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INDONESIA
Jurnal Farmasi Indonesia
Published by Universitas Setia Budi
ISSN : 16938615     EISSN : 23024291     DOI : -
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology
Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang hasil penelitian laboratorium, lapangan, studi kasus, telaah pustaka yang erat kaitannya dengan bidang kefarmasian, kesehatan dan lingkungan hidup.
Arjuna Subject : -
Articles 271 Documents
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Efektivitas dan Keamanan Terlipressin pada Acute Variceal Haemorhage: Sebuah Kajian Naratif Steven Victoria Halim; Eko Setiawan
Jurnal Farmasi Indonesia Vol 17 No 1 (2020): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (328.041 KB) | DOI: 10.31001/jfi.v17i1.786

Abstract

Providing appropriate yet timely treatment to stop bleeding is the key pathway in the management of acute variceal haemorhage (AVH). Several agents can be used to manage bleeding, and one of the new agent recently approved in Indonesia in 2019 is Terlipressin. Information toward the efficacy dan safety of Terlipressin is essentially needed to help optimising effort to use this agent responsibly, specifically in this early phase of entering Indonesian market. This narrative review mainly includes the basic profile, the current updated evidence of the efficacy and safety, the position in the therapy, and the cost of Terlipressin compared with other vasoactive agents. Only systematic review and meta-analysis articles were used to describe the efficacy and safety of Terlipressin considering it were ranked at the top level of evidence-based ladder. Some unique pharmacokinetics and pharmacodynamics properties of Terlipressin, which are not found in other vasoactive, can provide advantages when it is administered to patients in the clinical practice. However, it does not necessarily mean that Terlipression is more superior compared to other vasoactive agents. Findings of our review on three systematic review and meta-analysis found that the efficacy and safety of Terlipressin were not significantly different compared to other vasoactive agents. Therefore, Terlipressin is not the only recommended agent to be used as the first-line vasoactive agent in the management of AVH. Owing to it is relatively new introduced in Indonesia, the cost of using Terlipressin is relatively higher compared to other first-line vasoactive agent. It therefore could be suggested to use Terlipressin only for patients who can attain benefit at most such as patients with contraindications or history of side effect from other vasoactive agents
PENGGUNAAN OFF-LABEL DRUG PADA PASIEN GERIATRI DENGAN PENYAKIT DEGENERATIF DI APOTEK WILAYAH SURAKARTA Nila Darmayanti Lubis; Santi Dwi Astuti
Jurnal Farmasi Indonesia Vol 18 No 1 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i1.642

Abstract

ABSTRACT Off-label drug use in geriatric patients who have degenerative diseases has the potential to cause medication errors or adverse drug reactions but off-label is not always bad and harmful. The purpose of this study was to determine the prevalence of off-label drug use in the categories of indication, dosage, contraindication and age in geriatric patients with degenerative diseases. This study used a descriptive design. Data were collected by retrospectively. Samples were taken with a purposive sampling technique from several Pharmaceutical Installation in the Surakarta that served prescriptions with inclusion criteria for geriatric patients with degenerative diseases, prescriptions were written by specialists, prescriptions were redeemed at pharmacies that had collaborated with specialist doctors, prescriptions that had complete information, prescriptions that entered the pharmacy in April-May 2019 and matched the information on the use of the drug with the medicine leaflet. The evaluation results of the use of off-label drugs in geriatric patients with degenerative diseases in pharmacies in the Surakarta region are the prevalence of the use of off-label drug indicative categories of 7.6%; the prevalence of off-label drug use in the dose category is 33.92%; the prevalence of off-label drug use is contraindicated and age category is 0%.
Uji Aktivitas Antibakteri dan Antijamur Dari Kombinasi Minyak Nyamplung (Calophyllum Inophyllum L.) Dengan Virgin Coconut Oil Dan Pengembangannya Sebagai Face Anif Nur Artanti; Khairunisa Nursita Rahmawati; Fea Prihapsara
Jurnal Farmasi Indonesia Vol 17 No 2 (2020): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v17i2.760

Abstract

Face oil merupakan salah satu perawatan kulit yang pada pengembangannya, perlu dicari suatu agen yang memiliki sifat antimikroba, contohnya adalah minyak nyamplung dan VCO. Minyak nyamplung yang diperoleh dari pengepresan biji nyamplung akan dikombinasikan dengan VCO pada seri konsentrasi 25:75, 40:60, 50:50, 60:40 dan 75:25% (v/v) yang kemudian diuji antibakteri serta antijamur menggunakan Propionibacterium acnes dan Malassezia furfur dengan menggunakan metode difusi cakram serta diamati diameter zona hambatnya. Perbandingan kombinasi kedua minyak yang memiliki aktivitas antimikroba tertinggi akan dikembangkan menjadi sediaan face oil yang kemudian diuji sifat fisik sediaan diantaranya uji stabilitas, organoleptis, pH, homogenitas, daya sebar, serta uji kadar air selama 4 minggu penyimpanan pada suhu ruang. Hasil penelitian menunjukkan bahwa kombinasi minyak nyamplung dan VCO yang memiliki aktivitas antibakteri paling tinggi adalah seri konsentrasi 25:75 dan 50:50% (v/v) (DDH=12,33 mm), namun kombinasi minyak tersebut tidak memiliki aktivitas antijamur (DDH=0 mm). Hasil analisis data uji sifat fisik diuji menggunakan Repeated Measures ANOVA dengan Post Hoc Bonferroni dan diketahui bahwa sediaan face oil stabil selama 4 minggu penyimpanan, namun pada uji pH sediaan face oil mulai tidak stabil pada minggu ke-3 dan ke-4.
Stimulantia Effect Of Single Bulb Garlic Extract (Allium Sativum Var.Solo Garlic) in Swiss Webster Mice Ika Buana Januarti
Jurnal Farmasi Indonesia Vol 17 No 2 (2020): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v17i2.762

Abstract

Stimulant is an agent that stimulates the central nervous system thereby increasing physical and mental abilities and minimizing fatigue. The use of synthetic caffeine stimulants of 10 mg / kg BW is known to have side effects of increasing total cholesterol and increasing LDL, therefore alternative stimulants from natural ingredients are needed. Natural materials that have been studied contain flavonoids and phenolic as a stimulant compound is a single garlic bulbs. The purpose of this study was to determine the stimulant effect of a single garlic bulbs ethanolic extract on mice from the difference in swimming time. The research experimental used Pre test and Post test control design. Sample of this research used mice which were divided into 6 groups. Group 1 pretest dose 5 g / kgBB, group 2 (negative control), group 3 (caffeine), group 4 extract dose 5g / kgBB, group 5 dose 10g / kgBB and group 6 dose 20g / kgBB. Data was analyze using one way Anova continued with Post Hoc test. The group of single garlic bulb ethanolic extract dose 20 g / kgBB had the highest stimulant effect with 222,722 minutes fatigue time difference and statistically have significant difference (p <0.05) than the negative control group. Group of single garlic bulb extract can influence the time of fatigue of mice by extending the swimming time of mice so that it has a longer fatigue time which means it has a stimulant effect
Penggunaan Kontrasepsi Oral dan Risiko Obesitas Pada Wanita Usia Subur Iqlima Den Firza; Nurmainah Nurmainah
Jurnal Farmasi Indonesia Vol 18 No 1 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i1.793

Abstract

Oral contraception is a method that can be used to support family planning programs. However, there are some side effects that can be caused by the use of oral contraceptives, one of which is weight gain, which is a major risk factor for obesity. Obesity is known as a factor in the development of hypertension and diabetes mellitus. This research aimed to analyze the correlation between duration of use and type of oral contraception that is alleged to have a risk of obesity. This study using an observational method with an analytic cross-sectional study design. The data was taken based on acceptors’ medical records for the period January 2018-March 2019. Data collection techniques using purposive sampling with samples that comply with the inclusion and exclusion criteria is 68 samples. The results showed that the longer used of oral contraception, the higher the risk of obesity in oral contraception acceptors (p = 0.001; OR = 20.7; CI95% = 4.87-87.95). Using the type of combined oral contraceptives also has a higher risk of obesity in oral contraception acceptors (p = 0.011; OR = 10.2; CI95% = 1.25-82.87). The conclusion of this study that duration of use and type of oral contraception has a correlation with the risk of obesity.
Pengaruh Pemberian Ekstrak Adas (Foeniculum vulgare Mill ) Pada Tikus Laktasi Terhadap Sel Neuroglia Anak Tikus Dwi Ningsih
Jurnal Farmasi Indonesia Vol 17 No 2 (2020): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v17i2.794

Abstract

Breast Milk is a natural baby food that is rich in nutrients and contains higher immunological factors compared to formula milk. Foeniculum vulgare Mill plants have long been used by the community as enhancing the production of breast milk (ASI). The purpose of this study was to determine the effect of lactogogum extracts of Foeniculum vulgare Mill leaves and stems in lactation mice, as seen from mouse neuroglia cells. Foeniculum vulgare Mill extract was made by maceration method using 96% ethanol solvent. The test animals used in the study were white rats, divided into 6 groups namely, normal control, control without drugs (cmc-na 0.5%), comparison of asifit drugs (67.86 mg / KgBB), ethanol extract groups of leaves and stems fennel dosage 315 mg / kg body weight, 630 mg / kg body weight, and 945 mg / kg body weight. The results of the research that have been done show that the ethanol extract of Foeniculum vulgare Mill leaves and stems dose 315 mg / kg body weight, 630 mg / kg body weight, and 945 mg / kg body weight have a lactagogum effect seen from the parameters of the number of glia cells in the brains of breastfed mice. The effect increase is not as large as the dose increase given. The ethanol extract of Adas leaves and stems of 630 mg / kg BW has an optimal lactagogum effect equivalent to drug control on the market as seen from the parameters of the number of glia cells in the brains of breastfed rat.
Formulasi, Uji kualitas Dan Uji Organoleptik Sabun Mandi Padat Menggunakan Bahan Aditif Daun Jambu Biji (Psidium guajava L.) Sri Handayani; Aris Tiana Anjali
Jurnal Farmasi Indonesia Vol 17 No 2 (2020): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v17i2.798

Abstract

Guava leaves have flavonoids, tannins, and alkaloids as main compounds which have been shown to be active as antibacterial and anticarcinogenic agents. However, they have never been used as additives in skin care products because they have a rough texture. The purpose of this research are to formulate the method in the production of bath soap with the leaves as additives, and they were examined in quality and organoleptic tests. Formulation in production of the soap was carried out by means of variations of the method of extracting guava leaves as additives, namely: without additive as a control (A), with water solvent (B), with vegetable oil solvent (C), and powder dried as a scrub (D). The soap quality tests based on SNI 2016 including tests for alkaline or free fatty acid levels, insoluble ingredients in ethanol and unsaponified fat fractions. Organoleptic test was carried out involving 20 panelists. Data were analyzed by ANOVA-Duncan test. It was found that soap quality test for all samples meet INS except free alkali levels in D soap. The hedonic test results show that all soap samples can be accepted by panelists. Based on quality and organoleptic tests, the formulation method for adding guava leaf extract as an additive that produces the best soap is extraction using a water solvent (soap B). For the next study, it is necessary to confirm the biological activity of soap with guava leaf additives because it is very potential to be used as an antimicrobial soap.
Enoxaparin vs Fondaparinux Dalam Penurunan CK-MB yedy purwandi sukmawan; Keni Idacahyati; Rezky Fahrizal Firdaus
Jurnal Farmasi Indonesia Vol 17 No 2 (2020): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v17i2.810

Abstract

Ischemic Heart Disease (Non ST Elevated Myocardial Infarction-NSTEMI) is the leading cause of death in Indonesia after Stroke. Enoxaparin and Fondaparinux are the drugs of choice for this condition. However, there is a little study about these drugs in Indonesian people. Therefore, the objective of the study is to determine the effectivity of enoxaparin and fondaparinux in CK-MB reduction in Indonesian people. The methods of the study is retrospective observational study. A total of 43 patients were met inclusion criteria (32 in the enoxaparin group and 11 in the fondaparinux group). The outcome of the study was CK-MB reduction and the time of dyspnea was disappeared. The results of the study showed no statistic difference between enoxaparin and fondaparinux in reducing CK-MB blood plasma level (-29.00 vs -33.09; p 0.715), and also the time of dyspnea was disappeared (3.44 vs 3.09 days; p 0.347). Therefore, the choice of these agents are based on clinical condition, adverse effects and pharmacoeconomic aspects.
Efektivitas Kombinasi Dua Obat Antihipertensi Pasien Hipertensi Rawat Jalan RSUD Karanganyar Tri Wulandari; Anindhita Yudha Cahyaningtyas
Jurnal Farmasi Indonesia Vol 18 No 1 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i1.811

Abstract

The aim of hypertension treatment was to manage and control blood pressure so that the risk of cardiovascular disorders and other complications can be minimized. Blood pressure control can be achieved faster with combination treatment than monotherapy. The use of drugs combination was more effective than inertia therapy and prevented the risk of cardiovascular damage. The purpose of this study was to analyze the effectiveness of combination therapy of 2 drugs that have the highest target achievement for controlling blood pressure in patients with hypertension age ≥ 60 years is <150/90 mm Hg, for patients <60 years is <140/80 mm Hg. The design of this study was retrospective and observational analytic with a cross-sectional approach. Data collection was conducted by reviewing the record of patients. The study samples were outpatients in Karanganyar District Hospital who suffer from hypertension and received the same drug combination therapy for three months successively. The patient's blood pressure was measured during inspection every month. The number of samples in this study was 59 respondents. The results showed that the combination of two antihypertensive drugs most widely used by the CCB + ARB group with achievement target by 92.3% and the lowest achievement target from the combination of diuretic + ARB groups by 20%. The P-value of this research is 0.001 indicated that there were significant differences in the selection of an antihypertensive combination of 2 drugs.
Analisis Biaya Riil Dan Kesesuaian Dengan Tarif INA-CBGs Pada Pasien Kanker Ovarium Di RSUD Dr. Moewardi Surakarta Tahun 2018 Eka Oktafiani
Jurnal Farmasi Indonesia Vol 17 No 2 (2020): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v17i2.824

Abstract

Ovarian cancer according to the Indonesian Society of Gynecological Oncology ranks second after cervical cancer. Treatment of ovarian cancer is done by surgery, radiotherapy, and chemotherapy. The study aimed to understand the suitability of real costs with INA-CBG rates and the factors that influence real costs in ovarian cancer patients at hospital Dr. Moewardi Surakarta. The study was taken analytically, the data was taken retrospectively. Subjects were ovarian cancer patients hospitalized at Dr. Moewardi Surakarta in 2018. The analysis used a t-test sample and multivariate analysis to find out research on aid funds with factors related to aid. The results of the study there were 93 patients, 87 patients included in the classification of chemotherapy and 24 patients included in the classification of surgery. Chemotherapy C-4-13-I class 3 has a difference of Rp-2,685,296, in surgery W-1-20-I class 1 the difference is Rp-3,486,814, for class 3 the difference is Rp -6,933,878, W-1 surgery -20-II class 2 the difference is Rp -6,492,889, grade 3 the difference is Rp -20.450.634, and in surgery W-4-10-III class 2 the difference is Rp -13,714,831. The factor that influences the real cost is LOS (Length Of Stay) (p = 0,000) on chemotherapy. The irregular cycle of chemotherapy leads to the cost of chemotherapy for patient ovarian cancer in Dr Moewardi Surakarta 2018.

Page 18 of 28 | Total Record : 271

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