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INDONESIA
JFIOnline
Published by Ikatan Apoteker Indonesia
ISSN : 14121107     EISSN : 2355696X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Farmasi Indonesia yang diterbitkan oleh Pengurus Pusat Ikatan Apoteker Indonesia. Isi website memuat seluruh jurnal yang telah diterbitkan mencakup semua aspek dalam ilmu pengetahuan dan teknologi kefarmasian antara lain farmakologi, farmakognosi, fitokimia,farmasetika, kimia farmasi, biologi molekuler, bioteknologi, farmasi klinik,farmasi komunitas, farmasi pendidikan, dan lain-lain.
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Articles 443 Documents
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Aktivitas Antidiabetika Kombinasi Fraksi Etil Asetat Buah Pare (Momordica charantia L.) dan Rimpang Zamzani, Irfan; Nugroho, Agung Endro; Widodo, Gunawan Pamudji
Jurnal Farmasi Indonesia Vol 9, No 2 (2017)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v9i2.575

Abstract

Diabetes Mellitus type 2 can be caused by the resistance of tissue towards insulin accompanied by relative deficiency in insulin secretion. Insulin resistance factor can result from obesity. This research aims to investigate anti- diabetic activity of the compound of FEA of curcuma (Curcuma domestica Val) and bitter melon (Momordica charantia L.). Subjects of this research were 40 albino Wistar rats (Rattus norvegicus) aged 5-8 weeks. The rats were randomly grouped into 8 experimental groups in which each group consisted of'5 rats. The tested animals were divided into 6 groups, KG) metformin 45 mg/Kg BB, P1: FEA curcuma 10 mg/ 200g BB, P2: FEA bitter melon 04 mg/ 200g BB, P3: Compound of FEA curcuma : FEA bitter melon 5 : 0,8 mg/200g BB, P4: Compound of FEA curcuma : FEA bitter melon 10 : 04 mg/200g BB, and P5: Compound of FEA curcuma : FEA bitter melon (20 : 02mg9/200g BB). The animals were inducted with insulin resistance with the giving of HFD-fructose. Result showed that the compound of FEA of curcuma (Curcuma domestica Val) and FEA of bitter melon (Momordica charantia L.) had the activity of lowering blood glucose level: the best anti-diabetic activity was identified in the compound of FEA of curcuma and FEA of bitter melon at the dose of 20: 0,2m9g/200g BB in the rats with HFD- fructose.Diabetes Mellitus type 2 can be caused by the resistance of tissue towards insulin accompanied by relative deficiency in insulin secretion. Insulin resistance factor can result from obesity. This research aims to investigate anti- diabetic activity of the compound of FEA of curcuma (Curcuma domestica Val) and bitter melon (Momordica charantia L.). Subjects of this research were 40 albino Wistar rats (Rattus norvegicus) aged 5-8 weeks. The rats were randomly grouped into 8 experimental groups in which each group consisted of'5 rats. The tested animals were divided into 6 groups, KG) metformin 45 mg/Kg BB, P1: FEA curcuma 10 mg/ 200g BB, P2: FEA bitter melon 04 mg/ 200g BB, P3: Compound of FEA curcuma : FEA bitter melon 5 : 0,8 mg/200g BB, P4: Compound of FEA curcuma : FEA bitter melon 10 : 04 mg/200g BB, and P5: Compound of FEA curcuma : FEA bitter melon (20 : 02mg9/200g BB). The animals were inducted with insulin resistance with the giving of HFD-fructose. Result showed that the compound of FEA of curcuma (Curcuma domestica Val) and FEA of bitter melon (Momordica charantia L.) had the activity of lowering blood glucose level: the best anti-diabetic activity was identified in the compound of FEA of curcuma and FEA of bitter melon at the dose of 20: 0,2m9g/200g BB in the rats with HFD- fructose.Diabetes Mellitus type 2 can be caused by the resistance of tissue towards insulin accompanied by relative deficiency in insulin secretion. Insulin resistance factor can result from obesity. This research aims to investigate anti- diabetic activity of the compound of FEA of curcuma (Curcuma domestica Val) and bitter melon (Momordica charantia L.). Subjects of this research were 40 albino Wistar rats (Rattus norvegicus) aged 5-8 weeks. The rats were randomly grouped into 8 experimental groups in which each group consisted of'5 rats. The tested animals were divided into 6 groups, KG) metformin 45 mg/Kg BB, P1: FEA curcuma 10 mg/ 200g BB, P2: FEA bitter melon 04 mg/ 200g BB, P3: Compound of FEA curcuma : FEA bitter melon 5 : 0,8 mg/200g BB, P4: Compound of FEA curcuma : FEA bitter melon 10 : 04 mg/200g BB, and P5: Compound of FEA curcuma : FEA bitter melon (20 : 02mg9/200g BB). The animals were inducted with insulin resistance with the giving of HFD-fructose. Result showed that the compound of FEA of curcuma (Curcuma domestica Val) and FEA of bitter melon (Momordica charantia L.) had the activity of lowering blood glucose level: the best anti-diabetic activity was identified in the compound of FEA of curcuma and FEA of bitter melon at the dose of 20: 0,2m9g/200g BB in the rats with HFD- fructose.
Analisis Senyawa L-arginine pada Bawang Putih Tunggal dan Black Garlic Tunggal Dengan Menggunakan Metode HPLC (High Performance Liguid Chromatography) Setiawan, Abdul Aziz; Nesha, Tafriani Sucianti; Pratiwi, Dina
Jurnal Farmasi Indonesia Vol 9, No 2 (2017)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v9i2.576

Abstract

L-Arginine is a semi essential amino acid and has a function in arterial vascular relaxation and improves blood flow. Single-bulb black garlic was produced from ordinary single-bulb garlic clove by process from maillard browning at temperature at 700C and 95Y of humidity controlled room for a month. It is known that single-bulb black garlic has benefits as antidiabetes, uric acid, cholesterol, hypertension, endurance and others. This study aims to determine the content of L-Arginine compound on single-bulb garlic and single-bulb black garlic by using HPLC (High Performance Liguid Chromatography)method.The mobile phase used consists of buffer A and buffer B. Buffer A consists of Na-Acetate (pH 6.5), Na-EDTA, Methanol, and Tetrahidrofuran. While B buffer consists of Methanol and Water Pro Injection. Thermo Scientific Column ODS-2 Hyersil C18, flow rate 1 ml / min, using Flouresensi detector with 350 nm wavelength. Based on the results obtained L-Arginine compound contained in a single-bulb garlic of 2.504 while for single-bulb black garlic that is egual to 06704. The content of L-Arginine compounds in single garlic is greater than that of a single black garlic. L-Arginine is a semi essential amino acid and has a function in arterial vascular relaxation and improves blood flow. Single-bulb black garlic was produced from ordinary single-bulb garlic clove by process from maillard browning at temperature at 700C and 95Y of humidity controlled room for a month. It is known that single-bulb black garlic has benefits as antidiabetes, uric acid, cholesterol, hypertension, endurance and others. This study aims to determine the content of L-Arginine compound on single-bulb garlic and single-bulb black garlic by using HPLC (High Performance Liguid Chromatography)method.The mobile phase used consists of buffer A and buffer B. Buffer A consists of Na-Acetate (pH 6.5), Na-EDTA, Methanol, and Tetrahidrofuran. While B buffer consists of Methanol and Water Pro Injection. Thermo Scientific Column ODS-2 Hyersil C18, flow rate 1 ml / min, using Flouresensi detector with 350 nm wavelength. Based on the results obtained L-Arginine compound contained in a single-bulb garlic of 2.504 while for single-bulb black garlic that is egual to 06704. The content of L-Arginine compounds in single garlic is greater than that of a single black garlic.
Nilai Indeks Glikemik dan Indeks Transit Usus Tepung Porang (Amorphophallus muelleri Blume.) pada Mencit Putih Laksmitawati, Dian Ratih; Prilasari, Sharon Alia; Marwati, Umi
Jurnal Farmasi Indonesia Vol 9, No 2 (2017)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v9i2.577

Abstract

To prevent hyperglycemia, people need alternative source of carbohydrate with low glycemic index. Porang bulbs from Amorphophallus muelleri Blume plant is rich on glucomannan, that could prevent elevation of blood glucose level. The aim ofthis study is to determine aglycemic index and intestinal transit index of porang bulbs flour. Glycemic index determined by glucose tolerance test method and intestinal transit index determined by measuring the intestinal transit distance of mice administered 1,5 kg BW intragastically the porang suspense. Forty-five minute later mice was given carbo absorben as a marker. At 15 minute later mice was sacrificed by cervical dislocation and the distance of charcoal marker was measure from pillory. The results shows that porang has glycemic index 85 compare with glucose 100 and treatment with porang flour caused the intestinal motility was faster (intestinal transit index -0,42) rather than wheat four (0,32). Its mean that, porang flour shorten the retention time of chymus in intestinum s0 it will inhibit the absorbtion of'glucose. To prevent hyperglycemia, people need alternative source of carbohydrate with low glycemic index. Porang bulbs from Amorphophallus muelleri Blume plant is rich on glucomannan, that could prevent elevation of blood glucose level. The aim ofthis study is to determine aglycemic index and intestinal transit index of porang bulbs flour. Glycemic index determined by glucose tolerance test method and intestinal transit index determined by measuring the intestinal transit distance of mice administered 1,5 kg BW intragastically the porang suspense. Forty-five minute later mice was given carbo absorben as a marker. At 15 minute later mice was sacrificed by cervical dislocation and the distance of charcoal marker was measure from pillory. The results shows that porang has glycemic index 85 compare with glucose 100 and treatment with porang flour caused the intestinal motility was faster (intestinal transit index -0,42) rather than wheat four (0,32). Its mean that, porang flour shorten the retention time of chymus in intestinum s0 it will inhibit the absorbtion of'glucose.
Kurkumin Meningkatkan Sensitivitas Sel Kanker Payudara terhadap Tamoksifen melalui Penghambatan Ekspresi P-glikoprotein dan Breast Cancer Resistance Protein Sianipar, Erlia Anggrainy; Louisa, Melva; Wanandi, Septelia Inawati
Jurnal Farmasi Indonesia Vol 9, No 2 (2017)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v9i2.578

Abstract

Background:The decreased of sensitivity or resistance to tamoxifen occured after long-term treatment in breast cancer. One of the major factor in tamoxifen resistance is over expression of efflux transporter P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP). Curcumin has known as inhibitor of P-gp and BCRP. The addition of curcumin to the tamoxifen resistant cells is expected to increase the sensitivity of breast cancer cells to tamoxifen. Method:MCF-7 breast cancer cell linewas induced with tamoxifen 1 uM for 10 passage (MCF-7(T)), then cell viability and mRNA expression of P-gp and BCRP were analyzed. To the MCF- 7(T) cells, curcumin was given at of 5/10/20 uM with or without tamoxifen for 5 days and cell viability and mRNA expression of P-gp and BCRP were analyzed on day 5. As positive control, verapamil 50 uM was used as P-gp inhibitor, ritonavir 15 yM and nelfinavir 15 yM were used as BCRP inhibitor. Result:MCF-7(T) cells sensitivity to tamoxifen has decreased with 11,8 times reduction in sensitivity towards tamoxifen, the increased of cell viability, and mRNA expression of P-gp and BCRP mRNA increased 10,82 and 4,04 fold respectively in MCF-7(T) cells. Then after administration of curcumin with or without tamoxifenfor5 days then the cell viability and the mRNA expression of P-gp mRNA and BCRP decreased. Conclusion:Curcumin iIncreased the sensitivity of MCF-7(T) to tamoxifen, characterized by the decreased of cell viability and mRNA expression of P-gp and BCRP. But the administration of combination curcumin with tamoxifen was more potent than curcumin alone. The iIncreased sensitivity was estimated at least in part through the inhibition of P-gp and BCRP MRNA expression by curcumin. Background:The decreased of sensitivity or resistance to tamoxifen occured after long-term treatment in breast cancer. One of the major factor in tamoxifen resistance is over expression of efflux transporter P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP). Curcumin has known as inhibitor of P-gp and BCRP. The addition of curcumin to the tamoxifen resistant cells is expected to increase the sensitivity of breast cancer cells to tamoxifen. Method:MCF-7 breast cancer cell linewas induced with tamoxifen 1 uM for 10 passage (MCF-7(T)), then cell viability and mRNA expression of P-gp and BCRP were analyzed. To the MCF- 7(T) cells, curcumin was given at of 5/10/20 uM with or without tamoxifen for 5 days and cell viability and mRNA expression of P-gp and BCRP were analyzed on day 5. As positive control, verapamil 50 uM was used as P-gp inhibitor, ritonavir 15 yM and nelfinavir 15 yM were used as BCRP inhibitor. Result:MCF-7(T) cells sensitivity to tamoxifen has decreased with 11,8 times reduction in sensitivity towards tamoxifen, the increased of cell viability, and mRNA expression of P-gp and BCRP mRNA increased 10,82 and 4,04 fold respectively in MCF-7(T) cells. Then after administration of curcumin with or without tamoxifenfor5 days then the cell viability and the mRNA expression of P-gp mRNA and BCRP decreased. Conclusion:Curcumin iIncreased the sensitivity of MCF-7(T) to tamoxifen, characterized by the decreased of cell viability and mRNA expression of P-gp and BCRP. But the administration of combination curcumin with tamoxifen was more potent than curcumin alone. The iIncreased sensitivity was estimated at least in part through the inhibition of P-gp and BCRP MRNA expression by curcumin.
Senyawa Asam 2-(4-(Klorometil)) Benzoiloksi)Benzoat Terhadap Agregasi Trombosit Dengan Metode Pengujian Thrombocyte Aggregation Test Dan Flow Cytometry Pada Plasma Manusia Jarra, Febrina Fatkiyah; Caroline, Caroline; YudyTjahjono, YudyTjahjono
Jurnal Farmasi Indonesia Vol 9, No 2 (2017)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v9i2.587

Abstract

Asam asetilsalisilat (AAS) merupakan senyawa yang sering digunakan secara per-oral sebagai analgetika dan obat anti-agregasi trombosit. Penelitian ini  bertujuan untuk menguji pengaruh asam 2-(4-klorometilbenzoiloksi)benzoat terhadap proses agregasi trombosit manusia menggunakan PRP (trombosit rich plasma) manusia dengan metode Thrombochyte Aggregation Test (TAT) dan Immuno-flow cytometry. Diharapkan data yang diperoleh dapat digunakan untuk pengembangan senyawa baru yang lebih efektif dan kurang toksik jika dibandingkan dengan asam asetilsalisilat. Pada penelitian ini, darah diambil melalui venipunktur pada lengan pasien normal, atau aortapunktur pada mencit. Setelah PRP diisolasi dengan sentrifugasi darah, kemudian diklasifikasikan dalam beberapa kelompok: kontrol negatif (ditambahkan Buffer Hepes 50 mM), kontrol positif (ditambahkan AAS 277μM/Hepes 50 mM) dan kelompok senyawa uji (ditambahkan asam 2-(4-klorometilbenzoiloksi)benzoat 277μM/Hepes 50 mM). Konsentrasi senyawa 277 µM ekuivalen dengan dosis AAS 500mg/Kg BB. Setelah penambahan dan inkubasi, dilakukan uji TAT dan uji Immuno-Flow Cytometry (meliputi uji reaktivitas antibodi pada trombosit dan uji agregasi trombosit) dengan penambahan agonis Kolagen. Uji immuno-flow cytometry menggunakan antibodi PE anti human AP-3 dan Alexa Flour 488 anti human AP-3. Pada uji TAT diperoleh nilai rata-rata agregasi (vmax) pada senyawa uji (Asam 2-(4-(klorometil)benzoiloksi)benzoat+Buffer Hepes 50 mM) (0,311±0,031% detik), sebanding dengan kelompok kontrol negatif adalah (Buffer Hepes 50 mM) adalah (0,367±0,061% detik) dan dibawah kontrol positif (0,179±0,062% detik). Pada uji Immuno-Flow Cytometry diperoleh rata-rata % agregasi pada senyawa uji sebesar 17,02 ± 1,44%), sedikit diatas kontrol negatif ((16,18 ± 1,07%) dan signifikan di bawah kontrol positif (10,57 ± 2,13%). Dari kedua eksperimen diatas, dapat disimpulkan bahwa senyawa asam 2-(4-klorometilbenzoiloksi)benzoat tidak menunjukkan efek anti agregasi trombosit dalam metode pemeriksaan invitro.
AMBARAN FUNGSI HATI PASIEN SKIZOFRENIA YANG MENGKONSUMSI RISPERIDONE DENGAN LORAZEPAM Kurniati, Tripeni; Darmawan, Endang; Anggriani, Hesti
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v10i1.579

Abstract

Treatment with risperidone 1.5-6.0 mg/day provides good benefits for schizophrenia treatment, severe psychiatric disorder with long-term disability potential and limited availability of treatment options. According to the average percentage of patients with abnormal liver function tests, patients with clinically significant improvement (> 3 times of the normal upper limit for SGPT, aspartate aminotransferase.Abnormalities that are commonly without any symptom occur within 6 weeks of antipsychotic use (Correll et al., 2015). The purpose of this study is to analyze the liver function of schizophrenic in-patients who take risperidone and lorazepam in Amino Gondohutomo’s psychiatric hospital of Central of Java Province. The research subjects were 132 schizophrenic diagnosed patients who take risperidone and combination of risperidone and lorazepam. We used Chi Square Tests, Paried T Tests and One Sample Test.Based on the research results, it can be concluded that there is a correlation between readmisi and age group, in age group > 29 years more risk relapse than age group <29 years. Also, it can be concluded the combination of risperidone and lorazepam at risk 0,933 times will increase SGOT than get treatment with risperidone only and therapy the combination of risperidone and lorazepam at risk twice will increase SGPT rather than receive treatment with risperidone only.
KUALITASDAN AKTIVITAS ANTIBAKTERI MADU Apis dorsata YANG BERKOLONI PADA TIGA POHON BERBEDA DI KALIMANTAN UTARA Widowati, Retno; Camin, Yeremiah Rubin; Suryono, Annisa Nur’aini; Azkawati, Elok; Lusiana, Diana Intan Gabriella; Kusmaryeni, Siti; Sinaga, Ernawati
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v10i1.580

Abstract

Honey has an important role as an anti-oxidant, anti-inflammatory and anti-bacterial agent, make it has high value for therapeutic puposes. North Kalimantan Indonesia is one of the honey producing regions of honey bee Apis dorsata, which colonizing on Gita tree (Alstonia scholaris), Menggeris tree (Koompasia malaccensis), and Pomatodon tree (Canarium decumanum). The aims of this research was to know the quality, phytochemistry and antibacterial activity of three types of honey produced byA. dorsata that colonized on three different trees in North Kalimantan. The honey quality test method was based on SNI 01-3454-2004. The phytochemicals tested included alkaloids, phenolics, hydroquinones, steroids and triterpenoids. Anti-bacterial activity was tested using well diffusion method with honey concentration 25%, 50%, 75% and 100%, against pathogenic bacteriaE.coli, S. typhi, S.aureus, S. epidermidis, and P. aeruginosa. The results showed that the honey tested complied with Indonesian honey quality standard SNI 01-3454-2004, except for water content, acidity and reducing-sugar content. The active compound present in all three types of honey are saponin. Honey from Gita treeat concentration 100% showed the strongest antibacterial activity against all of test bacteria. The antibacterial properties of the honey are probably derived from saponins and low pH of the honey. Honey has an important role as an anti-oxidant, anti-inflammatory and anti-bacterial agent, make it has high value for therapeutic puposes. North Kalimantan Indonesia is one of the honey producing regions of honey bee Apis dorsata, which colonizing on Gita tree (Alstonia scholaris), Menggeris tree (Koompasia malaccensis), and Pomatodon tree (Canarium decumanum). The aims of this research was to know the quality, phytochemistry and antibacterial activity of three types of honey produced byA. dorsata that colonized on three different trees in North Kalimantan. The honey quality test method was based on SNI 01-3454-2004. The phytochemicals tested included alkaloids, phenolics, hydroquinones, steroids and triterpenoids. Anti-bacterial activity was tested using well diffusion method with honey concentration 25%, 50%, 75% and 100%, against pathogenic bacteriaE.coli, S. typhi, S.aureus, S. epidermidis, and P. aeruginosa. The results showed that the honey tested complied with Indonesian honey quality standard SNI 01-3454-2004, except for water content, acidity and reducing-sugar content. The active compound present in all three types of honey are saponin. Honey from Gita treeat concentration 100% showed the strongest antibacterial activity against all of test bacteria. The antibacterial properties of the honey are probably derived from saponins and low pH of the honey. Honey has an important role as an anti-oxidant, anti-inflammatory and anti-bacterial agent, make it has high value for therapeutic puposes. North Kalimantan Indonesia is one of the honey producing regions of honey bee Apis dorsata, which colonizing on Gita tree (Alstonia scholaris), Menggeris tree (Koompasia malaccensis), and Pomatodon tree (Canarium decumanum). The aims of this research was to know the quality, phytochemistry and antibacterial activity of three types of honey produced byA. dorsata that colonized on three different trees in North Kalimantan. The honey quality test method was based on SNI 01-3454-2004. The phytochemicals tested included alkaloids, phenolics, hydroquinones, steroids and triterpenoids. Anti-bacterial activity was tested using well diffusion method with honey concentration 25%, 50%, 75% and 100%, against pathogenic bacteriaE.coli, S. typhi, S.aureus, S. epidermidis, and P. aeruginosa. The results showed that the honey tested complied with Indonesian honey quality standard SNI 01-3454-2004, except for water content, acidity and reducing-sugar content. The active compound present in all three types of honey are saponin. Honey from Gita treeat concentration 100% showed the strongest antibacterial activity against all of test bacteria. The antibacterial properties of the honey are probably derived from saponins and low pH of the honey.
Analisis Selektivitas Senyawa Turunan Diosmetin Sebagai Antioksidan Baru dengan menggunakan Metode MolecularDocking Martati, Titiek; Mumpuni, Esti; Mulatsari, Esti; Maryanto, Kenny
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v10i1.581

Abstract

Free radicals are compounds that have nofree electron pair, so it ws unstable and too reactive, to be able to ward off free radicals, required an antioxidant. Antioxidant can prevent the occurrence of oxidative reactions that can cause various diseases. The commonly used antioxidant compounds are vitamin C, vitamin E, and flavonoids. One of flavonoid compound that have the potential to be developed into antioxidants is diosmetin. The results of the study using the QSAR method, state that some of diosmetin derived compounds have better antioxidant activity than diosmetin. In this research, the selectivity of diosmetin derived compounds in several enzymes as an antioxidant was tested by using molecular docking methods. Software used for molecular docking were PLANTS, YASARA, MarvinSketch. This study used 15 diosmetin derived compounds, diosmetin as a parent compound, and comparison compounds used were vitamin C, vitamin E, and quercetin. Validated target proteins are 7 (seven) receptors with PDB codes 1QQW, 1V4S, 1XAN, 2BEL, 2C9V, 4K7O, and 5M2F. The results of this study have obtained the best selective compounds to receptors and compounds in each receptor. The best compounds are 6,8-difluoro diosmetin (1QQW), 8-amine diosmetin (1V4S), 6.8-difluoro diosmetin (1XAN), 6.8-diamine diosmetin (2BEL), 5'-amine diosmetin ( 2C9V), 5'-amine diosmetin (4K7O), and 8-amine diosmetin (5M2F). Free radicals are compounds that have nofree electron pair, so it ws unstable and too reactive, to be able to ward off free radicals, required an antioxidant. Antioxidant can prevent the occurrence of oxidative reactions that can cause various diseases. The commonly used antioxidant compounds are vitamin C, vitamin E, and flavonoids. One of flavonoid compound that have the potential to be developed into antioxidants is diosmetin. The results of the study using the QSAR method, state that some of diosmetin derived compounds have better antioxidant activity than diosmetin. In this research, the selectivity of diosmetin derived compounds in several enzymes as an antioxidant was tested by using molecular docking methods. Software used for molecular docking were PLANTS, YASARA, MarvinSketch. This study used 15 diosmetin derived compounds, diosmetin as a parent compound, and comparison compounds used were vitamin C, vitamin E, and quercetin. Validated target proteins are 7 (seven) receptors with PDB codes 1QQW, 1V4S, 1XAN, 2BEL, 2C9V, 4K7O, and 5M2F. The results of this study have obtained the best selective compounds to receptors and compounds in each receptor. The best compounds are 6,8-difluoro diosmetin (1QQW), 8-amine diosmetin (1V4S), 6.8-difluoro diosmetin (1XAN), 6.8-diamine diosmetin (2BEL), 5'-amine diosmetin ( 2C9V), 5'-amine diosmetin (4K7O), and 8-amine diosmetin (5M2F). Free radicals are compounds that have nofree electron pair, so it ws unstable and too reactive, to be able to ward off free radicals, required an antioxidant. Antioxidant can prevent the occurrence of oxidative reactions that can cause various diseases. The commonly used antioxidant compounds are vitamin C, vitamin E, and flavonoids. One of flavonoid compound that have the potential to be developed into antioxidants is diosmetin. The results of the study using the QSAR method, state that some of diosmetin derived compounds have better antioxidant activity than diosmetin. In this research, the selectivity of diosmetin derived compounds in several enzymes as an antioxidant was tested by using molecular docking methods. Software used for molecular docking were PLANTS, YASARA, MarvinSketch. This study used 15 diosmetin derived compounds, diosmetin as a parent compound, and comparison compounds used were vitamin C, vitamin E, and quercetin. Validated target proteins are 7 (seven) receptors with PDB codes 1QQW, 1V4S, 1XAN, 2BEL, 2C9V, 4K7O, and 5M2F. The results of this study have obtained the best selective compounds to receptors and compounds in each receptor. The best compounds are 6,8-difluoro diosmetin (1QQW), 8-amine diosmetin (1V4S), 6.8-difluoro diosmetin (1XAN), 6.8-diamine diosmetin (2BEL), 5'-amine diosmetin ( 2C9V), 5'-amine diosmetin (4K7O), and 8-amine diosmetin (5M2F).
ANALISIS KERASIONALAN PENGOBATAN PASIEN SKIZOFRENIA DI INSTALASI FARMASI RUMAH SAKIT UMUM DAERAH KOTA X PADA JANUARI-JUNI 2015 Nur’aini, Nur’aini; Rahayu, Mustika; Wijayanti, Rahayu
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v10i1.582

Abstract

Schizophrenia is a severe mental disorder with signs and symptoms which are diverse, both in degree and kind, and is often characterized with a chronic and recurrent trips. According to research in the various countries, the prevelance in the general population ranges from 1% - 3%. Antipsychotic drugs are considered as first-line therapy in schizophrenia. This study aimed to analyze the rationalization of the treatment of schizophrenia at pharmacy Plant of General Hospital X in January-June, 2015. Based on 8 T, namely the right diagnosis, precise indications of the disease, proper drug selection, right dosage, right route of administration, proper interval time of administration, appropriate duration of administration, wary of side effects on the population by the method of retrospective or data that are past which were then analyzed using Microsoft excel and are presented in tables and diagrams. The result of the data were taken from the installation of the patient medical record with the number 60. The results showed that of 60 patients 52 or 86.7% of them were not rational and 8 patients, or 13.3% rational. Proper diagnosis, appropriate treatment regimens, the exact time interval of drug administration, appropriate duration of administration have the same percentage that the level of rationalization of the 60 (100%) patients, the exact indication of the disease by 48 (80%) patients was not rational, and 12 (20 %) patients rational, be aware of drug side effects 50 (83.3%) patients who were not rational, and 10 (16.6%) patients who had a rational, appropriate doses of 58 (96.7%) patients and 2 (3,3%) irrational patients, the proper selection of drugs 14 (23.3%) patients that were not rational, and 46 (76.67%) rational
SINTESIS ANALOG UK-3A : 6-HIDROKSI-N-FENILNIKOTINAMIDA DAN 6-HIDROKSI-N- FENILPIKOLINAMIDA DAN UJI SITOTOKSISITAS SECARA IN VITRO TERHADAPSEL KANKER MURINE LEUKEMIA P388 Febriyanti, Lilis; Hanafi, Muhammad; Hayun, Hayun
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v10i1.583

Abstract

The Novel compound of analog UK-3A defined as HF-1 (6-hydroxy-N-phenylnicotinamide) and HF-2 (6-hydroxy-N-phenylpicolinamide)was successfully synthesized by amidation reaction of aromatic carboxilyc acids and primary amine by adding the activator of DCC (dicyclohexylcarbodiimide), catalyst DMAP (4-dimethyl aminopyridine, and DMSO (dimethyl sulfoxide) as the solvent. Reaction run for 24 hours in 55oC. Result shows yield of HF-1 as much as 52%, and for HF-2 is 16%. The analogue compounds structure of UK-3A were characterized by spectrophotometer FT-IR, LCMS, and NMR. Citotoxicity assay against Murine Leukemia cells of HF-1 and HF-2 by MTT (3-(4,5-dimethylltiazo-2-yl-) 2,5-diphenyltetrazolium bromide) assay. The result of bioassay showed IC50(inhibitory concentration)value 71 µg/mL and 63 µg/mL for HF-1 and HF-2 respectively. It informed that the analogue compounds have lower activity than UK-3A compound which has IC50 value 38 µg/mL.

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