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INDONESIA
Jurnal Farmasi Indonesia
Published by Universitas Setia Budi
ISSN : 16938615     EISSN : 23024291     DOI : -
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology
Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang hasil penelitian laboratorium, lapangan, studi kasus, telaah pustaka yang erat kaitannya dengan bidang kefarmasian, kesehatan dan lingkungan hidup.
Arjuna Subject : -
Articles 271 Documents
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Analisis Biaya Langsung Medis Terapi Seftriakson Dibandingkan Dengan Levofloksasin Pada Pasien Pneumonia Komunitas di Rumah Sakit Pemerintah X NTB Cyntiya Rahmawati; Baiq Leny Nopitasari
Jurnal Farmasi Indonesia Vol 18 No 1 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i1.1117

Abstract

Pneumonia is a respiratory tract infection with the highest number of cases in Government Hospital X in NTB in 2018. The worst impact of pneumonia are death and high cost of health services risk. So management of costs is needed for effectively and efficiently. The therapeutic choice for community acquired pneumonia (CAP) used in X Hospital is ceftriaxone and levofloxacin which have a high price difference. This study aims to calculate the average direct medical costs in hospitalized CAP patients who use ceftriaxone and levofloxacin therapy at Government Hospital X in NTB in 2018. This research type is quantitative analysis using secondary data that compares the average direct medical costs of two alternative treatments for CAP with the BPJS Kesehatan perspective. The cost component are cost of medicine, care, doctor, emergency room, accommodation, and laboratory. The number of samples was 65 patients. The results showed: (1) The average direct medical costs using ceftriaxone was Rp.3.034.965, while levofloxacin was Rp.1.594.053; (2) There is significant difference in the average direct medical cost of Rp.1.440.912 perpatient; (3) Levofloxacin provide the lowest rupiah than ceftriaxone in community acquired pneumonia patients.
Pengembangan Molecular Imprinted Polymer Untuk Pemisahan Vitamin C dalam Sediaan Multivitamin Untung Gunawan; Eko Adi Prasetyanto; Shannen Ivanka Gunardi
Jurnal Farmasi Indonesia Vol 18 No 1 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i1.1155

Abstract

Vitamin C has chromophore group that can be analyzed using UV-Vis spectrophotometry, however if the complex matrix to be analyzed like multivitamins, a selective separation method is required to eliminate matrix interferences. One of the selective separation methods is Molecular Imprinted Polymer (MIP) which which hasn’t been widely used in multivitamin samples. The purpose of this study was to obtain selective MIP for separation of vitamin C in multivitamins.. Research methods included interaction observation of vitamin C with functional monomers using UV spectrophotometry, MIP was synthesized using bulk method for 24 hours at 60 °C. MIP was characterized using spectrophotometry, infrared and scanning electron microscopy MIP selectivity were determined by determination of imprinting factor and its recovery with the liquid-liquid extraction method (LLE) and SPE C18 for separation of vitamin C in multivitamin samples on the market using a validated method. Hypsochromic shift showed interaction between vitamin C and functional monomers, which hydrogen bonds were taking role in MIP synthesis. Imprinting factor more than 1 and recovery value close to 100% indicated MIP selectivity to vitamin C. MIP-1 had the highest selectivity compared to the ECC and SPE C18 methods for separation of vitamin C in multivitamin samples with recovery of 98.17 ± 2.31%, 69.42 ± 3.01%, and 93.26±4.24% respectively. Synthesized MIP-1 was selective for the separation of vitamin C in multivitamins.
The Perbandingan Kuesioner EQ-5D-5L dan SF-6D untuk Mengukur Kualitas Hidup Pasien Penyakit Ginjal Kronik di RSUD Kota Yogyakarta NI WAYAN SUKAWATI
Jurnal Farmasi Indonesia Vol 18 No 2 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i2.715

Abstract

Penyakit ginjal kronik adalah suatu proses patofisiologis dengan etiologi yang beragam, mengakibatkan penurunan fungsi ginjal yang progresif, dan pada umumnya berakhir dengan gagal ginjal. Tujuan penelitian ini adalah untuk mengetahui kualitas hidup pasien penyakit ginjal kronik di RSUD Kota Yogyakarta yang dinilai menggunakan instrumen EQ-5D-5L dan SF-6D. Penelitian ini merupakan jenis penelitian deskriptif dengan menggunakan rancangan cross sectional. Pengambilan data dilakukan dengan cara prospektif, dengan membagikan kuesioner EQ-5D-5L dan SF-6D kepada pasien penyakit ginjal kronik yang melakukan pemeriksaan rawat jalan di RSUD Kota Yogyakarta. Hasil penelitian menunjukkan bahwa kuesioner SF-6D dan EQ-5D-5L valid dan reliabel untuk digunakan dalam menggambarkan kualitas hidup pasien penyakit ginjal kronik rawat jalan di RSUD Kota Yogakarta. Nilai utilitas pasien penyakit ginjal kronik pada kuesioner SF-6D sebesar 0,739 dan pada kuesioner EQ-5D-5L sebesar 0,617. Faktor yang mempengaruhi kualitas hidup pasien penyakit ginjal kronik adalah jenis kelamin dan stadium yang dinilai dengan kuesioner SF-6D dan EQ-5D-5L.
Uji Efektifitas Gel Ekstrak Sambung Nyawa (Gynura Procumbens (Lour.)Merr.) Terhadap Penyembuhan Luka Pada Kelinci Hiperglikemia Ganet Eko Pramukantoro; Sri Rejeki Handayani
Jurnal Farmasi Indonesia Vol 18 No 2 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i2.778

Abstract

Hyperglycemia can inhibit the wounds healing process. Giving life-sustained leaf extract gel (Gynura procumbens (Lour.) Merr.) Is one of the options. The long-term goal of this study is to prove that the gel extract (Gynura procumbens (Lour.) Merr.) Leaf extract gel is able to heal wounds in hyperglycemic test animals. The specific target to be achieved is to obtain efficacious natural medicines to prevent the occurrence of diabetic wounds and to know the effective dosage of gel extract extract (Gynura procumbens (Lour.) Merr.) As a cure for diabetic wounds. This study used 5 white rabbits. Testing is done by making a wound on the back of DM alloxan-induced test animals. Wound healing activity is seen by dividing the backs of test animals into 5 parts which are treated according to their groups. The treatment group and the positive control group were applied with gel twice a day for 9 days and measured the length of the wound on days 1, 3, 5, 7, and 9. Diabetic wound healing activity was shown by calculating the wound length of each treatment and analyzed with the Anova test one way with a 95% confidence level. The results of the study showed that the formulation of life grafting gel extract based on CMC Na had good physical quality test results such as organoleptic color test according to the color of the extract, distinctive aroma of the life span leaf extract, viscous, homogeneous appearance, had a pH of 6. For the dispersion test , adhesion, and viscosity, each meets the desired requirements. The wound healing activity test showed that the grafted leaf extract with a concentration of 5% was able to heal the best, with a percentage of wound healing of 67.00%.
Uji Efek Penghambatan Enzim Xantin Oxidase Kombinasi Ekstrak Daun Kumis Kucing (Orthosiphon aristatus L.) dan Daun Sidaguri (Sida rhombifolia L.) Nitya Nurul Fadilah
Jurnal Farmasi Indonesia Vol 18 No 2 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i2.807

Abstract

Hyperuricemia is a high level of uric acid in the blood and can cause gout. One of the drugs used to treat hyperuricemia is allopurinol with a mechanism of inhibiting the activity of xanthine oxidase (XO). The use of these drugs can cause various side effects if used for a long period of time. Sidaguri and kumis kucing plants are known to contain flavonoids and are proven to treat gout with each plant can reduce uric acid levels in the blood and increase its excretion in urine. This study was carried out to test the combination of sidaguri and kumis kucing extracts with certain ratios in inhibiting the activity of the xanthine oxidase enzyme. In this study, a combination of extracts was made using maceration method. The inhibition of xanthine oxidase activity by ethanol extract in vitro was determined by decreasing the production of uric acid monitored with a spectrophotometer at (λ) 292nm with xanthine as a substrate. Then determined the best IC50. As a comparison allopurinol is used. Based on the results of in vitro tests, the best comparison of the combination of kumis kucing extract and sidaguri extract can inhibit the activity of XO enzymes with the best IC50 in a row is the combination of kumis kucing and sidaguri extracts 1:1 (20.99ppm), 1:2 (39.64ppm), and 1:0.5 (52.28ppm).
Analisis Biayariil Dan Kesesuaian Dengan Tarif INA-CBG’S Pada Pasien Kanker Kolorektal Di RSUD Dr. Moewardi Surakarta Tahun 2018 Annora Rizky Amalia
Jurnal Farmasi Indonesia Vol 18 No 2 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i2.823

Abstract

Colorectal cancer is cancer that starts from the colon or rectum. Colorectal cancer occurs when tumors form in the lining of the large intestine. The high real cost of colorectal cancer chemotherapy is a major factor in creating a national health insurance program through the INA-CBG package. The purpose of this study was to determine the suitability of real costs with INA-CBG package rates and factors that affect real costs in colorectal cancer patients hospitalized in Dr. Moewardi Surakarta. This study uses observational cross-sectional methods. Data taken retrospectively. The subjects of this study were colorectal cancer patients who were hospitalized at Dr. Moewardi Surakarta in 2018. Subjects and objects of this study were colorectal cancer chemotherapy patients who hospitalization and medical record data and inpatient claim service files at Dr. Moewardi general hospital of Surakarta for the period of January - December 2017. The analysis used is one-sample t-test to determine the suitability between real costs and INA-CBG rates and bivariate correlation analysis to determine the relationship of real costs with factors that affect real costs. The results showed the complex intestinal procedure (K-1-20-I / II / III) had an average cost that was higher than the other procedures which was Rp. 20,889,414.64. This relates to the increase in costs for medical treatment and also pharmaceutical costs. Based on the magnitude of the difference between the real rates with the INA-CBG package in colorectal cancer patients in Dr. Moewardi Surakarta in 2018 the procedure that has the highest cost difference in chemotherapy procedures at the severity of C-4-13-I with a total difference of Rp - 671,021,073,14 (negative difference). The most influential factor is Length of Stay (LOS) in anal procedures with INA-CBG's K-1-50 code with a value of p <0.05 (0,000) and in digestive tumor procedures with INA-CBG's K-4-10 code with p-value <0.05 (0.001).
Uji Sitotoksik Ekstrak Etanol Daun Stevia (Stevia Rebaudiana Bertoni) pada Kultur Sel Hela Ghani Nurfiana Fadma Sari; Endang Sri Rejeki
Jurnal Farmasi Indonesia Vol 18 No 2 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i2.875

Abstract

In Indonesia cervical cancer ranks second after breast cancer experienced by women. Stevia is a shrub that is used as a low-calorie sweetener. Stevia also has bioactive compounds such as steviosida, alkaloids, tanin, steroid and flavonoid which are useful as a treatment. Stevia leaf research as an anticancer has not been done much. Therefore, research on the cytotoxic effects of stevia leaves on HeLa cells. The purpose of this study was to determine the IC50 value of stevia leaves on HeLa cells. Stevia leaf extraction was carried out by maceration method using 96% ethanol solvent. The ethanol extract of stevia leaves was tested for its effect on HeLa cells using the MTT method with a concentration series of 500; 250; 125; 62.5; 31.25; 15,625 µg / mL. Cisplastin (Kalbe) is used as a positive control and cell control as a negative control. The results of testing the cytotoxic activity of stevia leaf ethanol extract on HeLa cells showed an IC50 value of 512.94 ± 1.62 µg / ml and IC50 value of Cisplatin 16.16 ± 1.75 µg / ml. This shows that ethanol extract of stevia leaves can be used as a cancer chemo preventive agent that acts to prevent the development of cancer cells
Formulasi Hair Tonic dari Ekstrak Etanol, Fraksi Etanol, dan Fraksi Kloroform-Metanol Kayu Secang (Caesalpinia sappan L.) Dina Yuspita Sari; Ratna Widyasari; Weni Puspita
Jurnal Farmasi Indonesia Vol 18 No 2 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i2.954

Abstract

Secang wood (Caesalpinia sappan L.) has been used as an antioxidant in cosmetic products. The bioactive compound contained in secang wood are brazilin, brazilein, 3´-O-methylbrazilin, sappanone, chalcone, and sappankalkon as secondary metabolite components. This study aims to formulating hair tonic from extracts and fractions of secang wood and to determine the quality of hair tonic formulas using ethanol extract (Eet), ethanol fraction (Fen), and chloroform-methanol fraction (Fkm) of secang wood. The extraction process was carried out using maceration with 96% ethanol as ellent, after that extact partitioned using n-hexane. Fen was then applied using vacuum column chromatography using chloroform, chloroform: methanol (5:1), and methanol as eluent. Eet, Fen, and Fkm of secang wood were then formulated. Hair tonic evaluation includes organoleptic test, determination of pH value, viscosity determination, homogeneity test, and hair growth activity. The results showed that the three hair tonic formulas produced red-orange color, smelled aromatic in solution form, had a pH of 7, were homogeneous, had a viscosity of 3 cps, and showed activity on hair growth and hair weight of rabbits. FIII gave significantly different results from negative control (p <0.05) on rabbit hair length data on day 30, so ii can be concluded that FIII shows the best activity. All three formulas were qualify according to standard requirements and has activity on hair growth.
Literature Review: Aktivitas Batang dan Daun Sambiloto (Andrographis Paniculata Nees) terhadap Target Molekular Terapi Diabetes Nurul Hidayatul Mar'ah
Jurnal Farmasi Indonesia Vol 18 No 2 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i2.959

Abstract

Andrographis paniculata Nees, so-called sambiloto is a plant that is effective as an alternative therapy for diabetes mellitus (DM). Sambiloto is a multi-compound plant that contains diterpenoids, flavonoids and polyphenols. This study aims to explain the activity of chemical compounds contained in the stems and leaves of sambiloto against five molecular targets for DM therapy, namely Dipeptidyl Peptidase 4 (DPP4), Protein Tyrosine Phosphatase (PTP1B), α-glucosidase, Glucose Transporter (GLUT) and glucokinase. This study uses a systematic review method by making PRISMA checklists and flow diagrams, determining inclusion-exclusion criteria, search engines and keywords to get relevant data. The data is obtained from the primary research results presented in the data extraction table, and then is analyzed comprehensively. The results of the study are: the diterpenoids and flavonoids can provide activity against molecular targets, such as 19-triphenyl isoandrographolide which can inhibit DPP4, α-glucosidase and activate glucokinase; andrographolactone can inhibit PTP1B; deoxyandrographolide increase translocation and acceleration of GLUT4; 15-p-methoxybenziliden 14-deoxy-11,12-didehydroandrographolide inhibits α-glukosidase; and flavonoid groups such as apigenin compounds can inhibit DPP4, PTP1B, and activate glucokinase.
Sistematik Review Aktivitas Buah Pare (Momordica charantia L.) Terhadap Target Molekuler Antidiabetes Mega Ayu Kusniawati
Jurnal Farmasi Indonesia Vol 18 No 2 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i2.974

Abstract

Diabetes mellitus (DM) is a chronic disease that occurs either when the pancreas does not produce enough insulin, or when the body cannot effectively use the insulin it produces. The purpose activity of bitter melon fruit against molecular targets antidiabetic in literatre review. Analysis and systematic web search reviews were carried out on the research literature related to bitter melon which is used for DPP4, PTP1B, α-glucosidase, and increasing GLUT4 levels. The data were collected from several journals with inclusion criteria. The data were extracted and synthesized. The charantin, cucurbitacin, dan momordicoside D compound from bitter melon fruit has activating the TGR5 and GLP1 receptor simultaneously inhibiting DPP4. The cucurbitane 25-O-methylkaraviagein D the of bitter melon fruit has inhibitory activity against the PTP1B enzyme which is associated with the presence of –OH, The 3β,7β,25-trihydroxycucurbita-5,23(E)-dien-19-al, charantal, charantoside XI, dan 25ξ- isopropenylchole-5, 6-ene-3-O- D-glukopiranosida α-glucosidase predicted to have inhibitory activity of binding to the active side of the protein. The vicine, polypeptide-p, 5-,19-epoxy-3-, 25-dihydroxycucurbita-6,23 (E) -diene dan 3-7-,25-trihydroxycucurbita-5,23 (E)-dien-19-al can increase the amount of GLUT4 on the cell surface.

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