cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Msy Rulan Adnindya
Contact Email
rulanadnindya.md@fk.unsri.ac.id
Phone
-
Journal Mail Official
jurnalkedokteranunsri@gmail.com
Editorial Address
Faculty of Medicine Universitas Sriwijaya, Indonesia.
Location
Kab. ogan ilir,
Sumatera selatan
INDONESIA
SRIWIJAYA JOURNAL OF MEDICINE
Published by Universitas Sriwijaya
ISSN : -     EISSN : 26223589     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Sriwijaya Journal of Medicine (SJM) is a scientific journal managed by Faculty of Medicine Universitas Sriwijaya, Indonesia. It publishes original research articles and reviews in Biomedical Sciences, Medicine (Neurology, Cardiovascular, Respiratory, Gastrointestinal, Urogenital, Endocrine and Metabolism, Integument, Mental Health, Obstetry and Gynecology, Ophtalmology, ENT, Musculosceletal) and Public Health Medicine. Sriwijaya Journal of Medicine (SMJ) published three times a year (January, April, October).
Arjuna Subject : Kedokteran - Anatomi
Articles 315 Documents
 24   25   26   27   28 
Management of Breast Cancer with Curcumae Rhizoma: A Therapeutic Approach Atik Diah Mutiara Ningsih; Rafif Shidqi; Syarinta Adenina
Sriwijaya Journal of Medicine Vol. 6 No. 2 (2023): Vol 6, No. 2, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i2.203

Abstract

Breast cancer has the highest incidence in women, covering 2.3 million new cases per year and a mortality rate of 23%. Therapeutic strategies applied in breast cancer treatment include surgery, chemotherapy, endocrine therapy, and radiation. All of these therapies have relatively high side effects, so alternative therapies are needed that are more effective with minimal side effects. One of the herbs known to be effective in treating breast cancer is Curcumae Rhizoma from Curcumae longa extract. The essential components of this drug are Curcumol and Curcumin. Literature searches were obtained from various online portals such as Pubmed, Google Scholar and Science Direct using the keywords "breast cancer", "Curcumae", "Curcuma Rhizoma" and "herbal medicine". Curcuma Rhizomae can inhibit the formation and spread of cancer cells by utilizing anti-angiogenic effects, disrupting the cell proliferation cycle, and inducing apoptosis. In Indonesia, Curcumae or turmeric is commonly used as a spice ingredient. Its anti-cancer potential can be used as a breast cancer therapy in Indonesia.
Rhizophora apiculata Bark Ethanolic Extracts Prevent Kidney Damage Caused by Cigarette Smoke in Male Rats Syazili Mustofa; Sarasmita Nirmala Dewi
Sriwijaya Journal of Medicine Vol. 6 No. 1 (2023): Vol 6, No. 1, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i1.204

Abstract

Rhizophora apiculata mangrove bark contains high levels of antioxidants, including triterpenoids, steroids, saponins, and tannins. The high antioxidant content can prevent oxidative stress, one of which is caused by free radicals from cigarette smoke. This research aimed to determine the potential of Rhizophora apiculata mangrove bark to protect against damage to the kidney organs of male white rats (Rattus novergicus) of the Sprague-Dawley strain exposed to cigarette smoke. This study used 25 mice divided into 5 groups for 30 days, namely group K(-), which was not given exposure to cigarette smoke and mangrove bark extract; group K(+), which was only given exposure to cigarette smoke; group P1, which was given the extract mangrove bark with a dose of 26.27 mg/kg BW and given exposure to cigarette smoke 24 cigarettes per day, group P2 which was given mangrove bark extract with a dose of 56.55 mg/kg BW and given exposure to cigarette smoke 24 cigarettes per day, and group P3 which was given mangrove oil bark extract at a dose of 113.1 mg/kg BW and given exposure to cigarette smoke 24 cigarettes per day. On day 31, the rats were euthanized, and their kidneys were prepared for histology. Kidney histology was observed, and kidney damage was assessed from the histology of glomerular and renal tubular damage. The kidney damage score is 0 if there was no damage, 1 if inflammatory cell infiltration was found, 2 if Bowman space edema or swelling of tubular epithelial cells was found, 3 if necrosis was found. Then, take the average of each renal tubular and glomerular damage score and add them together for a total damage score, namely 0-6. The median kidney damage score in the K (-) group was 0.4, the K (+) group was 3.6, the P1 group was 2.4, the P2 group was 2.4, and the P3 group was 2.2. The results of the Kruskal-Wallis test obtained a p-value of 0.001, meaning there were significant differences in at least the two treatment groups. This research showed that administering Rhizophora apiculata mangrove bark extract could prevent histological damage to the kidneys of male white rats of the Sprague-Dawley strain caused by cigarette smoke.
Correlation Between the Severity of Dry Eye Disease and Fluorescein Break-Up Patterns (FBUP) Petty Purwanita; Putri Dwi Kartini
Sriwijaya Journal of Medicine Vol. 6 No. 3 (2023): Vol 6, No. 3, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i3.205

Abstract

Dry eye disease is a disorder of the eye surface characterized by instability of the tear film. The FBUP examination is one of the examinations used to determine the stability of the tear film. The various symptoms that occur in each type of dry eye indicate differences in break-up patterns (BUP). This study aims to determine the correlation between the severity of dry eye disease and the appearance of FBUP at RSUP dr. Mohammad Hoesin Palembang. A correlative analytical cross-sectional study was undertaken at the Eye Polyclinic, Infection- Immunology Subdivision, Dr. Mohammad Hoesin General Hospital Palembang from January to June 2022. There were 32 patient samples with 60 dry eye samples that met the inclusion criteria. The correlation between the Schirmer Test, TBUT and the severity of dry eye disease with the appearance FBUP was analyzed using the Spearman Rho's test. All data were analyzed with SPPS version 23.0. In this study, the results showed that there was a moderate and significant positive correlation between the degree of the Schirmer test and the appearance FBUP (r = 0.482; p = 0.000) and a moderate and significant positive correlation between the TBUT degree and the appearance FBUP (r = 0.435; p = 0.001) . In addition, the results showed that there was a moderate and significant positive correlation between the severity of dry eye disease and the appearance of FBUP (r = 0.478; p = 0.000). Using the multivariate test, it was concluded that the degree of dry eye was statistically significantly related to age (p = 0.001) and gender (p = 0.001). There is a correlation between the severity of the disease and the appearance FBUP of patients with dry eye disease.
Bioinformatics Analysis of Disc Large Homolog-4 (DLG-4) As Parameters in Neuroplasticity Eka Febri Zulissetiana; Irfannuddin Irfannuddin
Sriwijaya Journal of Medicine Vol. 6 No. 3 (2023): Vol 6, No. 3, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i3.206

Abstract

Disc Large Homolog-4 (DLG-4), also known as Post Synaptic Density 95 (PSD95) is believed to have an important role in the function and organization of the synapse. DLG-4 is the main protein structure at the synapse that is able to bind to various molecules on the surface of the postsynaptic membrane. This review aims to determine the biomolecular characteristics of DLG-4 and the role of DLG-4 as an important parameter in neuroplasticity. Biomolecular characteristic analysis was obtained through various bioinformatics websites namely NCBI, PROTPARAM, TMHMM, PEPTIDE CUTTER, NETNGLYC, TARGETP and KEGG PATHWAY. The DLG-4 gene is located on chromosome 17p13.1 and has 25 exon. The DLG-4 protein consists of 764 amino acids with a molecular weight of 80.47 kDa. DLG-4 has a structure of 3 N-terminal PDZ domains, a Src Homology 3 (SH3) domain and a guanilate kinase-like C-terminal domain. This protein has a stability score of 48.61. The aliphatic index is 85.42. DLG-4 is found inside, outside, and on transmembranes, as determined by THMM. There are 37 enzymes that are predicted to be able to split the DLG-4 protein. The DLG-4 protein shows 3 potential sites of glycosylation of amino acids. The target location of the DLG-4 protein is mostly in other locations (other = 0.6556), secretory pathway (0.3328), and only slightly in mitochondria (0.0116). The DLG-4 protein is strongly associated with the glutamatergic system in postsynaptic neurons. The glutamatergic system is concerned with the molecular mechanism of memory development and cognitive function, long-term potentiation (LTP). These findings support the fact that DLG-4 protein plays a role in neuroplasticity mechanisms in the brain.
A Subacute Toxicity Test of Rhizophora apiculata Stem Bark Ethanol Extract on the Number, Motility, and Morphology of Male Rattus Norvegicus Spermatozoa Syazili Mustofa; Rheza Paleva
Sriwijaya Journal of Medicine Vol. 6 No. 2 (2023): Vol 6, No. 2, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i2.207

Abstract

Indonesia has the largest mangrove ecosystem in the world. Rhizophora apiculata is a mangrove often used as traditional medicine by Indonesians. It has previously been researched that the ethanol extract of Rhizophora apiculata stem bark has benefits as a source of natural antioxidants. However, there has yet to be much research on the toxicity of this extract. Therefore, researchers want to know the subacute toxic dose of Rhizophora apiculata bark extract on fertility parameters. The type of research is experimental research with a completely randomized research design. The sample consisted of 30 male rats, which were divided into 5 groups, namely the control group, which received no treatment, and the P1-P4 treatment group, which was given Rhizophora apiculata bark extract every day with 4 dose levels starting from 114 mg/kg BW to a dose of 912 mg/kg BW for 28 days. On day 30, the rats were euthanized, and the fertility parameters of the rat spermatozoa were examined using a microscope. Kruskal-Wallis analysis and One-Way ANOVA showed p<0.05 for the spermatozoa's number, motility, and morphology. The toxic dose that can reduce the number of spermatozoa is found at 912 mg/kg BW; the toxic dose that reduces spermatozoa motility is 228 mg/kg BW; and the toxic dose that affects spermatozoa morphology is 456 mg/kg BW. This research concludes that the subacute toxic dose of the ethanol extract of Rhizophora apiculata stem bark against the spermatozoa of the male Rattus norvegicus Sprague Dawley strain in the subchronic toxicity test was 228 mg/kg BW.
Importance of Exercise in Mitigating Age-Related Cardiac Apoptosis: English Mustika Anggiane Putri; Patwa Amani; Donna Adriani; Rita Khairani
Sriwijaya Journal of Medicine Vol. 6 No. 3 (2023): Vol 6, No. 3, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i3.208

Abstract

Aging causes a progressive decline in heart function. Loss of cardiomyocytes through programmed cell death or apoptosis is a critical factor contributing to this age-related damage. As we age, the heart undergoes structural changes, such as loss of cardiomyocytes, cardiomyocyte hypertrophy, and increased connective tissue with changes in heart geometry. It is widely known that mitochondria are vital sites of apoptosis. Mitochondrial-mediated apoptotic pathways are important regulators of apoptosis with aging. Mitochondrial dysfunction and oxidative stress also contribute to the cardiac remodeling and apoptosis associated with the aging process. On the other hand, exercise can improve heart function and reduce the risk of heart disease. Recent studies suggest that aging increases apoptotic signaling in the left ventricle. However, chronic exercise reduces this mitochondrial-mediated apoptotic signaling pathway in the aging heart. This review will describe the impacts of aging and exercise on cardiac apoptosis, highlighting the importance of exercise in reducing age-related cardiac apoptosis.
Curve Analysis After Bracing in Scoliosis Patients Rury Tiara Oktariza; Indriyani Indriyani; Ecian Nada Utami; Erwin Maulana
Sriwijaya Journal of Medicine Vol. 7 No. 1 (2024): Vol 7, No 1, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i1.209

Abstract

Bracing is one of the scoliosis treatment methods recommended for patients with a curve of 25° to 40° still growing child or with curves less than 25°. Bracing aims to prevent the progression of curvature. This study aimed to evaluate the decrease in the Cobb angle after a 3-month bracing in scoliosis patients. We retrospectively reviewed the medical records of 67 scoliosis patients for age, gender, and the Cobb angle before and after wearing a brace for 3 months. The data was analyzed using a paired t-test with a confidence level of 95%. The research results showed that scoliosis is predominant in females (76.12%) and at 10-15 years old (60.78%). The mean pre-brace Cobb angle of 24.94° (±7.24) was reduced significantly (P < 0.001) to 16.37° (±7.34). The use of a brace in scoliosis patients, especially teenagers, can correct the curvature of the spine.
Description of the Incidence of Anemia in Young Women at SMPN 2 Depok, Yogyakarta Dani Ferdian; Rohman Hikmat; Yogi Lasril; Abdullah Anshor; Triyanto Triyanto
Sriwijaya Journal of Medicine Vol. 7 No. 1 (2024): Vol 7, No 1, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i1.210

Abstract

Anemia is an important problem experienced by many teenagers. Anemia is a lack of red blood cells in the body. Young women are more susceptible to anemia, this is related to their own condition of experiencing menstruation (menstruation) and the result of an unhealthy diet. Therefore, further research is needed to describe anemia in adolescent girls. The aim of this study is to describe the incidence of anemia in adolescent girls at SMPN 2 Depok, Yogyakarta. The method used in this research is descriptive study. The sample in this study used total sampling. The sample was 57 8th grade teenage girls at SMPN 2 Depok, Yogyakarta. data analysis using descriptive analysis. As much as 56.14% of the 51 teenage girls who took part in the activity had anemia or anemia (32 teenage girls). This shows that the incidence of anemia among adolescent girls at SMPN 2 Depok is still high. One of the causes of anemia in adolescent girls is the lack of prevention of anemia in adolescent girls, such as taking blood supplement tablets and consuming foods with balanced nutrition. The incidence of anemia in adolescent girls is still high, so efforts are needed to prevent anemia by schools collaborating with nearby health facilities.
Medication Safety as an Effort to Prevent Medication Errors in Midwifery Nina Zuhana; Suparni Suparni; Yulian Wahyu Permadi
Sriwijaya Journal of Medicine Vol. 7 No. 1 (2024): Vol 7, No 1, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i1.215

Abstract

Patient safety is defined as an effort to prevent things that endanger patients in the process of administering drugs. Overall patient safety or prevention and reduction of errors of various risks resulting from such errors. During the process of health services, especially in the treatment of patients, mistakes can be made by health workers. The incidence of Drug Error is a measure of patient safety achievement. The purpose of this study was to analyze the implementation factors of medication safety in an effort to prevent drug errors in obstetrics. The research design chosen is qualitative . This research will be carried out at RSIA Aisyiyah on midwives who work in the inpatient room. Data collection techniques in this study conducted in-depth interviews with 10 informants consisting of midwives in the treatment room. Data analysis is carried out to process qualitative data. Some factors that influence the application of patient safety principles in hospital X include leadership factors, namely lack of supervision from the leadership, lack of human resources for health servants both nurses and pharmacy personnel, workplace environmental factors that are less conducive, unavailability of SPO drug administration with principle 7 correct, socialization that is not carried out consistently and continuously and does not run training or training programs. Some suggestions that may be considered by hospital X in order to provide safe services and in accordance with patient safety principles in drug administration.
Comparison of Germ Patterns between Cholesteatom Tissue and Tympanic Cavum Mucosa Tissue in COSM with Cholesteatom at Dr. Mohammad Hoesin Hospital, Palembang Resti Ramdani; Abla Ghanie; Fiona Widyasari; Ahmad Hifni; Irfannuddin Irfannuddin
Sriwijaya Journal of Medicine Vol. 7 No. 1 (2024): Vol 7, No 1, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i1.218

Abstract

Chronic Suppurative Otitis Media (CSOM) is middle ear inflammation due to infection characterized by otorrhea through perforation of the tympanic membrane that occurs for more than three months. Identifying bacterial patterns in CSOM is essential for managing CSOM patients with cholesteatoma. Proper administration of antibiotics is crucial to overcome infection and prevent widespread resistance. To compare the germ patterns between cholesteatoma tissue and tympanic cavum mucosal tissue in CSOM patients with cholesteatoma. This observational study has a cross-sectional design, and data collection was carried out using primary data taken from 27 CSOM patients with cholesteatoma who underwent mastoidectomy surgery with a total of 54 research samples taken from the examination of cholesteatoma tissue swabs and tympanic cavum mucosal tissue from August to October 2023. From the reliability coefficient between the two tissues using the Cohen's Kappa technique, there is a significant concordance in the germ pattern between the tympanic cavum mucosa tissue and the tympanic cavum mucosa of 0.580 (Moderate) p<0.005, with Pseudomonas aeruginosa, Proteus mirabilis and Klebsiella pneumoniae with a significance value of 0.656 (Good) p<0.001. There is a significant concordance in the germ pattern between cholesteatoma tissue and tympanic cavum mucosa tissue in CSOM cases with cholesteatoma. The most common bacteria in both tissues are Gram-negative, namely Pseudomonas aeruginosa, proteus mirabilis, and Klebsiella pneumoniae.

Page 26 of 32 | Total Record : 315

 24   25   26   27   28 

Filter by Year

2018 2025


Reset
Filter By Issues
All Issue Vol. 8 No. 3 (2025): Vol 8, No 3, 2025 Vol. 8 No. 2 (2025): Vol 8, No 2, 2025 Vol. 8 No. 1 (2025): Vol 8, No 1, 2025 Vol. 7 No. 3 (2024): Vol 7, No 3, 2024 Vol. 7 No. 2 (2024): Vol 7, No 2, 2024 Vol. 7 No. 1 (2024): Vol 7, No 1, 2024 Vol. 6 No. 3 (2023): Vol 6, No. 3, 2023 Vol. 6 No. 2 (2023): Vol 6, No. 2, 2023 Vol. 6 No. 1 (2023): Vol 6, No. 1, 2023 Vol. 5 No. 3 (2022): Vol 5, No. 3, 2022 Vol. 5 No. 2 (2022): Vol 5, No. 2, 2022 Vol. 5 No. 1 (2022): Vol 5, No 1, 2022 Vol. 4 No. 3 (2021): Vol 4, No 3, 2021 Vol. 4 No. 2 (2021): Vol 4, No 2, 2021 Vol. 4 No. 1 (2021): Vol 4, No 1, 2021 Vol. 4 No. 1 (2021): Sriwijaya Journal of Medicine Vol. 3 No. 3 (2020): Vol 3, No 3, 2020 Vol. 3 No. 2 (2020): Vol 3, No 2, 2020 Vol. 3 No. 1 (2020): Vol 3, No 1, 2020 Vol. 3 No. 3 (2020): Sriwijaya Journal of Medicine Vol. 3 No. 2 (2020): Sriwijaya Journal of Medicine Vol. 3 No. 1 (2020): Sriwijaya Journal of Medicine Vol. 2 No. 3 (2019): Vol 2, No 3, 2019 Vol. 2 No. 2 (2019): Vol 2, No 2, 2019 Vol. 2 No. 1 (2019): Vol 2, No 1, 2019 Vol. 2 No. 3 (2019): Sriwijaya Journal of Medicine Vol. 2 No. 2 (2019): Sriwijaya Journal of Medicine Vol. 2 No. 1 (2019): Sriwijaya Journal of Medicine Vol. 1 No. 3 (2018): Vol 1, No 3, 2018 Vol. 1 No. 2 (2018): Vol 1, No 2, 2018 Vol. 1 No. 1 (2018): Vol 1, No 1, 2018 Vol. 1 No. 3 (2018): Sriwijaya Journal of Medicine Vol. 1 No. 2 (2018): Sriwijaya Journal of Medicine Vol. 1 No. 1 (2018): Sriwijaya Journal of Medicine More Issue