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INDONESIA
JFIOnline
Published by Ikatan Apoteker Indonesia
ISSN : 14121107     EISSN : 2355696X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Farmasi Indonesia yang diterbitkan oleh Pengurus Pusat Ikatan Apoteker Indonesia. Isi website memuat seluruh jurnal yang telah diterbitkan mencakup semua aspek dalam ilmu pengetahuan dan teknologi kefarmasian antara lain farmakologi, farmakognosi, fitokimia,farmasetika, kimia farmasi, biologi molekuler, bioteknologi, farmasi klinik,farmasi komunitas, farmasi pendidikan, dan lain-lain.
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Articles 443 Documents
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PENGARUH KONSENTRASI ETANOL TERHADAP PENJERAPAN NIFEDIPIN PADA FORMULA ETHOSOME Rizal, Rizal; Ismail, Isriany
Jurnal Farmasi Indonesia Vol 10, No 2 (2018)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v10i2.584

Abstract

Researched about the influence of ethanol consentration to entrapment of nifedipin in ethosome formula. This research suppose to know about the influence of etanol consentration tonifedipine entrapment, form and size of ethosome, to decide the optimal consentration of etanol forming ethosome with high PDE (Percent Drug Entrapment) in nifedipin, and to know the ethosome characteristic. Ethosome formula  made in by hot method, using variation consentration of ethanol, phosphatidilcholin 1.5% and nefidepin 0,05%. Nifedipin concentration that entrapment in ethosome measured byUV-VIS Spectrophotometer at wavelength 336 nm, form and ethosome size fixed by using microscope.  Ethosome with  high  percent drug entrapment have taken from formula by using ethanol 50% with entrapment 71.440%. The formed ethosome is Multy Lameral Vesicle (MLV) and Multy Vesicular Vesicle (MVV) with the size about 1 μm until 15μm.
KEJADIAN EFEK SAMPING PADA PENGGUNAAN OBAT-OBAT TANPA RESEP DI APOTEK KECAMATAN KOTAGEDE YOGYAKARTA 2016 Muhlis, Muhammad; Ghina, Ghina
Jurnal Farmasi Indonesia Vol 10, No 2 (2018)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v10i2.585

Abstract

Swamedikasi yang tidak rasional dipengaruhi oleh rendahnya tingkat pengetahuan, keterampilan, dan perilaku masyarakat dalam pemilihan obat. Tujuan dari penelitian ini adalah untuk mengetahui efek samping apa saja yang paling sering muncul, serta mengetahui hubungan antara kejadian efek samping obat dengan cara penggunaan obat, dan mengetahui faktor apa saja yang menimbulkan efek samping dalam penggunaan obat bebas, obat bebas terbatas, OWA pada masyarakat di Kecamatan Kotagede, Yogyakarta. penelitian ini didisain secara observasional dengan metode survei,pengambilan data menggunakan kuisionerpada 100 pasien. Data yang diperoleh dianalisis dengan metode Uji Fisher dengan taraf kepercayaan 95%. Hasil penelitian diperoleh bahwa efek samping yang umum dirasakan oleh pasien adalah mengantuk, nyeri pada perut, dan jantung berdebar. Berdasarkan hasil Uji Fisher menunjukan bahwa tidak ada hubungan yang bermakna antara cara penggunaan obat dengan kejadian efek samping obat, faktor yang mempengaruhi efek samping pada penggunaan obat-obat tanpa resep adalah kurangnya pengetahuan masyarakat tentang bagaimana cara penggunaan obat yang baik dan benar, ketidak patuhan pasien dalam aturan pemakaian obat yang sudah dijelaskan oleh apoteker, danadanya perbedaan respon tubuh terhadap obat yang dikonsumsi tiap pasien. Kesimpulan, hasil uji statistik tidak terdapat hubungan yang bermakna antara penggunaan obat yang benar atau tidak benar dengan muncul atau tidak muncul efek samping obat, namun pada kenyataannya penggunaan obat-obat yang dibeli tanpa resep dokter dapat menimbulkan berbagai efek samping dan adanya perbedaan respon tubuh terhadap obat yang dikonsumsi tiap pasien.
UJI EFEKTIVITAS KOMBINASI EKSTRAK KULIT KAYU MANIS (Cinnamomum verum J. Presl) DAN DAGING BUAH MAHKOTA DEWA (Phaleria macrocarpa (Scheff.) Boerl.) TERHADAP PENURUNAN KADAR KOLESTEROL TOTAL DAN LDL PADA TIKUS PUTIH JANTAN YANG DIINDUKSI ALOKSAN DAN PAKAN Sunaryo, Hadi; Dwitiyanti, Dwitiyanti; Suriantika, Cipto
Jurnal Farmasi Indonesia Vol 10, No 2 (2018)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v10i2.586

Abstract

Deficiency insulin results increased of lipid in people with diabetes. It happens because of the disruption of insulin function as a result complications of high blood fat levels, especially cholesterol and triglycerides. This research was conduct to determine effec of the combination of Cinnamomum verum extract (KM) and Phaleria macrocarpa extract (MD) on decreasing of total cholesterol and LDL in rat. The research divided into 8 treatment groups that is normal, negative, positive, dose combination 1 (KM 300 mg/kg BB+MD 1000 mg/kg BB), dose combination 2 (KM 300 mg/kg BB+MD 500 mg/kg BB), dose combination 3 (KM 300 mg/kg BB+MD 250 mg/kg BB), dose combination 4 (MD 1000 mg/kg BB+KM 150 mg/kg BB), dose combination 5 (MD 1000 mg/kg BB+KM 75 mg/kg BB). Tukey test results showed a decrease in the optimal combination 4 with a percentage decrease in total cholesterol and LDL by 42.83% and 35.01% but the decline is not comparable to the positive control (atorvastatin) amounted to 47.13% and 47.15%.
StudiIn SilicoSenyawaTurunan8-Tersubtitusi-7-Methoxy-2h-Chromen-2-OneSebagaiPenghambatEnzim Telomerase Tahir, Masdiana; Damayanti, Sophi; Hadi, Daryono; Tjahyono, Tjahyono
Jurnal Farmasi Indonesia Vol 10, No 2 (2018)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v10i2.588

Abstract

Adjustment of telomere length by telomerase is considered as a biological marker which determine the proliferation of cancer cells. The telomerase activity in cancer cells is potential to be targeted for cancer therapies. The aim of this study was QSAR studies to determine the descriptors that affect the anticancer activity of 8-substituted-7-methoxy-2H-chromen-2-one derivatives. The descriptors were calculated by using software MOE® 2009.10. to design new derivative compounds that have anticancer potency, to predict pharmacokinetic properties by using preADMET, and to predict tocixity by ADMET predictorTM and interaction predict to telomerase by using Autodock 4.2.6  The results showed QSAR equation was log IC50 = -1.358 (± 1.149) - 2.957 (± 1.019) × AM1_LUMO + 0.041 (± 0.011) × E_vdw + 2.367 (± 0.748) × glob + 0.487 (± 0.100) × log S. Fourteen of the new derivative compounds were designed based on QSAR equation revealed higher activity prediction than the lead compound and performed good absorption in the intestine. Compound (33) is predicted to have low permeability in Caco-2 cells and weakly bound to plasma proteins. Compound (50) predicted weakly bound to plasma proteins as well. Toxicity prediction showed that 9 derivatives compounds were predicted to have lower nearly equal toxicity to the toxicity of the lead compound. The study of the interaction of compounds with the receptor showed that derivatives (2), (4), (40) and (41) have the highest affinity to the receptor TERT with the binding free energy is −9.60 kcal / mol, −9.39 kcal / mol, −9.20 kcal / mol and -9.08 kcal / mol. Based on QSAR study, pharmacokinetic profile, toxicity, and the study of the interaction, four compounds have the potential to be develop as anticancer with telomerase inhibition.
Polimorfisme Gen Sitokrom P450 2A6 Alel *1, *4, *7 dan *9 pada Subyek Uji Perokok Suku Thionghoa Indonesia Patramurti, Christine; Candaya, Evan Julian; Kiatarto, Stella Felina; Karut, Agnes Kurniati
Jurnal Farmasi Indonesia Vol 11, No 1 (2019)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v11i1.589

Abstract

The CYP2A6 gene, encodes the CYP2A6 enzyme, has a highly polymorphism. These ezyme have played a role in nicotine metabolism, one of the active compounds in cigarettes that causes of cigarette dependence. The active form of the CYP2A6 gene allele is * 1 allele and some inactive forms of the CYP2A6 gene allele are * 4, * 7 and * 9 alleles. The inactive alleles would reduce the activity of the CYP2A6 enzyme. The genotypes of CY2A6 gene (CYP2A6* 1, * 4, * 7 and * 9) among Chinese Indonesian smokers were determined by allele-specific polymerase chain reaction (PCR) followed by electrophoresis method. The cigarette dependence was analyzed using the Fagerstrom Test for Nicotine Dependence (FTND) method.This study showed that there are CYP2A6 polymorphism genes among 30 smokers who participate in these study. The frequencies of the genotypes of CYP2A6 alleles were CYP2A6 *1/*1 (46.7%), CYP2A6 *1/*4 (16.7%), CYP2A6 *1/*7 (3.3%), CYP2A6 *1/*9 ( 10%), CYP2A6 *1/*4/*7 (6.7%), CYP2A6 *1/*4/*9 (10.0%), CYP2A6 *1/*7/*9 (3.3% ) and CYP2A6 *4/*7/* 9 (3.3%). The presence of inactive alleles can reduce the activity of the CYP2A6 enzyme in metabolizing nicotine, which can reduce the effects of cigarette dependence. The CYP2A6 gene, encodes the CYP2A6 enzyme, has a highly polymorphism. These ezyme have played a role in nicotine metabolism, one of the active compounds in cigarettes that causes of cigarette dependence. The active form of the CYP2A6 gene allele is * 1 allele and some inactive forms of the CYP2A6 gene allele are * 4, * 7 and * 9 alleles. The inactive alleles would reduce the activity of the CYP2A6 enzyme. The genotypes of CY2A6 gene (CYP2A6* 1, * 4, * 7 and * 9) among Chinese Indonesian smokers were determined by allele-specific polymerase chain reaction (PCR) followed by electrophoresis method. The cigarette dependence was analyzed using the Fagerstrom Test for Nicotine Dependence (FTND) method.This study showed that there are CYP2A6 polymorphism genes among 30 smokers who participate in these study. The frequencies of the genotypes of CYP2A6 alleles were CYP2A6 *1/*1 (46.7%), CYP2A6 *1/*4 (16.7%), CYP2A6 *1/*7 (3.3%), CYP2A6 *1/*9 ( 10%), CYP2A6 *1/*4/*7 (6.7%), CYP2A6 *1/*4/*9 (10.0%), CYP2A6 *1/*7/*9 (3.3% ) and CYP2A6 *4/*7/* 9 (3.3%). The presence of inactive alleles can reduce the activity of the CYP2A6 enzyme in metabolizing nicotine, which can reduce the effects of cigarette dependence. The CYP2A6 gene, encodes the CYP2A6 enzyme, has a highly polymorphism. These ezyme have played a role in nicotine metabolism, one of the active compounds in cigarettes that causes of cigarette dependence. The active form of the CYP2A6 gene allele is * 1 allele and some inactive forms of the CYP2A6 gene allele are * 4, * 7 and * 9 alleles. The inactive alleles would reduce the activity of the CYP2A6 enzyme. The genotypes of CY2A6 gene (CYP2A6* 1, * 4, * 7 and * 9) among Chinese Indonesian smokers were determined by allele-specific polymerase chain reaction (PCR) followed by electrophoresis method. The cigarette dependence was analyzed using the Fagerstrom Test for Nicotine Dependence (FTND) method.This study showed that there are CYP2A6 polymorphism genes among 30 smokers who participate in these study. The frequencies of the genotypes of CYP2A6 alleles were CYP2A6 *1/*1 (46.7%), CYP2A6 *1/*4 (16.7%), CYP2A6 *1/*7 (3.3%), CYP2A6 *1/*9 ( 10%), CYP2A6 *1/*4/*7 (6.7%), CYP2A6 *1/*4/*9 (10.0%), CYP2A6 *1/*7/*9 (3.3% ) and CYP2A6 *4/*7/* 9 (3.3%). The presence of inactive alleles can reduce the activity of the CYP2A6 enzyme in metabolizing nicotine, which can reduce the effects of cigarette dependence.
PHYSICAL ACTIVITY AND VITAMIN D LEVEL IN ASTHMA AND NON-ASTHMA AKTIVITAS FISIK DAN KADAR VITAMIN D PADA PASIEN ASMA DAN NON-ASMA Lorensia, Amelia; Suryadinata, Rivan Virlando; Saputra, Rifaldi
Jurnal Farmasi Indonesia Vol 11, No 1 (2019)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v11i1.591

Abstract

Worsen asthma symptoms is associated with low vitamin D levels that increases asthma attacks risk. Physical activity is one factor that affects vitamin D levels in the blood. This study aimed to identify relationship physical activities effects with vitamin d levels on asthma and non-asthma patients. The study was conducted in March-June 2018. The subjects were asthma patients and non-asthma adults and didn’t have other comorbidities. Data analysis used pearson test to determine physical activity effect with vitamin D levels. There were significant differences in vitamin D levels (P <0.000) and physical activity (P <0.000) in asthma and non asthma respondents. The results of the correlation test between vitamin D levels and physical activity in Approximate Significance value was 0.965, which means there were very strong relationships between vitamin levels and physical activity on the respondents of asthma and non asthma. So, the asthma patients with sufficient physical activity will have normal vitamin D levels to improve control of asthma symptoms. Worsen asthma symptoms is associated with low vitamin D levels that increases asthma attacks risk. Physical activity is one factor that affects vitamin D levels in the blood. This study aimed to identify relationship physical activities effects with vitamin d levels on asthma and non-asthma patients. The study was conducted in March-June 2018. The subjects were asthma patients and non-asthma adults and didn’t have other comorbidities. Data analysis used pearson test to determine physical activity effect with vitamin D levels. There were significant differences in vitamin D levels (P <0.000) and physical activity (P <0.000) in asthma and non asthma respondents. The results of the correlation test between vitamin D levels and physical activity in Approximate Significance value was 0.965, which means there were very strong relationships between vitamin levels and physical activity on the respondents of asthma and non asthma. So, the asthma patients with sufficient physical activity will have normal vitamin D levels to improve control of asthma symptoms.
Formulasi Sediaan Tablet Kunyah Kompleks Inklusi Dimenhidrinat–β-Siklodekstrin dengan Metode Pengeringan Semprot (Chewable Tablet from Inclusion Complexes of Dimenhydrinate– β-Cyclodextrine using Spray Drying Method) Faizatun, Faizatun; Joenoes, Luvita; Nafisa, Safira
Jurnal Farmasi Indonesia Vol 11, No 1 (2019)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v11i1.593

Abstract

Taste becomes an important parameter in the delivery of a chewable tablet, primarily aimed for childrens. The purpose of this study is to mask the bitter taste and create dimenhydrinate chewable tabletas motion sickness drug that meet the physical and chemical quality. The method used to mask the bitter taste of dimenhydrinate is inclusion complexes with β-cyclodextrin in spray drying. Inclusion complex powders evaluation included flowcity and water content, and characterized by infrared spectrophotometry and DSC (Differential Scanning Calorimetry). Inclusion complex powders was made into chewable tablet with direct compression method. Chewable tablet was evaluated including tablets concentration (94.33-106,47%), the diversity of weights (85-115%), tablets diameter (1.013 cm), tablets thickness (0.49 cm), hardness (3.75-4.58 kg/cm2), friability (2,98-3,42%,). Dimenhydrinate chewable tablet taste test were statistically analyzed with non-parametric Kruskal-Wallis which results a significant differences of the bitter taste that masked among the five molar concentration differences of dimenhydrinate and β-cyclodextrine. The higher molar ratio of β-cyclodextrin (0,5-3) used, has the better result for masking the bitterness of dimenhydrinate. The used of β-cyclodextrin with the ratio in five molar concentration differences can not optimally mask the bitter taste of dimenhydrinate. Chewable tablet of formula IV has met the best physical and chemical quality. Taste becomes an important parameter in the delivery of a chewable tablet, primarily aimed for childrens. The purpose of this study is to mask the bitter taste and create dimenhydrinate chewable tabletas motion sickness drug that meet the physical and chemical quality. The method used to mask the bitter taste of dimenhydrinate is inclusion complexes with β-cyclodextrin in spray drying. Inclusion complex powders evaluation included flowcity and water content, and characterized by infrared spectrophotometry and DSC (Differential Scanning Calorimetry). Inclusion complex powders was made into chewable tablet with direct compression method. Chewable tablet was evaluated including tablets concentration (94.33-106,47%), the diversity of weights (85-115%), tablets diameter (1.013 cm), tablets thickness (0.49 cm), hardness (3.75-4.58 kg/cm2), friability (2,98-3,42%,). Dimenhydrinate chewable tablet taste test were statistically analyzed with non-parametric Kruskal-Wallis which results a significant differences of the bitter taste that masked among the five molar concentration differences of dimenhydrinate and β-cyclodextrine. The higher molar ratio of β-cyclodextrin (0,5-3) used, has the better result for masking the bitterness of dimenhydrinate. The used of β-cyclodextrin with the ratio in five molar concentration differences can not optimally mask the bitter taste of dimenhydrinate. Chewable tablet of formula IV has met the best physical and chemical quality. Taste becomes an important parameter in the delivery of a chewable tablet, primarily aimed for childrens. The purpose of this study is to mask the bitter taste and create dimenhydrinate chewable tabletas motion sickness drug that meet the physical and chemical quality. The method used to mask the bitter taste of dimenhydrinate is inclusion complexes with β-cyclodextrin in spray drying. Inclusion complex powders evaluation included flowcity and water content, and characterized by infrared spectrophotometry and DSC (Differential Scanning Calorimetry). Inclusion complex powders was made into chewable tablet with direct compression method. Chewable tablet was evaluated including tablets concentration (94.33-106,47%), the diversity of weights (85-115%), tablets diameter (1.013 cm), tablets thickness (0.49 cm), hardness (3.75-4.58 kg/cm2), friability (2,98-3,42%,). Dimenhydrinate chewable tablet taste test were statistically analyzed with non-parametric Kruskal-Wallis which results a significant differences of the bitter taste that masked among the five molar concentration differences of dimenhydrinate and β-cyclodextrine. The higher molar ratio of β-cyclodextrin (0,5-3) used, has the better result for masking the bitterness of dimenhydrinate. The used of β-cyclodextrin with the ratio in five molar concentration differences can not optimally mask the bitter taste of dimenhydrinate. Chewable tablet of formula IV has met the best physical and chemical quality.
Evaluasi Aktivitas Anti-Bakteri dan Anti-Oksidan Ekstrak n-Heksan, Etil Asetat dan Metanol Daun Pohpohan (Pilea melastomoides (Poir.) Weda.) Violeta, Violeta; Kumala, Shirly
Jurnal Farmasi Indonesia Vol 9, No 2 (2017)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (7967.596 KB) | DOI: 10.35617/jfi.v9i2.574

Abstract

ABSTRACT: Infection desease still a problem in developing country. The researcher search for the plant that have antibacterial agent to cure infection deseases. One the plant that the layman use to cured the infection deseases is Pohpohan (Pilea melastomoides (Poir.) Wedd) that containe flavonoids compunds. This study used n-hexane, ethyl acetate, and methanol extract as non-polar, semi-polar, and polar. This study aims to test the antibacterial activity and also antioxidants by multilevel extraction methods. The method used is extraction, with maceration of each stratum, each extract is done by phytochemical screening test with result of flavonoid compound, tannin, and essential oil. Thereafter, an antimicrobial test with a Staphylococcus aureus, and Escherichia coli microorganisms using a solid dilution method (Diameter of Inhibition Diameter) was performed with an extract concentration of 12.519: 2519: 5046, chloramphenicol used as positive controls. The result of antimicrobial assay had activity on n-hexane extract to form inhibit zone of 24.6 - 25.4 mm, ethyl acetate extract formed inhibit zone of 16.8 - 25.1 mm, While methanol extract formed inhibit zone of 15.1 - 23.3 mm, then Pohpohan leaf extract from each solvent was tested antioxidant by DPPH method, Result of antioxidant test (1IC50) of n-hexane extract (113.60 bpj), ethyl acetate (9444 bpj), and methanol (73.14 bpj). In conclusion, it shows that Pohpohan leaf extract has activity as antibacterial, andantioxidant. ABSTRACT: Infection desease still a problem in developing country. The researcher search for the plant that have antibacterial agent to cure infection deseases. One the plant that the layman use to cured the infection deseases is Pohpohan (Pilea melastomoides (Poir.) Wedd) that containe flavonoids compunds. This study used n-hexane, ethyl acetate, and methanol extract as non-polar, semi-polar, and polar. This study aims to test the antibacterial activity and also antioxidants by multilevel extraction methods. The method used is extraction, with maceration of each stratum, each extract is done by phytochemical screening test with result of flavonoid compound, tannin, and essential oil. Thereafter, an antimicrobial test with a Staphylococcus aureus, and Escherichia coli microorganisms using a solid dilution method (Diameter of Inhibition Diameter) was performed with an extract concentration of 12.519: 2519: 5046, chloramphenicol used as positive controls. The result of antimicrobial assay had activity on n-hexane extract to form inhibit zone of 24.6 - 25.4 mm, ethyl acetate extract formed inhibit zone of 16.8 - 25.1 mm, While methanol extract formed inhibit zone of 15.1 - 23.3 mm, then Pohpohan leaf extract from each solvent was tested antioxidant by DPPH method, Result of antioxidant test (1IC50) of n-hexane extract (113.60 bpj), ethyl acetate (9444 bpj), and methanol (73.14 bpj). In conclusion, it shows that Pohpohan leaf extract has activity as antibacterial, andantioxidant. ABSTRACT: Infection desease still a problem in developing country. The researcher search for the plant that have antibacterial agent to cure infection deseases. One the plant that the layman use to cured the infection deseases is Pohpohan (Pilea melastomoides (Poir.) Wedd) that containe flavonoids compunds. This study used n-hexane, ethyl acetate, and methanol extract as non-polar, semi-polar, and polar. This study aims to test the antibacterial activity and also antioxidants by multilevel extraction methods. The method used is extraction, with maceration of each stratum, each extract is done by phytochemical screening test with result of flavonoid compound, tannin, and essential oil. Thereafter, an antimicrobial test with a Staphylococcus aureus, and Escherichia coli microorganisms using a solid dilution method (Diameter of Inhibition Diameter) was performed with an extract concentration of 12.519: 2519: 5046, chloramphenicol used as positive controls. The result of antimicrobial assay had activity on n-hexane extract to form inhibit zone of 24.6 - 25.4 mm, ethyl acetate extract formed inhibit zone of 16.8 - 25.1 mm, While methanol extract formed inhibit zone of 15.1 - 23.3 mm, then Pohpohan leaf extract from each solvent was tested antioxidant by DPPH method, Result of antioxidant test (1IC50) of n-hexane extract (113.60 bpj), ethyl acetate (9444 bpj), and methanol (73.14 bpj). In conclusion, it shows that Pohpohan leaf extract has activity as antibacterial, andantioxidant.
StudiIn SilicoSenyawaTurunan8-Tersubtitusi-7-Methoxy-2h-Chromen-2-OneSebagaiPenghambatEnzim Telomerase Tahir, Masdiana; Damayanti, Sophi; Hadi, Daryono; Tjahyono, Tjahyono
Jurnal Farmasi Indonesia Vol 10, No 2 (2018)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2960.084 KB) | DOI: 10.35617/jfi.v10i2.588

Abstract

Adjustment of telomere length by telomerase is considered as a biological marker which determine the proliferation of cancer cells. The telomerase activity in cancer cells is potential to be targeted for cancer therapies. The aim of this study was QSAR studies to determine the descriptors that affect the anticancer activity of 8-substituted-7-methoxy-2H-chromen-2-one derivatives. The descriptors were calculated by using software MOE® 2009.10. to design new derivative compounds that have anticancer potency, to predict pharmacokinetic properties by using preADMET, and to predict tocixity by ADMET predictorTM and interaction predict to telomerase by using Autodock 4.2.6  The results showed QSAR equation was log IC50 = -1.358 (± 1.149) - 2.957 (± 1.019) × AM1_LUMO + 0.041 (± 0.011) × E_vdw + 2.367 (± 0.748) × glob + 0.487 (± 0.100) × log S. Fourteen of the new derivative compounds were designed based on QSAR equation revealed higher activity prediction than the lead compound and performed good absorption in the intestine. Compound (33) is predicted to have low permeability in Caco-2 cells and weakly bound to plasma proteins. Compound (50) predicted weakly bound to plasma proteins as well. Toxicity prediction showed that 9 derivatives compounds were predicted to have lower nearly equal toxicity to the toxicity of the lead compound. The study of the interaction of compounds with the receptor showed that derivatives (2), (4), (40) and (41) have the highest affinity to the receptor TERT with the binding free energy is −9.60 kcal / mol, −9.39 kcal / mol, −9.20 kcal / mol and -9.08 kcal / mol. Based on QSAR study, pharmacokinetic profile, toxicity, and the study of the interaction, four compounds have the potential to be develop as anticancer with telomerase inhibition.
ANALISIS KERASIONALAN PENGOBATAN PASIEN SKIZOFRENIA DI INSTALASI FARMASI RUMAH SAKIT UMUM DAERAH KOTA X PADA JANUARI-JUNI 2015 Nur’aini, Nur’aini; Rahayu, Mustika; Wijayanti, Rahayu
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1037.933 KB) | DOI: 10.35617/jfi.v10i1.582

Abstract

Schizophrenia is a severe mental disorder with signs and symptoms which are diverse, both in degree and kind, and is often characterized with a chronic and recurrent trips. According to research in the various countries, the prevelance in the general population ranges from 1% - 3%. Antipsychotic drugs are considered as first-line therapy in schizophrenia. This study aimed to analyze the rationalization of the treatment of schizophrenia at pharmacy Plant of General Hospital X in January-June, 2015. Based on 8 T, namely the right diagnosis, precise indications of the disease, proper drug selection, right dosage, right route of administration, proper interval time of administration, appropriate duration of administration, wary of side effects on the population by the method of retrospective or data that are past which were then analyzed using Microsoft excel and are presented in tables and diagrams. The result of the data were taken from the installation of the patient medical record with the number 60. The results showed that of 60 patients 52 or 86.7% of them were not rational and 8 patients, or 13.3% rational. Proper diagnosis, appropriate treatment regimens, the exact time interval of drug administration, appropriate duration of administration have the same percentage that the level of rationalization of the 60 (100%) patients, the exact indication of the disease by 48 (80%) patients was not rational, and 12 (20 %) patients rational, be aware of drug side effects 50 (83.3%) patients who were not rational, and 10 (16.6%) patients who had a rational, appropriate doses of 58 (96.7%) patients and 2 (3,3%) irrational patients, the proper selection of drugs 14 (23.3%) patients that were not rational, and 46 (76.67%) rational

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