ekstrak etanol diformulasikan menjadi sirup dengan variasi konsentrasi ekstrak. Evaluasi sirup meliputi organoleptis, homogenitas, bobot jenis, viskositas, dan pH. Pengujian aktivitas antidiare terhadap ekstrak etanol dan sirup dari ekstrak etanol kulit buah jeruk sambal menggunakan metode proteksi dengan oleum ricini sebagai penginduksi diare. Larutan uji meliputi Na CMC (kontrol negatif), Loperamid HCl (kontrol positif), EELP dosis 0,042; 1,491; dan 2,94 g/kg BB, dan sirup EELP dengan konsentrasi 3,26; 4,26; dan 5,26%. Ketiga formula sirup menghasilkan warna hijau pekat, bau khas kulit jeruk sambal dan rasa manis sedikit pahit, homogen, pH 6, bobot jenis 1,2; dan viskositas 1,65 mPa s. Persentase antidiare ekstrak etanol kulit jeruk sambal dan sirup masing-masing sebesar 41,20; 65,11; dan 82,62%, serta 42,41; 47,08; dan 57,08%. EELP 1,492 dan EELP 2,940g/kg menunjukkan aktivitas berbeda nyata dengan kontrol negatif. Ketiga formula sirup EELP memiliki aktivitas sebagai antidiare yang ditunjukkan. Dapat disimpulkan bahwa ekstrak dan formula sirup dari ektrak etanol kulit jeruk sambal berpotensi sebagai antidiare.

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