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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 20 Documents
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Search results for , issue "Vol 20 No 2 (2022): JIFI" : 20 Documents clear
Aktivitas Anti-Acne Daun Turi (Sesbania grandiflora (L.) Poir.) terhadap Propionibacterium acne Alvi Kusuma Wardani; Anna Pradiningsih; Nurul Qiyaam; Shah Iqbal Ikraman Akbar
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1086

Abstract

Turi (Sesbania grandiflora (L.) Poir.) is a native Indonesian plant with many benefits. One of the benefits of Turi leaves is that they can be used as antibacterial agents. Turi leaves contain several compounds with antibacterial bioactivity including tannins, flavonoids, and saponins. This study aimed to examine the activity of Turi leaf extracts against Propionibacterium acne, a bacterium that causes acne. Antibacterial activity testing was performed using the good diffusion method with three replicates. The test groups were X1, X2, and X3, which had extract concentrations of 5%, 7.5%, and 10%, respectively. The positive control group was treated with clindamycin disks. The results of measurements of the diameter of the inhibition zone showed that the mean for groups X1, X2, and X3 were 19.67 mm, 22 mm, and 23.67 mm, respectively. The positive control group was 37 mm. Based on the classifi cation of bacterial growth inhibition responses, the results of the inhibition zone diameter after deducting the good diameter × 10 mm were classifi ed as less eff ective for group X1 and weak for groups X2 and X3. The positive control group was classifi ed as strong. This study concluded that the antiacne activity of Turi leaf extracts at a concentration of less than 10% was weak when compared to the positive control.
Aktivitas Antimikroba Sabun Antiseptik Bunga Eceng Gondok (Eichhornia crassipes) dengan Basis Minyak Jelantah Nangsih Sulastri Slamet; Fihrina Mohamad; Hartati Hartati; Fadli Husain; Zulfiayu Sapiun
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1078

Abstract

Water hyacinth flowers (Eichhornia crassipes) contain antibacterial phenols, flavonoids, alkaloids, tannins, terpenoids, sterols, and glycosides that can be made into antiseptic soaps. Used cooking oil purifi ed with banana peel can be used to make soap. This study aimed to determine how to process used cooking oil, formulate and test antimicrobial antiseptic soaps using water hyacinth flower extract. The method uses antiseptic soap formulated with 10%, 15%, and 20% water hyacinth infusion. Physical, chemical, irritation, and antibacterial testing of the preparation. Used cooking oil is refined and clear, not thick. Water hyacinth flower extract can be formulated into antiseptic soap with a 1.5 cm foam height, cleaning power in criteria 3, pH in the range 9-10, water content >15%, and free alkali content of 0.6- 1.3%. Formula A (19.17 mm), B (20.01 mm), and C have strong antibacterial activity against E. coli based on the diameter of the barrier (20.13 mm). Water hyacinth flower extract and used cooking oil can be used to make antimicrobial antiseptic soap.
Penentuan Kurva Pertumbuhan dan Aktivitas Antibakteri dari Isolat Ekstrak Etil Asetat Bakteri (Te.325) terhadap Staphylococcus aureus dan Escherichia coli Alfian Syarifuddin; Ratna Wijayatri; Ichsan Feri Kurniawan; Herma Fanani Agusta
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1079

Abstract

The development of infection cases and inappropriate use of antibiotics has led to cases of antibiotic resistance. An alternative to overcoming the many antibiotics that are already resistant to bacteria has led to the discovery of new antibiotics. One of the processes of discovering antibiotics is from microorganisms, namely bacteria. The exploration process for the discovery of antibiotics uses a bacterial growth phase approach, namely the stationary phase which produces secondary metabolites, one of, which are bacteria that contain antibiotic compounds. Te.325 isolate is a producer of bacterial antibiotics but The growth phase is not yet known and can be used to approach the process of obtaining antibiotics. The study was to obtain the growth phase time of the Te.325 isolate and to extract antibiotic compounds from the isolate. The determination of the growth curve is based on the weight of cell biomass and the absorbance value on UV/ Vis spectrophotometry of the culture sampled every day for 14 days of culture incubation. The results showed a log/exponential phase on 5th day and a stationary phase on 9th day. The activity test of the ethyl acetate extract was carried out using the well method with an extract concentration of 40%, which resulted in an average diameter of 8.04mm in Staphylococcus aureus and 9.035mm in Escherichia coli. The ethyl acetate extract of Te.325 has medium potency.
Formulasi Sediaan Pelembab Ekstrak Buah Melon Orange (Cucumis melo L. var. reticulatus) Dalam Bentuk Krim Mellisa Laura Mintoro; Farida Lanawati Darsono; Sumi Wijaya
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1164

Abstract

Environmental factors such as extreme sunlight may disrupt skin’s moisture balance and cause the skin to dry out. Therefore, skincare products such as moisturisers are highly needed. In this study, orange melon (Cucumis melo L. var. reticulatus) was added to increase the value of the moisturiser product. Orange melon contains sucrose as the moisturising substance and antioxidant substance which helps to normalize the skin. The extraction process was carried out using juicer. The fruit extract was used at 10% (FI), 20% (FII), and 30% (FIII). This study aims to know the impact of increasing orange melon extract concentration on the physical characteristics of cream and its moisturising effect and antioxidant activity as well as the best formula. The evaluations consisted of physical characteristics, moisturising effect, and antioxidant test with DPPH method. The statistical results showed that the increase in extract concentration significantly affect the physical characteristics (pH, viscosity, spreadibility, ease of removal, adhesivity) and moisturising effect of the creams. Increasing extract concentration would cause a significant increase in the moisturising effect of creams containing synthetic humectants. The best formula which fulfilled the requirements of physical characteristics and effectiveness test, while possessing antioxidant effect was F2 (20% orange melon extract).
Analisis Natrium Siklamat pada Kue Telur Gabus yang Beredar di Pasar Ir Soekarno Sukoharjo Ronal Tolkhah; Makhabbah Jamilatun; Dewi Saraswati Fadhillah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1225

Abstract

Cork egg cake is a traditional cake famous for its sweet taste. Sodium cyclamate is a sweetener that is added to snacks, one of which is cork egg cake. Excess sodium cyclamates can trigger cancer development. The Head of the National Food and Drug Agency of the Republic of Indonesia issued regulation number 4 of 2014 concerning the maximum limit for the use of food additives. The sweetener in the snack food category was 250 mg/kg. This study was conducted to determine the level of sodium cyclamate in cork egg cakes circulating in Ir. Soekarno Sukoharjo market. The type of research was quantitative with a descriptive research design. The method used in this research was qualitative analysis using the precipitation method and quantitative analysis using UV-Vis spectrophotometry. Qualitative analysis showed that samples B and C were positive for sodium cyclamate. The results of the quantitative analysis showed that the average levels of sodium cyclamate in cork egg cakes B and C were 1.02 mg/kg and 1.03 mg/kg. The concentrations of the two samples were still below the limit requirements of BPOM No. 4 in 2014.
Analisis Efektivitas Biaya Seftriakson sebagai Antibiotik Profilaksis Pada Seksio Sesarea: Dosis Tunggal Versus Dosis Berulang Bayu Pertiwi; Hesty Utami Ramadaniati; Prih Sarnianto; Dwirani Amelia
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1084

Abstract

The provision of single-dose prophylactic antibiotics within 30 to 60 minutes before caesarean has been highly recommended, yet its implementation in hospitals varies considerably. This research aimed to analyze the cost-effectiveness of prophylactic antibiotics given a single dose versus multiple doses during caesarean section surgery. A retrospective observational study with a crosssectional design involved pregnant women undergoing caesarean section and receiving a ceftriaxone single dose before surgery (Group 1) versus those receiving multiple ceftriaxone doses (Group 2). The study calculated direct medical costs (hospital perspective), with surgical site infection (SSI) as the effectiveness parameter. The chi-square test was used to compare SSI between the two groups. There were 806 patients (group 1) and A total of 250 patients (Group 2) met the inclusion criteria. Analysis of total cost revealed no significant difference between both groups (approximately IDR 13,000,000/patient), yet patients receiving prolonged Ceftriaxone were associated with significantly higher antibiotic costs (p-0.000). The study documented 1.2% SSI in Group 1 and 0.8% in Group 2 (p=0.742). Calculation of the incremental cost-effectiveness ratio found that an extra IDR 3,278,000 was needed to provide additional success to prevent SSI by administering multiple doses of ceftriaxone. In conclusion, a single dose prophylactic antibiotic provides comparable efficacy to a multiple-dose regimen, but at a lower cost.
Optimalisasi Produksi Fikosianin pada Sianobakteria Laut BTM 11 dan Uji Aktivitas Antioksidannya Baso Didik Hikmawan; Swastika Praharyawan; Kintoko Kintoko
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1198

Abstract

Phycocyanin (PC)-producing cyanobacteria has shown many pharmaceutical applications, the main one is the antioxidant properties. Biosynthesis of PC-producing cyanobacteria is affected by many factors like nitrogen availability and light intensity during cultivation. This study aims to analyze the optimum concentration of nitrogen and light intensity during the cultivation of PC biosynthesis of marine cyanobacteria BTM 11 and identify its antioxidant properties This study was an experimental laboratory method and the PC level was determined through the variation of sodium nitrate (NaNO3) as a source of nitrogen dissolved in media and using different light intensities. The most optimum nitrogen and light intensity values of PC were measured by its antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical capture method. Data was analyzed by one-way ANOVA and the post-hoc Duncan to see whether p<0.05. The result showed that there was a significant difference in the PC level that was cultivated with the variation of NaNO3 concentrations. The highest PC level was observed in media containing 525 mg of NaNO3 and the optimum light intensity of 4500 lux. The result of the antioxidant activity assay showed that the BTM11’s PC’s antioxidant activity had its IC50 at 91.89 μg/mL and the IC50 of ascorbic acid was 2.39 μg/mL
Uji Aktivitas Antibakteri Fraksi n-Heksan, Kloroform, Etil Asetat Rimpang Bangle (Zingiber casumounar Roxb.) terhadap Staphylococcus aureus Hamdayani Lance Abidin; Laode Zubaerdhon; Herlina Rante
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1140

Abstract

The Zingiber casumounar Roxb. It is often used by the public as a traditional medicine for the treatment of rheumatism and throat inflammation. The purpose of this study was to determine the antibacterial activity of the n-hexane fraction, chloroform, and ethyl acetate of the bangle rhizome against Staphylococcus aureus. In this study, antibacterial activity testing of the n-hexane fraction, chloroform, and ethyl acetate of the rhizome of Z. casumounar Roxb was performed. against S. aureus by using the diffusion method. Fractions obtained from the liquid partition results of the ethanol extract 96% of Z. casumounar Roxb. using n-hexane, chloroform, and ethyl acetate. The test results of antibacterial activity of all three fractions indicated the ability to inhibit the growth of S. aureus. Antibacterial activity shows different inhibition zones, namely with an average value in crude extracts of 8.59±0.4 mm, while extracts of n-hexane fractions of 11.67±1.0 mm, chloroform fractions of 11.39±0.6 mm and ethyl acetate fractions of 13.21±0.3 mm. The ethyl acetate fraction had the highest antibacterial activity based on the area of its inhibitory zone.
Aktivitas Anti-inflamasi Parem Instant Tradisional dari Bahan Usada Bali pada Mencit Inflamasi yang Diinduksi Karagenan Putu Era Sandhi Kusuma Yuda; Gusti Ayu Putu Yosinta Sasmita; Erna Cahyaningsih
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1076

Abstract

The increase of adverse reactions from anti-inflammatory drugs that are used in the long term by rheumatic patients requires a relatively safer alternative therapy. This research was aimed to evaluate the effectiveness of Usada Bali's instant parem (BIO-PAREM) as an anti-inflammatory agent against carrageenan-induced inflammatory mice. The method used was randomized pre-test and post-test with control group design using 24 mice which were divided into 4 treatment groups. The negative control group was given a vehicle, the positive control group was given anti-inflammatory gel of diclofenac sodium, group 3 (P1) was given BIO-PAREM with a concentration of 12.5% and group 4 (P2) was given BIO-PAREM with a concentration of 25%. All groups were induced with 1% carrageenan, then the mice's paw edema volume was calculated using a plethysmometer at 0, 1, 2, 3, and 4 hours. The Kruskal Wallis and Mann Whitney test were used to analyse the relative change of inflammation volume. The BIO-PAREM phytochemical screening assay showed the presence of alkaloids, flavonoids, tannins, steroids and triterpenoids. BIO-PAREM showed significant inhibition of mice's paw edema at concentrations of 12.5% and 25% (p <0.05) indicating its potential as a candidate for topical alternative treatment for rheumatism.
Mekanisme Molekuler Imunomodulasi oleh Huangqi (Astragali Radix) Menggunakan Sistem Farmakologi Jejaring Raymond Rubianto Tjandrawinata; Anindini Winda Amalia; Hartati Tuna; Viedya Novalinda Said; Santi Tan
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1301

Abstract

Astragali Radix (Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao, also known as Huangqi) has been used to improve stamina and immunity for thousands of years. However, the bioactive components and their mechanisms are still unclear, limiting its clinical application. In this research, for the first time, network pharmacology was used to investigate the molecular mechanisms of Huangqi and its bioactive components that play an important role in improving the immune system. An amount of 1,430 immunomodulation-related target proteins was collected from the human genome database, with 171 target proteins from 20 bioactive components, and resulted in 60 intersection target proteins. Subsequently, the networks of common target and protein-protein interaction (PPI) were analyzed. The results showed that Huangqi influenced the modulations of lymphocytes (B cells and T cells), natural killer cells, macrophages, cytokines, immunoglobulins, and immune signal transduction. To a certain limit, this study revealed the potential bioactive components and pharmacological mechanisms of Huangqi in immunomodulation. It was able to direct novel drug development for treating immune system deficiency.

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