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Journal Of Widya Medika Junior
Published by Universitas Katolik Widya Mandala Surabaya
ISSN : -     EISSN : 26561409     DOI : https://doi.org/10.33508/jwmj
Core Subject : Health,
Medicine & Pharmacology Public Health
Journal of Widya Medika Junioris our faculty's very first project in publishing the students' research, making them available for both students and faculty members to read. It is an endeavour to nurture our students' passion in doing scientific research through which process they will be encouraged to develop critical thinking, academic writing, an in-depth analysis of a particular topic using scientific method, and eventually produce knowledge.
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Articles 206 Documents
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THE DEGREE OF COLORECTAL CANCER DIFERENTIATION AND INFILTRATION WITH TISSUE INTELEUKIN 6 EXPRESSION Stanley Sugihwardojo; Bernadette Dian Novita; Imelda Theodora
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 5, No 3 (2023): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v5i3.4809

Abstract

Background: Colorectal cancer (CRC) is one of the most common malignancies reported in Indonesia, and it takes the fourth position as the most prevalent cancer just after lung carcinoma. Worldwide prevalence of CRC in 2020 is 34.189 cases, contributing to the 8.6% of all cancers reported. The diagnosis of nm is established through advanced examination such as colonoscopy, although other supporting examinations, consisted of occult blood test and histopathology examination are also performed to further evaluate the diagnosis. Pathogenesis of CRC involves the pro-carcinogenic factors (IL-6, IL-1 and TNFα) accompanied by genetic mutation that predominate the anti-carcinogenic factors ; this pathological process underlies the occurrence of CRC.Objectives: This study aimed to analyze the correlation between the degree of colorectal adenocarcinoma differentiation and infiltration with tissue IL-6 expression.Methods: This study conducted observational analytic method with retrospective study design. The degree of colorectal adenocarcinoma differentiation and infiltration were identified through histopathological examination; the degree of tissue IL-6 expression was measured by the absorption rate of pigment containing anti-IL-6. Correlation test was performed by using Spearman Rank test on SPSS version 25.Results: There was a significant correlation between the degree of adenocarcinoma differentiation with tissue IL-6 expression (p = 0.039; < 0.05), but not with the degree of tumor infiltration (p = 0.129 ; > 0.05). Statistical test also showed negative, significant correlation between sex and IL-6 expression, indicating male predominance of IL-6 expression on colorectal adenocarcinoma cases ; this finding is supported with T-test that revealed significant difference of interleukin-6 expression between male and female sex.Discussion: The reported results in this study correspond with the previous studies conducted, except for the correlation between the tumor infiltration and interleukin-6 expression. Tumor infiltration along with its differentiation describe a complex process and influenced by various factors, including hormone, cytokines, and growth factors.Conclusion: Tissue IL-6 expression is correlated with the degree of colorectal adenocarcinoma differentiation, but not with the degree of infiltration.
EFFECT OF ORAL INTAKE OF MICROPLASTIC ON THE CHANGES IN NEPHRON STRUCTURE AMONG MALE WISTAR RATS Priskilla Naomi Palyama; Yudhiakuari Sincihu; Irene Lingkan Parengkuan
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 5, No 3 (2023): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v5i3.4831

Abstract

Introduction: Microplastic bioaccumulation in nephron tissue can cause high levels of nephron mitochondrial reactive oxygen species, endoplasmic related stress proteins and inflammation-related proteins.Material and methods: This study observed damage to the tubular and glomerular structures of experimental animals due to oral intake of microplastics. 46 Wistar rats used were divided into one control(C)  and five experimental groups (Xn). The experimental group was exposed to low-density polyethylene microplastic doses of 0.0375 mg, 0.075 mg, 0.15 mg, 0.3 mg and 0.6 mg daily for 90 days with the probe, respectively. Damage to the tubular and glomerular structures was observed through microscopic examination of the preparations stained with hematoxylin eosin.Results: The results of One-Way ANOVA test showed a significant difference between groups with tubular damage (p <0.05). Meanwhile, the results of Kruskal Wallis test showed a significant difference between groups with glomerular damage (p <0.05).Conclusion: Multiple comparation indicated that exposure to microplastic started at 0.0375 mg daily had led to damage to the tubular and glomerular. Ingestion of microplastic particles causes renal tubular and glomerular damage in Wistar rats.
CRP LEVEL WITH THE SEVERITY OF COVID-19 PATIENTS AT GOTONG ROYONG HOSPITAL SURABAYA Christopher Christopher; Mulya Dinata; Yudita Wulandari
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 5, No 3 (2023): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v5i3.4807

Abstract

Background: Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). C-Reactive Protein (CRP) is an inflammatory protein that is synthesized in the liver and produced in response to inflammation. Several studies have shown a relationship between CRP levels and the severity of COVID-19.Objective: This study aims to analyze the relationship between CRP levels and the severity of COVID-19 at Gotong Royong Hospital Surabaya.Methods: This study used a cross-sectional design. Data collected through medical records from COVID-19 patients who were hospitalized at Gotong Royong Hospital Surabaya from July to December 2021.Results: There are 82 samples were collected in this study. Based on statistical analysis test, there is a significant relationship between CRP level and severity of COVID-19 with p = 0.000. The value of correlation coefficient is 0.660 which is indicating a positive correlation with a strong relationship between CRP levels and the severity of COVID-19. A high CRP level indicates a wider inflammation in the body, which is related to the severity of COVID-19.Conclusion: There is a significant relationship between CRP levels and the severity of COVID-19
THE EFFECT OF DRY RED JUJUBE FRUIT EXTRACT ON RATE ALKALINE PHOSPHATASE INDUCED WISTAR RATS ACETAMINOPHEN Maria Aloysia Praldinya Ere; Adi Pramono Hendrata; Laura Wihanto
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 5, No 3 (2023): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v5i3.4828

Abstract

Background: Many things can cause hepatotoxicity, including the use of chemicals such as acetaminophen consumed in toxic doses. Acetaminophen destroyed can damage liver tissue, block the biliary tract and end the release of ALP into the blood. Jujube fruit has antioxidants like flavonoids and phenolic, which can ward off free radicals due to excessive consumption of acetaminophen. Purpose: Knowing how giving dried red jujube fruit extract affects ALP levels of induced Wistar rats acetaminophen. Method: The method used is Posttest-Only Control Group Design. The technique used in examining ALP levels is using a colorimetric test essay which refers to the International Federation of Clinical Chemistry and Laboratory Medicine. The experimental animals used were Wistar rats which were given dried red jujube fruit extract doses of 70, 140, and 280 mg/kg BW for ten days. On the 9th day, the rats have induced with an acetaminophen dose of 3 g/kg BW, and on the 11th day, termination was carried out to examine ALP levels in the blood. Results: In this study, the normality test was generally distributed with a value of K(-) = 0.086, K(+) = 0.600, Kp1 = 0.156, Kp2 = 0.074, and Kp3 = 0.446. In the homogeneity test, the value of p = 0.0254 was obtained. On testone-way ANOVA, significant results were obtained with a p = 0.00. In the correlation test, a matter of 0.00 was obtained, which means a relationship exists between dried red jujube fruit extract and ALP levels. Conclusion: Giving dried red jujube fruit extract has an effect on ALP levels in induced rats' acetaminophen toxic dose.
SLEEP QUALITY AND COLLEGE STUDENT BLOOD PRESSURE IN WIDYA MANDALA CATHOLIC UNIVERSITY SURABAYA Cindy Clareta; Pauline Meryana; Endang Isbandiati
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 5, No 3 (2023): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v5i3.4808

Abstract

Background: Changes in sleep patterns that occur in college student due to the alteration of direct learning system, after 2 years of long distance education caused by the COVID-19 pandemic affect the adaptation process of circadian rhythm. Poor sleep quality that happened because of sleep changes patterns is liable to increased the mortality risk due to the escalation incidence of chronic diseases, cardiovascular disorder such as hypertension for the example. The prevalences of adolescent (population > 18 years) with hypertension in Indonesia is quite high at 34.11%.Objective: The study aims to learn the relationship between sleep quality and college student blood pressure in Widya Mandala Catholic University Surabaya.Method: The study used a cross-sectional approach in UKWMS faculty of medicine student. The method that used in this research, was simple random sampling and obtained 80 respondents. The data was carried out by sharing questionnaires in google forms that contains data related to sleep quality, after that we measured the blood pressure.Result: in this study, it was found out that the majority was the respondents who had a good sleep quality and normal blood pressure with a total of 37 students (77.1%), good sleep quality and abnormal blood pressure with a total of 11 students (22.9%), bad sleep quality and normal blood pressure with a total of 13 students (34.2%), bad sleep quality and abnormal blood pressure with a total of 25 students (65.8%) the result were p=0.00 (p<0.05), so it can be concluded that there was a relationship between sleep quality and blood pressure in Widya Mandala college student Surabaya.
AGE AND GENDER WITH DEGREE OF HYPERTENSION IN ADULTS AT THE CARDIOLOGY CLINIC OF GOTONG ROYONG HOSPITAL IN SURABAYA Putu Raka Prema Aristian; Epriyanto Tri Darmadi; Maria Patricia Dian Putri
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 5, No 3 (2023): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v5i3.4827

Abstract

Background : Hypertension is a condition that blood pressure in a person increases with systolic 140 mmHg and/or diastolic 90 mmHg, either based on clinical measurements or health care facilities. Hypertension is often called a "silent killer". Risk factors associated with the incidence of hypertension include age and gender. Goals : To examine the correlation between age and degree of hypertension in adults and the correlation between gender and degree of hypertension in adults at the Cardiology Clinic of Gotong Royong Hospital in Surabaya.Method : This research used an analytical observational method with a cross-sectional design. Data accumulation was obtained through medical records from the Cardiology Clinic of Gotong Royong Hospital in Surabaya. This research used simple random sampling as the sampling technique. Meanwhile, the expected analysis results from this research are p-value ≤ 0.05 and r value = 0.8 – 1.00.Result : The result of analysis after the Spearman test about the correlation between age and degree of hypertension in adults at the Cardiology Clinic of Gotong Royong Hospital in Surabaya this research found p value = 0.938 which is interpreted as a non-significant correlation and r value=   -0.012, which is interpreted as a very weak correlation. Then, the result of the analysis of the correlation between gender and degree of hypertension in adults at the Cardiology Clinic of Gotong Royong Hospital in Surabaya had a p-value = 0.632, which is interpreted as a non-significant correlation and an r value = -0.072, which is interpreted as very weak correlation.Conclusion : There is no correlation between age and degree of hypertension in adults, nor between gender and degree of hypertension in adults at the Cardiology Clinic of Gotong Royong in Surabaya.
DIFFERENCE OF BREAST CANCER ESTROGEN RECEPTOR (ER) BETWEEN OBESE PRE-MENOPAUSE WOMEN AND OBESE POST-MENOPAUSE WOMEN Viqi Vincentius Julio; Sindrawati Sindrawati; Fransiscus Arifin
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 5, No 3 (2023): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v5i3.4853

Abstract

Background: One of the risk of breast cancer is Obesity (BMI > 23Kg/m2) related to estrogen production between pre-menopause and post-menopause.Aim: To investigate the difference of breast cancer estrogen receptor (ER) in obese women based on menopausal status.Methods: This study was retrospective cross-sectional from secondary data (Medical Records) from Poliklinik Onkologi Satu Atap (POSA) RSUD Dr. Soetomo (ICD-10 C50) from 2013-2017 with inclusion criteria was BMI >23Kg/m2. Data were analyzed using Chi-Square.  Results: There were 138 patient medical records collected which is 63 were obese pre-menopause and 75 were obese post-menopause. There were statistically a significant difference (p<0,05) based on Chi square test of breast cancer estrogen receptor for obese post-menopause women (66,7%) to obese pre-menopause (39,7%). Obese post-menopause women have 1,68 times greater risk factor to become estrogen receptor positive (ER+) compared to obese pre-menopause women. (PR = 1,68; 95% CI = 1,191-2,370)  Conclusion : There is a significant difference of breast cancer estrogen receptor in obese post-menopause women more frequent than obese pre-menopause women.
PREMENSTRUAL SYNDROME AND SLEEP QUALITY AMONG MEDICAL STUDENT Gloria Fernandez; Benedictus Triagung Ruddy Prabantoro; Pauline Meryana
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 5, No 4 (2023): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v5i4.4955

Abstract

Background: Premenstrual syndrome (PMS) is a collection of physical, psychological, and behavioral symptoms associated with a woman's menstrual cycle due to hormonal changes during ovulation and menstruation. Data on New Delhi shows that 75% of women of childbearing age experience mild to severe PMS symptoms. PMS harms social and work life, leading to psychological and mental health problems affecting sleep quality. The incidence of PMS in medical students is 90.3%.Objective: To determine the relationship between PMS and sleep quality in female students of the Faculty of Medicine, Widya Mandala Surabaya Catholic University.Methods: The method used in this study was observational-analytic, cross-sectional, and simple random sampling. Data were collected using the Shortened Premenstrual Assessment Form (SPAF) questionnaire to assess the degree of PMS and the Pittsburgh Sleep Quality Index (PSQI) questionnaire to assess sleep quality. Data were tested using Fisher Exact Test.Results: Sixty-five female students met the inclusion criteria. Students with mild PMS or without PMS had good sleep quality, 38.3%, and 61.7% had poor sleep quality. In the moderate or severe PMS group, all (100%) experienced poor sleep quality. From the statistical analysis, the result of p = 0.103 (p>0.05) means no significant relationship exists between PMS and the sleep quality of female students of the Faculty of Medicine, Widya Mandala Surabaya Catholic University.Conclusion: There is no relationship between PMS and sleep quality in female medical students.
FONTAN CIRCULATION AND PREGNANCY: IS IT POSSIBLE Dorothea Kusumaningrat; Ellenora R Mustikaningrat; Gerardo AK Laksono; Paul L Tahalele
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 5, No 4 (2023): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v5i4.5089

Abstract

More than 85% of congenital heart disease in children survive to adulthood according to recent advances in pediatric cardiology and heart surgery practice. Fifty percent of  this population is made up of women, most of whom have reached child bearing age. In this group of patients, pregnancy represents a new challenge, whose natural history has been modified by surgery. In Fontan circulation,  the ventricle unable to compensate for the major restriction in the bottleneck and non physiological suction have to pull blood through the lungs, although the ventricles provide the driving force for the circuit.  Women with an adequate Fontan circulation can become pregnant without clinically significant long term sequele.  Pre-marital and pre-pregnancy consultation is important. A close collaboration between cardiologist, obstetrician and anaesthesiologist is mandatory in order to get the best outcome of pregnancy.
THE PREVALENCE OF CHILD STUNTING BEFORE AND DURING THE COVID19 PANDEMIC ERA IN GENDING DISTRICT Jose Giovanny; Nirwana Mila Safitri; Salvador Benedictus Borromeu; Sagung Putri Maharani; Nindya Amalia Biharjo Putri; Christian Jaya Sumarto Putra; Yudistira ..; Theresia Arum Hanitani; Bella Agustina Andreani; Julio Cesar Adhyaksa de Fatima; Yosephine Valentine Surya; Shallen Angelia Wijaya; Lukas Slamet Rihadi; Inge Wattimena; Florentina Sustini; Steven Wijono; Dewa Ayu Liona Dewi; Yudhiakuari Sincihu; Anisah Machmudah; Miza Nisrinah; Dwi Puspitasari
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 5, No 4 (2023): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v5i4.3852

Abstract

Background: In Indonesia, the first COVID-19 cases were announced on March 2, 2020. The first two cases were found in Jakarta, and the number continues to grow over time. Stunting is a condition in which children experience growth disorders so that the child's height does not match their age. The COVID-19 pandemic increases the risk of acute nutritional problems (undernutrition and malnutrition) in vulnerable groups. Even chronic nutrition problems (Stunting) can increase if the COVID-19 lockdown is set for long. However, data from the SSGI in 2019, 2020, and 2021 show a decline in the prevalence of Stunting from year to year. Purpose: This study was conducted to determine a difference in child Stunting prevalence before and during the COVID-19 pandemic in the Gending District. Methods: This research is an observational analytic study with a cross-sectional study. The population in this study was a child with an age range of 2-5 years before and during the COVID-19 pandemic at the Gending Public Health Center. Results: From 317 total samples, 50 stunted children were found in the period before the pandemic and 25 stunted children during a pandemic. The prevalence of child Stunting before and during the COVID-19 pandemic decreased by 28% to 16.1%. Based on the Pearson Chi-Square Test analysis test, the prevalence of Stunting was significantly (p= 0.031) different before and during the COVID-19 pandemic. Conclusion: There are differences in child Stunting prevalence before and during the COVID-19 pandemic. Keywords: Pandemic, COVID-19, Stunting.

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