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Molekul: Jurnal Ilmiah Kimia

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Published by Universitas Jenderal Soedirman

ISSN : 19079761 EISSN : 25030310 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

MOLEKUL is a peer-reviewed journal of chemistry published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Indonesia. Publishing frequency 2 issues per year, on May and November. This Journal encompasses all branches of chemistry and its sub-disciplines including Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry.

Arjuna Subject : -

Articles 331 Documents

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DEKOLORISASI LIMBAH BATIK TULIS MENGGUNAKAN JAMUR INDIGENOUS HASIL ISOLASI PADA KONSENTRASI LIMBAH YANG BERBEDA Ratna Stia Dewi; Sri Lestari
Molekul Vol 5, No 2 (2010)
Publisher : Universitas Jenderal Soedirman

Azo as batik dyes are textile dyes which difficult to degradate. Fungus as bioremidiation organism are choosed to decolorize the dyes because its transformation ability, it can degradate toxic dyes component. The aim of research are to explore the fungus from Sokaraja-Banyumas batik industrial dyestuff, to know potential indigenous species wich can degradate it, to know dyestuff consentration which is degradated.Result of research showed that the isolation process of indigenous fungi from batik dyestuff in District Sokaraja Banyumas produce 4 isolates that have the potential dekolorization, they are 3 isolates of the genus Fusarium, and 1 isolate of the genus Aspergillus. That indigenous fungus can be used to decolorize dyestuff batik the decolorize percentage 69.346% -82.421%.

SPECTROPHOTOMETRIC ANALYSIS OF DESLORATADINE MULTICOMPONENT CRYSTAL FORMULATION: COMPARISON OF CONVENTIONAL METHODS AND CHEMOMETRIC ANALYSIS Ainurofiq, Ahmad; Choiri, Syaiful
Molekul Vol 15, No 1 (2020)
Publisher : Universitas Jenderal Soedirman

Multicomponent crystal (MCC) formulation consists of drug and co-former that spectrophotometrically has an interference each other. The aim of this research was to evaluate and develop the analytical method to obtain a fast, cheap, efficient, and adequate method to estimate desloratadine (DES) in MCC formulation using three different methods. Single wavelength calibration model was constructed at 290 nm, multiple component equations was obtained from 273 nm and 283 nm, and multivariate analysis consists of PLS and PCA, a chemo-metric based, assisted the model selection and model calibration. Single wavelength method and multivariate analysis model had been fully validated i.e. range, specificity, accuracy, precision, limit of detection, and limit of quantification. A multivariate analysis had more adequate ability to estimate the DES and co-former in the MCC formulation.Keywords: Desloratadine, multicomponent crystal, multivariate, PLS

PENUMBUHAN DAN KARAKTERISASI LAPISAN TIPIS PbTiO3 YANG DISIAPKAN DENGAN TEKNIK SPIN COATING Bilalodin Bilalodin
Molekul Vol 3, No 1 (2008)
Publisher : Universitas Jenderal Soedirman

The growth of PbTiO3 ferroelectric thin films have successfully done. Thin films were made from bulk (powder) PbTiO3 dissolved in methanol solution. The condensation was mixed during 1 hour to get homogeneous condensation. Thin films were grown above corning substrates by spin coating method. Optimation was done by various of annealing temperature. The physical properties of thin films were characterized by Energi Dispersive X-Ray Spectroscopy (EDS), X-Ray Diffraction (XRD), Scanning and Electron Microscopy (SEM). EDS measurement showed that the stoichiometry composition ratio of Pb/Ti is 1/1.26 at annealing temperature 600oC and 1/1.29 at annealing temperature 700oC. The result of XRD pattern showed that crystal structure of PbTiO3 thin films are tetragonal. The calculated lattice parameters ontained from Chohen Method are a=b= 3.873 Å dan c= 4.130Å. The result of SEM PbTiO3 thin film showed that thin film has globular grain size.

SINTESIS DAN KARAKTERISASI PIGMEN WARNA HITAM, MERAH DAN KUNING BERBAHAN DASAR PASIR BESI Bilalodin Bilalodin; Zarah Irayani; Sehah Sehah; Sugito Sugito
Molekul Vol 10, No 2 (2015)
Publisher : Universitas Jenderal Soedirman

Sintesis dan karateristik pigmen warna hitam, merah dan kuning berbahan dasar pasir besi telah dilakukan. Tujuan penelitian ini adalah sintesis dan karakterisasi pigmen menggunakan bahan baku pasir besi menggunakan metode kalsinasi. Pembuatan pigmen warna hitam dilakukan dengan mencampurkan pasir besi dengan larutan NaOH dan NH4OH lalu dipanaskan pada suhu 800 °C. Pigmen merah dibuat dengan melarutkan pasir besi dalam larutan H2SO4 dan dipanaskan pada suhu 650 °C. Sedangkan pigmen kuning dibuat dari serbuk pigmen merah lalu dilarutkan ke dalam larutan HCl serta dipanaskan pada suhu 250 °C. Serbuk pigmen dikarakterisasi mengunakan XRD, SEM-EDX dan PSA dan Crommameter. Hasil penelitian menunjukkan bahwa serbuk pigmen warna hitam, merah dan kuning memiliki struktur kristal kubik dengan bentuk morfologi permukaan dan ukuran butir sebagai berikut: pada pigmen hitam partikel berbentuk butiran bulat seragam dengan ukuran butir 926,4 nanometer, pigmen merah memiliki bentuk butiran bulat seragam dengan ukuran butir 72,2 nm dan pigmen warna kuning memiliki bentuk butiran bulat seragam dengan ukuran 349 nm. Kandungan utama unsur pigmen hitam, merah dan kuning adalah besi (Fe) dan oksigen (O). Serbuk pigmen warna hasil uji colorimetri coordinat L*a*b* yaitu pada pigmen warna hitam nilai L*a*b* dan DE adalah 23,76; 1,35; 1,43 dan 2,34, pigmen merah 43,23; 16,00; 17,30 dan 9,89, dan pigmen warna kuning 66,76; 14,84; 49,95 dan 4,862. Pigmen warna yang dihasilkan telah sesuai dengan standar.

STUDI DEGRADASI ZAT PEWARNA AZO, METIL ORANYE MENGGUNAKAN FERRAT (FeO42-) Dian Windy Dwiasi; Mardiyah Kurniasih
Molekul Vol 3, No 1 (2008)
Publisher : Universitas Jenderal Soedirman

Synthesis of ferrate and its application to azo dyes degradation have been investigated. The synthesis was carried out by reacting Fe(NO3)3 solution with NaOCl in alkaline condition. Oxidation reaction of azo dyes was carried out by adjusting the molar ratio of ferrate to azo dyes. When ferrate reacted with azo dyes, its absorbance was monitored using UV-Vis spectrophotometer at pH condition that had been optimized. Kinetics study for azo dyes degradation was carried out at the absorbance maximum of azo dyes, as a function of time. Ferrate can oxidize azo dyes, methyl oranye effectively in optimum pH of 9.6. With the molar ratio of ferrate/azo dyes 5/1, it showed that the percentages of methyl oranye degradation reached 100%. The azo dyes degradation followed first order of kinetics. Analysis using UV-Vis spectrofotometry suggests that the products of azo dyes degradation are nitrate, ammonia, and benzene. This results showed that ferrate is an alternative and green oxidizing agent which can be used for azo dyes degradation.

Protective Effect of Ipomoea batatas L Leaves Extract on Histology of Pancreatic Langerhans Islet and Beta Cell Insulin Expression of Rats Induced by Streptozotocin Dody Novrial; Soebowo Soebowo; Parno Widjojo
Molekul Vol 15, No 1 (2020)
Publisher : Universitas Jenderal Soedirman

Sweet potato (Ipomoea batatas L) leaf is one of well known vegetables among Indonesian people. It is also often used as traditional medicine for diabetes mellitus. This research aimed to investigate the protective effect of I. batatas L leaves extract on the pancreas of IDDM animal model. Twenty five male Sprague-Dawley rats were divided into 3 treatment groups, and 2 control groups. Streptozotocin (STZ) was injected at multiple low doses (40 mg/kg BW) intraperitoneally for 5 consecutive days, I. batatas L leaves extract (doses 0.25, 0.8, and 2.5 g/ kg BW) were administered for 14 days after the first STZ injection. Fasting blood glucose was analyzed after complete STZ induction (day 6), and after 14 days treatment. At the end of the study, rats were terminated, and pancreas were removed for histological examination and immunohistochemical procedure using anti-insulin antibody. Diabetic rats treated with 2.5 g/kg BW I. batatas L leaves extract showed lowest fasting blood glucose among treatment groups, and had approximately 50% normal Langerhans islets with functional beta cells. These results suggest that I. batatas L leaves extract has anti diabetic activity through its protection effect on the pancreas.

Development of Urea Biosensor Based on Immobilized Urease in Chitosan Cryogel Zusfahair Zusfahair; Dian Riana Ningsih; Elok Dwi Putri Lestari; Amin Fatoni
Molekul Vol 14, No 1 (2019)
Publisher : Universitas Jenderal Soedirman

The development of biosensors using biological components has an important role in detecting the disease early because it has good selectivity and accuracy. In this study, a biosensor which made is a urea biosensor, based on immobilization urease in chitosan using adsorption techniques, to measure urea levels by colorimetric analysis with bromothymol blue (BTB) as an indicator. The purpose of this study was to find out how to measure urea levels using biosensors based on urease immobilization in chitosan and find out the biosensor performance including optimum enzymatic reaction time, linearity, the limit of detection, repetition, and determination of disrupting compounds. The study began with the making of an immobilization supporting matrix using chitosan which was made in the form of cryogel through an ionic gelation process which adsorbs the urease enzyme. Cryogel urease catalyzes the hydrolysis of urea into NH4+ and CO2-. The reaction product was added with the BTB indicator, and the color change formed was measured using a spectrophotometer. The results showed that the performance of urea biosensors was good enough for urea level detection systems by producing enzymatic reaction times at 15 minutes, linearity at 0.9951, detection limit at 0.018 mM, not affected by the addition of 0.05 mM ascorbic acid and 0.4 mM uric acid. This urea biosensor can be used up to 5 repetitions.

Design of New 2,4-Substituted Furo [3,2-B] Indole Derivatives as Anticancer Compounds Using Quantitative Structure-Activity Relationship (QSAR) and Molecular Docking Jufrizal Syahri; Nurul Hidayah; Rahmiwati Hilma; Beta Achromi Nurohmah; Emmy Yuanita
Molekul Vol 15, No 1 (2020)
Publisher : Universitas Jenderal Soedirman

This study aimed to propose new indole derivatives as anticancer through Quantitative Structure-Activity Relationship (QSAR) and molecular docking method. The best predicted anticancer activity of indole derivatives was recommended based on the QSAR equation. A data set consist of 18 indole derivatives from literature with anticancer activity against the A498 cell line was used to generate a QSAR model equation. The data set was divided randomly into training (14) and test (4) set compounds. The structure of indole compound was optimized first using AM1 semi-empirical methods, and the descriptors involved were analyzed using Multiple Linear Regression (MLR). The best QSAR equation obtained was Log IC50 = 65.596 (qC2) + 366.764 (qC6) – 92.742 (qC11) + 503.297 (HOMO) – 492.550 (LUMO) – 76.966. Based on the QSAR model, varying electron-withdrawing groups in C2 and C6 atom, as well as adding electron-donating groups in C11 were proposed could increase the anticancer activity of the indole derivatives. The QSAR analysis showed that compound 15 has the best predicted anticancer activity, supported by molecular docking results that showed hydrogen bond interaction with essential amino acids to build anticancer activity such as MET769, THR830, and THR766 residues.

Computational Approach to Evaluate Eugenol Affinity and Derivatives Empirical Against Cu(II) Muhammad Cholid Djunaidi; Tantri Nevi Astuti; Parsaoran Siahaan
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

A computational approach to assess the emperical results of eugenol affinity, eugenoxy acetate (EOA), and pyridine methyl eugenoxy acetate (PMEOA) against Cu2+has been done. This research aims to determine the effects of the functional groups (−OH, −COOH, and −N) on eugenol and their derivatives on the selectivity of Cu2+adsorption experimentally and to calculate the energy interaction between eugenol compounds and derivatives with Cu2+. The experimental approach was carried out by solvent extraction method, using 10 mL of Cu2+10 ppm solution along with 0.3089 mmol of eugenol, EOA and PMEOA. The remaining concentration of Cu2+metal after extraction in the water phase was measured using an Atomic Absorption Spectrophotometer (AAS). Assessments of the Cu2+metal interaction with eugenol, EOA and PMEOA compounds were carried out using the ab initio method with 6-31G** basis set to predict the interaction energy. The results showed that pyridine methyl eugenoxy acetate (PMEOA) can separate Cu2+better than eugenol and EOA with extraction efficiency (% E) = 78.76%. The calculation results of Cu2+metal interactions with eugenol, EOA, and PMEOA compounds found that PMEOA has the lowest energy of interaction compared to eugenol and EOA with Cu2+metal.

Effectiveness of Leaves Extract Fractions of Archidendron jiringa (Jack) I.C Nielsen Against Microbes Oom Komala; Sri Wardatun; Lia Puspita Sari
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

Archidendron jiringa(Jack) I.C Nielsen) contains a lot of essential oils, saponins, alkaloids, terpenoids, steroids, tannins, glycosides, and flavonoids. Flavonoid is a secondary metabolite compound in a plant as antimicrobial. This study aims to determine the antimicrobial activity of fractions of ethanol 96%, n-hexan, ethyl acetate, and ethanol-water leaves extractand determine levels of favonoids. A. jiringaleaves extract were tested against Streptococus mutans, Pseudomonas aeruginosa, and Candida albicans. The research using agar disc diffusion technique for antimicrobial activity and colorimetric method to know the total of flavonoid. Chloramphenicol and ketoconazole were used as a reference standard. The result of this study shows fractions of ethanol 96%, n-hexane, ethyl acetate, and ethanol-water A. jiringaleaves extract can inhibit microbial growth of S. mutans, P. aeruginosa, and C. albicans.Total of flavonoids on the extract respectively are 1.13%, 0.494%, 2.337%, and 0.549%. determined with complementary colorimetry to each leaf extract fractionA. jiringawith aluminum chloride method. Absorption spectrum measurement using a spectrophotometer. The higher percent of flavonoids would cause greater bacteriainhibitory zone but only 0.090 for pearson correlation value. Conclusions ethyl acetate leaves extract most effective inhibit microbial growth from the other fractions.

Page 23 of 34 | Total Record : 331

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Contact Name Amin Fatoni

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Editorial Address Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

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Contact Name
Amin Fatoni

Contact Email
aminfatoni@unsoed.ac.id

Phone
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Journal Mail Official
j.molekul@gmail.com

Editorial Address
Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location
Kab. banyumas,

Jawa tengah

INDONESIA