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Jurnal Farmasi Indonesia

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Published by Universitas Setia Budi

ISSN : 16938615 EISSN : 23024291 DOI : -

Core Subject : Health, Science, Engineering,

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang hasil penelitian laboratorium, lapangan, studi kasus, telaah pustaka yang erat kaitannya dengan bidang kefarmasian, kesehatan dan lingkungan hidup.

Arjuna Subject : -

Articles 271 Documents

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Ketidaksesuaian Dosis dan Interval Pemberian Antibiotik pada Lansia di Bangsal Penyakit Dalam RSUD dr Moewardi Solo serta Gambaran Timbulnya Efek Samping yang Merugikan Rita Septiana; Risma Sakti Pambudi
Jurnal Farmasi Indonesia Vol 16 No 2 (2019): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Aging causes a decrease in renal blood flow velocity and clearance values related to renal filtration function. A decrease in kidney filtration function results in a decrease in the ability of drug elimination so that the drug and its metabolites tend to accumulate in the blood. The dose of certain antibiotics must be adjusted to the patient's kidney function. Clinical estimates of kidney filtration function are expressed in terms of creatinine clearance (CrCl). This study aims to determine the percentage of suitability of the dose and interval of antibiotic administration with the CrCl value of elderly patients and to see description of the side effects arising from the administration of antibiotics. This research was observational with data retrospective retrieval of medical records. The subjects of the study were elderly patients who were hospitalized in the ward ward in dr. Moewardi Solo Hospital in the period January - May 2019 , ≥ 60 years aged with a diagnosis of Pneumonia, Urinary Tract Infection (UTI), Cellulitis and sepsis with complete medical record data. The antibiotics evaluated are all antibiotics given to the patient while being treated. The results showed the suitability of the dose and interval of antibiotic administration with the CrCl value of elderly patients hospitalized in the disease ward in RSUD Dr. Moewardi Solo for the period January-May 2019 was 63.35%, the incidence of side effects arising from the administration of antibiotics was nausea and vomiting (10 patients ) and diarrhea (4 patients).

Aktivitas Hepatoprotektif Ekstrak Daun Sukun (Artocarpus altilis (Park.) Fsb.) pada Mencit Balb/C yang Diinduksi Vaksin Hepatitis B TRI WIJAYANTI; VIVIN NOPIYANTI; IKA PURWIDYANINGRUM
Jurnal Farmasi Indonesia Vol 10 No 2 (2013): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Breadfruit leaves (Artocarpus altilis (Park.) Fsb.) is a medicinal plant that is thought to have potential as a hepatoprotective. In the community itself has been widely used and is reported to have many uses since it contains efficacious compounds in plants such as saponins, polyphenols, tannins, hydrocyanic acid, acetylcholine, riboflavin and flavonoids. This study aimed to determine the hepatoprotective effect of breadfruit leaves extract in mice induced by hepatitis B vaccine with the percentage of liver cell necrosis as parameter. Breadfruit leaves extract was made by percolation method with ethanol 70% as the solvent. The animal test was induced by hepatitis B vaccine, then they was grouped into 5 groups of negative control group were given CMC 1%, the positive control group were given Echinacea (Imboost®) and the treatment group of test animals were given breadfruit leaf extract at a dose 750 mg/kgBW, 1200 mg/kgBW, 1650 mg/kgBW. Hepatoprotective effect was observed by liver necrosis parameter on histopathologic liver mice preparations at day 35 after treatment. The results showed that the breadfruit leaf extract can provide hepatoprotective effect by reduction the liver necrosis. The percentage of reduction necrosis of the liver in the treatment of 70% ethanol extract of breadfruit leaves dose of 1200 mg/kgBW provides the most effective hepatoprotective effect on male mice induced hepatitis B vaccine.

Stabilitas Kimiawi Sirup Ekstrak Etanolik Bunga Kembang Sepatu (Hibiscus rosa-sinensis L.) PRAISELA RIZDHANIA; MIMIEK MURRUKMIHADI; Iswandi -
Jurnal Farmasi Indonesia Vol 9 No 1 (2012): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

The ethanolic extract of hibiscus flower (Hibiscus rosa-sinensis L.) on concentration 1,25% had mucolytic effect (Septyani 2009) with alkaloid as its marker substances. Syrup was suitable because its local effect so mucus will be able to go off easily. The aim of this research was to determined chemical stability of syrup based on optimum formulation by reduction value of alkaloid as its parameter. Hibiscus powder was extracted using maceration method with PE and its residue remacerated by ethanol 70%. Standard curve was made from isolate of alkaloid with various concentration on 5; 2,5; 1,25; 0,625; and 0,3125 μg/μl with regressional equation Y = -2,225 + 16,777 x. Syrup has been made in 3 formulation with various extract concentration on 1,00; 1,25; and 1,50%. Its physical stability including viscosity and decanted easily test has been checked then the chemical stability has been done by heated syrup on increasing term from 40º, 55ºC and 70ºC. The reduction of stability known by reduction of alkaloid value as AUC from densitometer. It was analyzed using Anova two ways followed by Dunnett T3 with significancy (p 0,05). The result showed that increasing term was influence to reduction of alkaloid value but various extract concentrations were not. So it was concluded that syrup with 1,25% extract concentration had the best stability.

Perbandingan Efek Afrodisiaka Infusa dan Ekstrak n-Heksana Kuncup Bunga Cengkeh (Syzygium aromaticum L.) pada Tikus Putih Jantan Galur Wistar ARIKA WIDYARINI; YUL MARIYAH; WIWIN HERDWIANI
Jurnal Farmasi Indonesia Vol 9 No 1 (2012): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Clove (Syzygium aromaticum L.) flower bud is one of medicinal plant that is used as aphrodisiac. The study was aimed to find out the aphrodisiac effect of infuse and n-hexane extract of clove flower buds on climbing frequency of white male rats wistar strain and to know a higher aphrodisiac effect between infuse and n-hexane extract of clove flower buds. The test animals used were divided into four test groups. Group I (negative control) was given CMC 1%. Group II (positive control) was given Dji Wo capsul dose of 9 mg/200 g BW. Group III was given the n-hexane extract dose of 350 mg/200 g BW. Group IV was given the infuse dose of 350 mg/200 g BW. All preparations were given orally twice a day (morning and evening) for 5 days. At day-5, climbing frequency was observed and making vaginal smear to observe the male rat sperms. The climbing frequency data was analyzed using two ways Anova followed by Dunnett T3 test at 95% confidence. The result showed that infuse and n-hexane extract of clove flower buds had aphrodisiac effect on white male rat wistar strain and the infuse of clove flower buds had aphrodisiac effect similar with n-hexane extract.

Uji Aktivitas Diuretik Ekstrak n-Heksana Daun Ceplukan (Physalis angulata L.) pada Tikus (Rattus norvegicus) Jantan Wistar INDRAWATI FITRIANA; AGUNG ENDRO NUGROHO; GUNAWAN PAMUDJI WIDODO
Jurnal Farmasi Indonesia Vol 9 No 1 (2012): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Ceplukan (Physalis angulata L.) empirically have diuretic effect. This study aimed to determined the diuretic effect of n-hexane extract of ceplukan leaves on Wistar male rats. Ceplukan leaves powder were extracted by maceration with n-hexane solvent. Test animal was used 25 Wistar male rats were divided into 5 groups: group I were given CMCNa 0.5% (negative control), group II (positive control) were given furosemide dose 4.32 mg/200 g BW, group III, IV, V were given n-hexane extract suspension dose of 375, 187.5, 93.75 mg/200 g BW respectivelly. The urine volume were measured in hours-6, 12, 18 and 24. Diuretic effect is obtained by calculating the cumulative urine volume and AUC (Area Under the Curve). The data obtained were analyzed by one way ANOVA with a level of 95% significant, then test by LSD (Least Significant Difference).The results showed that n-hexane extract of ceplukan leaves had diuretic effect. The effective dose of n-hexane extract of ceplukan leaves for diuretic effect was dose 375 mg / 200 g BW.

Evaluasi Pengaruh Sistem Informasi Manajemen (SIM) terhadap Kepuasan Pengguna di Instalasi Farmasi RS “X” di Cirebon dengan Model DeLone & McLean - SUPRIYATIN; EDIATI SASMITO; ELINA ENDANG SULISTYOWATI
Jurnal Farmasi Indonesia Vol 9 No 1 (2012): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Information systems and information technology has become an important part of businessand organizational success. Information systems have an important role is to support business processes and operations within the company to complete its tasks, and manage the data and obtain information, to improve the performance of companies or organization. To assess the performance of such systems based on user perceptions. The purpose of this study to determine the effect of SIM on user satisfaction on Pharmacy Installation of “X” Hospital in Cirebon. The research was conducted using questionnaires given to all users with SIM in Pharmacy Installation saturated sample method. Independent variables (system quality, information quality and service quality) with the dependent variable (user satisfaction) were analyzedby simple linier regression analysis and multiple linier regression analysis. The result showed that the type of quality system have a significant effect of 43,90%, 60,70% of quality information and service quality for 74,40 while the quality system, quality information and quality services jointly significant effect on user satisfaction by 75,20%.

Optimasi Proporsi Campuran Carbopol 941 dan CMC-Na dalam Pembuatan Gel Lendir Bekicot (Achatina fullica Ferr.) secara Simplex Lattice Design ELISABETH APRILIA; ILHAM KUNCAHYO; Siti Aisiyah
Jurnal Farmasi Indonesia Vol 9 No 1 (2012): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Snail (Achatina fulica Ferr) mucus efficacious as cure wounds. The use of snail mucus directly considered less practical, so that made the gel preparation. This study aims to obtain the optimum formula of snail mucus gel from carbopol 941 and CMC-Na mixtures using simplex lattice design. Snail mucus obtained by solving the top shell snail then shell reversed for inside snail mucus out. Optimum gel formula based on the simplex lattice design with 2 components, i.e: carbopol 941 (K) and CMC-Na (C) using 3 formulas, i.e: formula I (100% K: 0% C), formula II (50% K: 50% C) and formula III (0% K: 100% C). The physical properties observed were viscosity, adhesiveness and dispersive, which then is used to make the SLD equation. The equation used to make the optimum formula gel from the total response of the most large gel physical nature. Results obtained from the simplex lattice design equation compared with actual test results with t-test (T-test). The results showed an optimum gel formula of snail mucus obtained from of 30% carbopol 941 and 70% CMC-Na mixtures. From the results of t-test (T-tesf) against viscosity, adhesiveness and dispersive showed no significant difference between the predictions with actual experimental results.

Uji Efek Tonikum Infusa Batang Pasak Bumi dan Campuran Batang Pasak Bumi, Rimpang Jahe Merah dan Buah Cabe Jawa terhadap Mencit Putih Jantan MELINDA WIDIANINGRUM; - SUHARTINAH; WIWIN HERDWIANI
Jurnal Farmasi Indonesia Vol 9 No 1 (2012): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Eurycoma longifolia Jack. stem, Zingiber officinale Rosc. Var. Rubrum rhizome and Piper retrofractum fruits are traditional medicine plants, one of which is to overcome fatigue (tonic). This aim of the experiment was: first to find out whether infuse formula of single Eurycoma longifolia Jack. stem powder and infuse formula of a mixture of Eurycoma longifolia Jack., Zingiber officinale Rosc. rhizome, and Piper retrofractum fruit had tonic effect on male white mouse; the second, to obtain the most effective formula as tonic on for male white mouse. In this study the test animals were divided in 5 groups, and each group consisted of 5 male white mice, i.e. Group 1 F1 was Eurycoma longifolia Jack. stem, group II F2 was a mixture of (2:1:1), group III F3 was a mixture (1:1:1), group IV was positive control (caffeine), group V was negative control (distilled water). The study was conducted by making the orally given male white mice to swim, and then the exhausted times were observed and recorded before and after the treatment. The experiment concluded that first: infusa of single Eurycoma longifolia Jack. stem powder and infuse of a mixture of Eurycoma longifolia Jack., Zingiber officinale Rosc. rhizome, and Piper retrofractum fruit had tonic effect on male white mouse; the second, infuse of formula 3 (1:1:1) to have the best tonicum effect.

Analisis Seng Dan Besi dalam Air Minum Mineral Isi Ulang yang Berada di Kota Surakarta dengan Metode Spektrofotometri Serapan Atom SEPTINA DYAH NUGRAENI; - SUPRIYADI; RESLELY HARJANTI
Jurnal Farmasi Indonesia Vol 9 No 1 (2012): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

The mineral water is water that obtained directly from it sources, then processed with special treatment and packed. Mineral water may contained metal contamination, such as zinc and iron, which comes from water distribution pipes, production equipment, or even from other source that contains zinc and iron. Zinc and iron in large amount can cause toxicity for the body. This research aimed to know presence and amount of zinc and iron in refill drinking mineral water by atomic absorption spectrophotometry method. Samples were acidified with concentrated HNO3, then were evaporated and analyzed by qualitative and quantitative method. The amount obtained by entering absorbance data obtained from standard mutual curve regression equation. The research results showed that all samples of refill mineral drinking water are containing zinc and iron. The zinc content of the sample A (0.0011 ± 0.0005) ppm, the sample B (0.0019 ± 0.0000) ppm, sample C (0.0100 ±0.0004) ppm. The iron content of sample A (0.0176 ± 0.0015) ppm, the sample B (0.0176 ± 0.0015) ppm, sample C (0.0187 ± 0.0022) ppm. The amount of zinc and iron in three drinking water samples met the requirements set by the Indonesian National Standard No. 01-0220 - 1987.

Optimasi Pelarut Ekstraksi, Aktivitas Anthelmintika terhadap Ascaris lumbricoides Suis., dan Telaah Fitokimia Bunga Ekor Kucing (Acalypha hispida Burm. F.) MAMIK PONCO RAHAYU; ESTU SYA’BANA; AROFATUL HIDAYAH
Jurnal Farmasi Indonesia Vol 9 No 1 (2012): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Red hot cat's tail (Acalypha hispida Burm. F.) flowers is a traditional medicinal plant which can be used as an antelmintic. The aim of present study was to determine the solvent extraction of Red hot cat's tail flowers that produce the highest yield, to determine antelmintic activity against roundworms (Ascaris lumbricoides Suis.) and to determine the compounds in the extract. The powder was extracted by maceration with ethanol with four variations concentration. Extract was analyzed the soluble in ethanol extract concentration and the yield. The highest yield extract was tested on roundworms by in vitro. The worms were grouped into 12 groups randomly without regard to gender. The group consists of one negative control group was be given distilled water, the positive control group was be given piperazine citrate in 5 different concentrations, and the red hot cat's tail flowers group with 6 variations of concentration. Observation of the worm is done after 24 hours of treatment. Data were analyzed by probit method to determine the LC50. The results of this study were solvent extraction that produces the highest yield was 70% ethanol. The 70% ethanol extract had an antelmintic activity against roundworms with 6,61% w/v as LC50 values that equivalent to 0,12% w/v piperazine citrate. The 70% ethanol extract contained saponins, flavonoids, and tannins.

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