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Jurnal Farmasi Indonesia yang diterbitkan oleh Pengurus Pusat Ikatan Apoteker Indonesia. Isi website memuat seluruh jurnal yang telah diterbitkan mencakup semua aspek dalam ilmu pengetahuan dan teknologi kefarmasian antara lain farmakologi, farmakognosi, fitokimia,farmasetika, kimia farmasi, biologi molekuler, bioteknologi, farmasi klinik,farmasi komunitas, farmasi pendidikan, dan lain-lain.

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Articles 443 Documents

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Efek Antihipertensi Ekstrak Etanol Daun Sembung (Blumea balsamifera) pada Model Hewan Uji Induksi Epinefrin Sutjiatmo, Afifah Bambang; Bintussolihah, Falna; Vikasari, Suci Nar
Jurnal Farmasi Indonesia Vol 11, No 1 (2019)
Publisher : Jurnal Farmasi Indonesia

Hypertension is a non-communicable disease that has a high prevalence. Blumea balsamifera(Asteraceae) is one of the plants that has traditionally been used to treat high blood pressure. The aim of this study is to evaluate antihypertensive effect of ethanol extract of Blumea balsamiferaleaves on animal models induced epinephrine. The extract was made in 50% ethanol. Extraction was done using a set of Soxhlet tools. The antihypertensive effect test was carried out on male Wistar rats using epinephrine 0.25 mg/kg bwas inductor and blood pressure was measured indirectly through the tail using Kent Scientific's CODA system. The dose of extract was 8.75; 17.5 and 35 mg/kg bw, while propranolol at dose dose 1.8 mg/kg bw was used as comparator. The parameters were diastolic and systolic blood pressure. The results showed that the ethanol extract at doses of 8.75; 17.5 and 35mg/kg bw can prevent the increase in diastolic and systolic blood pressure in animals model induced epinephrine when compared to controls (p <0.05), where the best results is shown by the ethanol extract at dose of 17.5 mg/kg bw. The ability of the ethanol extract is equivalent to propranolol (p> 0.05). It can be concluded that Blumea balsamiferaleaves can be developed and have the potential to be antihypertensive.

UJI EFEKTIVITAS KOMBINASI EKSTRAK KULIT KAYU MANIS (Cinnamomum verum J. Presl) DAN DAGING BUAH MAHKOTA DEWA (Phaleria macrocarpa (Scheff.) Boerl.) TERHADAP PENURUNAN KADAR KOLESTEROL TOTAL DAN LDL PADA TIKUS PUTIH JANTAN YANG DIINDUKSI ALOKSAN DAN PAKAN Sunaryo, Hadi; Dwitiyanti, Dwitiyanti; Suriantika, Cipto
Jurnal Farmasi Indonesia Vol 10, No 2 (2018)
Publisher : Jurnal Farmasi Indonesia

Deficiency insulin results increased of lipid in people with diabetes. It happens because of the disruption of insulin function as a result complications of high blood fat levels, especially cholesterol and triglycerides. This research was conduct to determine effec of the combination of Cinnamomum verum extract (KM) and Phaleria macrocarpa extract (MD) on decreasing of total cholesterol and LDL in rat. The research divided into 8 treatment groups that is normal, negative, positive, dose combination 1 (KM 300 mg/kg BB+MD 1000 mg/kg BB), dose combination 2 (KM 300 mg/kg BB+MD 500 mg/kg BB), dose combination 3 (KM 300 mg/kg BB+MD 250 mg/kg BB), dose combination 4 (MD 1000 mg/kg BB+KM 150 mg/kg BB), dose combination 5 (MD 1000 mg/kg BB+KM 75 mg/kg BB). Tukey test results showed a decrease in the optimal combination 4 with a percentage decrease in total cholesterol and LDL by 42.83% and 35.01% but the decline is not comparable to the positive control (atorvastatin) amounted to 47.13% and 47.15%.

KUALITASDAN AKTIVITAS ANTIBAKTERI MADU Apis dorsata YANG BERKOLONI PADA TIGA POHON BERBEDA DI KALIMANTAN UTARA Widowati, Retno; Camin, Yeremiah Rubin; Suryono, Annisa Nurâ€™aini; Azkawati, Elok; Lusiana, Diana Intan Gabriella; Kusmaryeni, Siti; Sinaga, Ernawati
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Jurnal Farmasi Indonesia

Honey has an important role as an anti-oxidant, anti-inflammatory and anti-bacterial agent, make it has high value for therapeutic puposes. North Kalimantan Indonesia is one of the honey producing regions of honey bee Apis dorsata, which colonizing on Gita tree (Alstonia scholaris), Menggeris tree (Koompasia malaccensis), and Pomatodon tree (Canarium decumanum). The aims of this research was to know the quality, phytochemistry and antibacterial activity of three types of honey produced byA. dorsata that colonized on three different trees in North Kalimantan. The honey quality test method was based on SNI 01-3454-2004. The phytochemicals tested included alkaloids, phenolics, hydroquinones, steroids and triterpenoids. Anti-bacterial activity was tested using well diffusion method with honey concentration 25%, 50%, 75% and 100%, against pathogenic bacteriaE.coli, S. typhi, S.aureus, S. epidermidis, and P. aeruginosa. The results showed that the honey tested complied with Indonesian honey quality standard SNI 01-3454-2004, except for water content, acidity and reducing-sugar content. The active compound present in all three types of honey are saponin. Honey from Gita treeat concentration 100% showed the strongest antibacterial activity against all of test bacteria. The antibacterial properties of the honey are probably derived from saponins and low pH of the honey. Honey has an important role as an anti-oxidant, anti-inflammatory and anti-bacterial agent, make it has high value for therapeutic puposes. North Kalimantan Indonesia is one of the honey producing regions of honey bee Apis dorsata, which colonizing on Gita tree (Alstonia scholaris), Menggeris tree (Koompasia malaccensis), and Pomatodon tree (Canarium decumanum). The aims of this research was to know the quality, phytochemistry and antibacterial activity of three types of honey produced byA. dorsata that colonized on three different trees in North Kalimantan. The honey quality test method was based on SNI 01-3454-2004. The phytochemicals tested included alkaloids, phenolics, hydroquinones, steroids and triterpenoids. Anti-bacterial activity was tested using well diffusion method with honey concentration 25%, 50%, 75% and 100%, against pathogenic bacteriaE.coli, S. typhi, S.aureus, S. epidermidis, and P. aeruginosa. The results showed that the honey tested complied with Indonesian honey quality standard SNI 01-3454-2004, except for water content, acidity and reducing-sugar content. The active compound present in all three types of honey are saponin. Honey from Gita treeat concentration 100% showed the strongest antibacterial activity against all of test bacteria. The antibacterial properties of the honey are probably derived from saponins and low pH of the honey. Honey has an important role as an anti-oxidant, anti-inflammatory and anti-bacterial agent, make it has high value for therapeutic puposes. North Kalimantan Indonesia is one of the honey producing regions of honey bee Apis dorsata, which colonizing on Gita tree (Alstonia scholaris), Menggeris tree (Koompasia malaccensis), and Pomatodon tree (Canarium decumanum). The aims of this research was to know the quality, phytochemistry and antibacterial activity of three types of honey produced byA. dorsata that colonized on three different trees in North Kalimantan. The honey quality test method was based on SNI 01-3454-2004. The phytochemicals tested included alkaloids, phenolics, hydroquinones, steroids and triterpenoids. Anti-bacterial activity was tested using well diffusion method with honey concentration 25%, 50%, 75% and 100%, against pathogenic bacteriaE.coli, S. typhi, S.aureus, S. epidermidis, and P. aeruginosa. The results showed that the honey tested complied with Indonesian honey quality standard SNI 01-3454-2004, except for water content, acidity and reducing-sugar content. The active compound present in all three types of honey are saponin. Honey from Gita treeat concentration 100% showed the strongest antibacterial activity against all of test bacteria. The antibacterial properties of the honey are probably derived from saponins and low pH of the honey.

Formulasi Sediaan Tablet Kunyah Kompleks Inklusi Dimenhidrinatâ€“Î²-Siklodekstrin dengan Metode Pengeringan Semprot (Chewable Tablet from Inclusion Complexes of Dimenhydrinateâ€“ Î²-Cyclodextrine using Spray Drying Method) Faizatun, Faizatun; Joenoes, Luvita; Nafisa, Safira
Jurnal Farmasi Indonesia Vol 11, No 1 (2019)
Publisher : Jurnal Farmasi Indonesia

Taste becomes an important parameter in the delivery of a chewable tablet, primarily aimed for childrens. The purpose of this study is to mask the bitter taste and create dimenhydrinate chewable tabletas motion sickness drug that meet the physical and chemical quality. The method used to mask the bitter taste of dimenhydrinate is inclusion complexes with Î²-cyclodextrin in spray drying. Inclusion complex powders evaluation included flowcity and water content, and characterized by infrared spectrophotometry and DSC (Differential Scanning Calorimetry). Inclusion complex powders was made into chewable tablet with direct compression method. Chewable tablet was evaluated including tablets concentration (94.33-106,47%), the diversity of weights (85-115%), tablets diameter (1.013 cm), tablets thickness (0.49 cm), hardness (3.75-4.58 kg/cm2), friability (2,98-3,42%,). Dimenhydrinate chewable tablet taste test were statistically analyzed with non-parametric Kruskal-Wallis which results a significant differences of the bitter taste that masked among the five molar concentration differences of dimenhydrinate and Î²-cyclodextrine. The higher molar ratio of Î²-cyclodextrin (0,5-3) used, has the better result for masking the bitterness of dimenhydrinate. The used of Î²-cyclodextrin with the ratio in five molar concentration differences can not optimally mask the bitter taste of dimenhydrinate. Chewable tablet of formula IV has met the best physical and chemical quality. Taste becomes an important parameter in the delivery of a chewable tablet, primarily aimed for childrens. The purpose of this study is to mask the bitter taste and create dimenhydrinate chewable tabletas motion sickness drug that meet the physical and chemical quality. The method used to mask the bitter taste of dimenhydrinate is inclusion complexes with Î²-cyclodextrin in spray drying. Inclusion complex powders evaluation included flowcity and water content, and characterized by infrared spectrophotometry and DSC (Differential Scanning Calorimetry). Inclusion complex powders was made into chewable tablet with direct compression method. Chewable tablet was evaluated including tablets concentration (94.33-106,47%), the diversity of weights (85-115%), tablets diameter (1.013 cm), tablets thickness (0.49 cm), hardness (3.75-4.58 kg/cm2), friability (2,98-3,42%,). Dimenhydrinate chewable tablet taste test were statistically analyzed with non-parametric Kruskal-Wallis which results a significant differences of the bitter taste that masked among the five molar concentration differences of dimenhydrinate and Î²-cyclodextrine. The higher molar ratio of Î²-cyclodextrin (0,5-3) used, has the better result for masking the bitterness of dimenhydrinate. The used of Î²-cyclodextrin with the ratio in five molar concentration differences can not optimally mask the bitter taste of dimenhydrinate. Chewable tablet of formula IV has met the best physical and chemical quality. Taste becomes an important parameter in the delivery of a chewable tablet, primarily aimed for childrens. The purpose of this study is to mask the bitter taste and create dimenhydrinate chewable tabletas motion sickness drug that meet the physical and chemical quality. The method used to mask the bitter taste of dimenhydrinate is inclusion complexes with Î²-cyclodextrin in spray drying. Inclusion complex powders evaluation included flowcity and water content, and characterized by infrared spectrophotometry and DSC (Differential Scanning Calorimetry). Inclusion complex powders was made into chewable tablet with direct compression method. Chewable tablet was evaluated including tablets concentration (94.33-106,47%), the diversity of weights (85-115%), tablets diameter (1.013 cm), tablets thickness (0.49 cm), hardness (3.75-4.58 kg/cm2), friability (2,98-3,42%,). Dimenhydrinate chewable tablet taste test were statistically analyzed with non-parametric Kruskal-Wallis which results a significant differences of the bitter taste that masked among the five molar concentration differences of dimenhydrinate and Î²-cyclodextrine. The higher molar ratio of Î²-cyclodextrin (0,5-3) used, has the better result for masking the bitterness of dimenhydrinate. The used of Î²-cyclodextrin with the ratio in five molar concentration differences can not optimally mask the bitter taste of dimenhydrinate. Chewable tablet of formula IV has met the best physical and chemical quality.

Senyawa Asam 2-(4-(Klorometil)) Benzoiloksi)Benzoat Terhadap Agregasi Trombosit Dengan Metode Pengujian Thrombocyte Aggregation Test Dan Flow Cytometry Pada Plasma Manusia Jarra, Febrina Fatkiyah; Caroline, Caroline; YudyTjahjono, YudyTjahjono
Jurnal Farmasi Indonesia Vol 9, No 2 (2017)
Publisher : Jurnal Farmasi Indonesia

Asam asetilsalisilat (AAS) merupakan senyawa yang sering digunakan secara per-oral sebagai analgetika dan obat anti-agregasi trombosit. Penelitian iniÂ bertujuan untuk menguji pengaruh asam 2-(4-klorometilbenzoiloksi)benzoat terhadap proses agregasi trombosit manusia menggunakan PRP (trombosit rich plasma) manusia dengan metode Thrombochyte Aggregation Test (TAT) dan Immuno-flow cytometry. Diharapkan data yang diperoleh dapat digunakan untuk pengembangan senyawa baru yang lebih efektif dan kurang toksik jika dibandingkan dengan asam asetilsalisilat. Pada penelitian ini, darah diambil melalui venipunktur pada lengan pasien normal, atau aortapunktur pada mencit. Setelah PRP diisolasi dengan sentrifugasi darah, kemudian diklasifikasikan dalam beberapa kelompok: kontrol negatif (ditambahkan Buffer Hepes 50 mM), kontrol positif (ditambahkan AAS 277Î¼M/Hepes 50 mM) dan kelompok senyawa uji (ditambahkan asam 2-(4-klorometilbenzoiloksi)benzoat 277Î¼M/Hepes 50 mM). Konsentrasi senyawa 277 ÂµM ekuivalen dengan dosis AAS 500mg/Kg BB. Setelah penambahan dan inkubasi, dilakukan uji TAT dan uji Immuno-Flow Cytometry (meliputi uji reaktivitas antibodi pada trombosit dan uji agregasi trombosit) dengan penambahan agonis Kolagen. Uji immuno-flow cytometry menggunakan antibodi PE anti human AP-3 dan Alexa Flour 488 anti human AP-3. Pada uji TAT diperoleh nilai rata-rata agregasi (vmax) pada senyawa uji (Asam 2-(4-(klorometil)benzoiloksi)benzoat+Buffer Hepes 50 mM) (0,311Â±0,031% detik), sebanding dengan kelompok kontrol negatif adalah (Buffer Hepes 50 mM) adalah (0,367Â±0,061% detik) dan dibawah kontrol positif (0,179Â±0,062% detik). Pada uji Immuno-Flow Cytometry diperoleh rata-rata % agregasi pada senyawa uji sebesar 17,02 Â± 1,44%), sedikit diatas kontrol negatif ((16,18 Â± 1,07%) dan signifikan di bawah kontrol positif (10,57 Â± 2,13%). Dari kedua eksperimen diatas, dapat disimpulkan bahwa senyawa asam 2-(4-klorometilbenzoiloksi)benzoat tidak menunjukkan efek anti agregasi trombosit dalam metode pemeriksaan invitro.

Analisis Selektivitas Senyawa Turunan Diosmetin Sebagai Antioksidan Baru dengan menggunakan Metode MolecularDocking Martati, Titiek; Mumpuni, Esti; Mulatsari, Esti; Maryanto, Kenny
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Jurnal Farmasi Indonesia

Free radicals are compounds that have nofree electron pair, so it ws unstable and too reactive, to be able to ward off free radicals, required an antioxidant. Antioxidant can prevent the occurrence of oxidative reactions that can cause various diseases. The commonly used antioxidant compounds are vitamin C, vitamin E, and flavonoids. One of flavonoid compound that have the potential to be developed into antioxidants is diosmetin. The results of the study using the QSAR method, state that some of diosmetin derived compounds have better antioxidant activity than diosmetin. In this research, the selectivity of diosmetin derived compounds in several enzymes as an antioxidant was tested by using molecular docking methods. Software used for molecular docking were PLANTS, YASARA, MarvinSketch. This study used 15 diosmetin derived compounds, diosmetin as a parent compound, and comparison compounds used were vitamin C, vitamin E, and quercetin. Validated target proteins are 7 (seven) receptors with PDB codes 1QQW, 1V4S, 1XAN, 2BEL, 2C9V, 4K7O, and 5M2F. The results of this study have obtained the best selective compounds to receptors and compounds in each receptor. The best compounds are 6,8-difluoro diosmetin (1QQW), 8-amine diosmetin (1V4S), 6.8-difluoro diosmetin (1XAN), 6.8-diamine diosmetin (2BEL), 5'-amine diosmetin ( 2C9V), 5'-amine diosmetin (4K7O), and 8-amine diosmetin (5M2F). Free radicals are compounds that have nofree electron pair, so it ws unstable and too reactive, to be able to ward off free radicals, required an antioxidant. Antioxidant can prevent the occurrence of oxidative reactions that can cause various diseases. The commonly used antioxidant compounds are vitamin C, vitamin E, and flavonoids. One of flavonoid compound that have the potential to be developed into antioxidants is diosmetin. The results of the study using the QSAR method, state that some of diosmetin derived compounds have better antioxidant activity than diosmetin. In this research, the selectivity of diosmetin derived compounds in several enzymes as an antioxidant was tested by using molecular docking methods. Software used for molecular docking were PLANTS, YASARA, MarvinSketch. This study used 15 diosmetin derived compounds, diosmetin as a parent compound, and comparison compounds used were vitamin C, vitamin E, and quercetin. Validated target proteins are 7 (seven) receptors with PDB codes 1QQW, 1V4S, 1XAN, 2BEL, 2C9V, 4K7O, and 5M2F. The results of this study have obtained the best selective compounds to receptors and compounds in each receptor. The best compounds are 6,8-difluoro diosmetin (1QQW), 8-amine diosmetin (1V4S), 6.8-difluoro diosmetin (1XAN), 6.8-diamine diosmetin (2BEL), 5'-amine diosmetin ( 2C9V), 5'-amine diosmetin (4K7O), and 8-amine diosmetin (5M2F). Free radicals are compounds that have nofree electron pair, so it ws unstable and too reactive, to be able to ward off free radicals, required an antioxidant. Antioxidant can prevent the occurrence of oxidative reactions that can cause various diseases. The commonly used antioxidant compounds are vitamin C, vitamin E, and flavonoids. One of flavonoid compound that have the potential to be developed into antioxidants is diosmetin. The results of the study using the QSAR method, state that some of diosmetin derived compounds have better antioxidant activity than diosmetin. In this research, the selectivity of diosmetin derived compounds in several enzymes as an antioxidant was tested by using molecular docking methods. Software used for molecular docking were PLANTS, YASARA, MarvinSketch. This study used 15 diosmetin derived compounds, diosmetin as a parent compound, and comparison compounds used were vitamin C, vitamin E, and quercetin. Validated target proteins are 7 (seven) receptors with PDB codes 1QQW, 1V4S, 1XAN, 2BEL, 2C9V, 4K7O, and 5M2F. The results of this study have obtained the best selective compounds to receptors and compounds in each receptor. The best compounds are 6,8-difluoro diosmetin (1QQW), 8-amine diosmetin (1V4S), 6.8-difluoro diosmetin (1XAN), 6.8-diamine diosmetin (2BEL), 5'-amine diosmetin ( 2C9V), 5'-amine diosmetin (4K7O), and 8-amine diosmetin (5M2F).

PENGARUH JENIS LEMAK ALKOHOL SEBAGAI PENGENTAL TERHADAP STABILITAS FISIK SEDIAAN KONDISIONER RAMBUT BILAS (RINSE-OFF HAIR CONDITIONER) YANG MENGANDUNG EKSTRAK BUAH KIWI (Actinidia chinensis P.) Noviani, Yuslia; Noor, Siti Umrah; Raihanah, Raihanah
Jurnal Farmasi Indonesia Vol 10, No 2 (2018)
Publisher : Jurnal Farmasi Indonesia

Buah kiwi telah digunakan untuk perawatan rambut karena kandungan vitamin C, vitamin E dan arginin yang bermanfaat menjaga kesehatan rambut, membantu meningkatkan sirkulasi di kulit kepala dan melembutkan serta menutrisi rambut. Telah dilakukan penelitian formulasi sediaan untuk perawatan rambut yakni kondisioner rambut bilas (rinse-off hair conditioner) yang mengandung ektrak buah kiwi sebanyak 8 formula dengan variasi jenis lemak alkohol (setil alkohol, stearil alkohol, setostearil alkohol dan behenil alkohol) dengan konsentrasi masing-masing 4% untuk mendapatkan formula sediaan kondisioner rambut bilas dengan satu jenis lemak alkohol yang menghasilkan viskositas yang sesuai dan stabil secara fisik. Sediaan ini dibuat dengan cara pemanasan pada suhu 70-80oC dan pencampuran antara fase minyak dan fase air, yaitu fase minyak dicampurkan ke dalam fase air. Sediaan yang dihasilkan dievaluasi secara fisik dan kimia meliputi uji organoleptik, homogenitas, tipe emulsi, viskositas dan sifat alir, sentrifugasi dan ukuran partikel serta pH.

ANALISIS INTERAKSI OBAT ANTIDIABETIK ORAL PADA PASIEN RAWAT JALAN DI RUMAH SAKIT X DEPOK Purnasari, Santi; Jufri, Mahdi; Sari, Dini Permata
Jurnal Farmasi Indonesia Vol 4, No 1 (2008)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v4i1.3

Oral antidiabetic medications has been used over 40 years to control blood glucosa level. Type 2 diabetes mellitus usually complicate with several chronic disease that cause diabetic therapy usually combined with other medications. Â This increase the possibility of drug interaction. The present research was done to reveal the prescribing pattern and drug interaction problem in a hospital (Hospital X) at Depok. Data was collected from 307 prescriptions contain oral antidiabetic which were prescribe during January 2005-May 2006. Result showed that the most prescribe oral antidiabetic medication was glimepiride (45,89%). Drug interaction occurred in 41,69% prescriptions. Using statistical analysis Chi square it was revealed that there is significant correlation between the number of medication in one prescription with the number of drug interaction found. Â ABSTRAK Obat antidiabetik oral telah digunakan selama 40 tahun terakhir untuk mengontrol kadar glukosa darah. Pada pasien diabetes melitus tipe 2 umumnya disertai dengan beberapa penyakit menahun, sehingga dalam terapi diabetes biasanya dikombinasikan dengan obat-obat lain. Hal ini meningkatkan terjadinya interaksi obat yang merugikan pasien. Penelitian ini bertujuan untuk mengetahui gambaran peresepan dan masalah interaksi obat di Rumah Sakit X Depok. Data diambil dari 307 resep obat antidiabetik oral selama bulan Januari 2005-Mei 2006. Obat golongan sulfonilurea yang paling banyak diresepkan adalah glimepirid (45,89%). Sebanyak 41,69% resep obat antidiabetik oral memiliki interaksi. Dengan menggunakan uji stastistik Kai Kuadrat diketahui adanya hubungan yang bermakna antara jumlah obat dalam satu resep yang mengandung obatÂ antidiabetik oral dengan jumlah interaksi obat yang teridentifikasi.

PERENCANAAN DAN PENGADAAN OBAT DI PUSKESMAS SURABAYA TIMUR DAN SELATAN Athijah, Umi; Zairina, Elida; Sukorini, Anila Impian; Rosita, Efrita Mega; Putri, Anindita Pratama
Jurnal Farmasi Indonesia Vol 5, No 1 (2010)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i1.33

Primary Health Center as an organization of public health service has an excellent service quality character, besides qualified medical services. Service will run if the availability and quality of medicines is assured. This study was conducted to get an overview of planning and procurement of medicines at primary health centers. It was observational and descriptive study. The sample was the entire primary health centers in South and East Surabaya (n = 26) and the respondent was the staff of primary health center who manage planning and procurement of medicines. The data was collected by validated questionnaires and check list. Results showed that 57.7% respondents was pharmacists. Non-DOEN generic medicines and patent medicines were provided by 61.5%. The combined method (epidemiology-consumption method) was used by 61.5% staff to calculate the medicine need. The unschedule procurements have been reported by 57.7% respondents. "Received medicine was not always the same with the request" was reported by 69.2% staff. Only 19.2% respondents always check the medicine name, strength, quantity, dosage form, expired date, batch number and physical condition. To conclude, the medicine demand has not been well covered and only a few staff always check the medicines completely. ABSTRAK Penelitian ini dilakukan untuk mendapatkan gambaran tentang perencanaan dan pengadaan obat di puskesmas. Sampel adalah seluruh puskesmas di wilayah Surabaya Selatan dan Timur (n=26) dengan responden yaitu pengelola obat di setiap puskesmas. Pengambilan data menggunakan kuesioner dan check list yang telah divalidasi. Dari penelitian ini diketahui bahwa 57,7% pengelola obat di puskesmas adalah apoteker. Sebanyak 61,5% menyediakan obat generik non-DOEN dan obat paten selain obat generik DOEN yang dipersyaratkan. Metode campuran konsumsi dan epidemiologi digunakan oleh 61,5% pengelola dalam menghitung kebutuhan obat. Permintaan obat di luar jadwal pernah diajukan oleh 57,7% responden. â??Penerimaan obat tidak selalu sama dengan permintaanâ? dilaporkan oleh 69,2% pengelola, namun hasil pengamatan dalam checklist menunjukkan seluruh puskesmas mengalami hal tersebut. Hanya 19,2% responden melakukan pengecekan nama obat, kekuatan, jumlah, bentuk sediaan, tanggal kadaluarsa, nomor lot dan kerusakan obat. Kesimpulan yang diperoleh adalah kebutuhan obat di puskesmas masih belum terpenuhi dengan baik terutama karena faktor pengadaan dan hanya sebagian kecil pengelola obat yang melakukan pengecekan obat secara lengkap.

PERAN AGONIS RESEPTOR OPIOID KAPPA (-) U50,488H DALAM PROSPEK TERAPI GEJALA PUTUS OBAT MORFIN Khotib, Junaidi; SZ, Bambang; Yulistian, .; Syamsiah, Siti; Suzuki, Tsutomu
Jurnal Farmasi Indonesia Vol 3, No 1 (2006)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v3i1.65

Opioid receptor Kappa has different or even contradictive characteristic compare to opioid receptor mu. Stimulation of mu receptor with morphine, phentanyl, or DAMGO shows strengthening effect, locomotor increase, Â euphoria and drug craving, while activation of Kappa receptor by its agonist shows disphoria effect, sedative and drug rejection. This experiment revealed that treatment with 10 mg/kg morphine in group of ICRÂ mice significantly increase the locomotor activity from 490 to 2460 total activity (P<0.001; n=12 each group). This increase was significantly inhibit by selective pre-treatment Kappa receptor agonist (-) U50,488H 3 mg/kg. Drug carving effect was evaluated with conditioning place preference (CPP) method where pre-treatment with (-) U50,488H 3 mg/kg subcutaneous injection also decreased drug carving effect caused by morphine, i.e. from 127 to 30 CPP value (p<0.01).Â ABSTRAK Reseptor opioid kappa mempunyai sifat yang berbeda bahkan bertentangan dengan reseptor opioid mu. Stimulasi reseptor mu dengan morfin, fentanil atau DAMGO menunjukkan efek penguatan, peningkatan lokomotor, euphoria dan keinginan mendapatkan obat kembali (drug craving), sementara aktivasi reseptor kappa oleh agonisnya menunjukkan efek disphoria, sedative dan penolakan obat. Penelitian ini menunjukkan perlakuan dengan morfin 10 mg/kg pada mencit galur ICR meningkatkan secara bermakna efek aktivitas lokomotor dari 490 menjadi 2460 aktivitas total (P<0.001; n=12 tiap kelompok). Peningkatan ini diturunkan secara signifikan dengan pra-perlakuan selektif agonis reseptor kappa (-) U50,488H 3 mg/kg yaitu menjadi 1501 aktivitas total (p<0.01). Efek drug craving dievaluasi dengan metode conditioning place preference (CPP), pra-perlakuan dengan injeksi sub-kutan (-) U50,488H 3 mg/kg juga menurunkan efek drug craving yang disebabkan oleh morfin dari 127 menjadi 30 harga CPP (p<0.01). Untuk menjelaskan mekanisme penurunan gejala putus obat tersebut, dilakukan pengukuran kadar dopamin pada nucleus accumbens dan pengujian aktivitas protein G yang terikat pada reseptor dopamin pada limbic forebrain dengan metode [35S]GTPï§S binding assay. Dari hasil penelitian ini dapat disimpulkan bahwa pra-perlakuan (-) U50,488H dapat menurunkan gejala putus obat yang disebabkan oleh morfin.

Page 24 of 45 | Total Record : 443

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Journal Mail Official
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Dki jakarta

INDONESIA